ライフサイエンスコーパス: base excision repair

1 newly discovered fidelity checkpoint during base excision repair.

2 n or thymine DNA glycosylase (TDG)-dependent base excision repair.

3 oxidative products 5fC and 5caC, initiating base excision repair.

4 erated by DNA glycosylases that initiate DNA base excision repair.

5 more than two nucleotides during long-patch base excision repair.

6 nscription factor and an accessory factor in base excision repair.

7 inic/apyrimidinic lyase activity to initiate base excision repair.

8 ne DNA glycosylase (TDG) in conjunction with base excision repair.

9 g Okazaki fragment maturation and long patch base excision repair.

10 apurinic/apyrimidinic endonuclease acting in base excision repair.

11 ely during DNA lagging strand maturation and base excision repair.

12 e, two bases that can be removed from DNA by base excision repair.

13 endent dilution or DNA glycosylase-initiated base excision repair.

14 lase plays a key role in DNA maintenance via base excision repair.

15 ), and restoration of cytosine via follow-on base excision repair.

16 n and thymine DNA glycosylase (TDG)-mediated base excision repair.

17 ted intermediates and ensuring completion of base excision repair.

18 y the 5' and 3' margins of gapped DNA during base excision repair.

19 eparation of these critical functions during base excision repair.

20 and exhibit a gap-filling deficiency during base excision repair.

21 d to gastric carcinoma via interference with base excision repair.

22 emonstrated transcription-coupled nucleotide/base excision repair.

23 hymine DNA glycosylase (TDG), and subsequent base excision repair.

24 hich remove modified nucleobases to initiate base excision repair.

25 ications are not mutagenically copied during base excision repair.

26 9, a cytidine deaminase, and an inhibitor of base excision repair.

27 idative damage to DNA is mainly repaired via base excision repair, a pathway that is catalyzed by DNA

28 However, ATMIN also has a role in base excision repair, a process that has been demonstrat

29 In DNA base excision repair, a tight heterodimer complex formed

30 We reported here a new assay to detect base excision repair activities from purified enzymes, a

31 Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (D

32 represent associations with DNA mismatch or base excision repair and cisplatin therapy mechanisms.

33 lycosylase (TDG) plays critical roles in DNA base excision repair and DNA demethylation.

34 s suggest that XRCC1 is a component of plant base excision repair and functions at several stages dur

35 on, we show that Acr treatment also inhibits base excision repair and mismatch repair.

36 This severe phenotype involved defective base excision repair and non-homologous end-joining, pat

37 with their proposed biological functions in base excision repair and nonhomologous end joining.

38 cellular DNA damage response by controlling base excision repair and p53 protein levels.

39 , 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and prevent G to T transversion mut

40 that Pol epsilon participates in short-patch base excision repair and ribonucleotide excision repair.

41 eracts with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSB

42 amage known, abasic (AP) sites, sourced from base excision repair and spontaneous base loss, are the

43 This review focuses on the classical base excision repair and strand incision pathways in euk

44 licated in DNA repair pathways including the base excision repair and the interstrand cross-link repa

45 sed by uracil DNA glycosylase (UNG)-mediated base-excision repair and MSH2-mediated mismatch repair (

46 ation of DNA single-strand break repair, DNA base excision repair, and cell survival.

47 tions of the latter noncanonical proteins in base excision repair are unclear.

48 Mismatch and base-excision repair are important in the somatic expans

49 .21 and human cancer cells by recruiting the base excision repair-associated apurinic/apyrimidinic en

50 ely dependent on multiple pathways including base excision repair, ATR signaling, and splicing.

51 utant lacking the H2A and H3 N-tails rescues base excision repair (BER) activity but not MMS sensitiv

52 ation, and high-fat feeding from weaning, on base excision repair (BER) and DNA methylation and expre

53 PARP-1 DPCs during alkylating agent-induced base excision repair (BER) and formation of DPCs is enha

54 Base excision repair (BER) and mismatch repair (MMR) pat

55 nduced cytidine deaminase (AID) and requires base excision repair (BER) and mismatch repair (MMR).

