ライフサイエンスコーパス: bHLH

1 e identification and characterization of 175 bHLH transcription factors from apple (Malus x domestica

2 -encoding genes-and therefore distinct HLH-2:bHLH dimers-and formulate a "bHLH code" hypothesis for r

3 otyls, which is predominantly regulated by a bHLH transcription factor, PIF4.

4 hese results uncover a novel mechanism for a bHLH transcription factor to recognize a unique spatial

5 ith inhibition of the Notch effector Hey1, a bHLH transcription factor that we here characterize as a

6 TWIST is a bHLH transcription factor that promotes epithelial-mesen

7 iption factor complex consisting of a MYB, a bHLH and a WD repeat-containing protein (the MBW complex

8 s an example of target gene specificity of a bHLH protein being controlled allosterically by a domain

9 a nonsynonymous SNP mutation on exon 5 of a bHLH transcription factor was found to elevate the propo

10 Here, we characterize Sage, a bHLH transcription factor expressed exclusively in the D

11 vonol-4-reductase (DFR) in leaves, whereas a bHLH transcription factor was highly correlated with fla

12 distinct HLH-2:bHLH dimers-and formulate a "bHLH code" hypothesis for regulatory cell identity.

13 odule feedback regulates PIFs and additional bHLH factors that interact with ARF6, and thereby modula

14 he AP-1 and CEBPbeta recognition of 5mC; and bHLH (basic helix-loop-helix) proteins, exemplified by M

15 as SPA1/COP1 E3 ubiquitin ligase complex and bHLH transcription factors PIFs, would partially explain

16 s deduced where targets, such as AP2/ERF and bHLH transcription factors and chromatin remodelers form

17 specific gain-of-function alleles of MYB and bHLH proteins had an additive effect on GSL levels, as d

18 strates the absence of suitable R2R3-MYB and bHLH TFs for stimulating anthocyanin biosynthesis in the

19 e by simultaneous expression of R2R3-MYB and bHLH TFs, i.e. AmRosea1 and AmDelila from snapdragon (An

20 A complex of R2R3-MYB and bHLH transcription factors, stabilized by WD40 repeat pr

21 network that identifies the set of bZIPs and bHLHs that are most predictive of the expression of gene

22 Phylogenetic analysis of apple bHLH (MdbHLH) genes and their Arabidopsis thaliana (Arab

23 g the composition and diversity of the apple bHLH transcription factor family that will provide a pla

24 n of sT and the cell fate-determinant atonal bHLH transcription factor 1 (ATOH1) leads to development

25 1 interacts with several inhibitory atypical bHLHs, which likely keep HBI1 under negative control.

26 ) demonstrate unsuspected cross-talk between bHLH transcription factors, important regulators of orga

27 FERONIA and THESEUS1 and the non-DNA binding bHLH protein KIDARI, are functionally validated in Arabi

28 PAS domains, extending above the DNA-binding bHLH domain.

29 enesis and depends upon the function of both bHLH transcription factors, notably Hand2, and homeodoma

30 yase and pectinesterase, are targets of both bHLH transcription factors.

31 stinct domains bind HIF-2alpha and that both bHLH and PAS domains of HIF-2alpha interacted with ORF34

32 ories, whereas R sites mediate repression by bHLH repressors, which serves to restrict expression spe

33 y PHYTOCHROME-INTERACTING FACTOR (PIF)-class bHLH transcription factors in darkness, but light-activa

34 eins, which are characterized by a conserved bHLH domain, comprise one of the largest families of tra

35 tion, F187Y, was within the highly conserved bHLH domain.

36 endent, per ARNT-sim (PAS) domain containing bHLH transcription factor that mediates adaptive respons

37 ered that it encodes a PAS-domain-containing bHLH transcription factor, and that it is expressed in a

38 n in ms32 anthers, which possess a different bHLH defect.

39 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and mu

40 l kinds of transcription factors (TFs) (ERF, bHLH, WRKY, MYB, NAC, bZIP, and ARF), enzymes involved i

41 basic/helix-loop-helix transcription factor (bHLH TF), MdbHLH3.

