ライフサイエンスコーパス: aziridine

1 y the substitution at the C3 position of the aziridine.

2 the allene to a strained bicyclic methylene aziridine.

3 e >99%) from enantiopure trans-disubstituted aziridine.

4 so enables cross-coupling with Boc-protected aziridines.

5 y was achieved with the activation of cyclic aziridines.

6 2-azido-aminoalcohols, diaminoalcohols, and aziridines.

7 palladium-catalyzed cross-coupling of intact aziridines.

8 fied Stille conditions to afford substituted aziridines.

9 tric inductions and higher overall yields of aziridines.

10 ylmethyl imines with diazoesters to give cis-aziridines.

11 ared by the oxidative addition of Ni(0) with aziridines.

12 y2) generates trans-alpha-lithiated terminal aziridines.

13 tained with both alkyl- and aryl-substituted aziridines.

14 -catalyzed Csp(3)-Csp(3) cross-coupling with aziridines.

15 -98 %) and mostly >90 % optically active cis-aziridines.

16 oenriched 2-arylphenethylamines from racemic aziridines.

17 ctive construction of complex trisubstituted aziridines.

18 means for the synthesis of alkyl-substituted aziridines.

19 been studied using the structurally similar aziridines.

20 nd application in dynamic systems other than aziridines.

21 xchange are described for carbon-substituted aziridines.

22 dine opening of tosyl-activated cyclopentene aziridine 2 and optical resolution of racemic 1 with 10-

23 A novel rearrangement of 2-vinyl aziridine 2-carboxylates to unusual chiral cyclic sulfox

24 ate and methanediphosphonate anions afforded aziridine 2-methyl diphosphates and methanediphosphonate

25 nique reactivity of the resulting N-acylated aziridine-2-carbonyl peptides facilitates their subseque

26 ing of unprotected peptide thioacids and N-H aziridine-2-carbonyl peptides is reported.

27 a-GalNAc-Ser linkage via the ring opening of aziridine-2-carboxamides with pyranose C1-O-nucleophiles

28 sters, and unexpectedly, the N-Boc-protected aziridine-2-carboxylate 16b with a phenyl substituent in

29 e the scope of the reductive ring opening of aziridine-2-carboxylates with samarium diiodide.

30 mediated by the imino-BOROX catalyst to give aziridine-2-carboxylic esters with very high diastereo-

31 The key aziridine-2-methanol intermediates (6-OH, 7-OH, and 8-OH

32 ion and afforded, upon deprotection, the N-H aziridine 24 in 18-32% overall yield for the three steps

33 y classes of nitrogen heterocycles including aziridines, 2H-azirines, pyrrolidines, and piperidines.

34 under otherwise identical conditions, vinyl aziridine 3a and aldehydes 2a-2l engage in reductive cou

35 Using enantiomeric iridium catalysts, vinyl aziridine 3a reacts with unprotected chiral 1,3-diols 1m

36 of N-(p-nitrophenylsulfonyl) protected vinyl aziridine 3a with primary alcohols 1a-1l to furnish bran

37 raoxon (13 months), atrazine (5 months), and aziridine (52 h).

38 As expected, three-membered aziridine 6 was calculated to be significantly more reac

39 indole fragment, (b) formation of hexacyclic aziridine 80 from the reaction of cyanide with intermedi

40 -opening of the aziridinium ion derived from aziridine 80, and (d) base-promoted skeletal rearrangeme

41 idue in mutagenized enzyme, as only the beta-aziridine ABP can bind in its absence.

42 ibition of retaining beta-glucosidases, beta-aziridine ABPs do not.

43 use of cyclophellitol beta-epoxide- and beta-aziridine ABPs.

44 A first-order rate dependence on aziridine aldehyde dimer and a zero-order rate dependenc

45 A multicomponent reaction between an aziridine aldehyde dimer, isocyanide, and l-proline to a

46 the reactivity of cis- and trans-configured aziridine aldehyde dimers has been compared.