56 2 demonstrate the complementary roles of the base excision repair (BER) and mismatch repair pathways,

57 repeated DNA sequences and the efficiency of base excision repair (BER) and RER enzymes (OGG1, MUTYH,

58 rted into DNA double-strand breaks (DSBs) by base excision repair (BER) and then quickly repaired by

59 d to a linkage between oxidative DNA damage, base excision repair (BER) and TNR expansion, which is d

60 ome stability, DNA repair pathways including base excision repair (BER) are also employed by mammalia

61 NA bases and their inefficient processing by base excision repair (BER) are among the factors suggest

62 (PQS) in promoter-coding strands, initiating base excision repair (BER) by 8-oxoguanine DNA glycosyla

63 lymerase beta (Pol beta) plays a key role in base excision repair (BER) by filling in small gaps that

64 uding NEIL1 DNA glycosylase, which initiates base excision repair (BER) by removing damaged DNA bases

65 Recent studies have shown that DNA base excision repair (BER) can mediate TNR expansion and

66 ion and deletion, and it has been shown that base excision repair (BER) can result in CAG repeat dele

67 s Pol beta polymerase activity and increases base excision repair (BER) efficiency.

68 Base Excision Repair (BER) efficiently corrects the most

69 Further, depletion of the base excision repair (BER) enzyme DNA glycosylase augmen

70 Herein, it is shown that the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1

71 earby lesions in opposing DNA strands by the base excision repair (BER) enzymes can produce double-st

72 eracts with a key mitochondrial-specific DNA base excision repair (BER) enzymes, namely EXOG and DNA

73 iminary results on recognition of 5'-AODN by base excision repair (BER) enzymes.

74 Base excision repair (BER) functions not only in the mai

75 Gh and Sp are known to be substrates for base excision repair (BER) glycosylases; however, large

76 DNA base excision repair (BER) has a critical role in genome

77 ouble strand break repair, but a role in DNA base excision repair (BER) has not been described.

78 at histone lysine acetylation contributes to base excision repair (BER) in cells, their exact mechani

79 enome that are supposed to be substrates for base excision repair (BER) in the framework of active de

80 ion oligonucleotide fragments in addition to base excision repair (BER) incision products.

81 DNA alkylation damage is repaired by base excision repair (BER) initiated by alkyladenine DNA

82 Base excision repair (BER) initiated by alkyladenine DNA

83 In the absence of APTX activity, blocked base excision repair (BER) intermediates containing the

84 Base excision repair (BER) is a frontline repair system

85 Base excision repair (BER) is a highly conserved DNA rep

86 Base excision repair (BER) is an essential DNA repair pa

87 Expression of genes associated with base excision repair (BER) is increased with prostate ca

88 Base excision repair (BER) is initiated by DNA glycosyla

89 Base excision repair (BER) is one of several DNA repair

90 Base excision repair (BER) is one of the most frequently

91 Furthermore, base excision repair (BER) is responsible for causing CA

92 Base excision repair (BER) is the major cellular DNA rep

93 Base excision repair (BER) is the major cellular pathway

94 OGG1 initiated base excision repair (BER) is the major pathway for repa

95 Base excision repair (BER) is the predominant pathway fo

96 Oxoguanine DNA glycosylase1 (OGG1)-initiated base excision repair (BER) is the primary pathway to rem

97 Abortive ligation during base excision repair (BER) leads to blocked repair inter

98 Base excision repair (BER) maintains genomic stability t

99 Analysis of these maps revealed that base excision repair (BER) of alkylation damage is signi

100 Base excision repair (BER) of an oxidized base within a

101 ntly demonstrated to initiate prereplicative base excision repair (BER) of oxidized bases in the repl

102 is an essential protein that operates in the base excision repair (BER) pathway and is responsible fo

103 quences and the subsequent activation of the base excision repair (BER) pathway drive the spatiotempo

