ライフサイエンスコーパス: awake mice

1 etics and extracellular electrophysiology in awake mice.

2 ctional imaging of sensory input activity in awake mice.

3 inhibition of neurons deep in the brains of awake mice.

4 n real time based on single-unit feedback in awake mice.

5 ventricle ChP in whole-mount explants and in awake mice.

6 s--in the visual cortex of anaesthetized and awake mice.

7 cross these neuron types in anesthetized and awake mice.

8 maps of retinotopy in both anesthetized and awake mice.

9 iorated isoproterenol-induced arrhythmias in awake mice.

10 s, across all six layers in visual cortex of awake mice.

11 and optical imaging of intrinsic signals in awake mice.

12 t of activity, determines spine stability in awake mice.

13 in situ, but has not been studied in vivo in awake mice.

14 rainments of PVBC and OLM cell discharges in awake mice.

15 clic voltammetry in the nucleus accumbens of awake mice.

16 of visual processing by behavioral state in awake mice.

17 losure and monocular retinal inactivation in awake mice.

18 response enhancement in the visual cortex of awake mice.

19 dial perforant path-granule cell synapses in awake mice.

20 and ketamine/xylazine anesthesia than in the awake mice.

21 during hyperinsulinemic-euglycemic clamps in awake mice.

22 c stimulation was confirmed in recordings in awake mice.

23 and the anterior olfactory nucleus of adult awake mice.

24 ensory processing in association cortices of awake mice.

25 g of population neuronal calcium dynamics in awake mice.

26 ased clearance rates in the visual cortex of awake mice.

27 l CA1 reliably evoked convulsive seizures in awake mice.

28 imaging modalities, and can be performed in awake mice.

29 cal imaging(5) and behavioural monitoring in awake mice.

30 onal boutons in the dorsolateral striatum of awake mice.

31 neural activity across the dorsal cortex of awake mice.

32 hat cover much of the cerebral hemisphere in awake mice.

33 ene using a complex odor task and imaging in awake mice.

34 gh response to SO(2) inhalation challenge in awake mice.

35 o electrical stimuli in the visual cortex of awake mice.

36 45 mum below the brain surface in head-fixed awake mice.

37 of the hippocampus of both anesthetized and awake mice.

38 es in extracellular glucose concentration in awake mice.

39 ojections in the POA initiates NREM sleep in awake mice.

40 l Ca(2+) imaging sessions of up to 90 min in awake mice.

41 tated cell autonomously by PSD-95 in vivo in awake mice.

42 d-induced respiratory disturbances in adult, awake mice.

43 neural recordings with Neuropixels probes in awake mice.

44 tory auditory cortical neural populations in awake mice.

45 lar L-lactate in the somatosensory cortex of awake mice.

46 transients during seizures in the brains of awake mice.

47 ing neuronal activity from frontal cortex of awake mice.

48 concurrent hippocampal electrophysiology in awake mice.

49 tical layers was simultaneously monitored in awake mice.

50 e-locked responses to sensorimotor inputs in awake mice.

51 alcium imaging and Neuropixels recordings in awake mice.

52 uronal and behavioral recordings obtained in awake mice.

53 ted into changes in behavioral phenotypes of awake mice.

54 these when performing imaging experiments in awake mice.

55 activity of both pathways in the striatum of awake mice.

56 latory effect of glial Gq-GPCR activation in awake mice.

57 EB and neuronal activity in the neocortex of awake mice.

58 lar and subcellular resolution over weeks in awake mice.

59 vity of olfactory bulb inputs and outputs in awake mice.

60 imited imaging up to 850 um below the pia in awake mice.

61 expression and two-photon Ca(2+) imaging in awake mice.

62 ond-scale timing resolution in the brains of awake mice.

63 hese neurons in the primary visual cortex of awake mice.

64 2)) and flow in the whisker barrel cortex in awake mice.

65 pulations of neurons in the visual cortex of awake mice.

66 odor concentrations and in anesthetized and awake mice.

67 vation sufficient to evoke motor behavior in awake mice.

68 using chronic two-photon calcium imaging in awake mice.

69 ation-entrained rhythm in the hippocampus of awake mice.

70 ium imaging of the entire cortical mantle in awake mice.

71 al respiration rhythm" (HRR), also occurs in awake mice.

