ライフサイエンスコーパス: baboon

1 ons upstream of the type-I TGF-beta receptor Baboon.

2 naturally transmitted in a colony of captive baboons.

3 lar lavage was increased in old versus young baboons.

4 the tax sequences present in two individual baboons.

5 ving preexistent acute TTP signs in mice and baboons.

6 trol but strongly correlated in OLD and IUGR baboons.

7 ats and an intravenous dose of 0.06 mg/kg in baboons.

8 acept (n=5) in kidney allotransplantation in baboons.

9 TKO.hCD46.hTBM), that were transplanted into baboons.

10 A total of 68 lesions were identified in 64 baboons.

11 osition in a well-studied population of wild baboons.

12 on rate per generation in humans but also in baboons.

13 tic effects on gene expression levels in the baboons.

14 but an asymptomatic, persistent infection in baboons.

15 parable to that of allogeneic skin grafts in baboons.

16 immature neurons than socially dominant-like baboons.

17 ymokidney xenograft survival of >2 months in baboons.

18 iviruses are actively circulating in captive baboons.

19 lec-9) orthologs in humans, chimpanzees, and baboons.

20 a after xenogeneic kidney transplantation in baboons.

21 s and 3 Sm-p80-based vaccine formulations in baboons.

22 recent transmission of SWBV-1 among captive baboons.

23 hout substantial systemic anticoagulation in baboons.

24 GTKO (n = 5) and TKO (n = 3) pig kidneys in baboons.

25 idence of infection were present in all nine baboons.

26 ith early-stage atherosclerosis in pedigreed baboons.

27 RNA was present in the semen of five of nine baboons.

28 as (PPP) obtained from 28 healthy humans, 10 baboons, 12 rhesus monkeys, 20 Yorkshire pigs, 20 Spragu

29 (3324 pg/mL), in comparison to naive control baboons (214 pg/mL).

30 M, 8 F, 5.6 years), and normal elderly (OLD) baboons (6 M, 6 F, mean 15.9 years) revealed long-term L

31 ximately 25 years), and normal elderly (OLD) baboons (6 male, 6 female, mean 15.9 years).

32 r left ventricular (LV) CMRI studies in IUGR baboons (8 M, 8 F, 5.7 years - human equivalent approxim

33 We studied IUGR baboons (8 male, 8 female, 5.7 years), control offspring

34 ood vessel sizes, and distensibility in IUGR baboons (8 males, 8 females, 8.8 years, similar to 35 hu

35 was calibrated using experimental data from baboons administered a two-hour infusion of E coli and f

36 socially dominant- or subordinate-like (SL) baboons administered the antidepressant fluoxetine or ve

37 Nonetheless, in both mice and baboons, administration of NAC was not effective in reso

38 ere we describe cellular immune responses in baboons against a closely related virus, STLV-1.

39 L1 sequence in modern and archaic humans and baboons along with geographic distribution in present da

40 d oligomers formed by baboon amylin, but not baboon amylin fibers, are toxic to cultured beta-cells.

41 Baboon amylin forms amyloid on the same timescale as hum

42 ase collisional cross sections for human and baboon amylin monomers and dimers, with some differences

43 Preamyloid oligomers formed by baboon amylin, but not baboon amylin fibers, are toxic t

44 Photochemical cross-linking reveals that the baboon amylin, like human amylin, forms low-order oligom

45 nar distributions of [3H]CUMI-101 binding in baboon and human brain sections matched the known distri

46 tative autoradiography studies in postmortem baboon and human brain sections using the 5-HT1AR antago

47 ing and rapid and reversible kinetics in the baboon and human brain.

48 Mouse transgenic experiments from baboon and human genomic loci confirm these expression d

49 the activated partial thromboplastin time of baboon and human plasmas.

50 In general, the NPNs of the baboon and monkey BNC, including the specialized subtype

51 onpyramidal neurons (NPNs) in the BNC of the baboon and monkey using the Golgi technique.

52 nt, there were significant increases in both baboon and pig IL-6 in the baboon serum, especially in b

53 TG and PG parameters from baboon and rhesus macaque plasma approximated that of hu

54 s with eQTL significantly overlapped between baboons and a comparable human eQTL data set.