47 l for the three-component reaction driven by aziridine aldehyde dimers has predictive value for diffe

48 syn-stereoselectivity from readily available aziridine aldehyde dimers in the Petasis borono-Mannich

49 he multicomponent conversion of amino acids, aziridine aldehyde dimers, and isocyanides into chiral p

50 rsible dimer dissociation is instrumental in aziridine aldehyde transformations.

51 a range of functionalized isocyanides in the aziridine aldehyde-driven multicomponent synthesis of pi

52 ibitor calpastatin have motivated the use of aziridine aldehyde-mediated peptide macrocyclization tow

53 Unprotected aziridine aldehydes belong to the amphoteric class of mo

54 The cyclization chemistry centers on using aziridine aldehydes in a multicomponent reaction with pe

55 he related macrocyclization of peptides with aziridine aldehydes.

56 y, the synthesis and reactivity of methylene aziridines, allene oxides/spirodiepoxides, methylene sil

57 Here we show that the reduced amidicity of aziridine amide bonds provides an entry point for the si

58 the latter obtained by a Lewis acid-promoted aziridine amino acid ring opening with 4-boronated indol

59 The other aziridine analogues bearing the N-(alpha-methylene)bisho

60 rization of five racemic and two enantiopure aziridine analogues of PSPP and the evaluation of their

61 m the palladium(II) species bearing both the aziridine and aryl groups to form the hindered C-C bond.

62 A series of N-activated aziridines and 2-bromoindole derivatives with different

63 rization of enynes, [3 + 2] cycloaddition of aziridines and alkenes, and [4 + 2] hetero-Diels-Alder c

64 he phosphine-mediated [3 + 3] annulations of aziridines and allenes are experimentally simple reactio

65 ioselective ring-opening of chiral activated aziridines and azetidines with alcohols to nonracemic be

66 ation processes, leading to the synthesis of aziridines and beta-lactams (respectively), and is sugge

67 cross-coupling between tosyl-protected alkyl aziridines and commercially available (hetero)aryl iodid

68 hesized manno-epi-cyclophellitol epoxide and aziridines and demonstrate their covalent modification a

69 ring-opening of the corresponding activated aziridines and epoxides with amines followed by p-toluen

70 d cross-coupling reaction between N-sulfonyl aziridines and organozinc reagents is reported.

71 C bond-forming reaction between simple alkyl aziridines and organozinc reagents.

72 The reaction proceeds through a mixture of aziridines and oxazolines, which provides the trans-oxaz

73 vestigated using a variety of functionalized aziridines and phenols to determine the scope of the rea

74 report a [3 + 3] ring expansion of bicyclic aziridines and rhodium-bound vinyl carbenes to form comp

75 of the substituent in the 3-position of the aziridine, and whether the substituent in the 3-position

76 an), which is known to carbonylate epoxides, aziridines, and beta-lactones, was used to catalyze the

77 es, which induce the direct formation of the aziridines, and stereochemistry of the olefin is retaine

78 clopropanols, cyclopropenols and epoxides or aziridines are applied to the synthesis of acyclic versu

79 to add to the Si-face of the imine when cis-aziridines are formed and both to add to the Re-face of

80 o add to the Re-face of the imine when trans-aziridines are formed.

81 2,2,3-Trisubstituted aziridines are known to undergo ring opening at the more

82 Likewise, N-alkyl aziridines are prepared from N-alkylated DPH derivatives

83 nto azetidine derivatives, whereas methylene aziridines are the products resulting from alkylallenes.

84 Aziridines are useful precursors to the azomethine ylide

85 ormational transitions, which in the case of aziridines arise from inversion at the nitrogen center.

86 e-component coupling involving N-substituted aziridines, arynes, and water promoted by trifluoroaceti

87 reactions are the first reported examples of aziridines as reaction partners in nucleophilic phosphin

88 amma-thialysine) using freshly prepared (13C)aziridine at room temperature.