72 c imaging of cortex in both anesthetized and awake mice.

73 osterior nucleus, and V1 in anesthetized and awake mice.

74 during hyperinsulinemic-euglycemic clamp in awake mice.

75 movements in the superior colliculus (SC) in awake mice.

76 We found that, in awake mice, a complex spike in one PC suppressed convent

77 ed this method to estimate baseline CMRO2 in awake mice across cortical layers.

78 Oral gavage of lipid in awake mice activated neurones throughout the nucleus of

79 In awake mice, acute light-induced stimulation of islet per

80 image blood flow in cortical capillaries of awake mice and determine long-range correlations in spee

81 cium imaging to monitor cortical dynamics in awake mice and developed an approach to quantify rapidly

82 o investigate, we recorded spike trains from awake mice and estimated the network time constants usin

83 potentials and membrane voltage dynamics in awake mice and flies, resolving fast spike trains with 0

84 r cortical feedback in the olfactory bulb of awake mice and further probe its impact on the bulb outp

85 recorded GCs in the MOB of anesthetized and awake mice and identified state-dependent features of od

86 aged ensembles of Purkinje cell dendrites in awake mice and measured their calcium responses to perio

87 urons in layer 2/3 of the visual cortex from awake mice and recorded their spontaneous and visually e

88 shifted toward higher values in the dLGN of awake mice and responses were more sustained.

89 e, we use longitudinal two-photon imaging in awake mice and single-cell transcriptomics to elucidate

90 rom >50 spiking neurons per field of view in awake mice and ~30-minute continuous imaging in flies.

91 We examined this issue in brain slices, awake mice, and a computational model.

92 al seizures in primary visual cortex (V1) of awake mice, and compared their propagation to the retino

93 ordings in the dLGN of both anesthetized and awake mice, and found that a surprisingly high proportio

94 nts during interictal spikes and seizures in awake mice, and found that GABA-mediated tone decreases

95 on volumetric microscopy in visual cortex of awake mice, and from confocal microscopy in behaving Hyd

96 d the functional role of VIP interneurons in awake mice, and investigated the underlying circuit mech

97 ike train properties of cerebellar output in awake mice, and strongly supports rate coding in the cer

98 increased V1 visual responses in stationary awake mice, artificially mimicking the effect of locomot

99 veillance and injury response are reduced in awake mice as compared to anesthetized mice, suggesting

100 In awake mice astrocytic [Cl(-)](i) is lower and exhibits l

101 from 13 healthy participants at 7T and in 5 awake mice at 9.4T revealed a highly reproducible restin

102 In this study, we show in awake mice at rest that spiking activity of Purkinje cel

103 d local field potentials across V1 layers of awake mice (both sexes) while they viewed stimuli of var

104 In awake mice, both passive and active whisker touch elicit

105 In awake mice, brief repeated odor experience leads to a gr

106 tions from ensembles in the visual cortex of awake mice builds neuronal ensembles that recur spontane

107 rapid eye movement (REM) sleep compared with awake mice but are not elevated in non-REM sleep.

108 e function was normal by echocardiography in awake mice, but the smaller heart and a slower heart rat

109 pressure (Po2) measurements in the brain of awake mice, by performing two-photon phosphorescence lif

110 fluorescent glutamate imaging, we show that awake mice carrying a familial hemiplegic migraine type

111 Notably, PV+ neuron activation in awake mice caused a significant improvement in their ori

112 Here, we show that in awake mice chronically implanted with a glass window ove

113 om an early stage of olfactory processing in awake mice combined with machine learning techniques to

114 modeling study using a data set recorded in awake mice containing respiratory rate modulation.

115 Moreover, in vivo imaging in awake mice demonstrates reduced baseline and on-demand b

116 Our results in awake mice differed in several respects from previous da

117 method for full-featured 2-photon imaging in awake mice during free locomotion with volitional head r

118 rons in upper-layer primary visual cortex of awake mice during locomotion and quiet wakefulness.

119 sponses measured in primary visual cortex of awake mice during passive viewing.

120 yer 2/3 excitatory and inhibitory neurons in awake mice during passive visual stimulation and perform

121 ividual neuron and local network function in awake mice during stroke recovery.

