ライフサイエンスコーパス: autonomous

1 djacent mutant blood vessels (i.e., cell-non autonomous).

2 -CreCbfb+/56M mice, and this effect was cell autonomous.

3 th the notion that plant sanctioning is cell autonomous.

4 However, non-cell-autonomous activation of specific oncogenic pathways mig

5 ively patterned by D2-SPNs even though their autonomous activity is upregulated, (3) despite being di

6 s and obtain a policy that can be used by an autonomous aerial vehicle operating in a cluttered envir

7 The autonomous AI evaluation rules introduced here can help

8 d risks as well as the potential benefits of autonomous AI for their patients.

9 Ensuring that autonomous AI provides these benefits requires evaluatio

10 king decisions of high cognitive complexity; autonomous AI systems in healthcare are AI systems that

11 es these benefits requires evaluation of the autonomous AI's effect on patient outcome, design, valid

12 standing the potential risks and benefits of autonomous AI, and understand its design, safety, effica

13 les for AI, and derived evaluation rules for autonomous AI, grounded in bioethical principles.

14 emic Akt1 deletion inhibits metastasis, cell-autonomous Akt1 deletion does not.

15 mmary tumorigenesis and metastasis, but cell-autonomous Akt2 deletion prevents breast cancer tumorige

16 ental Sample Processor (ESP), was tested for autonomous analysis of eDNA from four commercial fish sp

17 This sequential dysregulation of tumor non-autonomous and -autonomous EGF signaling converts tissue

18 and provide critical neuromodulation to many autonomous and cognitive brain functions.

19 Herein, an autonomous and degradable, active microneedle delivery p

20 ese 12-h rhythms of gene expression are cell autonomous and evolutionarily conserved in marine animal

21 ctedly, this behavior is epithelial cell non-autonomous and independent of an intact immune system.

22 evelopment is determined by both cancer cell-autonomous and microenvironmental mechanisms, including

23 e that MYC is coordinately regulated by cell-autonomous and microenvironmental signals, and establish

24 , which through NRF2 drives HCC through cell-autonomous and non-autonomous mechanisms.

25 The cell-autonomous and non-autonomous roles of altered BCAA meta

26 surrounding stromal and immune cells through autonomous and non-autonomous signaling can influence co

27 rocyte function, which could impact the cell autonomous and non-cell autonomous contribution of astro

28 f MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene e

29 c transformation and survival in both a cell autonomous and non-cell autonomous manner.

30 tor during development, performing dual cell-autonomous and non-cell-autonomous functions.This articl

31 e, which were integrated to induce both cell-autonomous and non-cell-autonomous responses and transcr

32 Modular construction of an autonomous and programmable multi-functional heterogeneo

33 mental functions of p75 are largely cell non-autonomous and require p75 expression in other cell type

34 that the balance between opposing tumor cell-autonomous and stromal effects may determine net outcome

35 entified profound discrepancies between cell-autonomous and systemic Akt1- or Akt2-inducible deletion

36 irst, we analyse SCN timekeeping at the cell-autonomous and the circuit-based levels of organisation.

37 light emitting materials, but these are not autonomous, and do not use physical mutations.

38 t the expression of CMF genes in ECs is cell-autonomous, and not simply a result of technical contami

39 al marker of autophagy, that promotes a cell-autonomous antiviral response that arose before evolutio

40 Our cell-autonomous approach enabled parallel programming of hPSC

41 d octopus nervous system mediates relatively autonomous arm behavior is unknown.

42 Building autonomous artificial cells capable of homeostasis requi

43 a basolateral polarity regulator, in a layer autonomous as well non-autonomous manner.

44 mice from HFD-induced diabetes is beta-cell autonomous, as beta cell-specific Galpha(z)-null mice ph

45 gest that the model should also include cell-autonomous aspects, as well as the use of structural fea

46 tissue lipolysis independently of adipocyte-autonomous ATGL, and thereby worsen organ failure.

47 chromatin tethering to the nuclear envelope, autonomous behavior of small genomic segments, and euchr

48 d vision maturation, independently influence autonomous behaviours in healthy children.

49 thematical modeling to elaborate the minimal autonomous biochemical machinery necessary and sufficien

50 anslation feedback loops that establish cell-autonomous biological timing of ~24 h.

