ライフサイエンスコーパス: axon guidance molecule

1 ely by controlling the expression of retinal axon guidance molecules.

2 olfactory sensory neurons and expression of axon guidance molecules.

3 Semaphorins are members of these axon guidance molecules.

4 Wnts are morphogens that also function as axon guidance molecules.

5 Slits are large, secreted repulsive axon guidance molecules.

6 nd cell adhesion that predates their role as axon guidance molecules.

7 regulated by co-impinging signals from other axon guidance molecules.

8 gens in specifying cell fate can function as axon guidance molecules.

9 structurally related to the netrin family of axon guidance molecules.

10 bundant in the developing brain and binds to axon guidance molecules.

11 and reveal the existence of a new family of axon guidance molecules.

12 the retinotopic map depends on the action of axon guidance molecules, activity-dependent mechanisms a

13 e that site-directed genetic manipulation of axon guidance molecules after complete spinal cord injur

14 Here, we evaluate whether axon guidance molecules also regulate regenerative growt

15 grating neurons in the mammalian brain by an axon guidance molecule and the chemotactic responsivenes

16 Axon guidance molecules and neuronal activity have been

17 axon elimination.SIGNIFICANCE STATEMENT Both axon guidance molecules and neuronal activity regulate a

18 ssion of two members of the Netrin family of axon guidance molecules and the signalling protein Sonic

19 We provide evidence that the Slit family of axon guidance molecules and their Robo receptors contrib

20 tion cascades, transcriptional regulation of axon guidance molecules, and alterations in neural netwo

21 Myelin-associated molecules, repulsive axon guidance molecules, and extracellular matrix molecu

22 ation between transcription factors, surface axon guidance molecules, and individual VRs, thereby unc

23 ge our previous notions about morphogens and axon guidance molecules, and suggest that these proteins

24 Axon guidance molecules are frequently altered in pancre

25 is less clear which of the more conventional axon guidance molecules are involved.

26 that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of

27 and temporal cAMP and calcium codes used by axon guidance molecules are unknown.

28 cell-surface receptors, previously known as axon guidance molecules, are also responsible for the di

29 Our data describe a known vertebrate axon guidance molecule as a myelin-based inhibitor of ne

30 Using RABID-seq, we identified axon guidance molecules as candidate mediators of microg

31 t Slit and Robo proteins are candidate motor axon guidance molecules, as Robo proteins are expressed

32 odel of C2 hemisection SCI, we expressed the axon guidance molecule, brain-derived neurotrophic facto

33 aturation and plasticity, besides serving as axon guidance molecules, but the relevance of such synap

34 as functional diversification within related axon guidance molecules contributed to the evolution of

35 Axon guidance molecules, critical for neurodevelopment,

36 Here, we investigate the axon guidance molecules downstream of Satb2 and Ctip2 th

37 lorectal Cancer (DCC), which functions as an axon guidance molecule during development of the nervous

38 To explore the role of axon guidance molecules during regeneration in the lampr

39 the demonstration that null mutation in the axon guidance molecule EphA4 gene impairs the ability of

40 In mice lacking the axon guidance molecule EphA4, axonal misrouting of the c

41 hese findings describe a contribution of the axon guidance molecule, EphA4, in mediating TBI microvas

42 Although we observed that a classical axon guidance molecule, EphA4, was cleaved by BACE1 when

43 n of transcription factor paired box gene 6, axon guidance molecule Ephrin A5, and the receptor NMDA

44 unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum.

45 It is unknown whether the same repulsive axon guidance molecules expressed by glia and their prec

46 in both odor detection and the regulation of axon guidance molecule expression.

47 pha1 (GFRalpha1) can also act in trans as an axon guidance molecule for neurons.

48 During development, EphB proteins serve as axon guidance molecules for retinal ganglion cell axon p

49 ules that specify cell identity, also act as axon guidance molecules has raised the possibility that

50 factors' produced by neurons themselves, and axon guidance molecules have also been implicated in dev

51 Since axon guidance molecules have also been linked to neural

52 ptor sequence, G-protein cAMP signaling, and axon guidance molecules have been shown to direct axons

53 Gradients of axon guidance molecules have long been postulated to con

54 the psychostimulant cocaine markedly alters axon guidance molecules in adult brain of cocaine-treate

55 ge, conserved semaphorin gene family encodes axon guidance molecules in both invertebrates and verteb

56 ports a previously unrecognized function for axon guidance molecules in regulation of blood vessel de

57 are one of the best characterized inhibitory axon guidance molecules in the CNS and are widely expres

58 ngly, new functions are being identified for axon guidance molecules in the dynamic processes that oc

59 zed the role of the Slit family of repellent axon guidance molecules in the patterning of the axonal

60 erase chain reaction, we identified 17 of 26 axon guidance molecules in these cells, with varying lev

61 articipation of one of the major families of axon guidance molecules in this process, the Semaphorins

62 type highlights an underappreciated role for axon guidance molecules in tract cohesion and appropriat

63 es have identified Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates

64 neurons, implying that laminins may serve as axon guidance molecules in vivo.