42 basic helix-loop-helix transcription factor (bHLH)/PAS proteins in Drosophila melanogaster known as g

43 iotemporally specific transcription factors (bHLH/NR).

44 eir DNA-binding domains) from four families (bHLH, bZIP, ETS and Homeodomain), the ADM mixture models

45 s for expression of Notch and the hes family bHLH transcription factor (HES1) in colon tissues from m

46 a complex with the Notch effector hes family bHLH transcription factor 1 (HES1) and the protein deace

47 iscovered that the gene single minded family bHLH transcription factor 1a (sim1a) is dynamically expr

48 anscription factor, HEY2 (hes related family bHLH transcription factor with YRPW motif 2).

49 ompromises the onset of achaete-scute family bHLH transcription factor 1 (Ascl-1)(+) vomeronasal prog

50 Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays important role

51 tivation protein Ascl1 (achaete-scute family bHLH transcription factor 1) in proliferating hippocampa

52 sion of either Twist1 (encoding twist family bHLH transcription factor 1, known as Twist) or Snai1 (e

53 alidating the importance of the Twist-family bHLH dimer pool in limb morphogenesis.

54 conserved domains needed for their function (bHLH and PAS) and regulation (ODD and TAD).

55 is governed by GLABRA1 (GL1; R2R3MYB), GL3 (bHLH), and transparent TESTA GLABRA1 (TTG1; WD40).

56 a triad of R2R3-MYB, basic helix-loop helix (bHLH) and WD40 transcription factors (TFs).

57 (TF) [11, 12] subfamily of basic loop helix (bHLH) proteins by comparing gene function in early diver

58 n of phy-interacting basic Helix Loop Helix (bHLH) transcription factors (PIFs), such as PIF3, thereb

59 tors and DNA-binding basic helix-loop-helix (bHLH) and GATA transcription factors.

60 liana and associated basic helix-loop-helix (bHLH) and MYB transcription factors activate a variety o

61 in pathway genes and basic-helix-loop-helix (bHLH) ANTHOCYANIN1 (AN1), itself an essential component

62 class (VIIIc) of the basic helix-loop-helix (bHLH) class VIII transcription factor family.

63 ontains a C-terminal basic-helix-loop-helix (bHLH) DNA binding domain which recognizes the enhancer-b

64 a membrane-localized basic helix-loop-helix (bHLH) DNA-binding transcription factor now renamed Glyci

65 F-1, HdHIF-1 has one basic helix-loop-helix (bHLH) domain and two Per-Arnt-Sim (PAS) domains, and HdH

66 y interacts with the basic helix-loop-helix (bHLH) domain of Ascl1, and DNA-binding assays demonstrat

67 signaling regulates basic helix-loop-helix (bHLH) factors as an evolutionarily conserved module, but

68 nclear how these two basic helix-loop-helix (bHLH) factors mediate such fundamentally different outco

69 ) are members of the basic helix-loop-helix (bHLH) family of transcription factors in Arabidopsis.

70 The basic helix-loop-helix (bHLH) family of transcription factors orchestrates cell-

71 We analyzed the basic helix-loop-helix (bHLH) family of transcription factors, many of which are

72 iption factor of the basic helix-loop-helix (bHLH) family.

73 cription factor (TF) basic/Helix-Loop-Helix (bHLH) is important for plant growth, development, and st

74 We hypothesized that basic helix-loop-helix (bHLH) MIST1 (BHLHA15) is a "scaling factor" that univers

75 heterodimer via its basic helix-loop-helix (bHLH) motif, little is known about the conformational sa

76 the Ascl1 and Neurog basic helix-loop-helix (bHLH) proneural factors are expressed in a mosaic patter

77 under the control of basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key role

78 s ITF2 or E2-2) is a basic helix-loop-helix (bHLH) protein associated with Pitt-Hopkins syndrome, int

79 Expression of the basic helix-loop-helix (bHLH) protein NeuroD1 is restricted to endocrine cells i

80 onal analysis of the basic helix-loop-helix (bHLH) protein SPEECHLESS, one of three closely related t

81 of a plant-specific basic helix-loop-helix (bHLH) protein, FEHLSTART (FST), a defect in which leads

82 The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcrip

83 Basic helix-loop-helix (bHLH) proteins, which are characterized by a conserved b

84 tor (P) proteins and basic helix-loop-helix (bHLH) repressor (R) factors (a "P+R" regulatory code), w

85 ng of members of the basic helix-loop-helix (bHLH) TF family.