51 This feedback is predicted to be chromosome autonomous, but this has not been tested.

52 Our data suggest that EHD2 controls a cell-autonomous, caveolae-dependent fatty acid uptake pathway

53 evelop robust tau pathology in a 3D non-cell autonomous cell culture system.

54 ds to severe behavioral defects and non-cell autonomous changes in neurons.

55 edesign online environments for informed and autonomous choice.

56 her than to promote deliberate cognition and autonomous choice; information overload, finely tuned pe

57 The mammalian cell-autonomous circadian clock is built around a self-sustai

58 Cell-autonomous circadian system, consisting of core clock ge

59 To achieve this, cell-autonomous circadian timing by the ~20,000 SCN cells is

60 that the SFO contains an unexpectedly robust autonomous clock with unusual spatiotemporal characteris

61 subjects, implying a role for the islet cell-autonomous clocks in T2D progression.

62 rsectional genetic manipulations of the cell-autonomous clockwork can be used to determine how SCN ce

63 Autonomous closed-loop experimentation combined with adv

64 could be used in a variety of other non-cell-autonomous communication mechanisms.

65 To explore non-cell-autonomous components of AF substrate, we also created a

66 ould impact the cell autonomous and non-cell autonomous contribution of astrocytes to neurodegenerati

67 Importantly, Dg-Dys complex-mediated cell-autonomous control of F-actin fiber orientation relies o

68 during male sexual maturation under the cell-autonomous control of the sex-determination pathway.

69 , and has been previously linked to non-cell autonomous control of tumor growth and metastasis, howev

70 rning is an effective solution to real-world autonomous control problems in which neither conventiona

71 his improved algorithm yields more efficient autonomous data collection.

72 efits that result from including them in the autonomous decision-making process.

73 tion reveals that SAM loss results in a cell-autonomous defect in the proliferative expansion of myob

74 lation of innate immune receptors and a cell-autonomous defense mechanism that restricts the replicat

75 Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury.

76 Cas9 restriction to male germ cells elicits autonomous double-strand-break repair, consequently crea

77 APC(-/-) tumors induce rho in tumor cells by autonomous downregulation of E-cadherin (E-cad) and cons

78 ted to grow significantly with the advent of autonomous driving, which might render on-demand mobilit

79 tools in remote sensing, robotic vision, and autonomous driving.

80 In this work, we created an autonomous dual-control (ADC) system, by combining CRISP

81 Such versatile and effective autonomous dynamic microneedle delivery technology offer

82 has been modeled by a new three-dimensional autonomous dynamical system exhibiting very particular p

83 backbone technology for global collaborative autonomous ecosystem monitoring efforts.

84 ement in microelectronics technology enables autonomous edge computing platforms in the size of a dus

85 We reveal that the non-cell-autonomous effect of MyHC-emb on myogenic progenitors an

86 odegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS.

87 tially regulate cell autonomous and non-cell autonomous effects of oncogene expression.

88 Together, our data support cell-autonomous effects of vascular apoE on brain homeostasis

89 specific p53 activation, suggesting non-cell-autonomous effects.

90 and impaired fecundity, suggesting non-cell-autonomous effects.

91 l dysregulation of tumor non-autonomous and -autonomous EGF signaling converts tissue-level feedback

92 This integration paves the way towards fully autonomous electrochemical devices, in which the integra

93 one potential solution to energizing energy autonomous electronics, such as internet-of-things senso

94 bovine antibody knob domains can function as autonomous entities by binding antigen outside the confi

95 ith beta-catenin signaling, resulted in cell-autonomous EPO transcription in mouse and human hepatocy

96 nsient DNA polymerization systems, achieving autonomous evolution over multiple structural dynamic st

97 ently demonstrated a generalized approach to autonomous experimental control, based on generating a s

98 Methods for autonomous experimentation have become more sophisticate

99 ess than 10 mg, and machine-learning-enabled autonomous experimentation identifies stable composition

100 Autonomous experimentation is an emerging paradigm for s

101 The development of high-throughput and autonomous experimentation methods is reported for the e

102 validate a conditional mouse model for cell-autonomous expression of galactocerebrosidase (GALC), th

103 nd the first in vivo demonstration that cell-autonomous expression of mutant KIT in the ICC lineage l

104 These results highlight the diverse cell-autonomous expression of PI5P4Kalpha and PI5P4Kbeta and

105 nsfer from parenchymal cells to ECs, or cell-autonomous expression of these mRNAs in ECs.

