ライフサイエンスコーパス: be amplified

1 ces other than the target sequence will also be amplified.

2 ference in the sulfide ion concentration can be amplified.

3 an patient tumors, where the FoxM1 signature is amplified.

4 e peak, over the same region where BM motion is amplified.

5 their effect on FAO-dependent cell migration are amplified.

6 a perfect copy of the template from which it was amplified.

7 t increase after H-I, whereas another subset was amplified.

8 in 80% of the cohort while the oncogene MDM4 was amplified.

9 ted, the need for reference-free methods has been amplified.

10 nvelope protein, envelope-binding antibodies were amplified 100-fold, but qualitatively different imm

11 that the severity of droughts during El Nino is amplified (17%) by changes in aerosols.

12 Where there are hotspots, lateral inhibition is amplified; 2) Where no hotspots emerge, NE levels are

13 ated adjacent to the Myc gene, both of which were amplified 40-fold.

14 tic beads to capture PCA3 transcripts, which were amplified 97-fold and 7-fold higher than convention

15 ive cues, such that excitatory cue responses are amplified across learning.

16 eral early studies found that Aurora kinases are amplified and overexpressed at the transcript and pr

17 mational changes in the protein motor domain are amplified and redirected by nucleic acid structures.

18 ensures that only double-digested fragments are amplified and sequenced.

19 tional strains of alpha-synuclein, which can be amplified and detected by alpha-synuclein-PMCA.

20 o one bacterial plasmid vector that can then be amplified and paired-end sequencing by next-generatio

21 All reassortant-defective viruses could be amplified and propagated to high titers in cells comp

22 DNAs with different lengths can selectively be amplified and purified together.

23 nsive p53 targets, whereas the NRF2 response is amplified and accelerated.

24 In many GBMs, the EGF receptor gene (EGFR) is amplified and may be truncated to generate a constitu

25 ector of the Rab11 GTPases, including Rab25, is amplified and overexpressed in 10% to 25% of primary

26 HER2/Neu is amplified and overexpressed in a large proportion of

27 e (NAPRT), a second NAD(+)-producing enzyme, is amplified and overexpressed in a subset of common typ

28 ter GRB2-associated binding protein 2 (GAB2) is amplified and overexpressed in a subset of primary hi

29 Recent studies indicate that MCM7 is amplified and overexpressed in a variety of human mal

30 Tumor protein D52 (TPD52) is amplified and overexpressed in breast and prostate ca

31 The H3K4 demethylase KDM5B is amplified and overexpressed in luminal breast cancer,

32 Growth Factor 2 mRNA binding protein 2/IMP2 is amplified and overexpressed in many human cancers, ac

33 les are shown to occur when magnetic tension is amplified and transported upward through interactions

34 parametric statistics, the sample population is amplified and used to create a large number of virtua

35 sity where adipocyte-MR expression/signaling is amplified and vascular risk increased.

36 cancer genomic databases reveals that PHLDB3 is amplified and/or highly expressed in numerous human c

37 Prokaryotic 16 S rRNA gene was amplified and DGGE was performed.

38 mal internal transcribed spacer region 1 DNA was amplified and sequenced and fungal load determined b

39 ment of cytochrome c oxidase subunit I (COI) was amplified and sequenced for representative samples o

40 The HBV core gene was amplified and sequenced from 148 patients with chron

41 il DNA was extracted, and fungal ITS1 region was amplified and sequenced on an Illumina Miseq.

42 was isolated, and the 16S ribosomal RNA gene was amplified and sequenced.

43 (ITS2) region of the fungal ribosomal repeat was amplified and sequenced.

44 Viral RNA from nasal wash samples was amplified and the F gene sequenced to monitor presat

45 ne (RH1) and 9 microsatellite regions (SSRs) were amplified and analysed.

46 MiR200-b and its native flanking sequences were amplified and cloned into a pCAG-eGFP vector direct

47 isolated, and species-specific DNA sequences were amplified and identified by the biosensor using spe

48 the rearranged immunoglobulin receptor genes were amplified and sequenced from pretreatment specimens

49 NA; V1-V2 regions of 16S ribosomal RNA genes were amplified and sequenced on an Illumina MiSeq platfo

50 of the bacterial 16S ribosomal RNA sequences were amplified and sequenced to determine the compositio

51 genes (MF-HVR) from 53 MeV-positive samples were amplified and sequenced.

