ライフサイエンスコーパス: awake

1 homeostat, which rises as a function of time awake.

2 nt in advanced FECD in the first hours after awaking.

3 uced (18)F-FDG uptake was more pronounced in awake (+63.6%) than in anesthetized (+24.2%) animals.

4 Checkpoint blockade immunotherapy (CBI) awakes a host innate immune system and reactivates cytot

5 physiologically evoked neuronal activity in awake adult mice.

6 in opioid-induced respiratory depression in awake adult mice.

7 uch as starvation require the organism to be awake and active(4), the ability to switch to a memory c

8 litude spike-and-wave discharges in her best awake and alert state.

9 ing, but not preexisting GCs in vivo in both awake and anesthetized mice.

10 esponses over a range of visual contrasts in awake and anesthetized states.

11 gh spatiotemporal resolution in the brain of awake and behaving animals.

12 ible technique for cognitive neuroscience in awake and behaving human infants.

13 al connectivity patterns, in head-restrained awake and behaving mice, and investigated their modulati

14 tinct pattern of impairment linked with time awake and circadian phase.

15 sual motion processing as a function of time awake and circadian phase.

16 ronal interfaces hinder long-term studies in awake and freely behaving animals, as they are limited i

17 cro-endoscopes and in vivo neural imaging in awake and freely-behaving animals.

18 Under awake and idling conditions, spontaneous intracellular m

19 icantly enhanced at 30 d postsurgery in both awake and ketamine-xylazine anesthetized mice with elect

20 for optically guided surgery and imaging of awake and moving mice with multiplexed detection.

21 leep, and in a hybrid BCM incorporating both awake and NREM sleep states.

22 leep, and in a hybrid BCM incorporating both awake and NREM sleep states.

23 romodulators to simulate transitions between awake and SWS sleep, and synaptic plasticity to allow th

24 While daily patterns of when animals are awake and when they sleep are largely scheduled by the c

25 icipants performed the task both while fully awake and while getting drowsy, allowing for the charact

26 it to contribute to sensory processing in an awake animal remains unknown.

27 t) of the regional SUV quantification in the awake animals (0.424-0.555) was marginally lower than th

28 sence of sensory drive, cortical activity in awake animals is associated with self-generated and seem

29 e to investigation at the mesoscale level in awake animals or humans.

30 ation of neuronal activity in uninstrumented awake animals with potential for human applications as w

31 itional behavioral information, acquired for awake animals, showed increased motor activity on a mema

32 assessed by urodynamic examination in fully awake animals.

33 temperatures reported in the literature for awake animals.

34 ion disappears when birds are forced to stay awake at other times of the year; thus these protective

35 We measured EEG responses in 1- to 4-day-old awake, attentive human newborns to schematic facelike pa

36 these studies tested infants while they were awake, because of the significant and unique methodologi

37 nical difficulties, DRG neuronal activity in awake behaving animals remains unknown.

38 spatial firing properties of mossy cells in awake behaving animals, but how the activity of these hi

39 inevitable problem of multiphoton imaging in awake behaving animals, particularly when imaging synaps

40 processing in the central nervous system of awake behaving animals.

41 verlooked in electrophysiological studies in awake behaving animals.

42 measure the fine structure of SCCs in V1 of awake behaving macaques and assessed their dependence on

43 calcium imaging of the vermal cerebellum in awake behaving male and female mice to record granule ne

44 ythmic infra-slow activity patterns exist in awake behaving mice and whether such activity reflects t

45 imaging and single-cell electrophysiology in awake behaving mice following auditory associative train

46 We show in awake behaving mice that the onset of tremor is coincide

47 e cells extracted from in vivo recordings in awake behaving mice were near optimal.

48 in vivo model of focal cortical seizures in awake behaving mice, together with closed-loop optogenet

49 imary motor (M1) and visual cortexes (V1) of awake behaving mice, we find that discrete [Ca(2+)](mito

50 manipulate vHPC-NAc excitability directly in awake behaving mice.

51 to 1 x 1 x 1.22 mm volumes at up to 17 Hz in awake behaving mice.

