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1 ated by cytosolic poly I:C, reoviral RNA, or bacterial RNA.
2 -1beta induction and caspase-1 activation by bacterial RNA.
3 able on mechanisms underlying recognition of bacterial RNA.
4 ey has adapted to a role in the digestion of bacterial RNA.
5 creased demands for the enzyme for digesting bacterial RNA.
6 ll RNAs in the cell and is relatively stable bacterial RNA.
7 RNAs are homologous (of common ancestry) to bacterial RNA.
8 e profiled, including mRNA, miRNA, piRNA and bacterial RNA.
9 hagocytosis, impairing endosomal delivery of bacterial RNA.
10 ently, PKR has been found to be activated by bacterial RNA.
11 (FnCas9) is capable of targeting endogenous bacterial RNA.
12 including long noncoding RNA, pre-mRNAs and bacterial RNAs.
13 tion termination events and 3' maturation of bacterial RNAs.
14 Rfam data, focusing on microRNAs, viral and bacterial RNAs.
15 l features in this RNA, which are typical of bacterial RNAs, activate PKR in TRAP-free and TRAP/l-Trp
17 Here we describe two reproducible methods of bacterial RNA amplification that will allow previously i
18 ways involved in innate immune activation by bacterial RNA and analyze the physiological relevance of
19 sis to enable simultaneous quantification of bacterial RNA and inflammatory proteins in a single syst
20 dying small molecules that can interact with bacterial RNA and interrupt cellular activities is a pro
21 une responses, the stimulatory properties of bacterial RNA and its role during infections have just b
23 iRNA) array analysis revealed an increase in bacterial RNA and multiple host miRNAs (miR-145, miR-146
24 h rifampin or chloramphenicol, inhibitors of bacterial RNA and protein synthesis, respectively, showe
25 IL-1beta and IL-18 production in response to bacterial RNA and the imidazoquinoline compounds R837 an
26 I cleaves double-stranded (ds) structures in bacterial RNAs and participates in diverse RNA maturatio
27 adation profiles of mRNA vaccines, viral and bacterial RNA, and other valuable species, new sensitive
28 gh cytosolic double-stranded RNA (dsRNA) and bacterial RNA are known to activate the NLRP3 inflammaso
29 RNase P RNAs of eukaryotes, in contrast to bacterial RNAs, are not catalytically active in vitro wi
30 flux and the primary use of amino acids and bacterial RNA as a tricarboxylic acid cycle carbon sourc
33 storage regulator A) is a widely distributed bacterial RNA binding protein that regulates translation
39 hat contain all of the catalytic core of the bacterial RNA but lack phylogenetically variable, stabil
40 RNA contains a core structure similar to the bacterial RNA but lacks specific features that in bacter
43 The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landm
44 sults propose a wide repertoire of potential bacterial RNA capping molecules, and provide mechanistic
47 similarities between NSP2 and the unrelated bacterial RNA chaperone Hfq suggest that accelerating RN
50 f the proteins from different organisms, the bacterial RNA component, and a bacterial RNase P holoenz
51 rial RNA but lacks specific features that in bacterial RNAs contribute to catalysis and global stabil
53 results, together with recent insights into bacterial RNA decay, suggest a unifying model for the bi
57 Recently, the subcellular organization of bacterial RNA degradosomes was found to present similari
61 d little effect on invasion, indicating that bacterial RNA, DNA, and de novo protein synthesis are no
62 Our findings expand current knowledge of bacterial RNA editing in clinical contexts and provide a
63 A method was developed to detect 5' ends of bacterial RNAs expressed at low levels and to differenti
65 and blood was extracted at 8 hours to purify bacterial RNA for RNA-Seq with an Illumina platform.