86 pinal cord, Ptf1a, a basic helix-loop-helix (bHLH) transcription activator, maintains this delicate b

87 ipotent cells as the basic helix-loop-helix (bHLH) transcription factor (TF) E2A.

88 Atoh1, a basic helix-loop-helix (bHLH) transcription factor (TF), is essential for the di

89 TION FACTOR (FIT), a basic helix-loop-helix (bHLH) transcription factor (TF), regulates root Fe acqui

90 emi, which encodes a basic helix-loop-helix (bHLH) transcription factor and which controls these appa

91 We identified a basic helix-loop-helix (bHLH) transcription factor at chickpea's B locus that co

92 he expression of the basic helix-loop-helix (bHLH) transcription factor Atoh1.

93 ce deficient for the basic helix-loop-helix (bHLH) transcription factor Bhlhe40 (Bhlhe40(-/-)) are re

94 , we showed that the basic Helix-Loop-Helix (bHLH) transcription factor Cucumis sativus Irregular Vas

95 jasmonate-regulated basic helix-loop-helix (bHLH) transcription factor from clade IVa inducing the m

96 We show that basic helix-loop-helix (bHLH) transcription factor genes represented by Glyma04g

97 The basic helix-loop-helix (bHLH) transcription factor Hand2 has been implicated in

98 h sexes requires the basic-helix-loop-helix (bHLH) transcription factor HLH-2, the sole ortholog of t

99 ere, we identify the basic helix-loop-helix (bHLH) transcription factor homolog of brassinosteroid en

100 inhibit the atypical basic helix-loop-helix (bHLH) transcription factor INCREASED LEAF INCLINATION1 B

101 The basic helix-loop-helix (bHLH) transcription factor Math5 (Atoh7) is transiently

102 The Wnt-regulated basic helix-loop-helix (bHLH) transcription factor mesogenin 1 (Msgn1) has been

103 r-specific predicted basic helix-loop-helix (bHLH) transcription factor required for tapetal differen

104 the function of the basic helix-loop-helix (bHLH) transcription factor SPEECHLESS (SPCH).

105 molog 1 (Atoh1) is a basic helix-loop-helix (bHLH) transcription factor that is essential for the gen

106 We show that a basic helix-loop-helix (bHLH) transcription factor Upstream Regulator of IRT1 (U

107 was GRMZM2G021276, a basic helix-loop-helix (bHLH) transcription factor with tassel-specific expressi

108 h encodes a class II basic helix-loop-helix (bHLH) transcription factor, and causes Saethre-Chotzen s

109 in-22, a Hes-related basic helix-loop-helix (bHLH) transcription factor, increase seam cell number va

110 NeuroD2, a neuronal basic helix-loop-helix (bHLH) transcription factor, promotes the postnatal survi

111 y32 (ms32) encodes a basic helix-loop-helix (bHLH) transcription factor, which functions as an import

112 E SIX-LIKE1 (MpRSL1) basic-helix-loop-helix (bHLH) transcription factor, which is directly repressed

113 mologue 2 (Ascl2)--a basic helix-loop-helix (bHLH) transcription factor--is selectively upregulated i

114 f two genes encoding basic-helix-loop-helix (bHLH) transcription factors (TFs), NtMYC2a and NtMYC2b f

115 of master regulatory basic-helix-loop-helix (bHLH) transcription factors controls the initiation, pro

116 bers of the group XI basic helix-loop-helix (bHLH) transcription factors encoded by LOTUS JAPONICUS R

117 Class I Basic Helix-Loop-Helix (bHLH) transcription factors form homodimers or heterodim

118 e show that myogenic basic helix-loop-helix (bHLH) transcription factors induce myomaker expression i

119 , we have identified basic helix-loop-helix (bHLH) transcription factors Neurod2 and Neurod6 as key r

120 he activity of three basic-helix-loop-helix (bHLH) transcription factors of the PHYTOCHROME INTERACTI

