ライフサイエンスコーパス: bacterial chromosome

1 T gene (pcpF) is located next to pcpC on the bacterial chromosome.

2 se lead to hydroxyl radicals that damage the bacterial chromosome.

3 for integration of lambda prophage into the bacterial chromosome.

4 he enzyme responsible for replication of the bacterial chromosome.

5 regates the replication origin region of the bacterial chromosome.

6 recombination maintains the integrity of the bacterial chromosome.

7 intains integration of these elements in the bacterial chromosome.

8 es of homologous recombination to modify the bacterial chromosome.

9 tegration of the respective alleles into the bacterial chromosome.

10 proteins that modulate the structure of the bacterial chromosome.

11 tic change capable of affecting genes in the bacterial chromosome.

12 e phage genome and the attB site in the host bacterial chromosome.

13 d, in the long run, be incorporated into the bacterial chromosome.

14 age integration into and excision out of the bacterial chromosome.

15 ich is amplified relative to the rest of the bacterial chromosome.

16 nsDNA binding kinetics and affinity for the bacterial chromosome.

17 kDa that is essential for replication of the bacterial chromosome.

18 s provided a glimpse of the arrangement of a bacterial chromosome.

19 the shape and the genetic expression of the bacterial chromosome.

20 dnaA gene is required for replication of the bacterial chromosome.

21 nicity island located at centisome 63 of the bacterial chromosome.

22 lved operon reproducibly integrated into the bacterial chromosome.

23 ame attachment site for integration into the bacterial chromosome.

24 nt random mutagenesis of selected genes in a bacterial chromosome.

25 -specific single-strand discontinuities in a bacterial chromosome.

26 les in genome maintenance interacts with the bacterial chromosome.

27 ing other static and dynamic features of the bacterial chromosome.

28 n supercoiling and condensation of an entire bacterial chromosome.

29 p-regulated and can massively reorganize the bacterial chromosome.

30 he segregation apparatus with respect to the bacterial chromosome.

31 nisms by which NAPs remodel and organize the bacterial chromosome.

32 (GE P. putida), which was inserted into the bacterial chromosome.

33 can exist as an episome or integrated in the bacterial chromosome.

34 ed on plasmids should be integrated into the bacterial chromosome.

35 l been implicated in the organization of the bacterial chromosome.

36 reading frame (ORF) plasticity region of the bacterial chromosome.

37 understand higher-order organization of the bacterial chromosome.

38 ns in the coverage depth between viruses and bacterial chromosomes.

39 ation, segregation, repair and expression of bacterial chromosomes.

40 coordinating the appropriate segregation of bacterial chromosomes.

41 d conjugative element or ICE) that reside in bacterial chromosomes.

42 e locations to infer large-scale features of bacterial chromosomes.

43 processes that involve the origin region of bacterial chromosomes.

44 ved in the origins of replication of enteric bacterial chromosomes.

45 result of stronger selective constraints on bacterial chromosomes.

46 e and the plasticity of supercoil domains in bacterial chromosomes.

47 nthetic pathways via directed mutagenesis of bacterial chromosomes.

48 y calls into question the way that we define bacterial chromosomes.

49 tion immunity senses the domain structure of bacterial chromosomes.

50 ndensation that occurs during segregation of bacterial chromosomes.

51 stable inheritance of circular plasmids and bacterial chromosomes.

52 ed to investigate the supercoil structure of bacterial chromosomes.

53 rough the formation of resistance islands in bacterial chromosomes.

54 elements present as "genomic islands" within bacterial chromosomes.

55 ular DNA and selectively binds and condenses bacterial chromosomes.

56 ect the states of macromolecular assembly of bacterial chromosomes.

57 uted to shaping the distinct architecture of bacterial chromosomes.

58 ep sequencing (Hi-C) to map the structure of bacterial chromosomes.

59 , in maintaining or selecting for operons in bacterial chromosomes.

60 densins might be involved in organization of bacterial chromosomes.

61 a paradigm that a single condensin organizes bacterial chromosomes.

62 bility, but were subsequently found on a few bacterial chromosomes.

63 position to that of all completely sequenced bacterial chromosomes.