106 We propose that SMAPs are autonomous extracellular killing entities that deliver c

107 that DSB number is regulated in a chromosome-autonomous fashion and provide insight into how homeosta

108 Moreover, TLR9 functions in a muscle-autonomous fashion in ex vivo contraction-induced AMPK a

109 ation potential of the V-SVZ niche in a cell-autonomous fashion.

110 orizontal cell defects in a potentially cell-autonomous fashion.

111 diation in a previously unreported non--cell-autonomous fashion; in addition, Crb1 delays UV and blue

112 equire Nodal signaling in both cell- and non-autonomous fashions.

113 chymal progenitor cells (MPCs) that manifest autonomous fibrogenicity in xenograft models.

114 the elongation zone confirmed that roots are autonomous for GA biosynthesis, which occurs in multiple

115 -a large serine site-specific recombinase-is autonomous for phage integration (attP x attB recombinat

116 ally amplify the prescribed sequence through autonomous formation of a signaling concatemer.

117 e next generation of materials with embedded autonomous function are suggested.

118 ver, we reveal a lung cancer epithelial cell-autonomous function for p38alpha promoting the expressio

119 elop in the absence of T and suggests a cell-autonomous function of T as a gatekeeper between paraxia

120 unction molecule, which is regulated by cell-autonomous function of the worm homologs of a NMDAR subu

121 Class A PBPs thus constitute an autonomous functional entity which processes recently fo

122 performing dual cell-autonomous and non-cell-autonomous functions.This article has an associated 'The

123 of a cytomegalovirus (CMV) promoter confirms autonomous genome replication in transfected cells, with

124 lease of insulin is achieved highlighting an autonomous glucose-responsive microdevice operating as a

125 We demonstrate an autonomous, high-throughput mechanism for sorting of emu

126 The successful development of autonomous, highly controlled light-driven soft robots c

127 endent LC3B lipidation that may mediate cell-autonomous host defense, an unanticipated mechanism that

128 of differentiated cells resulted in non-cell-autonomous hyperproliferation of stem cells and prevente

129 eveloped a general methodology for rapid and autonomous identification of the crystal symmetry from E

130 n wild-type epithelia by inducing, via a non-autonomous IL-1beta-driven mechanism, both hyperplasia a

131 this technology, implements 24/7 continuous autonomous imaging, and enables the acquisition of petas

132 viral cap snatching and regulation of a cell autonomous immune response, and provides synergistic pro

133 ng stress signaling through a genuine tissue-autonomous immune response.

134 However, IFNgamma-dependent cell-autonomous immunity can destroy the vacuole and the para

135 w the Toxoplasma effector GRA15 affects cell-autonomous immunity in human and murine cells.

136 the extent to which Nurse Practitioners are autonomous in a state (Independent, Collaboration or Sup

137 udy demonstrates strong potential for remote autonomous in situ monitoring which open new possibiliti

138 reproductive tissues are being developed as autonomous in vitro units or as integrated multi-organ i

139 hat TDP-43-deleted astrocytes exhibit a cell-autonomous increase in GFAP immunoreactivity without aff

140 , various forms of swarming enable groups of autonomous individuals to transform uncertain informatio

141 These data show that both PDGFRs are cell-autonomous inhibitors of adipocyte differentiation and i

142 ed signaling molecules required for cell non-autonomous intestinal UPR(ER) activation, including the

143 eding, suggesting that Rab27a may alter cell-autonomous invasive properties of the tumor cells.

144 iron enzymes, and misregulation of the cell-autonomous iron regulatory system.

145 rily conserved gene product, Vip1, possesses autonomous kinase and pyrophosphatase domains capable of

146 sults uncover a previously unrecognized cell-autonomous, light-sensing mechanism in brown adipocytes

147 ature and extent of EPF peptides as non-cell autonomous local signals and provide a means for quantit

148 s pH-responsive cap dissolves, promoting the autonomous localized cargo release.