121 Basic-helix-loop-helix (bHLH) transcription factors play an important role in va

122 Basic helix-loop-helix (bHLH) transcription factors recognize the canonical E-bo

123 Core basic helix-loop-helix (bHLH) transcription factors regulating stomatal developm

124 This includes the basic helix-loop-helix (bHLH) transcription factors SPEECHLESS (SPCH), MUTE, FAM

125 Basic helix-loop-helix (bHLH) transcription factors were reduced, while secondar

126 up-regulation of two basic helix-loop-helix (bHLH) transcription factors with predicted effector bind

127 FACTORs, a group of basic helix-loop-helix (bHLH) transcription factors.

128 interactions between basic helix-loop-helix (bHLH) transcriptional activators and the transcriptional

129 RREN STALK1 (BA1), a basic helix-loop-helix (bHLH) transcriptional regulator necessary for axillary m

130 The proneural basic helix-loop-helix (bHLH) transcriptional regulators are key components for

131 twork are TFs of the basic helix-loop-helix (bHLH), nuclear factor I (NFI), SOX, and FOX families, wi

132 ormone receptor is a basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain protein, a novel type o

133 ptic excitation, the basic-helix-loop-helix (bHLH)-PAS family transcription factor ARNT2 recruits the

134 (ARNT) belong to the basic helix-loop-helix (bHLH)-PER-ARNT-SIM (PAS) family of transcription factors

135 modulated by another basic helix-loop-helix (bHLH)-Per-ARNT-SIM (PAS) protein, the repressor of AhR f

136 The MYB- basic helix-loop-helix (bHLH)-WD40 complexes regulating anthocyanin and proantho

137 ivated member of the basic helix-loop-helix (bHLH)/PER-ARNT-SIM (PAS) transcription superfamily, is k

138 he MBW (for R2R3MYB, basic helix-loop-helix [bHLH], and WD40) genes comprise an evolutionarily conser

139 down-regulation can target other basic HLH (bHLH) dimers as well.

140 decreased levels of the proneural basic HLH (bHLH) transcriptional regulators TCF4 and NEUROD6 and de

141 f a common downstream helix-loop-helix (HLH)/bHLH network, thus forming an incoherent feed-forward lo

142 PIF4 bound all direct and down-regulated HLH/bHLH targets of IBH1 and IBL1.

143 In addition, a tripartite HLH/bHLH module feedback regulates PIFs and additional bHLH

144 We then successfully reprogrammed the human bHLH NPAS2 to bind Cbf1p in vivo targets and a Tye7p tar

145 ughterless (Da), the only Drosophila class I bHLH protein, activates Atonal (Ato) expression and reti

146 The four subgroup Ib bHLH genes also showed reduced expression levels in deve

147 n content in single and multiple subgroup Ib bHLH genes, as well as transcript profiling of iron resp

148 ate the expression of these four subgroup Ib bHLH genes.

149 l proliferation/differentiation switch of ID-bHLH factors.

150 Here, we report that a newly identified bHLH factor, Repressor of MYC2 Targets 1 (RMT1), is acti

151 odels of spontaneous resistance, we identify bHLH/homeobox transcription factors and cell-cycle regul

152 E proteins that heterodimerize with class II bHLH proteins such as TWIST1.

153 orm homodimers or heterodimers with class II bHLH proteins.

154 genome, it has been puzzling how individual bHLH proteins selectively recognize E-box sequences on t

155 ression2 (BEE2) and cryptochrome-interacting bHLH (CIB1) partially inhibits immunity, indicating that

156 MYC2, MYC3 and MYC4 are JAZ-interacting bHLH transcription factors that play a major role in con

157 family of four Phytochrome (phy)-Interacting bHLH transcription Factors (PIFs) collectively promote s

158 f PIF4 and PIF5, two phytochrome-interacting bHLH-family transcription factors that play pivotal role

159 Acting through intestinal bHLH-PAS domain proteins Methoprene-tolerant (Met) and G

160 The subgroup IVc bHLH transcription factors, which have previously been s

161 so highlight the residues of other mammalian bHLH-PAS proteins that are likely involved in their homo

162 and CLOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and p

163 Many bHLH proteins act as heterodimers with members of a clas

164 transcription factor now renamed Glycine max bHLH membrane 1 (GmbHLHm1).