55 22 exists as a single copy in the genomes of baboons and high order primates, but not New World monke

56 current knowledge of the natural history of baboons and highlights directions for future research.

57 ial, behaviorally complex animals, including baboons and humans.

58 elaborate greeting rituals among male Guinea baboons and less aggression toward females.

59 infection in young and old rhesus macaques, baboons and old marmosets.

60 chosocial sources of early-life adversity in baboons and other long-lived species.

61 x was assessed in Old World monkeys (macaque/baboon) and Hominoidea (chimpanzee/human).

62 , no evidence for superinfection within each baboon, and a ready ability of T cells in each baboon to

63 observed in mutants for the TGFbeta receptor baboon, and epistasis tests showed that baboon is epista

64 the IL-6/IL-6Ralpha/STAT3 pathway in human, baboon, and pig cells, respectively.

65 vitro observations demonstrated that human, baboon, and pig IL-6 can activate the IL-6/IL-6Ralpha/ST

66 Rapamycin partially inhibited human, baboon, and pig IL-6/IL-6Ralpha/STAT3 pathways and suppr

67 grafts inserted into arteriovenous shunts in baboons, and reduced fibrin and platelet accumulation do

68 owing T cell lines were established from two baboons, animals 12141 and 12752.

69 Here, we compare recombinant human and baboon APOL1 orthologs, along with interspecies chimeras

70 These data demonstrate that male olive baboons approximate the male human ZIKV response, includ

71 manage the baboons' space use) revealed that baboons are at risk of being herded out of urban spaces

72 w data from previously understudied species, baboons are ideally suited for investigating the links b

73 eferentially following dominant individuals, baboons are more likely to follow when multiple initiato

74 rganisms, however, the genomic resources for baboons are severely lacking.

75 s has hindered the progress of studies using baboons as a model for basic biology or human disease.

76 ese results justify the use of STLV-infected baboons as a model system for vaccine development effort

77 range of the simian arteriviruses and define baboons as a natural host for these viruses.

78 ersity of the simian arteriviruses, identify baboons as a natural host of these viruses, and provide

79 nsive catalog of common genetic variation in baboons, as well as a fine-scale genetic map.

80 of human CD47 were infused into conditioned baboons at 3 time points over a 9-week period.

81 Aggression directed by male baboons at females during the early stages of their bree

82 Pregnant MNR baboons ate 70% of what controls ate from 0.16 to 0.9 ge

83 Baboon-attached motion/GPS tracking collars showed that

84 In the baboon baseline studies, the brain regional volume of di

85 data suggest a difference in sensitivity in baboons between a context-free and a context-sensitive g

86 (18)F-ASEM readily entered the baboon brain and specifically labeled alpha7-nAChR.

87 PET baboon brain distribution paralleled that seen in mouse,

88 l agonist, blocked (18)F-ASEM binding in the baboon brain in a dose-dependent manner, suggesting that

89 of regional binding potential values in the baboon brain was from 3.9 to 6.6.

90 ted progenitor cells within the SVZ of adult baboon brain.

91 of trapezoid body (MNTB) in preterm and term baboon brainstem slices to study the structural and func

92 In baboon but not macaque cell cultures, SHFV infection upr

93 uman IL-6 inhibitor) bound to both human and baboon, but not pig, IL-6 and suppressed activation of t

94 s the severity of P. knowlesi coinfection in baboons by mechanisms that may enhance innate immunity t

95 slets before Tx in nonhuman primates (NHPs) (baboons) by silencing a gene (caspase-3) responsible for

96 We suggest that baboons can serve as a valuable model for complex evolut

97 Our study probed baboons' capacity to learn two supra-regular grammars of

98 results show that, similarly to humans, the baboon CD8(+) T cell response narrowly targeted the Tax

99 TAT3 pathway was blocked by TCZ in human and baboon cells but not in pig cells (ie, pig IL-6R).

100 flicts arise over the direction of movement, baboons choose one direction over the other when the ang

101 rch Institute has maintained a large captive baboon colony for more than 50 yr.

102 e complexes detected in the plasma of septic baboons correlated with increase in histones and/or nucl

103 Baboon cultures produced higher levels of IL-10 than mac

104 V infection were observed in macaque but not baboon cultures, suggesting less efficient counteraction

105 e cultures produced higher virus yields than baboon cultures.