104 The base excision repair (BER) pathway historically has been

105 repairing oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing qu

106 The base excision repair (BER) pathway is an important DNA r

107 The base excision repair (BER) pathway is mainly responsible

108 Additionally, we find that the base excision repair (BER) pathway is required to mainta

109 The DNA base excision repair (BER) pathway is the frontline mech

110 Repair of these lesions via base excision repair (BER) pathway maintains genomic fid

111 and inflammation-induced DNA lesions by the base excision repair (BER) pathway prevents mutation, a

112 The base excision repair (BER) pathway repairs oxidized lesi

113 commonly used to kill cancer cells, but the base excision repair (BER) pathway they trigger can also

114 tosines by thymine-DNA glycosylase (TDG) and base excision repair (BER) pathway, but it is unclear to

115 ase beta (Pol beta), a key enzyme in the DNA base excision repair (BER) pathway, is pivotal in mainta

116 nuclease (APE1), which functions through the base excision repair (BER) pathway.

117 ylase (hUNG) perform the initial step in the base excision repair (BER) pathway.

118 and cytotoxic abasic lesions as part of the base excision repair (BER) pathway.

119 glycosylases catalyze the first step of the base excision repair (BER) pathway.

120 roxymethylcytosine, including members of the base excision repair (BER) pathway.

121 al of uracil in DNA as the first step in the base excision repair (BER) pathway.

122 8-oxoguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway.

123 of the nucleotide excision repair (NER) and base excision repair (BER) pathways work in a cooperativ

124 Base excision repair (BER) processes non-helix distortin

125 particularly sensitive to inhibitors of the base excision repair (BER) protein poly (ADP-ribose) pol

126 erase beta (Polbeta), known as a key nuclear base excision repair (BER) protein, in mitochondrial pro

127 Recent evidence suggests a role for base excision repair (BER) proteins in the response to D

128 Base excision repair (BER) recognizes and repairs minima

129 Base excision repair (BER) removes at least 20,000 DNA l

130 nduced mutation, it is unknown if subsequent base excision repair (BER) steps function on replication

131 induced cytidine deaminase (AID) followed by base excision repair (BER) was found not to be involved.

132 Oxidative DNA damage is mainly repaired by base excision repair (BER), a process initiated by DNA g

133 DNA polymerase (Pol) beta is a key enzyme in base excision repair (BER), an important repair system f

134 hway for correcting oxidized bases in DNA is base excision repair (BER), and in vertebrates DNA polym

135 beta (Pol-beta), a central player in the DNA base excision repair (BER), and this physical complex no

136 f the major abasic endonuclease in mammalian base excision repair (BER), apurinic/apyrimidinic endonu

137 maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-D

138 ine deacetylases contribute to DNA repair by base excision repair (BER), nucleotide excision repair (

139 y oxidative DNA base damage and fulfilled by base excision repair (BER), suggesting active roles for

140 ole in single strand break repair (SSBR) and base excision repair (BER), the p1p2 and p1p2k80 mutants

141 B formation when replication interferes with base excision repair (BER), the predominant pathway for

142 pol beta) is the main polymerase involved in base excision repair (BER), which is a pathway responsib

143 (CHB) patients is influenced by IFN-induced base excision repair (BER).

144 ioned whether Rev1 could also be involved in base excision repair (BER).

145 ambda (Pol lambda)-dependent MUTYH-initiated base excision repair (BER).

146 AX ADP-ribosylation plays a critical role in base excision repair (BER).

147 nondamaged DNA bases is vitally important in base excision repair (BER).

148 erase (pol) beta nucleotide insertion during base excision repair (BER).

149 d by thymine DNA glycosylase (TDG) initiated base excision repair (BER).

150 racil, causes DNA damage that is repaired by base excision repair (BER).

151 age, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER).

152 strand breaks (DSBs) by perturbing canonical base excision repair (BER).

153 idized bases that form in DNA are subject to base excision repair (BER).

154 NA repair enzymes responsible for initiating base excision repair (BER).

155 (8-oxoG), suggesting a noncanonical role in base excision repair (BER).

156 of a reactive DNA repair intermediate during base excision repair (BER).