89 er formation was explored with small N-alkyl aziridines, azetidines, pyrrolidines, and piperidines.

90 rently exist: doubly-activated molecules and aziridine based molecules, each of which employs a diffe

91 A water-soluble biocompatible aziridine-based biosensor with pendant anthracene units

92 The fluorescently labeled aziridine-based probes 3 and 4 inhibit the two human ret

93 alpha-Lithiated terminal aziridines bearing N-alkoxycarbonyl (Boc) protection und

94 In contrast, aziridines bearing N-organosulfonyl [tert-butylsulfonyl

95 the stage for future biochemical studies of aziridine biosynthesis and assembly.

96 n rates of cyclophellitol and cyclophellitol aziridine-both covalent retaining beta-glucosidase inhib

97 of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine building blocks with an array of amino alcohol

98 CH(2)OH/CH(3)CN desilylated a simple N-TBDPS aziridine but caused nucleophilic cleavage at C(1) as we

99 Selective labeling with fluorescent beta-aziridine but not beta-epoxide ABPs identifies the acid/

100 onfiguration at the terminal position of the aziridine by way of aziridine ring opening by Ni (invers

101 The S(N)2-type ring-opening of N-activated aziridines by anilines followed by Pd-catalyzed annulati

102 A continuous-flow synthesis of aziridines by palladium-catalyzed C(sp(3) )-H activation

103 st accelerates the ring opening of aliphatic aziridines by trimethylsilylazide, inducing nucleophilic

104 that heterolysis at C(10) is faster than at aziridine C(1), in contrast to the behavior of typical a

105 Optically active aziridine can be coupled with high enantiomeric purity (

106 The consumed enantiomer of aziridine can be further converted to an enantioenriched

107 If necessary, the N-4-nosyl Hough-Richardson aziridine can be isolated by filtration in a very good y

108 The activated aziridines can be converted to beta3-amino esters, and u

109 The aziridines can be derivatized to afford a range of chira

110 nation reaction of nonactivated alkynes with aziridines, catalyzed by Lewis or Bronsted acids, to for

111 otecting group could not be achieved without aziridine cleavage.

112 N-Toluenesulfonyl aziridines comprise effective second electrophiles in th

113 The azinomycins are a family of aziridine-containing antitumor antibiotics and represent

114 Vicinal aziridine-containing diamines have been obtained with hi

115 A synthesis of aziridine-containing peptides via the Cu(II)-promoted co

116 Excellent yields of the N-H-aziridines could be obtained with both alkyl- and aryl-s

117 describe a detailed mechanistic study of the aziridine cross-coupling reaction and the role of EDO li

118 corresponding aziridino complexes, that is, aziridine cross-metathesis.

119 ctive strategies for ring-opening of the new aziridines, deprotection of the Ts group, and subsequent

120 re alpha-acyl-beta-amino acid and 2,2-diacyl aziridine derivatives efficiently from Cu(OTf)(2) + 1,10

121 tion of fluorescent manno-epi-cyclophellitol aziridine derivatives enabled activity-based protein pro

122 philic ring-opening reactions of N-activated aziridine derivatives with thiols, beta-thioglycosyl thi

123 expansion of vinyloxiranes, -thiiranes, and -aziridines described in the literature from 1964 to 2013

124 ridine substitution patterns show that alkyl aziridines display similar reactivity to alkynyl aziridi

125 ubstituent groups on the biologically active aziridine do not function as TbNTR or TbCPR-activated pr

126 tended for the enantioselective synthesis of aziridines (ee up to 92%).

127 kyl azide was converted to the corresponding aziridine employing styrene as a substrate.

128 high asymmetric inductions as seen with cis-aziridines, enabling the development of an unprecedented

129 High yields of aziridines exceeding 90% can be obtained with a 1:1 olef

130 nd to react at accelerated rates relative to aziridine exclusively by means of the a Menshutkin-type

131 the first time, and their reactivity toward aziridines explored.

