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1 unisertib compared with those with increased autotaxin.
2 e responsible for a significant secretion of autotaxin.
3 ranscript for the major LPA-producing enzyme autotaxin.
4 r A7, angiopoetin 1, endothelial lipase, and autotaxin.
5  and a species homolog of the human cytokine autotaxin.
6 78 and comparable to or better than those of autotaxin (0.78), FIB-4 index (0.78), and APRI (0.76).
7 oach is illustrated with the results against autotaxin, a phospholipase implicated in cardiovascular
8                          Here, we found that autotaxin, a secreted enzyme that promotes inflammation
9 phosphonate (16c) mimicked LPA in inhibiting autotaxin, a secreted lysophospholipase D that produces
10 phatidylcholine variants indicates localized autotaxin activation and lysophosphatidic acid release.
11                                              Autotaxin activity increases locally following lung inju
12                         Serum bile acids and autotaxin activity remained unchanged.
13 lcholine for immunomodulation, inhibition of autotaxin activity, and/or blockade of lysophosphatidic
14 osphatidic acid (LPA), a lipid by-product of autotaxin activity, is involved in cancer, vascular defe
15                                              Autotaxin, an LPA synthesizing enzyme was upregulated in
16 fied mechanism by which galectin-3 regulates autotaxin and assign a novel role for NFAT1 during melan
17                             Plasma levels of autotaxin and its enzymatic product, lysophosphatidic ac
18 (50) = 0.24 muM, K(D) = 19.6 nM; inactive at autotaxin and LPA(2-6) receptors).
19  These data indicate that elevated levels of autotaxin and soluble markers of immune activation durin
20 o-enzymes, with notable exceptions of ENPP2 (Autotaxin) and ENNP6, which are secreted and glycosylpho
21  purines (CD38, CD39, CD73, ENPP1, and ENPP2/autotaxin), and signaling by key P2 purinergic receptors
22 actor family 4-1BB ligand, ephrin B1, stra6, autotaxin, and ISLR.
23 drive adaptive resistance in PDAC, revealing autotaxin as a therapeutic target and biomarker of galun
24             In this study, we validate Enpp2/Autotaxin as one of the highest expressed signature gene
25  expression of the autocrine motility factor autotaxin, as determined by Affymetrix gene chip, real-t
26                                       Plasma autotaxin associated with platelets during aggregation a
27                                              Autotaxin (ATX or ENPP2) is a secreted lysophospholipase
28        The extracellular lysophospholipase D autotaxin (ATX) and its product, lysophosphatidic acid,
29 r in EOC ascites, is an enzymatic product of autotaxin (ATX) and phospholipase A(2) (PLA(2))enzymes.
30 ented here identify the extracellular factor autotaxin (ATX) as a novel upstream signal modulating HD
31 program of forming joints, we used GDF-5 and Autotaxin (Atx) as joint tissue specific markers, and So
32 dic acid (LPA) are synthesized by the enzyme autotaxin (ATX) at cortical synapses and modulate glutam
33 d lipid, cytokines, phospholipase (PLA), and autotaxin (ATX) concentration.
34                                              Autotaxin (ATX) facilitates the hydrolysis of lysophosph
35                                              Autotaxin (ATX) generates the lipid mediator lysophospha
36 r3 or inhibition of the LPA-producing enzyme autotaxin (ATX) in pregnant mice leads to HB-EGF and COX
37                      We examined the role of autotaxin (ATX) in pulmonary LPA production during fibro
38                                              Autotaxin (ATX) is a key LPA-producing enzyme, and we hy
39                                              Autotaxin (ATX) is a secreted enzyme playing a major rol
40                                              Autotaxin (ATX) is a secreted enzyme responsible for the
41                                              Autotaxin (ATX) is a secreted enzyme that hydrolyzes lys
42                                              Autotaxin (ATX) is a secreted glycoprotein with lysophos
43                                              Autotaxin (ATX) is a secreted lysophospholipase D (lysoP
44                                              Autotaxin (ATX) is a secreted lysophospholipase D that c
45                                              Autotaxin (ATX) is a secreted lysophospholipase D that g
46                                              Autotaxin (ATX) is a secreted lysophospholipase D that g
47                                              Autotaxin (ATX) is a secreted lysophospholipase D that h
48                                              Autotaxin (ATX) is an ectoenzyme that catalyzes the conv
49                                              Autotaxin (ATX) is an exoenzyme that potently induces tu
50                                              Autotaxin (ATX) is an extracellular enzyme and an autocr
51 s modulated by the LPA-synthesizing molecule autotaxin (ATX) present in astrocytic perisynaptic proce
52 s, which are converted by fibroblast-derived autotaxin (ATX) to LPA.
53                                              Autotaxin (ATX) transforms lysophosphatidylcholine into
54                                              Autotaxin (ATX), a lysophospholipase D, plays an importa
55           LPA is produced extracellularly by autotaxin (ATX), a secreted lysophospholipase D, from ly
56 ramatically (approximately 100-fold) encodes Autotaxin (ATX), a secreted tumor motility-promoting fac
57 udy describes the identification and role of autotaxin (ATX), a secretory protein and a major source
58                     A key discovery was that autotaxin (ATX), an enzyme previously implicated in canc
59                                              Autotaxin (ATX), an exo-nucleotide pyrophosphatase and p
60 l evidence implicated the lysophospholipase, autotaxin (ATX), and its product, lysophosphatidic acid
61 8, monocyte chemoattractant protein (MCP-1), autotaxin (ATX), and Mac2-binding protein (Mac2BP) were
62                     We found that the enzyme autotaxin (ATX), and the metabolite it produces, lysopho
63 d by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an ar
64 clear factor of activated T cells 2 (NFAT1), autotaxin (ATX), lysophosphatidic acid (LPA), and beta-c
65 ial for the motility stimulating activity of autotaxin (ATX), one member of the exophosphodiesterase
66                                              Autotaxin (ATX), through its lysophospholipase D activit
67 ubstrate of the secreted lysophospholipase D autotaxin (ATX), which generates two bioactive lipids, l
68            Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospho
69 (+) monocytes were cultured with LPC, or its autotaxin (ATX)-derived product, lysophosphatidic acid (
70  Previous studies provide high evidence that autotaxin (ATX)-lysophosphatidic acid (LPA) signaling th
71 sor of autocrine motility-stimulating factor Autotaxin (ATX).
