ライフサイエンスコーパス: basement membrane

1 to collagen IV (Col4) in the subendothelial basement membrane.

2 by ultrastructural lesions of the glomerular basement membrane.

3 ix metalloproteinases and degradation of the basement membrane.

4 l shedding, leaving small patches of denuded basement membrane.

5 ng amnion mesenchymal cells (AMCs) through a basement membrane.

6 n IV, a main component of the breast lobular basement membrane.

7 in vitro induces thickening of the vascular basement membrane.

8 migrate from all sides to cover the denuded basement membrane.

9 o capillary networks that are enveloped by a basement membrane.

10 was, in part, attributable to damage of the basement membrane.

11 ition occurred linearly along the epithelial basement membrane.

12 rved that basal cells flattened to cover the basement membrane.

13 pport and cues to the cells as an engineered basement membrane.

14 ced using an antibody against the glomerular basement membrane.

15 lial cell junction proteins and a continuous basement membrane.

16 ing are modulated by components of the mural basement membrane.

17 in the testis: role of laminin alpha2 in the basement membrane.

18 d collagen IV immunoreactivity at the muscle basement membrane.

19 that stabilizes collagen IV scaffolds in the basement membrane.

20 e occurred frequently in expanded regions of basement membrane.

21 resulting in mosaic vessels with gaps in the basement membrane.

22 by ultrastructural lesions of the glomerular basement membrane.

23 rm of the mouse embryo become enveloped by a basement membrane.

24 along the subepithelial region of glomerular basement membrane.

25 ia transmission electron microscopy near the basement membrane.

26 bly of vasculature and the deposition of new basement membrane.

27 will alter extensile tensions on the tumour basement membrane.

28 CD was measured as number of goblet cells/mm basement membrane.

29 llagen IV from EC and deposition in vascular basement membranes.

30 the sulfilimine crosslink in collagen IV in basement membranes.

31 a structural protein of epidermal/epithelial basement membranes.

32 l. (2017) identify a mechanism for breaching basement membranes.

33 ized by weak interactions between muscle and basement membranes.

34 ulfilimine bonds to reinforce collagen IV in basement membranes.

35 olymerise to form a central component of all basement membranes.

36 essels or nerve bundles and their associated basement membranes.

37 ad accumulation of fibronectin at many organ basement membranes.

38 ity to study the composition and assembly of basement membranes.

39 etworks that provide mechanical stability to basement membranes, a specialized form of extracellular

40 ion, whereas endothelial cell and glomerular basement membrane abnormalities were associated with pro

41 ng cells and the leakage of laminin from the basement membrane across a compromised blood-brain barri

42 xpression of secreted proteases that degrade basement membrane, an ECM barrier surrounding all epithe

43 case of laminin111, Matrigel(TM), a complete basement membrane analog, also causes the clustering of

44 blood vessels, such as the expansion of the basement membrane and a loss of vascular cells(2-4).

45 cells to constrict basally, detach from the basement membrane and become internalised.

46 ing the sensory nerve fibers in crossing the basement membrane and branching into nerve endings.

47 These analyses revealed the evolution of basement membrane and cellular defects through the progr

48 l cells (BMECs) and pericytes, which share a basement membrane and comprise the microvessel structure

49 o disrupt laminin expression in the vascular basement membrane and demonstrate that microglia respond

50 sting of podocyte foot processes, glomerular basement membrane and endothelial cells.

51 n specialized areas of irregular endothelial basement membrane and enriched with vesicular activity.

52 Basement membrane and extracellular matrix (ECM) protein

53 vation, has multiple binding partners in the basement membrane and interacts genetically with the bas

54 thelium and is transmitted to the supporting basement membrane and internal elastic lamina macromolec

55 We have discovered that basement membrane and its major components can induce ra

56 genes mediating epithelial cell adhesion to basement membrane and mesenchymal-epithelial cross-talk.

57 GF-A165 b rescues the increase in glomerular basement membrane and podocyte slit width, as well as th

58 erve fiber branching points, penetrating the basement membrane and reaching into the stroma.