132 The success with the N-Bus aziridines facilitated the development of a new route to

133 lyzed SN2-type ring-opening of the activated aziridine followed by a concomitant 5-exo-dig cyclizatio

134 alkylation of 2-vinylindoles with activated aziridines followed by an intramolecular aza-Michael rea

135 rmation of gram quantities of a key tricylic aziridine from a challenging photochemical cascade react

136 or the synthesis of alkyl-substituted chiral aziridines from achiral starting materials.

137 direct synthesis of N-phosphorus-substituted aziridines from alkenes with dinitrogen as the byproduct

138 Methylene aziridines from alkylallenes derive from catalytic nitre

139 ubstituted imines, the optical purity of the aziridines from all of the imine substrates could be enh

140 metric catalytic synthesis of trisubstituted aziridines from imines and diazo compounds.

141 oselective synthesis of trisubstituted vinyl aziridines from these chiral sulfinamides, simply by cha

142 The nitrogen inversion of a N-phenyl aziridine fused to a succinimide ring is influenced by t

143 been elaborated, affording an unprecedented aziridine-fused spiro[imidazolidine-4,3'-oxindole] frame

144 ed aryl bromides and tertiary organometallic aziridines, generated from sulfinylaziridines by sulfiny

145 idines display similar reactivity to alkynyl aziridines, giving insight into mechanistic possibilitie

146 or the modified Wenker cyclization to afford aziridines has been achieved using biphasic conditions f

147 p-assisted C7 C-C coupling of indolines with aziridines has been developed by merging C-H activation

148 oss-coupling with 1,1-disubstituted styrenyl aziridines has been developed.

149 A series of novel, highly substituted N-PMP aziridines have been accessed in high yields by palladiu

150 tional methods for producing these activated aziridines have significant drawbacks.

151 nd nitrogen in the formation of oxiranes and aziridines; however, such reactivity is not known betwee

152 iastereoselective, affording the trans-vinyl aziridine in moderate-to-good yields.

153 ehydes were examined and found to give trans-aziridines in 60-88% yield with 60-98% ee and trans/cis

154 h aryl aldehydes were screened to give trans-aziridines in 73-90% yield with 82-99% ee and trans/cis

155 be directly transformed to the corresponding aziridines in a one-pot fashion.

156 MEDAM imines can be deprotected to give N-H aziridines in all cases except for some electron-rich ar

157 uents leads to the quantitative formation of aziridines in clean solid-to-solid reactions despite ver

158 selective formation of either functionalized aziridines in dimethylformamide (through direct bromide

159 verted into the corresponding N-H or N-alkyl aziridines in good to excellent yields.

160 c carbamates into [4.1.0]-carbamate-tethered aziridines in good yields and with ee values of up to 92

161 fast at ambient temperature, furnishing N-H aziridines in good-to-excellent yields.

162 available amines into synthetically valuable aziridines in high enantiomeric ratios.

163 forming the desired N-phosphorus-substituted aziridines in moderate to high yields and good enantiose

164 By employing substituted aziridines in single enantiomeric form, the correspondin

165 by radicalar polymerization of N-substituted aziridines in supercritical carbon dioxide.

166 [1,2-a]pyridine ring via the formation of an aziridine intermediate in Mannich bases derived from imi

167 rforms the second function of activating the aziridine intermediate toward nucleophilic attack.

168 yridinium perchlorate to generate a bicyclic-aziridine intermediate, which is transformed under aziri

169 nolithium-mediated conversion of beta-alkoxy aziridines into substituted allylic sulfonamides, use of

170 N-bound phenyl rings of amines, imines, and aziridine is achieved in the presence of H(2) and B(C(6)

171 s rate-limiting ring closure to form the cis-aziridine is implicated.