122 neurons in the anterior cingulate cortex of awake mice during the administration of psilocybin (2 mg

123 ntributions to receptive field plasticity in awake mice during two-photon calcium imaging of cerebell

124 of neurons from the primary visual cortex of awake mice during visual stimulation and spontaneous act

125 y visual cortex of lightly anaesthetized and awake mice, during sensory processing.

126 Whisker stimulation in awake mice evokes transient suppression of simple spike

127 tilized in vivo two-photon Ca(2+) imaging in awake mice expressing GCaMP6s in GABAergic or non-GABAer

128 In awake mice, following subcutaneous glucose injection, we

129 or three-photon imaging of brain activity in awake mice for improved high-speed longitudinal neuroima

130 As measured by nuclear scintigraphy in awake mice, gastric emptying of an ingested whole-egg me

131 Here we demonstrate that microglia in awake mice have a relatively reduced process area and su

132 hanged considerably as compared with that in awake mice, implying that responses in TeA are strongly

133 ty of cholinergic and noradrenergic axons in awake mice in order to determine the interaction between

134 he auditory cortex in acute brain slices and awake mice in response to electric and sound stimuli, re

135 ge-scale recordings of DCIC populations from awake mice in response to sounds delivered from 13 diffe

136 frequency whisker and visual stimulations in awake mice in single trials, opening the door to investi

137 onal populations in primary visual cortex of awake mice in the presence and absence of visual stimula

138 FP) activity in the whisker barrel cortex of awake mice is phase locked to respiration.

139 In awake mice, it revealed sensory-evoked excitatory-inhibi

140 lin action and signaling during the clamp in awake mice lacking IKK-beta.

141 ulated rates of muscle glucose metabolism in awake mice lacking pyruvate dehydrogenase kinase 2 and 4

142 In awake mice, light stimulation of Opn7b expressed in pyra

143 calcium recordings in the auditory cortex of awake mice listening to auditory stimuli, and compared t

144 ing of the activity of neuronal ensembles in awake mice minimally invasively with excellent signal-to

145 In single-unit recordings of adult awake mice, mutants had impaired odour-inhibited respons

146 nduced anesthesia to wakefulness (N = 5) and awake mice (N = 4).

147 ntation during the application of Cb-tDCS in awake mice (n=6).

148 We used an optogenetic approach in awake mice of both sexes to identify thalamostriatal and

149 Using calcium imaging in awake mice of both sexes, we show that the spatial frequ

150 uning properties of neurons to either eye in awake mice of either sex from eye opening to the closure

151 sly monitor these two neural ensembles while awake mice, of both sexes, passively viewed natural movi

152 the auditory cortico-collicular feedback in awake mice on responses of IC neurons to stimuli designe

153 tudinal imaging of the same brain regions in awake mice over multiple days during development.

154 ith a high frequency stimulation protocol in awake mice over-powers the cocaine-induced potentiation

155 yramidal neurons in somatosensory cortex, in awake mice performing one-vs-all whisker discrimination.

156 tput neurons in both anesthetized as well as awake mice, pointing to a potential mechanism by which t

157 otentials in primary visual cortex (V1) from awake mice presented with visual "oddball" paradigms, we

158 piking PV+ interneurons (FSIs) in head-fixed awake mice (PV-Cre:Ai-32, n = 18, 9 female) and determin

159 neurons in the primary visual cortex (V1) of awake mice raised in three different conditions (standar

160 olution pO2 measurements demonstrate that in awake mice recovered from brain surgery, neurovascular c

161 ation of SO(2) consistently evoked coughs in awake mice; responses were significantly smaller in TRPV

162 hermore, dense extracellular recordings from awake mice reveal changes of both single-neuron and popu

163 ction to the primary auditory cortex (A1) in awake mice reveal that LP improves auditory processing i

164 In vivo Neuropixels recordings in head-fixed awake mice revealed a similar prolonged excitation of mP

165 Two-photon imaging conducted in fully awake mice revealed activity-dependent Ca(2+) dysregulat

166 Single-unit recordings in awake mice revealed reduced average firing rates of fast

167 In vivo imaging in awake mice revealed that L2 cells had higher bandwidth t

168 Whole-cell recordings in L2/3 of awake mice revealed that the E/I ratio systematically de

169 Notably, in vivo visual cortex imaging in awake mice reveals highly dynamic neuronal PKA activity

170 Our work in the whisker system of awake mice reveals that neocortical ipsilateral activity

171 In vivo calcium imaging in awake mice reveals that PV cells are broadly tuned to od

172 Imaging of cAMPFIREs in awake mice reveals tonic levels of cAMP in cortical neur

173 gs to the whisker thalamocortical circuit of awake mice selectively expressing Channelrhodopsin-2 in