59 ibroblasts upon disruption of the epithelial basement membrane and that they induce signaling events

60 Signalling between the basement membrane and these tissues is critical for cell

61 he BBB through their proteolytic activity on basement membrane and tight junction proteins.

62 fter posterior vitreous detachment is a true basement membrane and to postulate its origin.

63 ted by their microenvironment, including the basement membrane and underlying mesenchymal cells.

64 XV/XVIII ortholog Multiplexin in the tissue-basement membranes and the phagocytosis receptor Eater o

65 in which surgical removal of the epithelium, basement membrane, and anterior stroma was performed.

66 r, carry erythrocytes, are enclosed within a basement membrane, and can always be traced back to the

67 IgG-positive immune deposits in the tubular basement membrane, and circulating antibodies reactive w

68 ne of the major constituents of the vascular basement membrane, and facilitates spirochete transmigra

69 animals featured endothelial gaps, thickened basement membrane, and fibrin-like intraluminal deposits

70 athway: ECs secrete factors that remodel RPE basement membrane, and integrin receptors sense these ch

71 e-dimensional (3D) spheroids are cultured in basement membrane, and one such state is associated with

72 rastructure of collagen fibers in the vessel basement membrane, and the kinetics of regression were d

73 tissue extracts had significantly more anti-basement membrane antibodies than sera from patients wit

74 In GEC(HO-1) rats with anti-glomerular basement membrane antibody mediated, complement-dependen

75 Ts via DNase I did not alter anti-glomerular basement membrane antibody-induced glomerular injury, as

76 sted in an attenuated passive antiglomerular basement membrane antibody-induced glomerulonephritis mo

77 e with MPO and a low dose of anti-glomerular basement membrane antibody.

78 e in glomerular podocytes and the underlying basement membrane are frequently observed in disease, ir

79 Basement membranes are often remodeled in chronic AMR.

80 iche cell wrapping templates a laminin-based basement membrane around the gonad primordium.

81 cific proteoglycan, Col18a1, pointing to the basement membrane as part of the stem cell niche.

82 hibitory role, suggesting that regulation of basement membrane assembly requires a complex interplay

83 ve role, alpha9beta1 has an opposing role in basement membrane assembly/maturation through reduced la

84 s (co-isolated with the islets) and restored basement membrane-associated type VI collagen, which wer

85 Our findings suggested that basement membrane attachment provided survival signals.

86 Cell invasion across basement membrane barriers is important in both normal d

87 How cells breach basement membrane barriers remains an area of active res

88 In particular, the basement membrane below the pial meninx (pBM) is require

89 ent serum, and control serum and assayed for basement membrane binding by means of ELISA.

90 We identified basement membrane (BM) and collagen IV in Ctenophora, an

91 r assessment of the mean number of layers of basement membrane (BM) around peritubular capillaries (P

92 Cell invasion through basement membrane (BM) barriers is crucial in developmen

93 obust mechanical anisotropy in the ECM-based basement membrane (BM) but not in the underlying epithel

94 th retention of collagen IV, reiterating the basement membrane (BM) changes observed in vivo.

95 cause endoplasmic reticulum (ER) stress and basement membrane (BM) defects, and recent data suggest

96 ail to accumulate F-actin in the OF prior to basement membrane (BM) degradation.

97 of the follicle cell basal domain, oriented basement membrane (BM) fibrils and F-actin stress fibers

98 is one of the constituent components of the basement membrane (BM) in adult rat testes.

99 ctive oxygen species (ROS) and damage of the basement membrane (BM) in all neoplastic, but not hyperp

100 The islet basement membrane (BM) influences islet function and sur

101 The endothelial cell basement membrane (BM) is a barrier to migrating leukocy

102 The basement membrane (BM) is a thin layer of extracellular

103 othelial cells (ECs) enhances subendothelial basement membrane (BM) stiffness, which, in turn, promot

104 vasive cells use small invadopodia to breach basement membrane (BM), a dense matrix that encases tiss

105 IV scaffold is a principal component of the basement membrane (BM), a specialized extracellular matr

106 The emergence of the basement membrane (BM), a specialized form of extracellu

107 dings of a local regulatory axis between the basement membrane (BM), the blood-testis barrier (BTB),

108 in is a well-defined component of the airway basement membrane (BM).