172 r the oxidative annulation of indolines with aziridines is accomplished employing the combination of

173 Conversion of the triazolines to aziridines is also described.

174 zation reactions of alpha-lithiated terminal aziridines is detailed.

175 n of a range of carbon acids with N-sulfonyl aziridines is reported.

176 diate as the nitrene donor and a symmetrical aziridine-like transition state.

177 ] with Me3SiCl releases the N-functionalized aziridine Me3SiN(CH2CHPh) while simultaneously generatin

178 The aziridine-mediated peptide ligation concept is exemplifi

179 g HSQC NMR peaks were identified in the (13C)aziridine-modified enzyme, corresponding to detection of

180 were replaced, the former with a substituted aziridine moiety and the latter with an NCO-alkyl residu

181 d that aspartic acid is the precursor of the aziridine moiety.

182 ents, that aspartate is the precursor of the aziridine moiety.

183 Despite the prevalence of the N-H aziridine motif in bioactive natural products and the cl

184 h a N-tosyl group, rendering these alpha-CF3-aziridines much more susceptible to nucleophilic ring op

185 in E showing that the enzyme functions as an aziridine N-methyltransferase.

186 re the development of a new synthesis of the aziridine necessary for the aziridine--pi-nucleophile cy

187 modified carbohydrates afforded enantiopure aziridines, nitrocyclopropane, and dihydrofuran.

188 to serve as protecting groups for the labile aziridine nitrogen found within the highly sensitive azi

189 In contrast, a nosyl group on the aziridine nitrogen leads efficiently to the bicyclic rin

190 es with three different substitutions on the aziridine nitrogen.

191 bstrate established that ring opening of the aziridine occurs with inversion of stereochemistry.

192 ped a short and practical synthesis of 1 via aziridine opening of tosyl-activated cyclopentene azirid

193 rough electrochemical amination, Cu-mediated aziridine opening, and a remarkable base-induced macrola

194 trideoxy-L-hex-2-enopyranosides, followed by aziridine opening, leads to 3-amino-3-N-,4-O-carbonyl-2,

195 The initial aziridine opening/cyclodehydration strategy was also dir

196 lization of allyl azidoformates to construct aziridine/oxazolidinone-fused bicyclic structures.

197 Mono- and disubstituted aziridines perform well, with complete retention of ster

198 synthesis of the aziridine necessary for the aziridine--pi-nucleophile cyclization.

199 tion, the effect of fluorine substitution at aziridine positions other than nitrogen was studied.

200 Compound A (CpdA) is a stable analogue of an aziridine precursor from the African shrub Salsola tuber

201 C horizontal lineC bond is maintained in the aziridine product (cis or trans).

202 he starting amino alcohol is retained in the aziridine product.

203 f the starting material and formation of the aziridine product.

204 yst while still maintaining>or=90% ee in the aziridine product.

205 s were utilized to afford the functionalized aziridine products as single diastereoisomers with reten

206 e of regio- and enantiocontrol to afford the aziridine products in good to excellent yields in highly

207 strated through derivatization of the chiral aziridine products to obtain a diverse array of function

208 yields at room temperature, into valuable NH aziridine products.

209 formed with dirhodium catalysts, which favor aziridine products.

210 s enables the rapid assembly of unique amino aziridine products.

211 unique strain and structure of the methylene aziridine promotes a ring-opening/ring-closing cascade t

212 The resulting [3.1.0] bicyclic aziridines prove to be versatile synthons for the prepar

213 N-protected aziridines, pyrrolidines, piperidines, and azepanes bear

214 pid generation of peptides incorporating the aziridine residue has been developed.