52 The VP1 gene from EV71 and CA16 isolates was amplified, and the sequences were analyzed.

53 However, traction is amplified approximately fivefold in groups.

54 When IgHPolyFab is used, the signal is amplified as a result of the binding of multiple poly

55 SENP2 is amplified as part of the chromosome 3q amplification

56 d for CRISPR guide RNAs targeting genes that are amplified at high copy number.

57 with climate change, and that these impacts are amplified at higher trophic levels.

58 ssment reveals that this feedback process is being amplified at the rate of ~8.9% every year during 1

59 uence specific of Mycobacterium tuberculosis is amplified at 65 degrees C, providing 3x10(6) amplific

60 1alpha directly, and the discovery that IRE1 is amplified at mucosal surfaces by gene duplication sug

61 ing subsystems, their isolated behaviour may be amplified, attenuated, or be subject to more complica

62 The amount of DNA in a single cell needs to be amplified before sequencing and multiple displacement

63 plification, where the signal from the qubit is amplified before noise sources are introduced and roo

64 The splittings are amplified by a factor of 3 as compared to the corres

65 This paper investigates how rumors are amplified by a group of users who share similar inte

66 tory fish, environmental MeHg concentrations are amplified by a million times or more.

67 deficits triggered by GR in the hippocampus are amplified by A2AR over-activation and were rescued b

68 Resultant cDNAs are amplified by adapter-based PCR and subjected to high

69 c activity-dependent potassium currents that are amplified by gap junction-mediated tumour interconne

70 hole genomes of the polar bodies and oocytes are amplified by multiple displacement amplification and

71 can also arise from small perturbations that are amplified by nonlinear positive feedbacks within the

72 l sea-level model, we show that AIS dynamics are amplified by Northern Hemisphere sea-level forcing.

73 of events that lead to neurodegeneration and are amplified by pathogenic mechanisms related to brain

74 d cell sorting (FACS), and V(D)J transcripts are amplified by RT-PCR.

75 mic transposon "junkyards" (piRNA clusters), are amplified by the "ping-pong" pathway, yielding secon

76 ffects of a small external control parameter are amplified by the electronic correlations.

77 hallenges for therapeutic development, which are amplified by the highly polygenic and pleiotropic na

78 change, causing impacts on human health that are amplified by the microclimatological effects of buil

79 where positive particle number fluctuations are amplified by trapping, leading to the formation of p

80 on-based resequencing of regions that cannot be amplified by a single primer pair, a directed graph a

81 il to represent the immune response that can be amplified by chemotherapy when dosed appropriately.

82 s and metastases, and that these effects can be amplified by coadministration of sunitinib.Significan

83 However, the economic value of biomass might be amplified by diversifying the range of target product

84 entrations triggered by nAChR activation can be amplified by GABA release.

85 The increased radiatively forced SAT will be amplified by increased dynamically induced SAT when t

86 DNA synthesis (TLS) polymerases and then can be amplified by PCR.

87 monstrates that small structural changes can be amplified by self-assembly and impact on nanoscale bi

88 These effects may be amplified by social mixing patterns, while the variab

89 The effect is found to be amplified by space; in this scenario we find that sel

90 DNA lesions exist in low levels, and cannot be amplified by standard PCR because they are frequently

91 s a major threat to public health, which can be amplified by the ability of bacteria to swim upstream

92 The success of this method can be amplified by the introduction of multiple Wolbachia c

93 oncolytic vaccinia viruses, all of which can be amplified by the multitargeted kinase inhibitor sunit

94 actions could offset carbon gains, which may be amplified by the shift toward forest plant communitie

95 A local hyperpolarization can be amplified by the voltage-dependent activation of Kir

96 For PPIP5K2, Pi sensing by InsP8 is amplified by a 2-fold activation of 5-InsP7 kinase ac

97 This variability is amplified by a correlation between speed and directio

98 ess exacerbates risk for TMD, and the effect is amplified by allelic variants in a gene, catechol-O-m

99 istic paracrine signalling via IL-6/8, which is amplified by cell proliferation and cell density, to

100 te, and the mechanosensory response of MyoII is amplified by chemical signaling initiated by cell adh

101 for core-projecting neurons; this difference is amplified by cocaine.