52 amic feeding and midbrain reward circuits in awake behaving mice.

53 eased inhibition of DCN baseline activity in awake behaving mice.

54 be generalized as a tool to track HR of the awake behaving monkey, for ethological, behavioural, neu

55 wards, by recording from dopamine neurons in awake behaving monkeys during performance of an effortfu

56 ar recordings in several cortical regions of awake behaving monkeys.

57 t to the head motion that can be observed in awake behaving monkeys.

58 monitor the activity of neuronal networks in awake, behaving animals over long periods of time.

59 lidated measures of sensorimotor behavior in awake, behaving animals revealed dysfunction after chron

60 e a method to identify striosomes on-line in awake, behaving macaques.

61 vering all layers of PPC in anesthetized and awake, behaving male rats.

62 oss a population of individual neurons in an awake, behaving mammal.

63 ctivity in the extrastriate visual cortex of awake, behaving marmosets (Callithrix jacchus).

64 ity; however, physiological investigation in awake, behaving marmosets is necessary to physiologicall

65 spread across the entire dorsal neocortex of awake, behaving mice during a three-option lick-to-targe

66 al in vivo calcium imaging of DLS SST-INs in awake, behaving mice identified a stable population of f

67 x, hippocampus, and striatum) of head-fixed, awake, behaving mice.

68 spikes and subthreshold voltage dynamics in awake, behaving mice.

69 ayers 2-4 and layer 6, but not in layer 5 of awake, behaving rats.

70 s to GVS applied to the mastoid processes of awake-behaving monkeys.

71 lly defined neurons at deep locations during awake behavior.

72 y their head direction tuning offsets during awake behavior.

73 different responses in both anesthetized and awake birds.

74 'Local sleep-like cortical reactivity in the awake brain after focal injury', by Sarasso et al. (doi:

75 ity whereas complex responses typical of the awake brain were present when stimulating the contralesi

76 throughput monitoring of hemodynamics in the awake brain, we expect Bessel TPLSM to make broad impact

77 s states of ongoing cortical activity in the awake brain, which could have implications for variabili

78 on of sleep-like cortical dynamics within an awake brain.

79 tive sleep apnea can breathe adequately when awake but experience repeated episodes of upper airway c

80 patients providing compelling insights into awake cognition [4, 5].

81 ctivity in the cortex suggests that, as with awake cognition, the hippocampus plays a significant rol

82 their cognitive content and function during awake, conscious behavior remains unclear.

83 A number of studies suggest that the awake, conscious state is not the default behavior of an

84 wake rest, the direct causal contribution of awake consolidation mechanisms to later behavior is uncl

85 imulation (TMS) and fMRI to test the role of awake consolidation processes by targeting hippocampal i

86 A rare case of a deaf signer undergoing awake craniotomy has revealed that sensorimotor cortex i

87 The index patient ultimately required an awake craniotomy procedure to confirm safe resection mar

88 cal surface of profoundly deaf signer during awake craniotomy.

89 g a longer latency to fall asleep, more time awake during the night, a decrease in slow-wave sleep, d

90 ermediate state and instantaneously restored awake dynamics and the top task performance while the an

91 is highly associated with BECTS on a brief, awake EEG has the potential to improve diagnostic screen

92 is, were computed from 30-second segments of awake EEG signals.

93 machine learning approach, but only 32.5% of awake epochs.

94 memory consolidation.SIGNIFICANCE STATEMENT Awake experience is consolidated into long-term memories

95 nvestigate cystometry-induced micturition in awake female and male rats.

96 d tsDCS to attenuate abnormal muscle tone in awake female mice with spinal cord injuries were investi

97 single neurons in the auditory cortex of the awake ferret, showing adaptive efficient neural coding o

98 esponses from the primary auditory cortex in awake ferrets exposed passively to stimuli with two corr

99 ing whole-cell recordings from V1 neurons of awake, fixating macaque monkeys.

100 ed baseline conditions (evaluated at 8 hours awake following 8 hours of sleep) on neurobehavioral res

101 eted a 10-min PVT every 2 h while being kept awake for >=24 hours.