149 Our group recently characterized a cell-autonomous mammalian 12-h clock independent from the cir

150 ll leukemia/lymphoma 6 (BCL6) acts in a cell-autonomous manner to regulate the commitment but not the

151 nd senescence in larval tissues in a noncell autonomous manner, creating an inflammatory environment.

152 regulator, in a layer autonomous as well non-autonomous manner.

153 ysfunction, and hyperproliferation in a cell-autonomous manner.

154 mere shortening promotes cancer in a noncell autonomous manner.

155 to promote cell proliferation beyond a cell-autonomous manner.

156 d B cell development in a hematopoietic cell-autonomous manner.

157 vation can induce astrogenesis in a non-cell autonomous manner.

158 h factor beta (TGF-beta) signaling in a cell-autonomous manner.

159 that retain their spatial identity in a cell autonomous manner.

160 vival in both a cell autonomous and non-cell autonomous manner.

161 ines and immunomodulatory proteins in a cell-autonomous manner.

162 -cadherin in the second layer in a layer non-autonomous manner.

163 tivation of the B2 family of SINEs in a cell-autonomous manner.

164 rrow and stimulates granulopoiesis in a cell-autonomous manner.

165 ual insights into fuel-driven automatons and autonomous materials design.

166 We demonstrate an autonomous materials discovery methodology for functiona

167 er aid the field and help the development of autonomous materials with life-like properties.

168 Over many hours, this autonomous mechanism alone can lead to a change in the d

169 s (hepatocyte-like cells) is the primary non-autonomous mechanism for cardiac aging.

170 ociated fibroblasts, representing a non-cell autonomous mechanism for colon cancer progression.

171 motoneuron properties do not mature by cell autonomous mechanisms alone, but also depend on developi

172 Finally, we highlight how tumour cell-autonomous mechanisms might be exploited by combining DD

173 Cardiac myocytes have multiple cell autonomous mechanisms that facilitate stabilization and

174 We suggest that in addition to autonomous mechanisms, motoneuron development depends on

175 rmal function in the V-SVZ also involves non-autonomous mechanisms.

176 2 drives HCC through cell-autonomous and non-autonomous mechanisms.

177 s in the tumor microenvironment via non-cell-autonomous mechanisms.

178 omatically and continuously cleansed by cell-autonomous mechanisms.

179 ng recognition of the importance of non-cell autonomous-mediated neurotoxicity, it is critical to inv

180 , a known secreted YAP target, is a non-cell autonomous mediator of cell survival, while another unid

181 While truly autonomous medical robotic systems are still beyond reac

182 Thus, we demonstrate a non-cell-autonomous metabolic mechanism that controls the fate of

183 tly overlap those of BP, implying a non-cell autonomous mode of meristem control via one or more GSL

184 ibutions could not be fit by any simple cell-autonomous model of growth arrest, yet were easily fit b

185 h either their binding to allergens or their autonomous modulation of immune receptors.

186 show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling prod

187 ing new modular approaches for the design of autonomous molecular machines that emulate nature's fine

188 observed tuning behavior in the coherence of autonomous motion of the coupled system.

189 Moreover, the evolutionarily optimized autonomous MtCM, which had 11 of its 90 amino acids exch

190 ich the same signaling pathway promotes both autonomous muscle growth and non-autonomous synapse grow

191 We find that cell-autonomous mutations within interneurons disrupts morpho

192 d failures along the way highlighted how the autonomous nature of the American academic research ente

193 ield of view, with potential applications in autonomous navigation, reconnaissance, and even medical

194 or artificial intelligence and robotics with autonomous navigation.

195 Thus, we identified a novel non-cell autonomous neuroprotective signaling cascade mediated th

196 of eukaryotic cells, thereby providing cell-autonomous nutrients and removing harmful cargos.

197 control in normal tissues, than to any cell-autonomous, 'oncogene-induced' program of senescence.

198 omotypic BCR-BCR interaction that results in autonomous, oncogenic BCR signaling after acquiring R110

199 A gene signature reflecting tumor cell-autonomous PADI4 inhibition was associated with poor out

200 concept that IPF fibroblasts acquire a cell-autonomous pathological phenotype early in their differe

201 avior is consistent with a role for M1 as an autonomous pattern generator that drives muscles to give

202 PDX) cells, ultimately resulting in non-cell-autonomous PIM1 upregulation by endogenous IL7.

203 tumour-derived antigens, cDC1 function as an autonomous platform capable of antigen processing and pr

204 effectively design and interact with future autonomous platforms.

