ライフサイエンスコーパス: base pair mismatch

1 ack the effects of incorporating a CA single base pair mismatch.

2 cyclization of DNA sequences that contain a base pair mismatch.

3 nce of an excess of a sequence with a single-base-pair mismatch.

4 nol is sensitive to the presence of a single base-pair mismatch.

5 ecting local dynamic motions associated with base pair mismatches.

6 icinity of this position was destabilized by base pair mismatches.

7 purine and pyrimidine deaminated lesions or base pair mismatches.

8 rmation of weaker or fewer hydrogen bonds in base pair mismatches.

9 nfluence of the cooperative effect on single base pair mismatches.

10 ic for recognition of insertion/deletion and base pair mismatches.

11 idization, could readily discriminate single-base pair mismatches.

12 were analyzed for binding to DNA containing base pair mismatches.

13 ex that specifically binds to DNA containing base pair mismatches.

14 exes with Msh6p and also failed to recognize base pair mismatches.

15 ld effectively distinguish and reject single base-pair mismatches.

16 kle-catalyzed TMSD rates remain sensitive to base-pair mismatches.

17 e to dsDNA sequences containing one- and two-base-pair mismatches.

18 donor carries different densities of single-base-pair mismatches.

19 in length consisting of a single or multiple base-pair mismatches.

20 is a biological sensor and a locator of DNA base-pair mismatches.

21 ns), yet longer than the dynamic motions of base pair mismatches (0.1-10 ns).

22 he detection system could discriminate a one base pair mismatch (1BPM) target and was functional with

23 ty of the assay was further evaluated by one base pair mismatched (1BPM) DNA detection, where a maxim

24 anganate, tested on a complete set of single base pair mismatches and a number of small insertion/del

25 n fidelity and genome integrity by resolving base pair mismatches and insertion/deletion loops.

26 utS family of DNA repair proteins recognizes base pair mismatches and insertion/deletion mismatches a

27 c MutS and eukaryotic Msh proteins recognize base pair mismatches and insertions or deletions in DNA

28 2-Msh6, which is responsible for identifying base pair mismatches and other discrepancies in DNA, has

29 In yeast, MSH2 interacts with MSH6 to repair base pair mismatches and single nucleotide insertion/del

30 deletion mismatches and with Msh6p to repair base pair mismatches and single-nucleotide insertion/del

31 eukaryotes, the Msh2-Msh6 complex recognizes base pair mismatches and small insertion/deletions in DN

32 ety of interactions, including microhomology base pairing, mismatched and flipped-out bases, and 3' t

33 nal loop zippers up through the formation of base-pair mismatches and a base-triple on complex format

34 ynamic energy penalty associated with single-base-pair mismatches and the metal-ion-controlled enzyma

35 rable properties include duplex stem length, base pair mismatches, and loop length.

36 Single-base-pair mismatches are easily detected.

37 ases copy DNA with remarkable accuracy, some base-pair mismatches are incorporated at low frequency,

38 bed, which allows for the presence of single-base pair mismatches arising from sequencing error.

39 U and created oligonucleotides with a single base pair mismatch (as a positive control) to perform el

40 An adaption of an RNA/RNA duplex, base pair-mismatch assay is capable of detecting rifampi

41 n good agreement with the predicted sites of base-pair mismatches at a few-nanometer resolution.

42 of detection of 1nM and can detect a single base pair mismatch between probe and complementary DNA.

43 In addition, the engineering of base pair mismatches between the fluorogenic imager prob

44 dyl-tRNA within the P site, we now show that base-pairing mismatches between the peptidyl-tRNA antico

45 , these studies suggest that the repair of a base pair mismatch by the Msh2p-Msh6p complex is depende

46 ts demonstrate that the presence of a single base pair mismatch can be identified by the conductance

47 Even a single base-pair mismatch can cause a substantial difference in

48 (MMR) system that normally recognizes single base pair mismatches could specifically recognize 5-FU i

49 l attenuation upon incorporation of a single base-pair mismatch demonstrates that CT is DNA-mediated.

50 ric field denaturation control allows single base pair mismatch discrimination to be carried out rapi

51 Selectivity evaluation showed that one base pair mismatched DNA for SMN1 and uidA could be disc

52 n, with the capabilty to discriminate single-base-pair mismatched DNA mutation (single nucleotide pol

53 In addition to discriminating against base pair mismatches, DNA polymerases exhibit a high deg

54 Single base pair mismatched DNAs can be readily discriminated f

55 s tend to localize and potentially trigger a base pair mismatch during replication.

56 ing analysis that MPG, but not UDG, bound to base-pair mismatches especially to less stable pyrimidin

57 Comparative in-situ studies on single/triple base-pair mismatched, gamma-irradiated and complementary

58 hesis of 17mers and discrimination of single base pair mismatched hybrids.