64 Horizontally acquired genetic information in bacterial chromosomes accumulates in blocks termed genom

65 on of the ParA ATPase releases ParA from the bacterial chromosome, after which it takes a long time t

66 djacent araC-P(BAD) control element into the bacterial chromosome allows dynamic control of T7 promot

67 hether the stationary-phase mutations in the bacterial chromosome also occur via a recombination prot

68 ux genes are present as single copies on the bacterial chromosome and are vertically inherited.

69 ne disruptions and modifications of both the bacterial chromosome and bacterial plasmids are possible

70 h loci are likely to appear by chance in the bacterial chromosome and could act as cryptic sites for

71 py demonstrated defective segregation of the bacterial chromosome and DNA degradation.

72 age response to mobilize themselves from the bacterial chromosome and infect other cells.

73 (NAPs) play key functions in organizing the bacterial chromosome and regulating gene transcription g

74 entally the fundamentally soft nature of the bacterial chromosome and the entropic forces that can co

75 lates the transcription of genes on both the bacterial chromosome and the large virulence plasmid, pA

76 onal stationary-phase mutation occurs in the bacterial chromosome and thus can be a general strategy

77 ystems are broadly conserved on plasmids and bacterial chromosomes and have been well characterized a

78 The faithful segregation and inheritance of bacterial chromosomes and low-copy number plasmids requi

79 Many bacterial chromosomes and low-copy plasmids, such as the

80 ParA-ATPase, ensure faithful segregation of bacterial chromosomes and low-copy-number plasmids.

81 faithful segregation and inheritance of many bacterial chromosomes and low-copy-number plasmids.

82 on systems ensure stable inheritance of many bacterial chromosomes and low-copy-number plasmids.

83 HU is one of the most abundant proteins in bacterial chromosomes and participates in nucleoid compa

84 Studies of bacterial chromosomes and plasmids indicate that their r

85 Toxin-antitoxin systems are found in many bacterial chromosomes and plasmids with roles ranging fr

86 composition, or 'genomic signature', between bacterial chromosomes and plasmids.

87 f proteins needed for stable partitioning of bacterial chromosomes and plasmids.

88 c arrangement, and to close the sequences of bacterial chromosomes and plasmids.

89 ICEs are prevalent in bacterial chromosomes and play a major role in bacterial

90 proteins (NAPs) maintain the architecture of bacterial chromosomes and regulate gene expression.

91 ages) can integrate their phage genomes into bacterial chromosomes and replicate with bacterial hosts

92 loci evolved very early in the evolution of bacterial chromosomes and that the absence of parS, parA

93 romotes the initiation of replication of the bacterial chromosome, and of several plasmids including

94 include viruses that can integrate into the bacterial chromosome, and they can carry genes that prov

95 ontal transfer introduces new sequences into bacterial chromosomes, and deletions remove segments of

96 The genes encoding TA systems also exist on bacterial chromosomes, and it has been speculated that t

97 on of complete and accurate physical maps of bacterial chromosomes, and the many maps constructed in

98 With rare exceptions, FRTs introduced to the bacterial chromosome are targeted with high efficiency r

99 The realization that bacterial chromosomes are actively translocated through

100 Bacterial chromosomes are confined in submicrometer-size

101 Bacterial chromosomes are folded to compact DNA and faci

102 Bacterial chromosomes are highly compacted structures an

103 To fit within the confines of the cell, bacterial chromosomes are highly condensed into a struct

104 Bacterial chromosomes are immense polymers whose faithfu

105 Bacterial chromosomes are most often circular DNA molecu

106 Bacterial chromosomes are organized in stereotypical pat

107 Bacterial chromosomes are organized into polycistronic c

108 A picture is thereby developing of how bacterial chromosomes are organized within the cell, how

109 Recent studies provide evidence that bacterial chromosomes are replicated by an enzyme factor

110 eukaryotes, histones fulfil this role, while bacterial chromosomes are shaped by nucleoid-associated

111 The reason for this is that even bacterial chromosomes are so large that biochemical and

112 Bacterial chromosomes are spatiotemporally organized and

113 Because bacterial chromosomes are tightly packed with genes and

114 The mini-lambda DNA integrates into the bacterial chromosome as a defective prophage.

115 findings support an emerging picture of the bacterial chromosome as off-equilibrium active matter an

116 odified target sequences within the resident bacterial chromosome, as opposed to incoming 'foreign' D

117 ase, including the prospect of single-contig bacterial chromosome assembly.