68 a protocol for isolation of microarray-grade bacterial RNA from Escherichia coli K1 interacting with
71 eloped a technique for specific isolation of bacterial RNA from within infected murine macrophages, a
72 In addition to functioning as a tether, the bacterial RNA gates access of substrates to the Ro60 cav
73 uctures and mechanisms of enzymes comprising bacterial RNA-guided CRISPR-Cas immune systems and deplo
74 dvent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9 system in animals and p
80 modimerization domain with homology to other bacterial RNA helicases, and mass photometry data confir
81 unambiguously identify TLR8 as receptor for bacterial RNA in primary human monocyte-derived macropha
82 l-length protein in Escherichia coli package bacterial RNAs in amounts equivalent to the viral pregen
84 racellular nucleic acid receptor involved in bacterial RNA-induced inflammasome activation and releas
85 -like receptor 8 (TLR8) recognizes viral and bacterial RNA, initiating inflammatory responses that ar
92 RNA to generate the probes, especially when bacterial RNA is used for hybridization (50 microg of ba
93 the eucaryal RNase P RNA, in contrast to the bacterial RNA, is catalytically inactive in the absence
95 n 2 degrees BP is characterized by increased bacterial RNA mass and dominance of culture-confirmed pa
97 l role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1, and prov
101 se) plays synthetic and degradative roles in bacterial RNA metabolism; it is also suggested to partic
104 mechanistic function similarity between the bacterial RNA polymerase (RNAP) "switch region" and the
105 ntibiotic GE23077 (GE) binds directly to the bacterial RNA polymerase (RNAP) active-center 'i' and 'i
106 a nucleoside-analog inhibitor that inhibits bacterial RNA polymerase (RNAP) and exhibits antibacteri
108 ocrosslinking to define interactions between bacterial RNA polymerase (RNAP) and promoter DNA in the
109 x was tracked by mapping cross-links between bacterial RNA polymerase (RNAP) and transcript RNA or te
112 proach was used to investigate inhibition of bacterial RNA polymerase (RNAP) by sorangicin (Sor), a m
113 ads to rapid and selective inhibition of the bacterial RNA polymerase (RNAP) by the 7 kDa T7 protein
114 anism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid ant
115 e resonance energy transfer, we have defined bacterial RNA polymerase (RNAP) clamp conformation at ea
119 e transcription from specific promoters, the bacterial RNA polymerase (RNAP) core enzyme must associa
123 majority of biochemical characterizations of bacterial RNA polymerase (RNAP) have been focused; the p
132 uring transcription of protein-coding genes, bacterial RNA polymerase (RNAP) is closely followed by a
145 er specificity factor is distinct from other bacterial RNA polymerase (RNAP) sigma factors in that it
146 To explore the domain-scale flexibility of bacterial RNA polymerase (RNAP) throughout its functiona
147 well known that ppGpp and DksA interact with bacterial RNA polymerase (RNAP) to alter promoter activi
148 actors, the key regulatory components of the bacterial RNA polymerase (RNAP), direct promoter DNA bin
149 complex containing the major variant form of bacterial RNA polymerase (RNAP), Esigma(54), requires en
151 'switch region' - has been identified within bacterial RNA polymerase (RNAP), the enzyme that mediate
163 nds has been attributed to the inhibition of bacterial RNA polymerase activities, although the exact
164 domain that resembles the alphaCTD domain of bacterial RNA polymerase alpha; and this domain preferen
170 act upon the sigma54-containing form of the bacterial RNA polymerase belong to the extensive AAA+ su
173 escribe a structural basis for inhibition of bacterial RNA polymerase by the antibiotic streptolydigi
174 gs highlight how nonconserved regions of the bacterial RNA polymerase can be targets of regulatory fa
175 nt termination of the S box leader region by bacterial RNA polymerase depends on SAM but not on methi
176 etermined the X-ray crystal structure of the bacterial RNA polymerase engaged in reiterative transcri
178 rogen regulatory protein C (NtrC) contacts a bacterial RNA polymerase from distant enhancers by means
180 o define the three-dimensional structures of bacterial RNA polymerase holoenzyme and the bacterial RN
181 dvance was the high-resolution structures of bacterial RNA polymerase holoenzyme and the holoenzyme i
182 ptional activators that act upon the sigma54 bacterial RNA polymerase holoenzyme belong to the extens
185 iously reported for the sigma subunit in the bacterial RNA polymerase holoenzyme, consisting of a ser
188 nts on diverse DNA probes were used with two bacterial RNA polymerase holoenzymes that differ in how
189 p. ID38640, a soil isolate that produces the bacterial RNA polymerase inhibitor pseudouridimycin.