102 of the nucleus tractus solitarius (rNTS) in awake, freely licking rats show lick-related firing.

103 developed and validated brain PET imaging of awake, freely moving mice.

104 cal results were validated against empirical awake functional MRI data obtained from the same mice.

105 r 2/3 of primary visual cortex, i.e., V1) in awake head-fixed mice (Setd1a(+/-) vs. wild-type litterm

106 Optogenetic stimulation in awake head-fixed mice consistently induced an increase i

107 ere we used in vivo two-photon microscopy in awake head-fixed mice to assess the role of spontaneous

108 xperimentally validated these predictions in awake head-fixed mice.

109 We measured oxygen levels in the cortex of awake, head-fixed mice during locomotion using polarogra

110 calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic fe

111 Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R a

112 and evoked dilation in cortical arteries in awake, head-fixed mice.

113 Awake, head-restrained mice were trained to lick differe

114 known, however, especially as it pertains to awake human memory retrieval.

115 ing challenges of bulk motion to apply it in awake humans.

116 Our results emphasize the importance of awake imaging for studying microglia-neuron interactions

117 iness also decreased significantly with time awake in all experimental conditions.

118 ast, donepezil and xanomeline increased time awake in rodents and engendered dose-limiting adverse ef

119 After 53 years of quiescence, Mount Agung awoke in August 2017, with intense seismicity, measurabl

120 erformance decrements that dissipate as time awake increases.

121 enges, with the goal of creating methods for awake infant fMRI that can reveal the inner workings of

122 We imaged 83 awake infants (159 eyes) at 36 +/- 1 weeks postmenstrual

123 To measure retinal activity in the awake, intact brain, we imaged the synaptic boutons of r

124 o-hundred twenty-eight of 402 patients (57%) awoke: late awakening (> 48 hr from sedation stop; media

125 avalanches, while ketamine allowed for more awake-like dynamics to persist.

126 However, in motor cortex of the awake macaque monkey, we observe very different dynamics

127 ture selectivity of individual V4 neurons in awake macaques (1 male, 1 female) and found that V4 neur

128 In contrast, our method allows to extract awake macaques HR from both RGB and IR videos and is par

129 Video photoplethysmography allows to extract awake macaques HR from RGB videos.

130 ductance is found in layer 2/3 V1 neurons of awake macaques, anesthetized mice, and acute brain slice

131 electrophysiology and two-photon imaging in awake macaques.

132 hat optogenetic activation of AON neurons in awake male and female mice was not perceived as an odora

133 ayer 2/3 pyramidal cells and interneurons in awake male and female mice, we measured the spectrum and

134 state of accessory olfactory bulb output in awake male and female mice.

135 In conclusion, IEG mapping in awake male and female rats has extended our understandin

136 sing a functional MRI adaptation paradigm in awake male macaques.

137 RNs) and assessed their temporal dynamics in awake male mice.

138 8)F]fallypride PET and resting-state fMRI in awake male rhesus monkeys after oral administration of v

139 e-unit activity in the auditory forebrain of awake male zebra finches while presenting rare repetitio

140 Single-unit studies in awake marmosets (Callithrix jacchus) have shown that a s

141 th cortical resting-state networks (RSNs) in awake marmosets using resting-state fMRI and then compar

142 vity with cortical resting-state networks in awake marmosets using resting-state fMRI, then to compar

143 ur observations in single-unit recordings in awake marmosets.

144 rm intracellular recordings in the cortex of awake marmosets.