157 ast majority of these lesions are subject to base excision repair (BER).

158 preferentially repaired in promoters via the base excision repair (BER)/single-strand break repair (S

159 homozygous germline nonsense mutation in the base-excision repair (BER) gene NTHL1.

160 Indeed, nutrient deprivation led to impaired base-excision repair (BER) in cardiomyocytes in vitro, a

161 nitiate active DNA demethylation through the base-excision repair (BER) pathway.

162 This process may involve base excision repair, C-C bond cleaving reactions or dea

163 dings demonstrate that a modest decrement in base excision repair capacity can render the brain more

164 n DNA repair and suggest that Mag1-initiated base excision repair compensates for the absence of oxid

165 base lesions in the human genome to initiate base excision repair, contains an intrinsically disorder

166 ides into nascent DNA followed by incomplete base excision repair contribute to the ROS-dependent com

167 lomere regions would block completion of the base excision repair cycle potentially causing telomere

168 indicate the exon alpha Pol beta variant is base excision repair deficient, but does conduct 5'-trim

169 harbour, including a deficiency in G:C > T:A base excision repair due to inactivation of MUTYH, which

170 and protein cofactors involved in eukaryotic base excision repair, emphasizing the challenge of integ

171 The DNA base excision repair enzyme DNA polymerase (pol) beta is

172 Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in DNA repair an

173 s missense mutation in the gene encoding the base excision repair enzyme Nei endonuclease VIII-like 3

174 8-Oxoguanine glycosylase (OGG1) is a base excision repair enzyme responsible for the recognit

175 removal of methylated cytosines requires the base excision repair enzyme TDG, but the mechanism by wh

176 uanine DNA glycosylase) is one such silenced base excision repair enzyme that can restore DNA integri

177 The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesi

178 idinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a num

179 We reasoned that the base excision repair enzyme thymine DNA glycosylase (TDG

180 om previously reported Vpr interactions with base excision repair enzyme uracil DNA glycosylase (UNG2

181 that DinG and Endonuclease III (EndoIII), a base excision repair enzyme, cooperate at long-range usi

182 se that is heterozygous for the critical DNA base excision repair enzyme, DNA polymerase beta.

183 ription-associated demethylation promoted by Base Excision Repair enzymes further modifies methylatio

184 We have characterized meningococcal base excision repair enzymes involved in the recognition

185 nactivation is required for stabilization of base excision repair enzymes, the failure of cells to do

186 ress, compared to strains deficient in other base excision repair enzymes.

187 reduced enzyme activity may have compromised base excision repair function, as evidenced by our methy

188 s two reactions at DNA gaps generated during base excision repair, gap-filling DNA synthesis and lyas

189 Additionally, mutations in a base-excision-repair gene (SMUG1) correlate with a C-to-

190 7ra (+) GC B cells to facilitate CSR-related base excision repair genes during the dark zone phase of

191 th decreased expression of CSR-related novel base excision repair genes that were otherwise predomina

192 etween XPD and Endonuclease III (EndoIII), a base excision repair glycosylase that also contains a [4

193 r mechanism may also be operative in related base excision repair glycosylases and provides a critica

194 age (homologs of HUS1, CHK2), nucleotide and base excision repair (homologs of XPF, XPC and AP-endonu

195 In the absence of additional factors, base excision repair in NCPs will stall at the gap-filli

196 ble to oxidation, few biochemical studies of base excision repair in telomeric DNA and quadruplex str

197 inant-negative manner and impairs long-patch base excision repair in vitro and in vivo.

198 eta carries out two of the four steps during base excision repair, including a lyase reaction that re

199 actor that modulates the delicate process of base-excision repair independently of its glycosylase ac

200 ier in mouse fibroblast cells treated with a base excision repair-inducing agent, we questioned wheth

201 droguanine (OG) to mark target promoters for base excision repair initiated by OG-glycosylase I (OGG1

202 ) sites in DNA form spontaneously and as DNA base excision repair intermediates are the most common t

203 Taken together, UNG-initiated base excision repair is a major mechanism counteracting

204 ests that, for poxviruses, DNA synthesis and base excision repair is coupled.