205 novo authorization of an example, the first autonomous point-of-care diabetic retinopathy examinatio

206 The differentiation of the medulla is a cell-autonomous process based on chromosomal sex identity (CA

207 elopment has traditionally been viewed as an autonomous process directed by the host genome.

208 to melanoma, is widely attributed to a cell-autonomous process of 'oncogene-induced senescence'.

209 ath from mitochondrial dysfunction is a cell-autonomous process.

210 By only assuming a memoryless Markov (autonomous) process, the types of dynamics represented a

211 Adoption of autonomous processes such as self-filtration, capillary

212 gen donors, enhances scar formation via cell autonomous production of collagen.

213 ramme of cancer cells facilitates their cell-autonomous proliferation and survival.

214 Controlling autonomous propulsion of microswimmers is essential for

215 ated the mechanisms underlying this non-cell-autonomous protective signaling in the inner ear.

216 regulates dendritic HCN channels via a cell-autonomous protein--protein mechanism.

217 that FMRP regulates HCN channels via a cell-autonomous protein-protein interaction.

218 ssion of pleiotrophin (PTN) and require cell-autonomous PTN signaling for CML pathogenesis in BCR/ABL

219 pment in BCR/ABL+ mice, suggesting that cell-autonomous PTN signaling was necessary for CML disease e

220 Human CML cells were also dependent on cell-autonomous PTN signaling, and anti-PTN antibody suppress

221 nhibition of coincident D2-SPN activity, (3) autonomous PV GPe neuron firing ex vivo was upregulated,

222 Integration of autonomous RAS can be viewed as a positive aid, but it m

223 n and the first data from clinical trials of autonomous RAS in urology are being published.

224 Now, autonomous RAS is on the horizon and the first data from

225 provides fundamental information concerning autonomous red light signaling pathways in guard cells.

226 The PTHS mouse models showed cell-autonomous reductions in OL numbers and myelination, fun

227 upon dietary challenges caused by adipocyte-autonomous regulation in vivo.

228 om non-cardiac tissues contribute to the non-autonomous regulation of age-related cardiac dysfunction

229 specific peroxisomal import in mediating non-autonomous regulation of cardiac aging.

230 and glucagon-positive cells through non-cell-autonomous regulation of ECM-integrin interactions and s

231 Thus, CD95 is part of a complex cell autonomous regulatory network that involves activation o

232 The sequential dissolution and autonomous release of the chemoattractant and killing ag

233 Autonomous replication and segregation of mitochondrial

234 the critical function of TBK1 as a beta-cell autonomous replication barrier and present PIAA as a val

235 Altogether, our data support a cell-autonomous requirement for Med23 in neural crest cells,

236 to induce both cell-autonomous and non-cell-autonomous responses and transcriptional plasticity.

237 xonal compartments allows for short-term and autonomous responses to extrinsic cues.

238 persed element-1 (LINE-1, or L1) is the only autonomous retrotransposon that is active in human cells

239 CD4(+) T cells lacking Nod2 reveals a T cell-autonomous, Rip2-independent mechanism for Nod2 in uveit

240 lution of the plant CME mechanism during the autonomous rise of multicellularity in eukaryotes.

241 the current state of online diagnostics and autonomous robotic experimentation strategies, toward th

242 les building a variety of reconfigurable and autonomous robots at both colloidal scales and macroscal

243 Autonomous rodent protoparvoviruses (PVs) are promising

244 niae cells to show that class A PBPs have an autonomous role during pneumococcal cell wall synthesis.

245 analysis of this mouse model reveals a cell autonomous role for GALC in the development and maturati

246 rmatid-related phenotypes, suggesting a cell autonomous role for MAFR-1 in nematode male fertility.