145 ime, impaired in vivo cortical plasticity in awake Mecp2 mutant animals to a natural, ethologically r

146 d local field potentials across V1 layers of awake mice (both sexes) while they viewed stimuli of var

147 veillance and injury response are reduced in awake mice as compared to anesthetized mice, suggesting

148 fluorescent glutamate imaging, we show that awake mice carrying a familial hemiplegic migraine type

149 Here, we show that in awake mice chronically implanted with a glass window ove

150 method for full-featured 2-photon imaging in awake mice during free locomotion with volitional head r

151 tilized in vivo two-photon Ca(2+) imaging in awake mice expressing GCaMP6s in GABAergic or non-GABAer

152 or three-photon imaging of brain activity in awake mice for improved high-speed longitudinal neuroima

153 Here we demonstrate that microglia in awake mice have a relatively reduced process area and su

154 We used an optogenetic approach in awake mice of both sexes to identify thalamostriatal and

155 ith a high frequency stimulation protocol in awake mice over-powers the cocaine-induced potentiation

156 neurons in the primary visual cortex (V1) of awake mice raised in three different conditions (standar

157 hermore, dense extracellular recordings from awake mice reveal changes of both single-neuron and popu

158 ction to the primary auditory cortex (A1) in awake mice reveal that LP improves auditory processing i

159 Magnetic resonance imaging in awake mice showed that fractional anisotropy is reduced

160 siological conditions, noradrenergic tone in awake mice suppresses microglial process surveillance.

161 anipulating Ca(2+) signaling in the brain of awake mice through non-invasive light delivery.

162 lamic (CT) neurons in the auditory cortex of awake mice to discern differences in sensory processing

163 ton Ca(2+) imaging in the auditory cortex of awake mice to show that heightened arousal, as indexed b

164 amics simultaneously in the barrel cortex of awake mice under whisker stimulation, we found that arte

165 rize the prefrontal cortical microcircuit in awake mice using subcellular-resolution two-photon micro

166 first definitive recording of OT neurons in awake mice using two-photon calcium imaging.

167 ic AMPARs across multiple cortical layers in awake mice using two-photon imaging.

168 effect on spiking in neighbouring neurons in awake mice viewing visual stimuli.

169 mn of the cerebral cortex > 1 mm in depth in awake mice with low (<20 mW) average laser power.

170 We found that, in awake mice, a complex spike in one PC suppressed convent

171 nts during interictal spikes and seizures in awake mice, and found that GABA-mediated tone decreases

172 pressure (Po2) measurements in the brain of awake mice, by performing two-photon phosphorescence lif

173 tput neurons in both anesthetized as well as awake mice, pointing to a potential mechanism by which t

174 present method enables brain PET imaging on awake mice, thereby avoiding the confounding effects of

175 racellular recordings of cortical neurons in awake mice, we measured the voltage dependence of sponta

176 Using chronic two-photon imaging in awake mice, we observed spontaneous subcellular calcium

177 ular recordings from lobules VI through X in awake mice, we show that silencing Purkinje neuron outpu

178 etics and extracellular electrophysiology in awake mice.

179 d-induced respiratory disturbances in adult, awake mice.

180 ted into changes in behavioral phenotypes of awake mice.

181 these when performing imaging experiments in awake mice.

182 activity of both pathways in the striatum of awake mice.

183 latory effect of glial Gq-GPCR activation in awake mice.

184 EB and neuronal activity in the neocortex of awake mice.

185 lar and subcellular resolution over weeks in awake mice.

186 vity of olfactory bulb inputs and outputs in awake mice.

187 imited imaging up to 850 um below the pia in awake mice.

188 expression and two-photon Ca(2+) imaging in awake mice.

189 ond-scale timing resolution in the brains of awake mice.

190 hese neurons in the primary visual cortex of awake mice.

191 2)) and flow in the whisker barrel cortex in awake mice.

192 pulations of neurons in the visual cortex of awake mice.

193 ium imaging of the entire cortical mantle in awake mice.

194 ventricle ChP in whole-mount explants and in awake mice.

195 in situ, but has not been studied in vivo in awake mice.

196 c stimulation was confirmed in recordings in awake mice.

197 ased clearance rates in the visual cortex of awake mice.

198 neural activity across the dorsal cortex of awake mice.

199 gh response to SO(2) inhalation challenge in awake mice.

200 45 mum below the brain surface in head-fixed awake mice.

201 function of cortical layer and cell type in awake mice.SIGNIFICANCE STATEMENT Sensory cortical areas

202 ation of SO(2) consistently evoked coughs in awake mice; responses were significantly smaller in TRPV

203 Here, however, in awake monkey recording experiments, we found that roughl

204 formed multi-electrode laminar recordings in awake monkey V1 to report significant synergistic intera

205 We show that in awake monkey V1, there exists a distinct cell type (>>30

206 d ECoG RFs from the primary visual cortex of awake monkeys (three female Macaca radiata).