72 ted neuronal activation molecules, including autotaxin (ATX, Enpp2), LPA receptor 1/3 (LPA1/3), betaC
73                         Dysregulation of the autotaxin (ATX, Enpp2)-lysophosphatidic acid (LPA) signa
74                                              Autotaxin (ATX, NPP2) has recently been shown to be the
75                                              Autotaxin (ATX, nucleotide pyrophosphate/phosphodiestera
76 ll membrane glycoprotein 1 (PC-1, or PDNP1), autotaxin (ATX, or PDNP2), and B10/PDNP3.
77 o LPA by the lysophospholipase D activity of autotaxin (ATX/lysoPLD).
78 acid (LPA), a potent neuronal activator, and autotaxin (ATX; ectonucleotide pyrophosphatase/phosphodi
79 mal models express significant quantities of autotaxin (ATX; ENPP2), a lysophospholipase D that catal
80                                              Autotaxin [ATX (NPP-2)], originally isolated as a tumor
81                                              Autotaxin determines colitis severity in mice and is sec
82  with itch severity and, in combination with autotaxin, distinguished pregnant women with itch that w
83 profiling identified the protumorigenic gene autotaxin (ENPP2) to be downregulated after silencing ga
84 tein expression, which resulted in decreased autotaxin expression and activity.
85     Here we report that galectin-3 regulates autotaxin expression at the transcriptional level by mod
86 nd that the alpha6beta4 integrin potentiates autotaxin expression through the upregulation and activa
87 ng sites in the promoter region of the mouse autotaxin gene (ATX, ENPP2), which we were able to verif
88 noma growth and metastasis by regulating the autotaxin gene (Enpp2).
89 s including osteoprotegerin, syndecan-2, and autotaxin have been refined from the general locations p
90                              Reexpression of autotaxin in galectin-3 silenced melanoma cells rescues
91 grin alpha6beta4-dependent overexpression of autotaxin in MDA-MB-435 cells is mediated by NFAT1, but
92 tib significantly increased plasma levels of autotaxin in patients enrolled in the H9H-MC-JBAJ study,
93                                    Paracrine autotaxin increased LPA-NFkappaB signaling in tumor cell
94                                          The autotaxin inhibitor IOA-289 suppressed NFkappaB activati
95        Structural modifications of the known autotaxin inhibitor lead compound 1, to attenuate hERG i
96                                           An autotaxin inhibitor was used to validate the iSCAR late
97 ibitors (bile salts) into potent competitive Autotaxin inhibitors that do not interact with the catal
98 h the use of siRNAs that specifically target autotaxin, integrin beta4, NFAT1 and NFAT5.
99                We evaluated plasma levels of autotaxin, interleukin 6 (IL-6), soluble CD14 (sCD14), s
100                                              Autotaxin is a circulating enzyme with a major role in t
101 ritical in regulating key fibrogenic protein autotaxin, leading to sustained beta-catenin activation
102                                              Autotaxin levels correlated with IL-6, sCD14, sCD163, Ma
103                   We observed greater plasma autotaxin levels in HCV-infected and HCV-HIV-coinfected
104 d by TGFbeta inhibition and that circulating autotaxin levels predict response to the combination tre
105                                              Autotaxin, LPA, and sCD14 levels normalized, while sCD16
106                               A role for the autotaxin/LPA axis has been suggested in many disease ar
107 gated LPA-stimulated vascular Akt signaling, autotaxin/LPA-driven phosphorylation of Akt and cyclin D
108                                          The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathw
109                 This study characterizes the autotaxin-lysophosphatidic acid signaling axis as a modu
110                 Transgenic overexpression of autotaxin/lysophospholipase D (Enpp2), the enzyme necess
111  but not resting platelets bound recombinant autotaxin/lysoPLD in an integrin-dependent manner.
112 y a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thromb
113 s and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a m
114 ating interferon-free HCV treatment and that autotaxin may be causally linked to immune activation du
115 nt focal adhesion turnover in LUAD cells and autotaxin-mediated CD8(+) T cell exhaustion, indicating
116                               The exo-enzyme autotaxin/NPP2 (ATX/NPP2) is a potent stimulator of cell
117           In blood and multiple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC
118                                              Autotaxin produces the bioactive lipid lysophosphatidic
119 wo consensus NFAT binding sites found in the autotaxin promoter strongly and specifically bind NFAT1
120                 These results establish that autotaxin secretion by CAFs is increased by TGFbeta inhi
121        We further demonstrate that increased autotaxin secretion from integrin alpha6beta4 expressing
122 ss motile to serum and 86-99% less motile to autotaxin than control vector transfectants.
123 itors of the lysophospholipase D activity of autotaxin, the dominant biosynthetic source of LPA.
124  mice increased levels in the vessel of both autotaxin, the lysophospholipase D enzyme responsible fo
125 ward an inflammatory phenotype that secretes autotaxin to drive adaptive resistance in PDAC, revealin
126                                              Autotaxin transcript was present, and GFs were found to
127 ly longer in patients without an increase of autotaxin upon treatment with galunisertib compared with

 
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