65 EOM SCs contain more abundant transcripts of axon guidance molecules, including Cxcl12, along with mo

66 ts is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive

67 Gradients of axon guidance molecules instruct the formation of contin

68 Although this axon guidance molecule is not by itself necessary for ap

69 utant mice lacking genes for one or more RGC axon guidance molecules is the presence of topographical

70 In addition to these archetypal axon guidance molecules, it is becoming apparent that mo

71 he optic nerve involves the growth promoting axon guidance molecules L1, laminin and netrin 1, each o

72 hown that semaphorin3A (Sema3A), a repulsive axon guidance molecule, localizes to the PNNs and is rem

73 henotype is due to ectopic expression of the axon guidance molecule netrin 1 (Ntn1), which regulates

74 We show that the secreted axon guidance molecule netrin-1 acts in vitro as an attr

75 Here, we identify the axon guidance molecule Netrin-1 as a key factor secreted

76 arteries is facilitated by secretion of the axon guidance molecule netrin-1 by arterial VSMCs.

77 We show that, while the axon guidance molecule Netrin-1 promotes nerve invasion

78 eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neur

79 Here, we show that at least two of these axon guidance molecules, NETRIN and SLIT, act through th

80 An axon guidance molecule, Neuropilin 2 (Nrp2), is known to

81 eved through the use of a gradient of shared axon guidance molecules, or through a retinal-matching m

82 e, a classical morphogen, Wnt3, acting as an axon guidance molecule, plays a role in retinotectal map

83 ion pathways may regulate gene expression of axon guidance molecules, potentially linking monoamine r

84 with the expression of two putative retinal axon-guidance molecules, RAGS and ELF-1, which are Eph-l

85 Recently identified mutations of the axon guidance molecule receptor gene, DCC, present an op

86 Netrin-1 is an attractive axon guidance molecule required for the proper navigatio

87 al BMP controls the graded expression of RGC axon guidance molecules, resulting in some dorsal RGCs p

88 Additionally, we show that the axon guidance molecules roundabout2 and roundabout3 (rob

89 emic stroke, we show that signaling from the axon guidance molecule Sema3A via eicosanoid second mess

90 Of interest, we found that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among

91 We investigated if the repulsive axon guidance molecule Semaphorin3A (Sema3A) plays a rol

92 Here we have examined the involvement of the axon guidance molecules Semaphorin3A and Slit2, and thei

93 1) was first described as a receptor for the axon guidance molecule, Semaphorin3A, regulating the dev

94 ins are neuronal receptors for the repulsive axon guidance molecule Semaphorins.

95 Expression of the axon guidance molecules semaphorins (SEMAs), which signa

96 e-pass transmembrane receptors that bind the axon guidance molecules semaphorins.

97 pamine receptors) affects gene expression of axon guidance molecules (semaphorins, ephrins, netrins,

98 respond to the class 3 semaphorin family of axon guidance molecules (SEMAs) and to members of the va

99 magnitude, duration, and spatial activity of axon guidance molecule signaling are precisely regulated

100 es and consider mechanisms by which abnormal axon-guidance-molecule signaling can cause loss of conne

101 innervation was driven by expression of the axon-guidance molecule SLIT2 in tumour vasculature.

102 ether, our studies reveal that the repulsive axon guidance molecule Slit3 is a novel and potent angio

103 Thus, axon guidance molecules such as DCC and NTN1 first regul

104 Axon guidance molecules such as netrins, semaphorins, Sl

105 cell-derived neurotrophic factor and release axon-guidance molecules such as ephrin B1 to promote axo

106 the other side of the cord is controlled by axon guidance molecules, such as Netrin-1 and DCC.

107 that was first identified 20 years ago as an axon guidance molecule that regulates midline crossing i

108 Semaphorins are a large family of axon guidance molecules that are known primarily as liga

109 ned new cohorts of transcription factors and axon guidance molecules that are uniquely expressed in S

110 Wnts are a large family of axon guidance molecules that can attract ascending axons

111 Lola is thus the examplar of a class of axon guidance molecules that control axon patterning by

112 Semaphorins are axon guidance molecules that signal through the plexin f

113 t crucial ligand-receptor combinations among axon guidance molecules, the Slit chemo-active ligands a

114 ucleus (dLGN) is established by gradients of axon guidance molecules, to allow initial coarse connect

115 -coupled receptors (GPCRs) and modulation of axon guidance molecules, we investigated whether GPCR ac

116 ceptors and their ephrin ligands function as axon guidance molecules while, in adults, these molecule

117 ssion of extracellular matrix components and axon guidance molecules, with these transcripts being en