207 dressed these issues by recording from V1 of awake monkeys implanted with an array of microelectrodes

208 dye imaging in primary visual cortex (V1) of awake monkeys to show that intracortical connections wit

209 th a genetically-encoded glutamate sensor in awake monkeys, and map the excitatory synaptic inputs on

210 Using this paradigm in awake monkeys, we show that suppressive traveling waves

211 nfirmed in novel analyses of recordings from awake monkeys.

212 ivity in response to natural images in V1 of awake monkeys.

213 Results: Awake (motion-corrected) PET images showed an (18)F-FDG

214 tion and connectivity in the lightly sedated awake mouse brain and provide evidence supporting an evo

215 s, we capture volumetric hemodynamics in the awake mouse brain at a spatiotemporal resolution suffici

216 cortical regions over two hemispheres of the awake mouse brain.

217 processing in the superior colliculus of the awake mouse by optically recording neural responses acro

218 al neurons in cortical layers L4 and L2/3 of awake mouse primary auditory cortex (A1) to characterize

219 en, biologically realistic simulation of the awake mouse primary visual cortex.

220 endrites of layer 5 pyramidal neurons in the awake mouse primary visual cortex.

221 wide-field and two-photon calcium imaging in awake mouse thalamus across arousal states associated wi

222 cale physiological survey of activity in the awake mouse visual cortex: the Allen Brain Observatory V

223 onse properties of collicular neurons in the awake mouse with large-scale electrophysiology.

224 in primary somatosensory cortex (S1) of the awake mouse, we optimized a data-driven cortical state c

225 urons in the medial prefrontal cortex of the awake mouse.

226 oxylipins can be obtained from the brains of awake moving animals using in vivo solid-phase microextr

227 nd memantine-challenge study was measured in awake (n = 8) and anesthetized (n = 8) C57BL/6 mice.

228 Awake neurosurgery requires patients to converse and res

229 Here we report the evaluation, in three awake non-human primates, of a previously reported near-

230 llular neuronal recordings from the brain of awake nonhuman primates have remained difficult to obtai

231 Using fUS imaging on two awake nonhuman primates performing a passive fixation ta

232 Here we show in awake nonhuman primates that the temporal profile of ava

233 This case series describes the proportion of awake, nonintubated inpatients with COVID-19 and hypoxem

234 synaptic connections due to the training in awake or replay during sleep.

235 lassifier which detects whether a subject is awake or unconscious achieving high performance.

236 Here, activity was recorded from 10 awake, parkinsonian patients (6 male, 4 female human sub

237 d responses in primary visual cortex (V1) of awake, passively behaving male mice increase as a functi

238 ields A1, R and RT) and auditory thalamus of awake, passively-listening marmosets.

239 acrophase timing were generally preserved in awake patients but dampened and delayed with increasing

240 tical reactivity in a cohort of 30 conscious awake patients with chronic focal and multifocal brain i

241 Cord hypothermia-rewarming, applied to awake patients, did not cause discomfort or neurological

242 nd 29.5% of respondents involved surrogates, awake patients, or bedside nurses, respectively.

243 We focus on reactivation during awake post-encoding periods, relationships between react

244 For multiple memories trained in awake, presenting stimulation cues associated with speci

245 or dendritic and somatic compartments in the awake primary visual cortex.

246 frequency organized neuron ensembles in the awake rabbit inferior colliculus (IC).

247 mic, contrast-enhanced MRI was used in fully awake rats to follow the redistribution of intraventricu

248 In unrestrained awake rats, unilateral injection of the glutamate (10 mm

249 rodes implanted above the MGB of young-adult awake rats.

250 transection of the L5 spinal nerve (SNT) in awake rats.