109 find that MMPs hasten invasion by degrading basement membrane (BM).

110 etween the muscle fiber cytoskeleton and the basement membrane (BM).

111 f fibrotic lung myofibroblasts to invade the basement membrane (BM).

112 Basement membranes (BMs) are cell-associated extracellul

113 Basement membranes (BMs) are planar protein networks tha

114 Basement membranes (BMs) are supramolecular matrices bui

115 Basement membranes (BMs) are thin, dense sheets of speci

116 Cancer cells typically invade through basement membranes (BMs) at key points during metastasis

117 pithelial cancers, cells must invade through basement membranes (BMs) to metastasize.

118 tein netrin 1 (Ntn1), which is necessary for basement membrane breakdown, although the underlying mol

119 sion, including experiencing disturbed flow, basement membrane breakdown, endothelial cell death, and

120 lls lose their epithelial morphology and the basement membrane breaks down.

121 l vascular digests, a subsequent increase in basement membrane bridges was also observed.

122 y contrast, hair cells lose contact with the basement membrane, but contribute to continued outgrowth

123 on silk films mimic features of the corneal basement membrane by providing biophysical cues to direc

124 dynamic distribution of perforations in the basement membrane by regulating the expression of matrix

125 s had no source of immune cells and that the basement membrane capsule surrounding the lens was a bar

126 irway subepithelial eosinophils per mm(2) of basement membrane (cells/mm(2) ).

127 t that allows LOXL2-mediated crosslinking of basement membrane collagen IV.

128 tion of NOTCH3 fragmentation products in the basement membrane, collagen fibers, and granular osmioph

129 d cancer cell invasion through reconstituted basement membrane compared with serum from saline contro

130 Perivascular access to smooth muscle basement membrane compartments also exhibited size-depen

131 er and putative smooth muscle and astroglial basement membrane compartments.

132 ment therapy, and they also suggest that the basement membrane components at the dermal-epidermal jun

133 for nuclear positioning and for secretion of basement membrane components via retrograde dynein-depen

134 On basement membrane components, these sliding focal adhesi

135 anogaster model to reveal a pivotal role for basement membrane composition in the formation of hemato

136 oodpasture antigen-binding protein (GPBP), a basement membrane constituent, played a role in this tra

137 ](2)alpha2(IV)) that represent a fundamental basement membrane constituent.

138 How a basement membrane continuously surrounds an organ that i

139 editary nephropathy (XLHN) have a glomerular basement membrane defect that leads to progressive juven

140 were characterized by amnion cell puckering, basement membrane degradation, and tunnels that extended

141 P-AscH(-) inhibited invasion, basement membrane degradation, decreased matrix metallop

142 Capillarization was characterized by ectopic basement membrane deposition, formation of a continuous

143 l functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptid

144 MMP to promote invasive behaviour leading to basement membrane disruption.

145 invasive phenotype such as lumen-filling and basement membrane disruption.

146 pical layer stiffness and confinement by the basement membrane drive fold formation but influence pos

147 S endothelium and secreted into the vascular basement membrane during BBB formation.

148 ding dry eye disease, anterior or epithelial basement membrane dystrophy, Salzmann nodular degenerati

149 erineuronal nets, interstitial matrices, and basement membranes, each composed of a set of collagens,

150 basement membrane) versus fibrous (i.e., non-basement membrane) ECM niche of antigen-removed bovine p

151 hat the posterior hyaloid membrane is a true basement membrane enveloping the posterior hyaloid surfa

152 porting cells, which retain contact with the basement membrane, exhibit biased protrusive activity an

153 ctin signalling depends on a cross-talk with basement membrane extracellular matrix (ECM) via beta1 i

154 ling law for linear elastic matrices such as basement membrane extract hydrogels (Matrigel) that allo

155 ies with intercellular gaps and a fragmented basement membrane, facilitate delivery of macromolecules

156 utrophils need to penetrate the perivascular basement membrane for successful extravasation into infl

157 Ultrastructural analysis reveals that basement membrane formation around the developing eye is

158 The glomerular basement membrane (GBM) is a key component of the glomer

159 by immigration of cells along the glomerular basement membrane (GBM) is under debate.