165 rabidopsis, a ternary complex formed by MYB, bHLH transcription factors and TTG1 modulates unicellula

166 hocyanin biosynthesis is controlled by a MYB-bHLH-WD40 (MBW) transcriptional activator complex.

167 non-hair cell fates are determined by a MYB-bHLH-WD40 transcription factor complex and are regulated

168 ffect between SPLs and the heterogeneous MYB-bHLH factors binding to TTG1.

169 tral to this process are the activity of MYB-bHLH-WD repeat (MBW) complexes that regulate the transcr

170 avan-3-ol accumulation by activating the MYB-bHLH-WD40 complex and reduced rust proliferation.

171 box DBD), Klf4 (zinc finger DBD), and c-Myc (bHLH DBD), which together reprogram somatic cells to plu

172 recruitment to chromatin by multiple neural bHLH factors to restrict gene expression in specific neu

173 lators of neurogenesis, including neurogenic bHLH transcription factors and dorsal interneuron progen

174 re transcriptional specification by neuronal bHLH proteins to execute an intrinsic program of remote

175 We found nine bHLHs expressed in stem cells and neurons that are requi

176 yod1-binding sites were co-enriched with non-bHLH motifs, possibly explaining why Ascl1 is less conte

177 ctor (TF) genes from 54 TF families, notably bHLH, MYB, ERF, MYB-related, NAC, and WRKY.

178 h expression domain of Hand1 defines a novel bHLH-dependent activity, and that disruption of establis

179 Numerous bHLH proteins have been documented to participate in the

180 l structure in association with its obligate bHLH-ZIP partner Max.

181 tion of PRDM13 in repressing the activity of bHLH transcriptional activators that together are requir

182 tory cell expresses a distinct complement of bHLH-encoding genes-and therefore distinct HLH-2:bHLH di

183 ypes simply by loss or ectopic expression of bHLH genes, and male-to-female and female-to-male transf

184 invariant association of loss of function of bHLH among the kabuli type, we conclude that the kabuli

185 Thus, the interplay of bHLH-PAS complexes at activity-dependent regulatory elem

186 on resulted from an increase in the level of bHLH transcription factor Atoh1 in response to inhibitio

187 y a three-layered gas-and-brake mechanism of bHLH protein interactions, adding a layer of complexity

188 d an evolutionarily conserved recruitment of bHLH subfamily II and III(a + c)1 in the regulation of t

189 ucleotides revealed that the basic region of bHLH domain adopts multiple conformations, including an

190 ggest that dimerization-driven regulation of bHLH protein stability may be a conserved mechanism for

191 l cues in the CNS and to examine the role of bHLH transcription factors in adult tissue regeneration.

192 However, there have been very few studies of bHLH proteins from perennial tree species.

193 ults suggest that variation in the timing of bHLH transcription factor gene expression can explain th

194 This activation required MYC proto-oncogene bHLH transcription factor (c-Myc) and depended on the ch

195 MAX also dimerizes with MYC, an oncogenic bHLH transcription factor.

196 We find one WD40 and one bHLH gene controlling anthocyanin pigmentation in the en

197 s for rapid dynamic changes between opposing bHLH proteins in cells approaching a terminal differenti

198 , indicating functional replacement by other bHLH genes.

199 independent, and instead regulated by other bHLH TFs and by yet unknown TFs.

200 Pathways driven by other bHLH-PAS transcription factors have a homologous repress

201 la genomes reveals that TWIST, but not other bHLH proteins, recognizes a unique double E-box motif wi

202 recently available X-ray structures of other bHLH-PAS protein dimers.

203 through which the expression of a particular bHLH factor influences RPC fate is unclear.

204 ila retina, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) controls photor

205 ophila eye, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) determines a ra

206 We identified 44 planarian bHLH homologs, determined their patterns of expression i

207 Sox2, it does cause suppression of proneural bHLH gene expression, indicating that PRC2 is crucial fo

208 of the highly conserved proneural proteins, bHLH transcriptional regulators.