251 lysis were obtained from 205 children in the awake-regional anaesthesia group and 242 in the general

252 22 were randomly allocated: 363 (50%) to the awake-regional anaesthesia group and 359 (50%) to the ge

253 mean FSIQ score was 99.08 (SD 18.35) in the awake-regional anaesthesia group and 98.97 (19.66) in th

254 pmental outcome at age 5 years compared with awake-regional anaesthesia in a predominantly male study

255 aesthesia group, with a difference in means (awake-regional anaesthesia minus general anaesthesia) of

256 ased randomisation service to receive either awake-regional anaesthetic or sevoflurane-based general

257 We examined the content of awake replay events following motivational shifts betwee

258 We therefore continuously tracked awake replay in the same hippocampal-prefrontal ensemble

259 psychomotor vigilance task taken at 20 hours awake (resilient: less than 6 attentional failures, n =

260 ppocampal-LOC interactions during periods of awake rest using fMRI.

261 ve been observed during sleep and periods of awake rest, the direct causal contribution of awake cons

262 During sleep and awake rest, the neocortex generates large-scale slow-wav

263 and hemodynamic signals was higher than the awake resting and REM states.

264 ocessing, whisker stimulation during genuine awake resting-state periods leads to highly specific red

265 the strongest and the most consistent during awake ripples.

266 ction of head movement, or head-fixation, of awake rodents allows for sophisticated investigation of

267 regardless of animal state (anesthetized vs awake, running vs stationary), SC depth (most superficia

268 so an excellent established test subject for awake scanning given their natural tolerance for restrai

269 cross layers of the frontoparietal cortex in awake, sleeping, and anesthetized macaques.

270 ily fluctuations in alertness in the regular awake state affect cognitive control.

271 equencies (8-16 Hz, which was present in the awake state) significantly decreased with propofol admin

272 the PTSD Checklist 5, or PCL5 survey) in the awake state, during N2 sleep, and in a hybrid BCM incorp

273 g sensitivity to the presence of PTSD in the awake state, during non-rapid eye movement (NREM) stage

274 HbT]) and arteriole diameter relative to the awake state, two to five times larger than those evoked

275 were highest during NREM, and lowest in the awake state.

276 "switch" that results in either the sleep or awake state.

277 exposed to mild intermittent hypoxia in the awake state.

278 the replay of hippocampal place-cells during awake states, generating small sequences of spatially re

279 ctivity at high spatiotemporal resolution in awake subjects within the whole depth of the cortex.

280 for dysfunctions, are ideally performed with awake subjects.

281 novelty exposure as a means to keep animals awake suggests that sleep (compared with wake) leads to

282 ingulum stimulation to reduce anxiety during awake surgery and as a possible approach for treating an

283 trode recordings and microstimulation during awake surgery for Parkinson's disease.

284 Here, we show that dH and vH awake SWRs occur asynchronously and activate distinct an

285 hows that DRG neuronal activity is higher in awake than anesthetized animals.

286 gnatures of stronger attentional states when awake than when under deep sedation and light anesthesia

287 was entirely absent when participants stayed awake the night after allergen exposure or were tested i

288 indings highlight the direct contribution of awake time periods to episodic memory consolidation.

289 arying total SB was categorized according to awake time spent sitting or lying down (<=6.5, 6.6-9.5,

290 als to infertility or inviability, the world awoken to the dawn of new species with intrinsic post-zy

291 ction in female and male patients undergoing awake tumor surgery.

292 o moderate sleep loss (evaluated at 20 hours awake two days later) in 151 healthy young participants

293 ability of the prototype was demonstrated in awake, (unsedated) dogs.

294 Our urge to sleep increases with time spent awake, until sleep becomes inescapable.

295 An awake uptake period was considered for the anesthesia sc

296 the supragranular layers of anesthetized and awake visual cortex in both male and female mice.

297 mpare resting-state functional MRI data from awake volunteers, propofol-anaesthetised volunteers, and

298 We previously identified WIDE AWAKE (WAKE) in Drosophila, a clock output molecule that

299 responses were assessed in barrel cortex of awake wild-type or eNMDAR loss-of-function mice using tw

300 ain tissue for up to 9 h and in patients who awake with stroke symptoms.