118 nic toxin A gene (speA), integrates into the bacterial chromosome at a gene for a serine tRNA.

119 ert site and orientation specifically in the bacterial chromosome at an attTn7 site downstream of the

120 ion, this plasmid stably integrated into the bacterial chromosome at attB.

121 t reveals protein occupancy across an entire bacterial chromosome at the resolution of individual bin

122 litate integration of single-copy genes into bacterial chromosomes at a neutral, naturally evolved si

123 the elements on the phage genome (attP) and bacterial chromosome (attB) required for CTXphi integrat

124 thway, Tn7 inserts into a unique site in the bacterial chromosome, attTn7, through specific recogniti

125 ic islands at a programmed insertion site in bacterial chromosomes, attTn7.

126 arning tool for distinguishing plasmids from bacterial chromosomes based on the DNA sequence and its

127 al support for a physical model in which the bacterial chromosome behaves as a loaded entropic spring

128 turn, trees obtained from plasmid-borne and bacterial chromosome-borne sequences were congruent with

129 Like many other bacterial chromosomes, both V. cholerae chromosomes cont

130 or determination of a restriction map of the bacterial chromosome but is based on the ability to meas

131 etagenome assemblers can generate contiguous bacterial chromosomes but often suppress strain-level va

132 Phage 4 integrated randomly into the bacterial chromosome, but integrations into motility-ass

133 ClpXP protects the bacterial chromosome, but little effect was detected on

134 that H-NS silences extensive regions of the bacterial chromosome by binding first to nucleating high

135 ent has been recently acquired from the host bacterial chromosome by illegitimate recombination, prov

136 rcbA helps to maintain the integrity of the bacterial chromosome by lowering the steady-state level

137 d used to replace the wild-type genes in the bacterial chromosome by marker exchange.

138 genizes the bacteria by integrating into the bacterial chromosome by site-specific recombination at o

139 ion, activated SaPIs form concatamers in the bacterial chromosome by switching between parallel genom

140 When DNA gyrase is trapped on bacterial chromosomes by quinolone antibacterials, rever

141 vide a possible explanation for how a linear bacterial chromosome can exhibit a circular genetic map.

142 ivation leads to complete destruction of the bacterial chromosome, causing cell death prior to comple

143 contains more parS sequences than any other bacterial chromosome characterized so far.

144 HU could act as an architectural protein for bacterial chromosome compaction and organization in vivo

145 Many bacterial chromosomes contain genomic islands, large DNA

146 Most bacterial chromosomes contain homologs of plasmid partit

147 Replicating bacterial chromosomes continuously demix from each other

148 The latter assays showed that bacterial chromosome copies accumulated severalfold duri

149 of a green fluorescent protein (GFP)-tagged bacterial-chromosome dihydrofolate reductase (DHFR) tran

150 ontains a fast DNA motor that is involved in bacterial chromosome dimer resolution.

151 lved in processes ranging from resolution of bacterial chromosome dimers to adeno-associated viral in

152 However, in the bacterial chromosome, duplications form at high rates (1

153 Here, we review bacterial chromosome dynamics and our understanding of t

154 measuring supercoil diffusion and analysing bacterial chromosome dynamics in vivo.

155 ight into how the organization of a complete bacterial chromosome encodes a spatiotemporal program in

156 , which is present on many plasmids and most bacterial chromosomes, encodes a P loop ATPase (ParA) th

157 ung homogenates; total counts are defined as bacterial chromosome equivalents (CEQ) enumerated by usi

158 Plasmid origins of replication are rare in bacterial chromosomes, except in multichromosome bacteri

159 anscription conflict is especially bitter in bacterial chromosomes, explaining why actively transcrib

160 Bacterial chromosomes fold into TAD-like chromosomal int

161 Our results show that E. coli bacterial chromosome folding in three dimensions is not

162 around parS to condense DNA and earmark the bacterial chromosome for segregation.

163 Genes must be stably integrated into bacterial chromosomes for complementation of gene deleti

164 Previous analyses of bacterial chromosomes for which the complete sequence ha

165 ich multiple TA paralogs encoded by a single bacterial chromosome form independent functional units w

166 y to specify a target, but also to spare the bacterial chromosome from interference.