160 During follow-up, glomerular basement membrane (GBM) width, mesangial fractional volu

161 eutral dextrans permeate into the glomerular basement membrane (GBM), in general agreement with Ogsto

162 ion of immune complexes along the glomerular basement membrane (GBM), phospholipase A2 receptor (PLA2

163 l thickening and splitting of the glomerular basement membrane (GBM).

164 (LAMB2), a major component of the glomerular basement membrane (GBM).

165 in the kidney, commonly along the glomerular basement membrane (GBM).

166 constitute the axial core of the glomerular basement membrane (GBM).

167 trigger GN, we used low-dose antiglomerular basement membrane globulin, which transiently recruits n

168 development: solid-cell cords form their own basement membrane, grow on the surface of initially homo

169 ore blisters at two or more sites and linear basement membrane IgG or C3).

170 onstrate that microglia respond to the mural basement membrane in an isoform-specific manner.

171 yte protrusions invading into the glomerular basement membrane in disease and these occurred frequent

172 However, the mechanical role of the basement membrane in post-implantation embryogenesis rem

173 ns anchor cell uses physical force to breach basement membrane in the absence of matrix metalloprotea

174 ain, a structural constituent protein at the basement membrane in the rat testis, likely via proteoly

175 In vivo, mechanical disruption of the basement membrane in wounded corneas prompted an increas

176 ustrated matrix proteins that constitute the basement membranes in the renal cortex are constantly re

177 Genetically decreasing the stiffness of basement membranes increases membrane tensions in silico

178 l accumulation and damage in anti-glomerular basement membrane-induced (anti-GBM-induced) glomerulone

179 Similarly, both anti-glomerular basement membrane-induced glomerulonephritis and experim

180 glomerulonephritis (GN) and anti-glomerular basement membrane-induced nephritis.

181 e collagen IV network, an event essential to basement membrane integrity.

182 The basement membrane is a specialized sheet-like form of th

183 tion, collagen IV deposition in the vascular basement membrane is reduced in mutant mice, leading to

184 astructural studies show that the glomerular basement membrane is thickened, podocyte slit width is i

185 are grown in substrata that have elements of basement membrane leading to the formation of tissue-lik

186 Furthermore, reconstitution of the basement membrane leads to characteristic cortical tissu

187 heir microenvironment and alterations of the basement membrane, led to ESC mislocalization and exhaus

188 munohistochemically staining for collagen IV basement membrane markers, in addition to extracellular

189 NIH (Bethesda, MD), where the reconstituted basement membrane Matrigel was discovered, I had the int

190 ised its surface, enabling the attachment of basement membrane matrix (Geltrex).

191 whole biopsy samples without the addition of basement membrane matrix favors the formation of PDX tum

192 Basement membrane matrix proteins, such as matrigel, are

193 twork formation on Matrigel, a reconstituted basement membrane matrix regularly used to promote EC ne

194 of the laminin-gamma2 chain is a hallmark of basement membrane maturation in the skin.

195 onducted a deeper investigation into how the basement membrane might further regulate the expression,

196 We observed that cells adjacent to the basement membrane mimetic Matrigel survived MEK inhibiti

197 umor 3D clusters that utilized Matrigel as a basement membrane mimetic.

198 uitment of ECs in vivo in a murine synthetic basement membrane model.

199 Impaired podocyte adhesion to the glomerular basement membrane most likely contributed to disease dev

200 Moreover, after induction of anti-glomerular basement membrane nephritis in young mice, iPLA2gamma KO

201 tes are vascular mural cells embedded in the basement membrane of blood microvessels.

202 biopsies of patients with SS reveal that the basement membrane of dermal postcapillary venules underg

203 and >4 mononuclear cells within the tubular basement membrane of nonatrophic tubules.