209 nctions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle

210 Overexpression of the HBI1-related bHLHs brassinosteroid enhanced expression2 (BEE2) and cr

211 how that MYB75, a component of the WD-repeat/bHLH/MYB complex regulating anthocyanin production, is a

212 Two classes of JA-responsive bHLH transcription factor (TF), CrMYC2 and BIS1/BIS2, ar

213 In the mouse retina, bHLH genes Atoh7 and Neurog2 have distinct functions, wi

214 rine 193 (S193) is phosphorylated in Atoh1's bHLH domain in vivo Knock-in mice of both sexes bearing

215 e via 2 basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) domain proteins-CLOCK and BMAL1.

216 of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are lin

217 to the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily.

218 is mechanism is later reinforced by specific bHLH factors.

219 ell-state and expression of lineage-specific bHLH/homeobox transcription factors.

220 tivity, ARNT2 recruits the neuronal-specific bHLH-PAS factor NPAS4 to activity-dependent regulatory e

221 1) and identified EAN1 as a tapetum-specific bHLH transcription factor necessary for tapetum degenera

222 gans' development; however, a tooth-specific bHLH factor has not been reported.

223 trated that AmeloD is a novel tooth-specific bHLH transcription factor that may regulate tooth develo

224 study, we identified a novel tooth-specific bHLH transcription factor, which we named AmeloD, by scr

225 omains has diverged, with the three stomatal bHLHs exhibiting absolute, partial, or no requirements f

226 rk suggested that the pathway of two tapetal-bHLH subfamilies is conserved in all land plants, and li

227 The bHLH code appears to be embedded in a bow-tie regulatory

228 The bHLH factor Twist is among the least well studied of the

229 The bHLH iridoid synthesis 1 (BIS1) transcription factor tra

230 The bHLH transcription factor Olig2 is expressed in cycling

231 The bHLH transcription factors SHARP1 and SHARP2 are partial

232 -length protein, and in particular about the bHLH domain-flanking N- and C-terminal segments, which a

233 In petunia petals, AN11 and the bHLH protein AN1 activate, together with the MYB protein

234 as EMT inducers, among them, Snail1 and the bHLH transcription factor E47.

235 in enhanced HIF-2alpha ubiquitination at the bHLH and PAS domains.

236 (2014) describe the signals regulated by the bHLH transcription factor HEC1 during Arabidopsis stem c

237 ncreased auxin biosynthesis, mediated by the bHLH transcription factor PHYTOCHROME-INTERACTING FACTOR

238 CF12 mutations identified were in either the bHLH domain, which is important for TCF12 function as a

239 ells proliferate and transiently express the bHLH transcription factor Ngn3.

240 Designer TALEs (dTALEs) for the bHLH transcription factors and the pectate lyase, but no

241 find that these roles are distinct from the bHLH protein Hairy (H), which we show restricts atonal (

242 We identify the bHLH factor E47 as a modulator of GR target genes.

243 Prior work has implicated the bHLH transcription factor Tal1 in endocardial tube forma

244 ch-5 allele carrying a point mutation in the bHLH domain that displayed normal growth, but had an ext

245 Of particular interest is the bHLH proneural factor Neurogenin2 (Ngn2), which orchestr

246 cking the growth-suppressing activity of the bHLH DNA-binding protein Daughterless (Da).

247 e also show that the C-terminal helix of the bHLH domain is involved in intermolecular interactions,

248 CH target genes require the integrity of the bHLH domain of SPCH.

249 ed allosterically by a domain outside of the bHLH region.

250 ur predictions by functional analysis of the bHLH TF OLIG2.

251 n the temporal and spatial regulation of the bHLH transcription factor Atoh1.

252 n depends on the regulated expression of the bHLH transcription factor Atoh1.

253 gested that the large-scale expansion of the bHLH transcription factor family occurred before the div

254 ing nuclear localization and activity of the bHLH transcription factor Tfe3.