167 the pathway targeting the attTn7 site in the bacterial chromosome has been extensively studied, the p

168 The physical nature of the bacterial chromosome has important implications for its

169 quisite temporal and spatial organization of bacterial chromosomes has only recently been appreciated

170 e-specific excision of phage lambda from the bacterial chromosome, has a much shorter functional half

171 ate, mitotic-like mechanisms that act on the bacterial chromosome have not been demonstrated.

172 Bacterial chromosomes have been found to possess one of

173 Contrastingly, most bacterial chromosomes have simpler organization with loc

174 cteria reside on plasmid genomes rather than bacterial chromosomes, implying that plasmids are havens

175 Temperate phages integrate into the bacterial chromosome in a dormant state through intricat

176 e an important mechanism for maintaining the bacterial chromosome in an expanded and dynamic state.

177 est a new model for how MukBEF organizes the bacterial chromosome in vivo.

178 rmation can site-specifically recombine with bacterial chromosomes in the absence of any additional p

179 bination by XerCD-dif or Cre-loxP can unlink bacterial chromosomes in vivo, in reactions that require

180 segregation and replication loci of the two bacterial chromosomes indicates that, immediately after

181 Replication of bacterial chromosomes initiates bidirectionally from a s

182 regation in higher cells, segregation of the bacterial chromosome is a continuous process in which ch

183 to a first approximation, the folding of the bacterial chromosome is consistent with, and may preserv

184 The bacterial chromosome is organized into multiple independ

185 Initiation of replication of bacterial chromosomes is accurately regulated by the Dna

186 The segregation of many bacterial chromosomes is dependent on the interactions o

187 The ability to engineer bacterial chromosomes is quintessential for understandin

188 arily responsible for the duplication of the bacterial chromosome, is a 3'-->5' exonuclease that func

189 The bacterial chromosome, known as its nucleoid, is an amorp

190 markers from 12q24.1 to screen large insert bacterial chromosome libraries and a chromosome 12-speci

191 because the distances that newly replicated bacterial chromosomes move apart before cell division ar

192 The bacterial chromosome must be compacted more than 1,000-f

193 Bacterial chromosome (nucleoid) conformation dictates fa

194 Regions of bacterial chromosomes occupy characteristic locations wi

195 esulting pdxY::omegaKan(r) mutation into the bacterial chromosome of a pdrB mutant, in which de novo

196 nstructed and analyzed in single copy on the bacterial chromosome or on low-copy-number plasmids.

197 Most are located on bacterial chromosomes or on broad-host-range R plasmids.

198 ciated proteins (NAPs) play central roles in bacterial chromosome organization and DNA processes.

199 e, we uncover several factors that influence bacterial chromosome organization by modulating the prob

200 During the last decades, knowledge of bacterial chromosome organization has advanced considera

201 erplay between transcription and topology in bacterial chromosome organization.

202 Recently a basal system for opening a bacterial chromosome origin (oriC) was proposed (2).

203 y on bacterial replication, the diversity of bacterial chromosome origin architecture has confounded

204 g the conserved sequence elements within the bacterial chromosome origin basal unwinding system (BUS)

205 re may represent an ancestral system to open bacterial chromosome origins.

206 e predicted to be present in the majority of bacterial chromosome origins.

207 Molecular mechanisms of bacterial chromosome packaging are still unclear, as bac

208 Bacterial chromosome partitioning and cell division are

209 y of ATPases is responsible for transporting bacterial chromosomes, plasmids and large protein machin

210 These systems are prevalent in bacterial chromosomes, plasmids, and phage genomes, but

211 It is now clear that bacterial chromosomes rapidly separate in a manner indep

212 distinct organization patterns observed for bacterial chromosomes reflect a common organization-segr

213 Faithful segregation of bacterial chromosomes relies on the ParABS partitioning

214 tize the lytic phage ICP1, excising from the bacterial chromosome, replicating, and mobilizing to new

215 , and minD, all of which encode products for bacterial chromosome replication and partition, were exp

216 New rounds of bacterial chromosome replication are triggered during ea

217 Bacterial chromosome replication is mainly catalyzed by

218 the significance of spatial organization in bacterial chromosome replication is only beginning to be