215 rine substitution at the carbon positions of aziridine results in profound enhancements of the rate o

216 nd carbenes with strained bicyclic methylene aziridines results in a formal [3+1] ring expansion to y

217 ladium(0) on the less-hindered carbon of the aziridine ring and that alkene insertion occurs in a syn

218 in DMA led to regioselective opening of the aziridine ring at C2 to give the corresponding bicyclic

219 Kibdelosporangium sp. MJ126-NF4, contain an aziridine ring attached to the polyketide core.

220 rans-oxazolines following in situ Heine-type aziridine ring expansion upon treatment with BF(3).OEt(2

221 tions of these genes, a possible pathway for aziridine ring formation in the azecimicins can now be p

222 odular one-pot, sequential protocol using an aziridine ring opening and intramolecular nucleophilic a

223 terminal position of the aziridine by way of aziridine ring opening by Ni (inversion), transmetalatio

224 kylation to effect regio- and stereospecific aziridine ring opening by oxygen, halogen, sulfur, and n

225 ine intermediate, which is transformed under aziridine ring opening conditions to the key intermediat

226 This aziridine ring opening reaction manifold has demonstrate

227 investigation of a regio- and stereospecific aziridine ring opening reaction presents new synthetic t

228 synthesized to change the electronics of the aziridine ring system.

229 ereoselective epoxidation and opening of the aziridine ring with hydrazoic acid afforded the 2-azidoc

230 or nucleophile-dependent ring-opening of the aziridine ring yields functionalized 1,2- and 1,3-diamin

231 oped by utilizing a newly discovered ethynyl aziridine ring-opening reaction in a longest linear sequ

232 The scope of the aziridine ring-opening reaction was substantially broade

233 new flow reaction could be combined with an aziridine-ring-opening reaction to give highly functiona

234 ks for tripeptide controls, a small molecule aziridine self-polymer mimetic, and a cysteine-minus con

235 s removal of the noncovalently protein-bound aziridine self-polymer using a novel chelating dialysis

236 ction kinetics showed zero-order in both the aziridine species and the aryl bromide.

237 The attachment of the aziridine structural motif was achieved by application o

238 ctural features such as the nature of the C2 aziridine substituent and the nature of the electrophile

239 tocol displays a broad scope with respect to aziridine substitution and N-protecting groups.

240 Studies to probe the effect of the aziridine substitution patterns show that alkyl aziridin

241 l aldehyde gave a 71% yield and 95% ee of an aziridine that was found to be the cis- and not the tran

242 The torquoselectivity of aziridines that lack a plane of symmetry was investigate

243 thetically exploited oxiranes and thiiranes, aziridines that lack electron-withdrawing substituents,

244 ds contain two electronically differentiated aziridines that undergo highly regioselective ring openi

245 of (R)-beta(3)-DOPA and L-DOPA from the same aziridine, the former by SmI2-mediated reductive opening

246 on of the nature of the N-substituent of the aziridine, the nature of the substituent in the 3-positi

247 Comparisons to alkenes, cyclopropanes, aziridines, thiiranes, and phosphiranes are also made.

248 triplet sensitizers that selectively produce aziridines through the spin-selective photogeneration of

249 t of nucleophilic iodide ring opening of the aziridine to generate an iodoamine as the active electro

250 gle catalyst transforms a racemic mixture of aziridines to a pair of regioisomeric products, each in

251 The hydrofluorination of aziridines to provide beta-fluoroamines using this laten

252 e we describe a new tool, methylthiocarbonyl-aziridine, to install acetyl-Lys mimics site-specificall

253 were developed for deprotection of the N-DAM-aziridines under acidic conditions without causing an ac

254 N-Sulfonyl aziridines undergo oxidative addition to palladium(0) co

255 -, tri-, and tetrasubstituted olefins to N-H aziridines using O-(2,4-dinitrophenyl)hydroxylamine (DPH

256 ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be de

257 probes elaborated from an inhibitor with an aziridine warhead were applied to the identification and

258 Subsequent nucleophilic attack of the aziridine was accomplished using RSH, R2NH, N3-, or ROH

259 tions, N-o-(trifluoromethane)benzenesulfonyl aziridine was efficiently ring-opened to afford the amin