204 ost universally deposited linearly along the basement membrane of NP tissue.

205 tension during gastrulation by rendering the basement membrane of the prospective primitive streak mo

206 east 1 of either IgM, IgG, IgA, or C3 at the basement membrane of the specimen; nondiagnostic when on

207 to the perivascular spaces and tunica media basement membranes of leptomeningeal arteries.

208 aste bud and a foot process extending to the basement membrane often contacting nerve processes along

209 f ECM niche (e.g., basement membrane vs. non-basement membrane) on repopulating cell phenotype and fu

210 vasive cellular protrusions that expand tiny basement membrane openings.

211 multilamination of the peritubular capillary basement membrane or arteriopathy manifesting as intimal

212 ucleus through adjacent tissue, penetrates a basement membrane, or enters a small blood capillary, ch

213 esion to laminin-332, is critical for proper basement membrane organization during skin development a

214 ect on the ability of alpha3beta1 to promote basement membrane organization.

215 he activity of matrix metalloproteinases and basement membrane perforations-to the posterior side of

216 e, softening and enhanced remodelling of the basement membrane promote tumour budding, while stiffeni

217 mote tumour budding, while stiffening of the basement membrane promotes folding.

218 e breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis.

219 acterized by autoantibodies directed against basement membrane protein BP180.

220 LVV was associated with accumulation of the basement membrane protein, collagen IV, in LVV-forming e

221 Basement-membrane protein loss is a prominent feature of

222 with plaque rupture, including inflammation, basement-membrane protein loss, and apoptosis.

223 ess this question by showing that individual basement membrane proteins are more dynamic than previou

224 Skin-specific basement membrane proteins called laminins play importan

225 By day 28, basement membrane proteins were reduced in drug-eluting

226 sion of genes encoding extracellular matrix, basement membrane proteins, and members of ERK, FGF and

227 er to new collagen I surfaces, and away from basement membrane proteins.

228 d human plaques, suggesting a major role for basement-membrane proteins in maintaining plaque stabili

229 and ruptured human plaques; however, several basement-membrane proteins were reduced in both SR-uPA(+

230 M (Extracellular matrix) proteins, including basement-membrane proteins, were decreased.

231 rtment: epithelium (basal region), reticular basement membrane (Rbm) and underlying lamina propria (L

232 ion in a macrophage-mediated anti-glomerular basement membrane reactive serum-induced immune nephriti

233 Laminin and the basement membrane receptor dystroglycan function to main

234 onfirmed the presence of COL6 throughout the basement membrane region of mouse lung tissue.

235 thelial cells within the islets and restored basement membrane-related proteins (eg, fibronectin and

236 chains, a major constituent component of the basement membrane, release the non-collagenous (NC) 1 do

237 ntact pObs only where an otherwise occluding basement membrane remains incompletely assembled.

238 links luminal hormone receptor signaling to basement membrane remodeling and stem cell activation.

239 This shows that interstitial matrix and basement membrane remodeling in RC may be distinguishabl

240 F-alpha and IL-17A were conducted to dissect basement membrane remodeling.

241 terior-posterior axis(8,9) further regulates basement membrane remodelling by localizing Nodal signal

242 Thus spatiotemporally regulated basement membrane remodelling contributes to the coordin

243 the importance of spatiotemporally regulated basement membrane remodelling during early embryonic dev

244 This basement membrane remodelling facilitates embryo growth

245 However, recent work has revealed roles for basement membrane remodelling in global tissue morphogen

246 iency, or the presence of mutant proteins in basement membranes represents an important gap in knowle

247 h acute edema due to spontaneous Descemet s (basement) membrane rupture in keratoconus, mimicking thi

248 These findings establish the basement membrane's active role in tissue sculpting.

249 und cells, while others provide a sheet-like basement membrane scaffold beneath epithelial cells.

250 llular polymerization of laminin trimers and basement membrane scaffolding.