106 of innervation was already formed in preterm baboons delivered at 67% of normal gestation.

107 lly protected against disease, whereas naive baboons developed illness (with 1 death) and leukocytosi

108 Naive infant baboons developed severe disease when challenged with B.

109 hus, the social relationships of male Guinea baboons differ markedly from those of other members of t

110 Overall, these raiding baboons display a time-activity balance that is drastica

111 Adversities experienced by female baboons early in life can affect the survival of their o

112 reflect the omnivorous dietary behaviour of baboons, even though health, food provisioning and other

113 A total of 81% of baboons exposed to chronic S. mansoni infection with or

114 Individual baboons expressed more gamma interferon and tumor necros

115 osely related STLV-1 genome sequences in two baboons, extremely low heterogeneity of STLV sequences w

116 the mouse and as early as three hours in the baboon eye tissues.

117 We measured LTL by qPCR in pedigreed baboons fed a chow (n = 105) or HCHF (n = 106) diet for

118 Lactating female baboons form close ties ("primary associations" hereafte

119 e oxygen and strontium isotope ratios of 155 baboons from 77 locations to estimate the geoprovenance

120 h)-6(th) centuries BC) and of two historical baboons from a zoo via shotgun metagenomics.

121 d an RNA sequencing (RNA-seq)-based study of baboons from an intensively studied wild population.

122 Baboons (genus Papio) are broadly studied in the wild an

123 Strikingly, baboon gut microbiota appeared to be highly dynamic such

124 Despite the dynamic nature of baboon gut microbiota, we identified a set of core taxa

125 SL baboons had lower numbers of proliferating cells and imm

126 Baboons had prolonged viral RNA shedding and substantial

127 mples collected over 13 years, we found that baboons harbour gut microbiota typical of other omnivoro

128 The evolution of baboons has been heavily shaped by climatic changes and

129 in GW infections in domestic dogs, cats and baboons has been reported.

130 Neuroblasts missing the activin receptor Baboon have a delayed intrinsic program as Imp is higher

131 ndividuals' nearest neighbours, we find that baboons have distinct preferences for particular neighbo

132 the oral microbiome of six ancient Egyptian baboons held in captivity during the late Pharaonic era

133 t to indicate that adult neurogenesis in the baboon hippocampal DG may be functionally relevant in th

134 ive (P. anubis) and yellow (P. cynocephalus) baboons housed at the SNPRC.

135 Humans form islet amyloid, but baboon IAPP has not been studied.

136 erum IL-6 because it could no longer bind to baboon IL-6Ralpha.

137 ced plasma LPS content in E. coli-challenged baboons, implying reduced complement-mediated bacterioly

138 use prospective, longitudinal data from wild baboons in Kenya to test the links between early adversi

139 uous, individual-based data from wild female baboons in the Amboseli ecosystem in Kenya, including pr

140 lower parasite burdens (P = 0.004) than the baboons in the P. knowlesi-only group and were protected

141 [PAP]), and complement (C3b, C5a, C5b-9) in baboons infused with factor Xa (FXa) and phospholipids (

142 ptor baboon, and epistasis tests showed that baboon is epistatic to Smad2 for disc overgrowth.

143 We find that the Activin receptor Baboon is required in R8 to receive non-redundant signal

144 esponse against STLV-1 in naturally infected baboons is largely directed against the Tax protein.

145 days) versus naked (MRT, 36 days; P < 0.01) baboon islets transplanted in the EFP site.

146 For in vivo studies, donor baboon islets were labeled with MN-siCas-3 and infused i

147 Recent survivals of our pig-to-baboon kidney xenotransplants have been markedly shorter

148 sulted in extensive genome admixture of nine baboon Lak phage populations.

149 sing a pattern extraction task, we show that baboons, like humans, have a learning bias that helps th

150 f human coagulation factors following pig-to-baboon liver xenotransplantation (LXT) using GalT-KO swi

151 onses to SARS-CoV-2 infection in macaque and baboon lungs, including innate and adaptive immune cells

152 human LCN2 (rh-LCN2) and autoradiography in baboon, macaque, and human brain sections, that LCN2 cro

153 e viruses, and provide further evidence that baboons may have played a role in previous outbreaks of

154 FV infected approximately 50% of macaque and baboon mDCs, virus replication was efficient in macaque

155 lication was efficient in macaque but not in baboon mDCs.