205 Base excision repair is hindered by nucleosomes.

206 Base excision repair is initiated by DNA glycosylases th

207 Base excision repair is responsible for correcting nucle

208 Base excision repair is the major pathway in mammalian c

209 C1), a key factor in single-strand break and base excision repair, is recruited into nuclear bodies f

210 ne DNA glycosylase, and subsequent action of base-excision repair machinery restores unmethylated cyt

211 ing that in humans gBGC is not caused by the base-excision repair machinery.

212 r of which takes place by a highly efficient base excision repair mechanism.

213 association with nucleotide excision repair, base excision repair, mismatch repair, and DNA double-st

214 nucleotide excision repair, mismatch repair, base excision repair, nonhomologous end joining, homolog

215 n for non-homologous end-joining (cku-80) or base excision repair (nth-1, exo-3), the Fanconi-related

216 romoter sequences, and transiently inhibited base excision repair of 8-oxoG.

217 In humans, short-patch base excision repair of 8-oxoG:dA base pairs requires hu

218 ethylpurine DNA glycosylase (hMPG) initiates base excision repair of a number of structurally diverse

219 glycosylase (AAG), the enzyme that initiates base excision repair of alkylated bases, the flipped-out

220 DNA glycosylase (AAG) is thought to initiate base excision repair of both 1,N (6)-ethenoadenine (eA)

221 s not known if histone acetylation modulates base excision repair of DNA lesions in chromatin.

222 L5 modulates and/or directly participates in base excision repair of endogenous DNA damage, thereby p

223 ed in active DNA demethylation by initiating base excision repair of G.T mispairs generated by a deam

224 a basis for understanding the mechanisms of base excision repair of ICLs.

225 he repair of double-strand DNA breaks and in base excision repair of oxidized guanine residues (8-oxo

226 ese enzymes have been known only to initiate base excision repair of small adducts by extrusion from

227 During base excision repair of this mispair, DNA polymerase (po

228 vity in mammalian cells, and a key factor in base-excision repair of DNA.

229 ,8-dihydro-8-oxoguanine (8-oxoG) via the DNA base excision repair pathway (OGG1-BER).

230 Conversely, inhibiting the base excision repair pathway accentuated NAD decline in

231 Our results indicate a synergism between the base excision repair pathway and direct alkylation repai

232 ated by DNA glycosylases, which initiate the base excision repair pathway by locating and excising ab

233 Mag1 initiates the base excision repair pathway by removing alkylated bases

234 Deletion of TPA1 along with the base excision repair pathway DNA glycosylase MAG1 render

235 s have on the efficiency and fidelity of the base excision repair pathway during the repair of opposi

236 integrity and define the specificity of the base excision repair pathway for discreet, detrimental m

237 ans, whereas >40% of tumors had mutations in base excision repair pathway genes in Caucasians.

238 n cells, NMPs are repaired by the multi-step base excision repair pathway initiated by human alkylade

239 The base excision repair pathway is largely responsible for

240 xoguanine DNA glycosylase-1 (OGG1)-initiated base excision repair pathway is primarily responsible fo

241 The DNA base excision repair pathway is the main system involved

242 damage; their rates were limited by upstream base excision repair pathway steps.

243 ckbone at the abasic site, thus initiating a base excision repair pathway that finally inserts an unm

244 reactive oxygen species, is repaired via the base excision repair pathway that is initiated with the

245 that utilizes DNA glycosylases found in the base excision repair pathway to excise the modification.

246 nitiated by DNA glycosylases, occurs via the base excision repair pathway using conserved repair and

247 ge, as well as a key intermediate during the base excision repair pathway, abasic sites are frequent

248 se)polymerase-1 (PARP-1), a component of the base excision repair pathway, in mouse bone marrow HSCs

249 Specifically, we show that the base excision repair pathway, the main pathway utilized

250 a DNA glycosylase involved in initiating the base excision repair pathway, the major cellular mechani

251 cells also has an adverse effect on the DNA base excision repair pathway, the major DNA repair syste

252 (ROS)-induced DNA damage is repaired by the base excision repair pathway.