190 as become clear that promoter recognition by bacterial RNA polymerase involves interactions not only
193 health as pathogens and commensals, and the bacterial RNA polymerase is a proven target for antibiot
197 his study finds that individual molecules of bacterial RNA polymerase move in single base-pair steps
199 ed the positions of the binding sites within bacterial RNA polymerase of the small-molecule inhibitor
200 The sigma-to-core protein interaction in bacterial RNA polymerase offers a potentially specific t
202 ubtilis, a member of the sigma(70)-family of bacterial RNA polymerase sigma factors, is negatively re
204 etween termination mechanisms of Pol III and bacterial RNA polymerase suggests that hairpin-dependent
205 l evidence from cryo-EM demonstrating that a bacterial RNA polymerase that is paused proximally to th
206 entified a few "hot spots" on the surface of bacterial RNA polymerase that mediate its interactions w
207 (70) as a protein factor that was needed for bacterial RNA polymerase to accurately transcribe a prom
208 (sigma(32) in Escherichia coli) directs the bacterial RNA polymerase to promoters of a specific sequ
210 reconstruction to 3 angstrom resolution of a bacterial RNA polymerase with preferred orientation, con
212 by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region
215 bacterial RNA polymerase holoenzyme and the bacterial RNA polymerase-promoter open complex in soluti
229 trinsic termination signals for multisubunit bacterial RNA polymerases (RNAPs) encode a GC-rich stem-
230 Transcription initiation complexes formed by bacterial RNA polymerases (RNAPs) exhibit dramatic speci
232 posed of plastid-encoded subunits similar to bacterial RNA polymerases (RNAPs) stably bound to a set
235 pe can be rate-limiting for transcription by bacterial RNA polymerases and RNA polymerase II of highe
237 direct DNA interaction (as sigma subunits of bacterial RNA polymerases do) or indirectly by their act
238 Here we have transcribed with phage and bacterial RNA polymerases, a human DNA sequence previous
239 scription, because unlike the eucaryotic and bacterial RNA polymerases, it is a single subunit enzyme
240 criptional initiation by pol II, pol III and bacterial RNA polymerases: a preformed single-stranded D
244 iew the mechanisms and functions of selected bacterial RNA regulators and discuss their importance in
246 e, but whether this is a general property of bacterial RNA remains unclear as are the pathways involv
248 ase (CthPnk), the 5'-end-healing module of a bacterial RNA repair system, catalyzes reversible phosph
249 ase (CthPnk), the 5' end-healing module of a bacterial RNA repair system, catalyzes reversible phosph
251 ocess of analyzing RNA-seq data sets, making bacterial RNA-seq analysis a routine process that can be
255 d Rockhopper that supports various stages of bacterial RNA-seq data analysis, including aligning sequ
256 ructures and transcriptomes, for analysis of bacterial RNA-seq data and de novo transcriptome assembl
257 used for efficient and accurate analysis of bacterial RNA-seq data, and that it can aid with elucida
259 e demonstrate that IgnaviCas9 can be used in bacterial RNA-seq library preparation to remove unwanted
271 also inhibited transcription/translation of bacterial RNA, suggesting a mechanism for its antibiotic
276 ligo-dT primers after polyadenylation of the bacterial RNA, the second using a set of mycobacterial a
277 analyses, we report the discovery of several bacterial RNA thermometers in the 5' untranslated region
278 Additionally, we used the ratio of human to bacterial RNA to adjust the input RNA to include equal a
280 able to distinguish between amplification of bacterial RNA transcripts and the DNA templates that enc
283 nstrates that PKR can signal the presence of bacterial RNAs under physiological ionic conditions and
284 dimensional structures of three large ornate bacterial RNAs using cryo-electron microscopy (cryo-EM).
285 quencing expanded the known diversity of the bacterial RNA virome, suggesting that additional ribovir
288 l as the priming for caspase-1 activation by bacterial RNA was dependent on UNC93B, an endoplasmic re
290 osslinking results and crystal structures of bacterial RNAs, we develop a tertiary structure model of
291 ation and IL-1beta production by transfected bacterial RNA were absent in MyD88-deficient cells but i
292 udy, we show that human monocytes respond to bacterial RNA with secretion of IL-6, TNF, and IFN-beta,
294 with bacteria engulfed are a major source of bacterial RNA within the tumor microenvironment (TME) an