156 Baboons, members of the genus Papio, comprise six closel

157 aternal vaccination confer protection in the baboon model and support further study of these strategi

158 We developed a baboon model for IUGR studies using a moderate 30% globa

159 ur findings suggest that the STLV-1-infected baboon model may recapitulate some of the important aspe

160 oon viruses suggest that the STLV-1-infected baboon model might be useful for developing a vaccine ag

161 cholesterol high fat (HCHF) diet on LTL in a baboon model of atherosclerosis.

162 g in vitro whole-blood assays and an in vivo baboon model of Escherichia coli sepsis.

163 l and maternal plasma FA concentrations in a baboon model of growth restriction with data that sugges

164 The present study used a baboon model of IUGR (maternal nutrient restriction, MNR

165 FA concentrations are decreased at term in a baboon model of IUGR.

166 The recent development of a baboon model of pertussis, along with the future develop

167 uble FMS-like tyrosine kinase-1 (sFLT1) in a baboon model of preeclampsia portends the development of

168 Here, we used a baboon model to test the protective potential of the nov

169 TTP signs, using well-established murine and baboon models for TTP.

170 e in cardiac xenotransplantation with pig to baboon models, the longest xenograft of which survived o

171 of their habitat to identify key drivers of baboon movement.

172 a process of shared decision-making governs baboon movement.

173 We find that baboon movements are best predicted by 4 to 6 neighbours

174 caque MPhis but in only approximately 10% of baboon MPhis.

175 Timed-pregnant baboons (n = 6) were inoculated via vaginal deposition o

176 Two groups of baboons (n = 8 each) and a schistosomiasis control group

177 Baboons naturally infected with simian T lymphotropic vi

178 heterogeneity of STLV sequences within each baboon, no evidence for superinfection within each baboo

179 estimated a mutation rate per generation in baboons of 0.57x10-8 per base pair, approximately half t

180 o enable translation to humans, we developed baboon offspring cohorts from mothers fed ad libitum (co

181 The toxicity of baboon oligomers and lack of significantly detectable to

182 tching the performance and error patterns of baboons on word classification.

183 cidating the rules that maintain cohesion in baboons 'on the move', as well as the different temporal

184 measurably displace [3H]CUMI-101 binding in baboon or human brain sections, thereby ruling out [3H]C

185 with human management, may have changed the baboons' oral microbiome.

186 by tocilizumab (TCZ) has been used in pig-to-baboon organ xenotransplant models, but whether it is be

187 inal pigment epithelium (RPE) from mouse and baboon over a series of post-mortem intervals.

188 d IgM responses in vaccinated and challenged baboons over a time course of 25 weeks.

189 er 2 years median LTL is shorter in HCHF fed baboons (P < 0.0001).

190 s have shown significant correlation between baboon (Papio anubis) and human brain.

191 cted a randomized controlled study using the baboon (Papio anubis) to analyze the effect of chronic s

192 infection and vertical transfer in the olive baboon (Papio anubis).

193 d semen and the immune response of the olive baboon (Papio anubis).

194 families (totaling 29 individuals) of olive baboons (Papio anubis), who reproduce at approximately 1

195 a virus closely related to HTLV-1, in olive baboons (Papio anubis).

196 ial-enhanced MR angiography was performed in baboons (Papio anubis; n = 4) by using Mn-PyC3A and Gd-D

197 In yellow and chacma baboons (Papio cynocephalus and P. ursinus), there is a

198 concentrations in five social groups of wild baboons (Papio cynocephalus) over an 11-y period.

199 For example, hamadryas baboons (Papio hamadryas) live in units consisting of on

200 To this end, 52 baboons (Papio hamadryas) underwent partial pancreatecto

201 emporium for luxury goods, including sacred baboons (Papio hamadryas), but its location is disputed.

202 with genetic relatedness data of wild Guinea baboons (Papio papio), we show that this species exhibit

203 related species in the vaginal microflora of baboons (Papio spp.).