253 xoguanine glycosylase 1 (OGG1)-initiated DNA base excision repair pathway.

254 stability via repair of DNA lesions via the base excision repair pathway.

255 tagenic and cytotoxic but are removed by the base excision repair pathway.

256 A by specific uracil-DNA glycosylases in the base excision repair pathway.

257 during repair of damaged DNA as part of the base excision repair pathway.

258 ial removal of abasic lesions as part of the base excision repair pathway.

259 involved in active DNA demethylation via the base excision repair pathway.

260 plicated in active DNA demethylation via the base excision repair pathway.

261 racted in an error-free manner by the uracil base excision repair pathway.

262 ual steps and over multiple steps of the DNA base excision repair pathway.

263 en translocation-catalyzed oxidation and the base excision repair pathway.

264 Vpr also interferes with the base-excision repair pathway by antagonizing the uracil

265 A Glycosylase 1 (MAG1), which is part of the base-excision repair pathway, and the DNA photolyase gen

266 Genes encoding direct repair and base-excision repair pathways are required by B. abortus

267 orporated into precise locations focuses the base excision repair process to read and catalyze remova

268 at the lesion site after processing via the base excision repair process.

269 hieved by modulating the initial step of the base excision repair process.

270 of restriction enzymes activities as well as base excision repair processes.

271 A base excision repair protein, Apurinic/apyrimidinic (AP)

272 The essential base excision repair protein, apurinic/apyrimidinic endo

273 r predisposition gene NTHL1, which encodes a base excision repair protein, revealed a mutational foot

274 A feature of many base excision repair proteins is that they contain [4Fe4

275 ion of 5-methylcytosine (mC), and downstream base excision repair proteins restore a G.C pair.

276 s 5fC and 5caC are recognized and removed by base excision repair proteins, the 5hmC base accumulates

277 e appropriate DNA lesions also interact with base excision repair proteins, we investigated whether C

278 nd an indication of the versatility of these base excision repair proteins.

279 for many of NEIL1's interactions with other base excision repair proteins.

280 CA1/BRCA2, transcription-coupled repair, and base excision repair seemed to be important for MLN4924

281 XRCC1 is a key component of DNA base excision repair, single strand break repair, and ba

282 in binary complex with template 8-oxoG in a base excision repair substrate.

283 Initiating base excision repair, TDG removes thymine from mutagenic

284 s of Okazaki fragment maturation, long-patch base excision repair, telomere maintenance, and stalled

285 the mispaired A giving way to the canonical base excision repair that ultimately restores undamaged

286 re enzymes that perform the initial steps of base excision repair, the principal repair mechanism tha

287 veal that beyond the known pathways, such as base excision repair, the process of transcription-coupl

288 cision repair may act as a backup pathway to base excision repair to remove uracils arising from cyto

289 Nei-like 1 (NEIL1) glycosylases followed by base excision repair to restore the unmodified state.

290 deaminating 5-methylcytosine in concert with base-excision repair to exchange cytosine.

291 n essential enzyme playing multiple roles in base excision repair, transcription regulation, and DNA

292 trary to current ideas, that cellular uracil base excision repair (UBER) enzymes target and cleave A3

293 iral DNA products are degraded by the uracil base excision repair (UBER) machinery with less than 1%

294 e also observed with RNA pol II using uracil base excision repair (UBER)-deficient human cells.

295 DNA polymerase X family that is involved in base excision repair, uses a processive hopping search m

296 ause detectable nuclear DNA damage even when base excision repair was blocked by an inhibitor of poly

297 beta to extend from 8-oxoG during long-patch base excision repair was unknown.

298 ts to all DNA-templated processes, including base excision repair where Pol beta catalyzes two key en

299 /U-containing CRE by UNG2 and, therefore, to base excision repair, whereas UNG2 exposure prevented CR

300 ce XPB-R(-/-) cells were not impaired in DNA base excision repair, XPB-R appears to function specific