174 ological recordings in the olfactory bulb of awake mice show that individual cells encode the timing

175 aging activity across the cortical mantle in awake mice, show in this issue of Neuron that touch by a

176 Magnetic resonance imaging in awake mice showed that fractional anisotropy is reduced

177 recording of opto-tagged vIRt(PV) neurons in awake mice showed that these cells spike tonically when

178 function of cortical layer and cell type in awake mice.SIGNIFICANCE STATEMENT Sensory cortical areas

179 During ripple oscillations in awake mice, spiking is much more likely in cells in whic

180 tonergic axons in primary visual thalamus of awake mice suppressed ongoing and visually evoked calciu

181 siological conditions, noradrenergic tone in awake mice suppresses microglial process surveillance.

182 The awake -/- mice tested with reflex modification audiometr

183 roscope we confirmed with calcium imaging in awake mice that hM4D activation by CNO inhibits striatop

184 in the primary somatosensory (S1) cortex of awake mice that is observed after repeated whisker stimu

185 Here, we show in awake mice that L2 cells respond to odors early during s

186 rties of neurons in primary visual cortex of awake mice that were allowed to run on a freely rotating

187 how, from recordings of over 5000 neurons in awake mice, that multisensory neurons reliably encode au

188 ierarchical stages of auditory processing in awake mice - the inferior colliculus (IC), medial genicu

189 In awake mice, the dip in pO2 was absent in capillaries as

190 uronal population whose activity reports, in awake mice, their actual HD as they explore their enviro

191 present method enables brain PET imaging on awake mice, thereby avoiding the confounding effects of

192 In awake mice, this cortical decay function predicted the t

193 vivo two-photon population Ca(2+) imaging in awake mice, this study investigated how neural represent

194 anipulating Ca(2+) signaling in the brain of awake mice through non-invasive light delivery.

195 d a 7 d intranasal insulin delivery (IND) in awake mice to ascertain the biochemical and behavioral e

196 aging of the indicator GCaMP6 in head-fixed, awake mice to characterize the organization of spontaneo

197 Here, we used two-photon calcium imaging in awake mice to compare visual responses in primary visual

198 e extracellular and whole-cell recordings in awake mice to contrast the brain state and ripple modula

199 calcium imaging and whole-cell recordings in awake mice to demonstrate that direction selectivity is

200 lamic (CT) neurons in the auditory cortex of awake mice to discern differences in sensory processing

201 lcium imaging via a closed cranial window in awake mice to investigate changes in the responses of me

202 both ACh and calcium across the neocortex of awake mice to investigate their relationships with behav

203 ordings in visual cortex of anesthetized and awake mice to measure intracellular activity; we then ap

204 ton Ca(2+) imaging in the auditory cortex of awake mice to show that heightened arousal, as indexed b

205 l recording and two-photon Ca(2+) imaging in awake mice to show that lateral inhibition shapes freque

206 To test this, we examined brain responses of awake mice to simple unisensory deviants (e.g., visual l

207 g and holographic optogenetic stimulation in awake mice to study how increased activity of single cel

208 ations in the piriform (olfactory) cortex of awake mice to understand their dependence on breathing a

209 o-photon calcium imaging in anesthetized and awake mice to visualize both odorant-evoked excitation a

210 vibrissa system and association cortices in awake mice under continuous exposure of repetitive air-p

211 voked responses in visual cortex recorded in awake mice under highly standardized conditions using ei

212 amics simultaneously in the barrel cortex of awake mice under whisker stimulation, we found that arte

213 aging of granule cell population activity in awake mice using a cortical window implant that leaves t

214 photon imaging across all cortical layers in awake mice using a microprism attachment to the cranial

215 We recorded cortical responses to flicker in awake mice using high-spatial-resolution widefield imagi

216 rize the prefrontal cortical microcircuit in awake mice using subcellular-resolution two-photon micro

217 evoked gamma activity in layers 2/3 of V1 of awake mice using targeted patch-clamp recordings and syn

218 in the somatosensory and visual cortices of awake mice using two-photon calcium imaging across corti

219 first definitive recording of OT neurons in awake mice using two-photon calcium imaging.