204 sidency times (PRTs) recorded from 54 chacma baboons (Papio ursinus) across two groups in natural (n

205 oural processes by which raiding male chacma baboons (Papio ursinus) exploit the opportunities and mi

206 Retrospective data from 33 septic baboons (Papio ursinus) subjected to Escherichia coli in

207 functions as sexual coercion in wild chacma baboons (Papio ursinus).

208 n use with experimental food patches in wild baboons (Papio ursinus).

209 The baboon peptide differs from human IAPP at three position

210 (mDCs), were differentiated from macaque and baboon peripheral blood monocytes and used to compare vi

211 ere evaluated in DISC1 mice (dissection) and baboons (PET).

212 948, (11)C-RO6931643, and (11)C-RO6924963 to baboons, PET scans indicated good brain entry, rapid was

213 ompound present at 90 min after injection in baboon plasma.

214 We demonstrate that these captive baboons possessed a distinctive oral microbiome when com

215 A previously unexplored social influence - baboons' preference for locations that other troop membe

216 To model maternal vaccination, adult female baboons primed with acellular pertussis vaccine were boo

217 IUGR programming in baboons produces myocardial remodelling, reduces systoli

218 Savannah baboons provide an excellent opportunity to test these h

219 Our mutation rate estimates for baboons raise a further puzzle, suggesting a divergence

220 Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in hum

221 After LXT, baboons received no coagulation factors (historical cont

222 artery patch xenotransplantation, recipient baboons received no immunosuppression (IS; n=3), or anti

223 Six baboons received rituximab before transplantation to dep

224 Baboons receiving acellular pertussis vaccine and infant

225 ient chimerism were substantially greater in baboons receiving hematopoietic cells from a pig express

226 graft into the intra-abdominal position in a baboon recipient for the study of transplantation and br

227 s to estimate the geoprovenance of mummified baboons recovered from ancient Egyptian temples and tomb

228 Three prospective pig-to-baboon renal transplants using kidneys from swine delive

229 s to understanding of ZIKV infection in male baboon reproductive tissues and begins to elucidate how

230 Although the social organization of Guinea baboons resembles that of hamadryas baboons, we found st

231 baboon virus 1 (SWBV-1), in wild and captive baboons, respectively, and demonstrate the recent transm

232 The current baboon result thus suggests that the cognitive roots res

233 rated here high-titer LVs pseudotyped with a baboon retroviral envelope glycoprotein (BaEV-LVs), resi

234 PET imaging in baboons reveals that all organs have a 2-phase (rapid an

235 In contrast, lower primates (baboons, rhesus monkeys) express 12-lipoxygenating enzym

236 6) were inoculated via vaginal deposition of baboon semen containing 10(6) focus-forming units (FFU)

237 zed that vaginal deposition of ZIKV-infected baboon semen would lead to maternal infection and vertic

238 Culture of isolated pig podocytes with naive baboon sera, which has preformed antipig natural antibod

239 Similarly, ex vivo incubation of baboon serum with thrombin, plasmin, or FXa did not show

240 increases in both baboon and pig IL-6 in the baboon serum, especially in baboons that received TCZ be

241 Ventilated preterm baboons show activation of the NLRP3 inflammasome with i

242 Baseline PET studies in the pig and baboon showed that (11)C-IMA107 and (11)C-MP-10 displaye

243 Baboons showed slower response times when violations occ

244 ns from Bangladesh and Tanzania, two African baboon social groups and Danish pigs; many of these micr

245 ucted with 'rangers' (employed to manage the baboons' space use) revealed that baboons are at risk of

246 xplain the distinct behavioral suites of two baboon species in Awash, Ethiopia, which differ markedly

247 PS tracking collars showed that raiding male baboons spent almost all of their time at the urban edge

248 ed but distinct from each other and from the baboon STLV-1 sequence in the NCBI sequence database.

249 Tax peptides corresponding to the reference baboon STLV-1 sequence.

250 expanded the number of available full-length baboon STLV-1 sequences from one to three and related th

251 Recent behavioral research in baboons suggests that non-human primates may provide an

252 ts and regulatory role of H3K4me3 within the baboon SVZ, we developed a technique to purify undiffere

253 the undifferentiated progenitor cells of the baboon SVZ.