260 us reactions between the five components, an aziridine was formed in 85% yield and 98% ee and only tw

261 Finally, activation of the N-H-aziridines was achieved with Boc, tosyl, and Fmoc groups

262 1-alkyl-2-(methyl/phenyl)-3-(trifluoromethyl)aziridines was developed starting from the corresponding

263 ese newly synthesized nonactivated alpha-CF3-aziridines was evaluated by applying N-protonation or N-

264 Furthermore, nonactivated alpha-CF3-aziridines were easily transformed into their activated

265 Aziridines were formed by copper-catalyzed intramolecula

266 catalyst; however, in those cases where cis-aziridines were formed, the configuration was opposite f

267 Fully substituted aziridines were obtained in a single step when enolates

268 N-Unsubstituted vinyl aziridines were synthesized via an amine-promoted regios

269 this can be particularly pronounced with cis-aziridines where a nearly equal mixture of the two is ob

270 generate separable, diastereomeric bicyclic-aziridines, which are then independently transformed to

271 the observed absolute stereochemistry of the aziridines, which undergo nucleophilic ring opening to y

272 have found that N-diphenylphospinyl and N-H aziridines, while participating in the initial ring-open

273 col is also equally effective for the phenyl aziridine with excellent regio- and stereoselectivity.

274 ia in situ formed N-4-nosyl Hough-Richardson aziridine with nitrogen nucleophiles under mild conditio

275 lso been synthesized via the ring-opening of aziridines with 2-bromobenzyl alcohols and -mercaptan, r

276 gh an S(N)2-type ring-opening of N-activated aziridines with 2-bromobenzylamine followed by a hithert

277 type ring opening of enantiopure N-activated aziridines with 2-bromoindoles followed by copper-cataly

278 been developed by ring-opening of activated aziridines with 2-hydroxyphenyl acrylates and 2-aminophe

279 ring opening cyclization (DROC) of activated aziridines with 2-vinylindoles is described.

280 s that are the predominant products for most aziridines with an N-activating group.

281 domino ring-opening cyclization of activated aziridines with aryl and alkyl isothiocyanates has been

282 talyzed reductive cross-coupling of styrenyl aziridines with aryl iodides is reported.

283 ing of unsubstituted and 2-alkyl-substituted aziridines with arylboronic acid nucleophiles is present

284 ions involve a regiospecific ring opening of aziridines with benzimidazoles to give benzoimidazolylet

285 the thermal C-C bond cleavage of unactivated aziridines with beta-bromo-beta-nitrostyrene, followed b

286 re applied in the cycloaddition reactions of aziridines with carbon dioxide (CO(2)) or carbon disulfi

287 lyzed S(N)2-type ring opening of substituted aziridines with electron-rich arenes/heteroarenes to pro

288 The preparation of C-iodo-N-Ts-aziridines with excellent cis-diastereoselectivity has b

289 -N-acyloxazolidinones to give trisubstituted aziridines with excellent diastereo- and enantioselectiv

290 synthetically useful chiral [3.1.0]-bicyclic aziridines with high diastereo- and enantioselectivity.

291 catalyzed SN2-type ring opening of activated aziridines with indoles having substitutions at 3- and o

292 eoselective deprotonation of simple terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide (L

293 ring-opening cyclization (DROC) of activated aziridines with malononitrile in excellent yield and ste

294 The intramolecular cyclization reactions of aziridines with pi-nucleophiles can be a useful route to

295 and aliphatic aldehydes both gave the trans-aziridines with the same absolute configuration with the

296 me imines with diazoacetamides to give trans-aziridines with the same high asymmetric inductions as s

297 the C-N cleavage product is observed for all aziridines with the strongly N-activating p-toluene sulf

298 We also report on the cyclization of aziridines with three different substitutions on the azi

299 Several trisubstituted aziridines, with different substitution patterns at the

300 HAT) reaction resulting in H2NTs and lowered aziridine yields.