220 ic AMPARs across multiple cortical layers in awake mice using two-photon imaging.

221 l principal neurons' activation functions in awake mice using two-photon optogenetics.

222 ated responses of visual cortical neurons in awake mice using volumetric two-photon calcium imaging d

223 nd visual cortical neurovascular function in awake mice, using two photon imaging of individual neuro

224 aging of the transverse hippocampal plane in awake mice via implanted glass microperiscopes, allowing

225 effect on spiking in neighbouring neurons in awake mice viewing visual stimuli.

226 In awake mice, visual evoked potentials (VEPs) recorded in

227 matched the hemodynamic response function of awake mice, was invariant across mice and stimulus condi

228 ology in the auditory cortex and thalamus of awake mice, we also demonstrate that cortical offset res

229 Using chronic in vivo two-photon imaging in awake mice, we confirm that cortical microglia show limi

230 unit activity from V1, dLGN, and pulvinar of awake mice, we demonstrate that layer 5, but not layer 6

231 ordings from over 15,000 cortical neurons in awake mice, we demonstrate that the effect of claustrum

232 extracellular recordings and opto-tagging in awake mice, we demonstrated that a group of dorsal mPFC

233 In awake mice, we discovered that functional hyperemia is b

234 Using large-scale population recordings in awake mice, we find distinct coding strategies facilitat

235 ing calcium imaging of cellular responses in awake mice, we find surprising asymmetries in the spatia

236 Using optogenetics and visual stimuli in awake mice, we found that acute, arterial endothelial ce

237 In awake mice, we found that auditory responses in entorhin

238 ation in the whisker somatosensory cortex of awake mice, we found that corticothalamic neurons show d

239 Here, using in vivo two-photon imaging in awake mice, we found that learning-induced spine reorgan

240 oton emission computed tomography imaging in awake mice, we identified brain structures activated dur

241 racellular recordings of cortical neurons in awake mice, we measured the voltage dependence of sponta

242 wo-photon calcium imaging in the thalamus of awake mice, we observed a higher fraction of direction-s

243 Using chronic two-photon imaging in awake mice, we observed spontaneous subcellular calcium

244 In awake mice, we performed high-speed membrane voltage flu

245 scence imaging of the barrel cortex in fully awake mice, we reveal that acute COX-1 inhibition reduce

246 y juxtacellular and whole-cell-recordings in awake mice, we show here that in the subiculum a subset

247 ular recordings from lobules VI through X in awake mice, we show that silencing Purkinje neuron outpu

248 ging of neurons in the superficial cortex of awake mice, we show that synchronized cell assemblies or

249 Using two-photon calcium imaging in awake mice, we show that the encoding of audiovisual sti

250 single-unit recordings in auditory cortex of awake mice, we show that this may not generally hold tru

251 microscopic (MTPM) and optrode recordings in awake mice, we show that VIP stimulation directly leads

252 Although astrocytes in visual cortex of awake mice were rarely engaged when neurons were activat

253 esia with urethane or isoflurane and whether awake mice were stationary or running on a treadmill.

254 rtex to drive spiking and vibrissa motion in awake mice when excited with red light through intact sk

255 xcitability during in vivo EEG recordings in awake mice where the effects of the proconvulsant pentyl

256 l(-) available for GABAergic transmission in awake mice, which represents a mechanism for modulation

257 ging of dendritic spines in barrel cortex of awake mice while being conditioned.

258 without simultaneous auditory white noise to awake mice while recording mouse movement and V1 neurona

259 omatosensory (POm) and visual (LP) nuclei of awake mice while tracking whisking and pupil size.

260 Multiphoton imaging in awake mice with HHcy revealed augmented Ca(2+) responses

261 mn of the cerebral cortex > 1 mm in depth in awake mice with low (<20 mW) average laser power.

262 (BC) occurring 2 s prior to the air-puff in awake mice with repetitive stimulation, which was not de