247 Our findings support a cell-autonomous role for postsynaptic neuronal SR in regulati

248 mice from both sexes, we demonstrate a cell-autonomous role for SR in regulating synaptic NMDAR func

249 erentiation suggesting a continuous and cell autonomous role for TGFbeta signaling in cell fate maint

250 urther, we find that beta-catenin has a cell autonomous role in the development of a medullary subset

251 Thus, apart from the cell autonomous role of short telomeres in contributing to ge

252 These results highlight the autonomous role the VDR has within skeletal muscle mass

253 onstrating a previously uncharacterized cell-autonomous role.

254 The cell-autonomous and non-autonomous roles of altered BCAA metabolism have been im

255 applications such as precision spraying and autonomous scouts.

256 This autonomous search identified photocatalyst mixtures that

257 search for areas of reactivity found through autonomous selection of the reagent types, amounts, and

258 Since two autonomous self-healing mechanisms result from viscoelas

259 tic polyurethane fibers and films capable of autonomous self-healing under ambient conditions.

260 Thus, the integration of chromosome-autonomous signaling and a nucleus-wide crossover-counti

261 and immune cells through autonomous and non-autonomous signaling can influence competition for survi

262 1 (-/-) fish to survive, suggesting cell non-autonomous signaling from hepatocytes.

263 arch highlighting the importance of cell non-autonomous signaling in modulating aging from C. elegans

264 nts illustrating the key role of tumour cell-autonomous signalling after radiotherapy.

265 broblasts (CAFs) cooperates with cancer cell-autonomous signals to increase MYC level, promoter occup

266 TEIN 1 (SRBP1) family that mediates non-cell-autonomous small RNA (sRNA) trafficking.

267 Active fluids comprised of autonomous spinning units injecting energy and angular m

268 r results reveal the existence of a non-cell-autonomous "Stentian" signal, engaged by activation of n

269 nal Sox9 expression also results in cell-non-autonomous stimulation of BP proliferation followed by i

270 tation, self-reactive B cells exhibit a cell-autonomous subversion of their response to self-antigen:

271 Some of these effects are cell autonomous, such as proliferation, while others are medi

272 Autonomous switches are key elements for improving the h

273 omotes both autonomous muscle growth and non-autonomous synapse growth.

274 Using this platform, we studied the autonomous synthesis and assembly of a structural comple

275 on three main challenges: 1) how to specify autonomous system behavior in the face of unpredictabili

276 independent cycles of evolution we show our autonomous system can produce spherical nanoparticles, r

277 The real-time closed-loop, autonomous system for materials exploration and optimiza

278 lity, and lifetime of their proteins with an autonomous system of chaperones, but the signals that di

279 focus a closed-loop, active learning-driven autonomous system on another major challenge, the discov

280 s suggest a dual guidance model, in which an autonomous system, involving interaction between cellulo

281 ction as belonging to different levels of an autonomous systems hierarchy.

282 ed foundation for developing next-generation autonomous systems is a must, and term the desired found

283 The hierarchy of autonomous systems that we put forth accounts for vocal

284 Use of autonomous technologies in the operating theatre will di

285 nique differences that suggest DlEPV is more autonomous than other long-term viral associations descr

286 c manipulations have been used to probe cell-autonomous timing in the SCN, identifying the integral c

287 extracellular isoforms of the protein and is autonomous to motor neurons.

288 ion of RXR suggesting that RXR may act as an autonomous transcription factor.

289 They are generated by cell-autonomous, transcriptional/translational feedback loops

290 To study the ability of monocytes to undergo autonomous transendothelial extravasation under biologic

291 tersectional genetics to manipulate the cell-autonomous TTFLs of VPAC2-expressing cells.

292 ed at submeter horizontal resolution from an autonomous underwater vehicle, enables calculation of ic

293 mune system is also a group of decentralized autonomous units (i.e. cells) which collectively navigat

294 However, achieving dynamic and autonomous up- and down-regulation of the metabolic modu

295 Autonomous vehicles (AVs) have the potential to shape ur

296 The transition of autonomous vehicles into fleets requires an advanced con

297 Autonomous water sampling technologies may help to overc

298 ctions of p75 in geniculate neurons are cell autonomous, we deleted p75 specifically in Phox2b + oral

299 ading the literature, leading to a universal autonomous workflow.

300 ction of systemic muscle wasting with tumour-autonomous Yorkie-mediated SLC36-family amino acid trans