59 MB DNA biosensor has selectivity with single base-pair mismatch identification capability.

60 rved that the incorporation of an A/C or G/T base pair mismatch in place of a perfect matched base pa

61 Our data indicate that a single base pair mismatch in the invader stalls branch migratio

62 A single G:C base pair mismatch in the target site decreases the (DNA

63 han RNase I for detecting single or multiple base pair mismatches in an RNA-DNA hybrid.

64 Structure and energetic properties of base pair mismatches in duplex RNA have been the focus o

65 wo tandem consensus binding sites with three base pair mismatches in each and a one base pair deletio

66 ases from different sources to cleave single base pair mismatches in heteroduplex DNA templates used

67 s for detection of single-strand regions and base pair mismatches in RNA.

68 Base pair mismatches in the 204-bp amplicon allowed disc

69 cal bases like 2,4-difluorotoluene or single base pair mismatches in the central region of the sense

70 Single base pair mismatches in the FPH-1 binding site were foun

71 ufficiently selective to differentiate a one-base-pair mismatch in a 16-mer target.

72 We show that the position of a single base-pair mismatch in the -ssDNA/microRNA duplex dramati

73 l was achieved through the introduction of a base-pair mismatch in the duplex of the hairpins.

74 he platform is capable of distinguishing two base-pair mismatches in a 22-base pairing segment of mic

75 erichia coli vsr endonuclease recognises T:G base-pair mismatches in double-stranded DNA and initiate

76 erichia coli vsr endonuclease recognises G:T base-pair mismatches in double-stranded DNA and initiate

77 Single base-pair mismatches in the annealing region reduce k(on

78 ch was successfully applied to detecting two-base-pair mismatches in the gene sequence of Microcystis

79 roporation of test plasmid DNA, containing a base pair mismatch, into donor cells prior to mating.

80 mplex relative to non-stacked termini and/or base pair mismatches is used to determine the identifica

81 he role of centrally located and distributed base pair mismatches ('melting bubbles') on localized be

82 We also examined the effects of single-base pair mismatch (MM) (all possible types and position

83 Among all 12 possible single base pair mismatches on the 3'-side of the nick, only T-

84 d the intrinsic dynamics of DNA containing 3 base-pair mismatches recognized in vitro by Rad4 (yeast

85 probes containing centrally localized single base pair mismatches relative to target sequence.

86 With every eighth base pair mismatched, repair was about 14% of that of co

87 With every sixth base pair mismatched, repair was still more than 5%.

88 nterparticle spacings, and (3). the superior base pair mismatch selectivity of PNAs is further enhanc

89 nd quantified with 50-pM sensitivity, single base-pair mismatch selectivity and in the presence of co

90 The affinity toward single base pair mismatched sequences is 4- to 8-fold lower if

91 s optimized to allow the detection of single base pair mismatched sequences, able to detect as low as

92 Control experiments were performed with 12-base pair mismatched sequences.

93 designated match site relative to the double base pair mismatch site, 5'-TATTA-3'.

94 ted match site, 5'-TGGTA-3', over the single base pair mismatch site, 5'-TGTTA-3'.

95 ch site, 5'-TGTTA-3', relative to the single base pair mismatch sites, 5'-TGGTA-3' and 5'-TATTA-3'.

96 ECL signals associated with two base pair mismatched ssDNA and noncomplementary ssDNA ca

97 between a fully complementary target and a 3 base pair mismatch target at a contrast ratio of 4:1.

98 ble to specifically cleave nearly all single base pair mismatches tested.

99 electivity of hybridization is the number of base pair mismatches that occur in an ungapped alignment

100 make quantitative distinctions on degree of base-pair mismatch through monitoring target binding kin

101 Other results suggest that the C1xA72 base pair mismatch, unique to eubacterial and organellar

102 ce microscopy-based method for detecting DNA base-pair mismatches using MutS protein isolated from E.

103 a putative NFkappaB-binding sequence with 3-base pair mismatches was identified in the DRE.

104 ), specific to ds-ON and highly sensitive to base pair mismatches, was consistently observed.

105 To determine the effect of MMR on single-base pair mismatches, we have measured reversion rates o

106 nd how MutS searches for and identifies rare base-pair mismatches, we characterized the dynamic movem

107 n forming DNA duplexes possessing A/C or G/T base pair mismatches were compared to those of correspon

108 iminated between two sequences with a single base-pair mismatch with high sensitivity (over an order

109 SNAP primers contain a single base pair mismatch within three nucleotides from the 3'

110 evant concentration levels as well as single base pair mismatch, without requiring complex and expens