219 wding and phase separation on the control of bacterial chromosome replication, segregation, and cell

220 e ICP1, which triggers PLE excision from the bacterial chromosome, replication, and transduction to n

221 Although many bacterial chromosomes require only one replication initi

222 T, expressed from its endogenous site on the bacterial chromosome, resulted in a 100-fold virulence d

223 rapped genomic DNA, previously developed for bacterial chromosome segments, to isolate megabase-sized

224 al regulation of the Caulobacter cell cycle, bacterial chromosome segregation and cytokinesis, and Ba

225 We discuss how the multistep view of bacterial chromosome segregation can help to explain and

226 rovide a perspective on current views of the bacterial chromosome segregation mechanism and how it re

227 that is more reminiscent of eukaryotic than bacterial chromosome segregation mechanisms.

228 ntil the discovery of CTPase activity in the bacterial chromosome segregation protein ParB.

229 Despite its fundamental nature, bacterial chromosome segregation remains poorly understo

230 tion system of ParA, ParB, and parS)-related bacterial chromosome segregation system.

231 Bacterial chromosome segregation utilizes highly conserv

232 ntial role of the actin-like MreB protein in bacterial chromosome segregation, we first demonstrate t

233 K2 has been studied as a simplified model of bacterial chromosome segregation.

234 wded cellular compartments as well as during bacterial chromosome segregation.

235 onserved ParABS system plays a major role in bacterial chromosome segregation.

236 SpoIIIE/FtsK ATPases are central players in bacterial chromosome segregation.

237 ll-known protein-DNA interaction involved in bacterial chromosome segregation.

238 ase that participates in the final stages of bacterial chromosome segregation.

239 t immunity can be used as a tool for probing bacterial chromosome structure.

240 ay a key role in the control of higher-order bacterial chromosome structure.

241 r members tend to be located more closely on bacterial chromosomes than expected by chance, which cou

242 into one of several known attB sites in the bacterial chromosome that consists of a pair of inverted

243 ) are abundant constituents of eukaryotic or bacterial chromosomes that bind DNA promiscuously and fu

244 s are enabling scientists to design modified bacterial chromosomes that can be used in the production

245 that serve to protect unmodified DNA in the bacterial chromosome: the primary pathway in which ClpXP

246 Deletion of ydgG also caused 31% of the bacterial chromosome to be differentially expressed in b

247 atterns can be horizontally transferred into bacterial chromosomes to program cell phenotypes.

248 The bacterial chromosome trafficking apparatus or the segros

249 The FtsK dsDNA translocase functions in bacterial chromosome unlinking by activating XerCD-dif r

250 Might bacterial chromosomes use a similar mitotic strategy for

251 drugs is caused by mutations within a single bacterial chromosome, use of bedaquiline in patients wit

252 ber of independent deletion mutations on the bacterial chromosome using a single drug marker.

253 a moves its viral genome into and out of the bacterial chromosome using site-specific recombination.

254 le replication origins on their chromosomes, bacterial chromosomes usually contain a single replicati

255 parS partition site), and interacts with the bacterial chromosome via an ATP-dependent nonspecific DN

256 ows random integration of lux genes onto the bacterial chromosome was constructed.

257 Integration of lambda into the bacterial chromosome was delayed in the lon ftsH backgro

258 Although further movement within the bacterial chromosome was undetectable, the retrotranspos

259 Sequences typical of origins of other bacterial chromosomes were not found at the origin of th

260 at a normal function of RA is to protect the bacterial chromosome when recombination generates unmodi

261 also include a variety of novel att sites in bacterial chromosomes where genome islands can form.

262 The ter region of the bacterial chromosome, where replication terminates, is t

263 ttes are often present in multiple copies on bacterial chromosomes, where they have been reported to

264 a natural comparative platform to examine a bacterial chromosome with multiple origins and a possibl

265 n origin.(1) Here, we discovered a dicentric bacterial chromosome with two replication origins, which

266 eoid Associated Proteins (NAPs) organize the bacterial chromosome within the nucleoid.

267 result from the spatial organizations of the bacterial chromosome without the involvement of membrane

268 xin-antitoxin (TA) systems are ubiquitous on bacterial chromosomes, yet the mechanisms regulating the