ライフサイエンスコーパス: base step

1 nt ZFNs available for targeting almost every base step).

2 y significant contacts to an adenine-thymine base step.

3 ues ranged from 20 degrees to 50 degrees per base step.

4 lue comparable to the stacking energy of one base step.

5 ues for helical rise and twist at individual base steps.

6 t deprotonation of the carboxylic acid under base (Step 4), while in the absence of base a stable car

7 f carboxylic acid to carboxylate anion under base (Step 4).

8 of a trapped proton cloud from the AMF using BASE-STEP(9)-a transportable, superconducting, autonomou

9 om a single guanine base to a double guanine base step across a single adenine.

10 ior determination of the pronounced 5'-TA/TA base-step affinity of the drug have prompted us to inves

11 This results in a centrally underwound base step and a number of subsequent overwinding steps l

12 ugh its dual functionality, with microtubule-based stepping and regulation of microtubule dynamics.

13 intercalated into the 5'-CG/CG and 5'-GA/TC base steps, and penetration of the duplexes occurred fro

14 with a DNA duplex containing a flexible TpA base step at the +1/+2-flanking sites of the target nucl

15 sence of a severely underwound central py.pu base step (average = 24.1 degrees), which lies on a crys

16 The base step between T4*A17 and FAPYG5*C16 was increased fr

17 ist decrease to approximately 30 degrees per base step, but every base step was approximately 30 degr

18 developed by exploiting the emulsion-droplet-based step-by-step growth featuring shape control.

19 Over 680 chiDL base steps capture the synthesis of six compounds throug

20 antihypertensive therapy with chlorthalidone-based stepped-care therapy resulted in a lower rate of c

21 o the development of more effective evidence-based stepped-care treatment algorithms for patients wit

22 (2) maintaining DNA structures dependent on base-step conformational tendencies consistent with the

23 es a detailed description of the dynamics of base-step conformational transitions and of the first st

24 icroscopy and developed a set of information-based step detection procedures to estimate the number o

25 twisting without an increase in intrastrand base-step distance.

26 We provide resampling-based step-down adjustments to correct the observed sign

27 oit et al. have advocated use of permutation-based step-down P-value adjustments to correct the obser

28 yields and purities, with a total of 24,936 base steps executed over 329 h of platform runtime.

29 rimental data, including local deviations in base step helicoidal parameters in the region of the GU

30 ccessible roll values were obtained for each base step in the relevant octanucleotide context to acco

31 is associated with unstacking of individual base steps in the target site.

32 mal cross-bridge cycling as the first muscle-based step in tremor genesis.

33 ty of applying the experimental and software-based steps in multiple-complete-digest mapping to a tar

34 ude the sequence-dependent differences among base steps, in which values ranged from 20 degrees to 50

35 npeptidic, single-digit micromolar mechanism-based STEP inhibitors with greater than 20-fold selectiv

36 red daily step count and established cadence-based step intensity measures (steps/min): incidental st

37 The base-step intercalation seen here is reminiscent of doma

38 and tilt were also more variable in certain base steps involving mismatched bases.

39 relationship between local structure at the base-step level and the global superhelical conformation

40 tecture in which segments as small as single base steps may be considered as modular recognition unit

41 useful stereochemical measures of the local base step movements operative in sequence-specific recog

42 photoadduct formation to the intended 5'-TpA base step next to the PNA-binding site, and the photoadd

43 line recapitulates the endoplasmic reticulum-based steps of the eukaryotic protein N-glycosylation ma

44 mber of complex and expensive chromatography-based steps, operated in batch mode, that rely heavily o

45 The curvature is due almost entirely to the base-step parameter roll.

46 The base step parameters which are most strongly coupled to

47 in groove narrowing through: (i) changes in base step parameters, including increased helical twist

48 Although variations in the other base-step parameters perturb the local path of the DNA,

49 performed using octamers containing various base steps present in the 'NMR sequences'.

50 The distribution of base-step roll values and corresponding strain energy re

51 eters in protein-DNA crystal structures, GpG base steps show A-like properties, reflecting their inna

52 elix is more similar to both the helical and base step structural parameters of A'-RNA rather than A-

53 he larger 3' bend, 10 degrees, occurs in two base steps: the first composed of tilt, -4.1 degrees, an

54 litated by a highly deformable local -C3-A4- base step, this amino group allows the B[a]P ring system

55 ads, zipper-like interdigitation and sheared base steps, together with base-base and base-sugar stack

56 degrees to 50 degrees kink at a central CpG base step towards the major groove, as dyad-related leuc

57 ximately 30 degrees per base step, but every base step was approximately 30 degrees, suggesting that

58 x 2 covalently modifies adenine at GA and TA base steps, which are high-affinity intercalation sites

59 h a structural distortion localized to an AT base step within the -10 element.