255 ed genes that could be direct targets of the bHLH transcription factors and therefore indirect target

256 retinoblasts, and functions upstream of the bHLH transcription factors ath5/atoh7 and neurod, and th

257 The rational design of inhibitors of the bHLH-ZIP oncoprotein c-Myc is hampered by a lack of stru

258 Singleminded-2s (SIM2s) is a member of the bHLH/PAS family of transcription factors and a key regul

259 Here we show that SIM2s, a member of the bHLH/PAS family of transcription factors, regulates DNA

260 zebrafish olfactory epithelium requires the bHLH proneural transcription factor Neurogenin 1 (Neurog

261 UV-B also stabilizes the bHLH protein LONG HYPOCOTYL IN FAR RED (HFR1), which can

262 yte Physcomitrella patens has shown that the bHLH and EPF components are also required for moss stoma

263 support this hypothesis by showing that the bHLH gene complement is both necessary and sufficient to

264 These findings suggest that the bHLH TF MdbHLH3 directly modulates auxin signaling in co

265 Here, we show that the bHLH transcription factor Hand2 limits the size of the e

266 In the present work, we demonstrate that the bHLH transcription factor NeuroD6 is specifically and tr

267 We demonstrated that the bHLH transcription factor R1 and hexokinase HEX9 might a

268 Here, we show that the bHLH transcription factors HECATE 1 (HEC1), HEC2 and HEC

269 In summary, we conclude that the bHLH transcription factors SHARP1 and SHARP2 are involve

270 In addition, we demonstrate that the bHLH/PAS transcription factor Single-minded (Sim) acts a

271 iptional regulation on a daily basis via the bHLH-PAS transcription factor CLOCK:BMAL1.

272 mechanisms, including interactions with the bHLH factor Ascl1, to repress Ascl1 activation of Tlx3.

273 e, both display significant overlap with the bHLH transcription factor DIMM, a known neuroendocrine (

274 JAZ13 interacts with the bHLH transcription factor MYC2 and the co-repressor TOPL

275 m, an absence of nested variation within the bHLH gene and invariant association of loss of function

276 s identify the first direct targets of these bHLH repressors.

277 nteracting Factors (PIFs) by releasing these bHLH transcription factors from phytochrome B-mediated i

278 Phylogenetic analysis indicates that these bHLH transcription factor genes are orthologous to Arabi

279 igand-binding domain, thus establishing this bHLH-PAS protein as a novel type of an intracellular hor

280 irect target of EZH2, and repression of this bHLH transcription factor is critical for neuronal diffe

281 ng analysis we identified five MYB and three bHLH transcription factors that were upregulated in the

282 temporal, and lineage inputs connect through bHLH genes to diverse outputs for terminal features and

283 ssible regions are more frequently linked to bHLH motifs and ASCL1 binding.

284 y characterizing a Phaeodactylum tricornutum bHLH-PAS nuclear protein, hereby named RITMO1, we shed l

285 physically interacts with the M. truncatula bHLH protein MtTT8 and the WDR family member MtWD40-1, a

286 Here Medicago truncatula bHLH MtTT8 was characterized as a central component of t

287 Two bHLH transcription factors in this network, Olig1 and Ol

288 hange and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5.

289 Here we show that Arabidopsis lacking two bHLH transcription factors produces pollen without sperm

290 ncestor, we identified the single class VIII bHLH gene from the charophyceaen alga Chara braunii (Cbb

291 Although the group VIII bHLH proteins, AtROOT HAIR DEFECTIVE6 and AtROOT HAIR DE

292 r findings show that the specificity of WD40-bHLH-MYB complexes is in part determined by interacting

293 While bHLH heterodimers are known to have diverse roles, littl

294 scl1 binding was exclusively associated with bHLH motifs, strong Myod1-binding sites were co-enriched

295 n prevent E2A from forming heterodimers with bHLH TFs or from forming homodimers.

296 hocyanin MYBs, BvMYB1 will not interact with bHLH members of heterologous anthocyanin MBW complexes b

297 Here, we analyzed 2 yeast bHLH TFs, Cbf1p and Tye7p, which have highly similar bin

298 minal basic helix-loop-helix leucine zipper (bHLH-LZ) domains of the oncoprotein c-Myc.

299 is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding protein.

300 (SEC14-like 3), bZIP (basic-leucine zipper), bHLH (basic helix-loop-helix) and SBP (SQUAMOSA promoter