251 resulted in renal clear cells, multi-layered basement membranes, severe cystic pathology, and ultimat

252 Independent of basement membrane, SGP wrapping performs a second, cruci

253 Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations

254 Agrin is a basement membrane-specific proteoglycan that can regulat

255 networks, which are essential for glomerular basement membrane stability and molecular ultrafiltratio

256 Drosophila follicle, a model system in which basement membrane stiffness instructs three-dimensional

257 Basement membrane structures on the serous side stimulat

258 ic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes.

259 etachment and disruption of the perivascular basement membrane surrounding the VECs.

260 ytoskeleton that initiate degradation of the basement membrane that holds a cell in place.

261 Cs) and Bruch's membrane, a highly organized basement membrane that lies between both cell types.

262 The basement membrane that seperates the endothelial cells a

263 ic proteins that are major components of the basement membranes that separate endothelia and epitheli

264 sues live in the interstitial spaces between basement membranes that spatially delimit complex organ

265 s with endothelial cells, their adherence to basement membranes, the internal elastica lamina, and ne

266 QR], 3.5% to 10.1%, P < .001), subepithelial basement membrane thickening (4.4 mum [25th-75th IQR, 4.

267 anges was associated with a higher degree of basement membrane thickening and edematous changes withi

268 Furthermore, DAPT prevented glomerular basement membrane thickening and proteinuria induced by

269 as of foot process effacement and glomerular basement membrane thickening and wrinkling.

270 y, mesangial matrix accumulation, glomerular basement membrane thickening, albuminuria, and podocyte

271 enlarged glomeruli, mesangial proliferation, basement membrane thickening, albuminuria, podocyte loss

272 pithelial shedding, goblet cell hyperplasia, basement membrane thickening, subepithelial fibrosis, ai

273 ation of fibrocytes/smooth muscle cells, and basement membrane thickening.

274 ard to pulmonary function indices, bronchial basement membrane thickness, and BAL fluid neutrophil an

275 th regard to epithelial integrity, reticular basement membrane thickness, glandular area, expression

276 rway smooth muscle (ASM) area, subepithelial basement membrane thickness, nerve fibers, and epithelia

277 After branch initiation, however, the basement membrane thins at branch tips; this remodeling

278 w and whether cells remodel their cortex and basement membrane to adapt to their microenvironment.

279 ave been proposed to require adhesion to the basement membrane to polarise.

280 h production and maintenance of the vascular basement membrane to prevent abnormal aortic expansion a

281 ells proliferate and spread onto the denuded basement membrane to reseal the barrier.

282 ells divide parallel or perpendicular to the basement membrane to self-renew or produce differentiate

283 c conditions affecting the competency of the basement membranes to which they contribute.

284 Basement membrane transmigration during embryonal develo

285 This basement-membrane-triggered mechanism produces rapid fib

286 s schlosseri, in which the disruption of the basement membrane triggers rapid, massive vascular retra

287 nd V collagen formation (PRO-C3 and PRO-C5), basement membrane type IV collagen formation (PRO-C4) an

288 Alport syndrome (AS), a rare disease of basement membrane type IV collagen, impacts the kidneys,

289 We aim to understand how serous (i.e., basement membrane) versus fibrous (i.e., non-basement me

290 Defining the effect of ECM niche (e.g., basement membrane vs. non-basement membrane) on repopula

291 cells to a shared point of fibronectin-rich basement membrane, where the neural folds first contact

292 ion is regulated by mechanical cues from the basement membrane, which are transduced by the Src tyros

293 pdgfr signaling leads to a reduced vascular basement membrane, which in turn results in enhanced dor

294 at the endothelium in developing bones lacks basement membrane, which normally isolates the blood ves

295 we identified sub-podocyte expansions of the basement membrane with both cellular and matrix gene def

296 a1, -gamma2 and -gamma3 chains in the limbal basement membrane, with LN-alpha5 representing a signatu

297 nd are separated from AT1 cells by a limited basement membrane without intervening pericytes.

298 Before branching, the basement membrane wraps the airway epithelium as a spati

299 en, an extracellular matrix component of the basement membrane zone forming the anchoring fibrils.

300 of human type VII collagen restricted to the basement membrane zone.