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1 s, including the essential invasion receptor Basigin.
2 tein to either of the two common isoforms of basigin.
3 elial crosstalk mediated at least in part by Basigin.
4 of expression of the major invasion receptor basigin.
5 nd that binds with its erythrocyte receptor, Basigin.
6 acid (SA), complement receptor 1 (CR1), and basigin.
7 g the interaction of PfRH5 with its receptor basigin.
8 t mouse basigin can functionally replace fly basigin.
9 fects and neuron-glia interaction defects of basigin.
10 o determine the identity of the receptor for basigin.
11 A-Ripr complex with the erythrocyte receptor basigin(1,2), which is an essential step for entry into
12 We show that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed spec
13 The specific and limited expression of 5A11/Basigin-2 explicitly within photoreceptor cells implies
15 to lactate or inhibitors in the presence of Basigin-2, a single transmembrane segment (TM)-containin
16 to lactate or inhibitors in the presence of Basigin-2, a single transmembrane segment (TM)-containin
19 in tissue remodeling and angiogenesis makes basigin a potential target for the development of strate
20 ial binding of PfRh5/CyRPA/PfRipr complex to basigin, a step linked to the formation of a pore betwee
23 recombinant chimeric antibody (Ab-1) against basigin, an erythrocyte receptor necessary for parasite
24 nding of the PfRH5/PCRCR invasion complex to Basigin, an interaction known to be essential for invasi
25 PvTRAg38 binds to two erythrocyte receptors basigin and band 3 through P2 and P4 regions, respective
26 wo single-pass transmembrane proteins, CD147/Basigin and CD44, both of which serve as chaperones for
29 ting that simultaneous blockade of the PfRH5-Basigin and PfRH5/PfRipr/CyRPA interactions produced an
30 functions as a membrane receptor for soluble basigin and this homophilic interaction is not dependent
33 ely blocked using low concentrations of anti-basigin antibodies; importantly, these effects were obse
38 ssion of a conserved Ig superfamily protein, Basigin, at the glial membrane of Drosophila where it as
40 ng CRISPR/Cas9, we deleted two host factors, basigin (BSG) and CD44, for which no natural nulls exist
43 atrix metalloproteinase (MMP)-2, MMP-14, and basigin (BSG) are major enzymes involved in the maintena
44 Reticulocyte-binding protein Homolog 5 (RH5)-Basigin (BSG) interaction in host-species selectivity an
46 hat cellular adhesion molecules integrin and basigin (BSG) promote the growth of tumor spheroids.
47 32, impaired in cargo binding, we identified Basigin (BSG), an immunoglobulin superfamily member, as
49 identified as the transmembrane glycoprotein basigin (BSG, CD147); more particularly, its low glycosy
51 zes the surface marker, CD147, also known as Basigin, can effectively kill various malignant HCC cell
57 ibodies or other therapeutics targeting host basigin could be an effective treatment for patients inf
58 assays with monoclonal antibodies targeting basigin coupled with PfRh5 next-generation amplicon sequ
60 to participate in invasion and interact with basigin, did not impact invasive susceptibility of retic
62 exes with a higher affinity than to isolated basigin ectodomain, making it likely that these are the
65 quire association with the accessory protein basigin, encoded by Bsg, for maturation and trafficking
66 results demonstrate that rBSG interacts with basigin expressed on the surface of fibroblasts and is s
67 of the SARS-CoV-2 spike do not interact with basigin expressed on the surface of human cells, and by
69 rane protein CD147 (also known as EMMPRIN or basigin) forms a specific heterodimeric complex in the m
71 nd the extracellular domains are crucial for basigin function in the visual system while the short in
74 alternative transcription initiation of BSG (Basigin) gene by differentially influencing RNAPII densi
75 srupted, via zinc finger nucleases, MCT4 and BASIGIN genes in colon adenocarcinoma (LS174T) and gliob
81 essential role for the erythrocyte receptor basigin in P. falciparum invasion and demonstrate rescue
86 r transgenic fly basigin or transgenic mouse basigin in the photoreceptors demonstrating that mouse b
88 the neural retina supporting a role for 5A11/basigin in the targeting of these transporters to the pl
89 hermal-shift-assays confirmed ACF binding to basigin in vitro and in live glioblastoma cells, respect
91 following: 1) the ability to block the PfRH5-basigin interaction in vitro is predictive of functional
92 sought to determine if disruption of the MCT-Basigin interaction may be achieved with a small molecul
100 the extracellular integrin-binding domain of Basigin is sufficient to rescue peripheral glial compres
101 In summary, our results demonstrate that basigin is very likely the apoD receptor and provide add
104 lin superfamily glycoprotein CD147 (emmprin; basigin) is associated with an invasive phenotype in var
105 oproteinase inducer) also known as CD147 and basigin, is a member of the immunoglobulin family that i
106 longer form, a splice variant of mouse 5A11/Basigin, is a member of the immunoglobulin gene superfam
107 have found that the Ok blood group antigen, basigin, is a receptor for PfRh5, a parasite ligand that
108 corresponding to the extracellular domain of basigin, it was demonstrated that the native, nonglycosy
109 potently inhibited by soluble basigin or by basigin knockdown, and invasion could be completely bloc
113 The EBA-175/glycophorin A (GPA) and Rh5/basigin ligand-receptor interactions, referred to as inv
115 culocyte-binding protein homolog 5 (RH5) and basigin makes RH5 a prime target for broadly neutralizin
116 disruption of MCT binding to their chaperon, Basigin, may be an effective approach to target GSC and
120 itudes in the electroretinograms in the 5A11/basigin null mouse (Bsg(-/-)) may be linked to altered e
121 e invasion was potently inhibited by soluble basigin or by basigin knockdown, and invasion could be c
122 oproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on
123 scued by expression of either transgenic fly basigin or transgenic mouse basigin in the photoreceptor
124 15 monoclonal antibodies recognizing EMMPRIN/basigin/OX-47/M6, a 45-55-kDa transmembrane protein with
132 C, and D (GPA/B/C/D), complement receptor 1, basigin, semaphorin 7a, Band 3/ GPA, Kx, and heparan sul
133 osaic animals that are mutant in the eye for basigin show altered cell structure with nuclei, mitocho
134 rting enzyme 2 was rarely expressed, whereas basigin showed diffuse expression, and alanyl aminopepti
135 ractions as weak or weaker than the proposed basigin-spike binding, we report no evidence for a direc
136 e transport isoform 1 (MCT1) and its partner basigin that are highly enriched on retinal glia and mye
137 an effort to determine the function of 5A11/Basigin, the molecular diversity of its expression was e
138 , when administered to 2-year-old mice, anti-Basigin therapy reinstates bone remodeling to significan
139 er and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization.
140 not reduce the binding of PfRH5 to monomeric basigin, they do reduce its binding to basigin-PMCA and
145 h of these functions, we have created mutant basigin transgenes coding for proteins that are altered
146 ermore, Ok(a-) erythrocytes, which express a basigin variant that has a weaker binding affinity for P
147 cificity of interaction between PvTRAg38 and basigin was confirmed by direct interaction where basigi
148 r mediator of SA-independent invasion, while basigin was essential for both SA-dependent and SA-indep
149 in was confirmed by direct interaction where basigin was specifically recognized by P2 and not by the
150 In addition, antibodies against CR1 and basigin were used to determine the contributions of thes
151 N-glycan exposed on the human receptor CD147/Basigin, while fucosylated derivatives of this N-glycan
152 comparision of the crystal structure of Rh5-basigin with the cryo-electron microscopy structure of R