254 ach unique Tax sequence and to the reference baboon Tax sequence were used to analyze recognition by

255 significant with the exceptions of human PG, baboon TG, rat TG and Guinea pig PG.

256 subfamily of Old World monkey, particularly baboons, than to those of African apes.

257 dentified two tentative enterotypes in adult baboons that differ from those of humans and chimpanzees

258 pig IL-6 in the baboon serum, especially in baboons that received TCZ before xenotransplant.

259 d viral sequence heterogeneity in individual baboons, the identity of the viral gene product that is

260 In IUGR baboons there was increased carotid arterial blood flow

261 habitats and dietary strategies to those of baboons, these findings suggest that convergent ecologie

262 D-1 and sEH knock-out mice and Papio anubis (baboon) through pretreatment with an sEH inhibitor to bl

263 The ability of a wild baboon to acquire and exploit social information depends

264 boon, and a ready ability of T cells in each baboon to recognize circulating Tax sequences.

265 PET nuclide and tested in vivo in tau-naive baboons to assess brain uptake, distribution, clearance,

266 e we use prospective data on 196 wild female baboons to show that cumulative early adversity predicts

267 and again in the peri-transplant period; 18 baboons treated only before transplantation served as hi

268 resolution GPS tracking of members of a wild baboon troop, we test whether collective movement in sta

269 Papio anubis baboons underwent PET scans of the brain after intraveno

270 measure the kinetics for 14 organs in a male baboon using (86)Y- 6 RESULTS: Compounds (86)Y- 4: - 6:

271 to analyze recognition by T cells from each baboon using intracellular cytokine staining (ICS).

272 d ejection abnormalities in IUGR young adult baboons using cardiac magnetic resonance imaging.

273 Baboons vaccinated with aP were protected from severe pe

274 Baboons vaccinated with radiation-attenuated cercariae d

275 arteriviruses related to SHFV, Mikumi yellow baboon virus 1 (MYBV-1) and Southwest baboon virus 1 (SW

276 yellow baboon virus 1 (MYBV-1) and Southwest baboon virus 1 (SWBV-1), in wild and captive baboons, re

277 he sequence similarity between the human and baboon viruses suggest that the STLV-1-infected baboon m

278 The metabolism of (18)F-FNDP in baboons was assessed using high-performance liquid chrom

279 dian survival of TKO pig kidneys (4 days) in baboons was significantly shorter than that of GTKO kidn

280 Through our previous work in olive baboons, we developed a nonhuman primate model that is p

281 f Guinea baboons resembles that of hamadryas baboons, we found stronger male-male affiliation and mor

282 Using shotgun metagenomic data from wild baboons, we found that social group membership and socia

283 Hence, in female baboons, weak social bonds in adulthood are not enough t

284 When BPZE1-vaccinated baboons were challenged with a high dose of a highly vir

285 Pregnant baboons were fed control (ad libitum, n=11) or an MNR di

286 Pregnant baboons were fed control or maternal nutrient restricted

287 Nine mature male baboons were infected with ZIKV (French Polynesian strai

288 Juvenile baboons were subjected to 40% to 55% total blood volume

289 Fourteen baboons were tested in a prediction task, requiring them

290 To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP

291 Baboons were vaccinated with acellular pertussis vaccine

292 , and blood flow pattern in young adult IUGR baboons, which may contribute to cardiac stress.

293 rdiac dysfunction and vascular impairment in baboons who were IUGR at birth because of moderate mater

294 Tracking wild baboons with a high-resolution global positioning system

295 models, particularly the infection of infant baboons with B. pertussis, are enabling longstanding que

296 anasal/intratracheal inoculation of juvenile baboons with BPZE1 resulted in transient nasopharyngeal

297 eactivities in post-mortem brains from adult baboons with cerebral hypoperfusive injury, induced by o

298 were co-administered into the peritoneum of baboons with endometriosis, cells in lesions selectively

299 h arterial blood sampling was performed in 3 baboons, with regional tracer binding quantified using d

300 ultaneous, high-resolution, tracking of wild baboons within a troop with a 3-dimensional reconstructi