102 the effects of environment, as when drought is amplified by competition.

103 and colleagues reveal that insulin secretion is amplified by cytosolic isocitrate dehydrogenase-depen

104 ErbB2 signalling, which is amplified by EphA2 binding, is an important therapeut

105 ctive inflammatory capability of macrophages is amplified by exposure to exogenous interferon-gamma,

106 This is amplified by payment systems and policies that create

107 and support a model wherein Abeta production is amplified by plaque-induced axonal lysosome transport

108 pression of protective antiviral interferons is amplified by positive-feedback loops mediated by indu

109 T-type Ca(2+) channels, and that this signal is amplified by saturation of endogenous buffer also med

110 ing an indirect competitive immunoassay that is amplified by secondary antibodies conjugated with Au

111 he motivational force of social mobilization is amplified by the fact that others benefit from the en

112 This need is amplified by the increasing number of biosimilars ent

113 a suggest that, as in S1, the thalamic input is amplified by the recurrent excitatory connections of

114 he fluorescence signal upon detection of LDH was amplified by 10 and 5-fold compared to that of a sin

115 The summation was amplified by a D2-like receptor antagonist and exper

116 The 5-HT-induced response was amplified by acute hyperglycaemia in control, but no

117 the 5-HT response and receptor distribution was amplified by acute hyperglycaemia only in control ra

118 of the typical solar dimming in China, which was amplified by approximately 20% by wind stilling.

119 r in those taking warfarin versus DE, and it was amplified by diabetes and previous vitamin K antagon

120 cting IFX in patients' serum, the SPR signal was amplified by employing gold nanoparticles functional

121 tration required tumor cell-derived CCL5 and was amplified by IFN-gamma-inducible, myeloid cell-secre

122 The ALT-lowering effect of rs72613567:TA was amplified by increasing adiposity, alcohol consumpti

123 cells, induced cell-cycle progression, which was amplified by MCL-specific cytokines (insulin-like gr

124 In infancy, mortality risk was amplified by obesity, whereas in older children mort

125 The highly variable region of MG192 was amplified by PCR from M. genitalium isolates obtaine

126 The dru region was amplified by PCR, sequenced, and analyzed.

127 The DNA of the bacteria was amplified by polymerase chain reaction using a quadr

128 Ebola cDNA was amplified by rolling circle amplification (RCA) on m

129 distinctiveness of the resulting body plans was amplified by the extinction of transitional forms an

130 This was amplified by the intensification of the snow accumul

131 Remarkably, this sensitivity was amplified by the overexpression of alpha-Synuclein (

132 om electrogenic bacteria in the sensing unit was amplified by the transistor and was transduced into

133 The pre-coded representation of context was amplified by training a feedback neuron to explicitl

134 component, located at the stimulation site, was amplified by visual attention.

135 umor, and antimetastatic effects of mpJX-594 were amplified by concurrent or sequential administratio

136 Seven breast cancer genetic markers were amplified by means of the MLPA reaction, which allo

137 Seven markers were amplified by MLPA, which allows for the simultaneou

138 owth of cultured cells and from proviral DNA were amplified by PCR and sequenced for evidence of clon

139 sequenced, compared to 158/164 samples that were amplified by PCR.

140 MicroRNAs (miRNA) in cerebrospinal fluid were amplified by quantitative PCR.

141 s, and somatic and nuclear calcium responses were amplified by release of calcium from ryanodine-sens

142 Dental plaque DNA samples were amplified by targeting the 16S rRNA gene V4 region,

143 HIV-RNA and HIV-DNA were amplified by ultrasensitive polymerase chain reacti

144 ic field effect on flavin photoreactions can be amplified chemically by slow radical termination reac

145 IgE transcripts were amplified, cloned, and sequenced using RT-PCR.

146 itation step, and we show that bound DNA can be amplified directly from the microparticle surface whe

147 , small vibrations of the sensory epithelium are amplified due to active electro-mechanical feedback

148 Local warming may have been amplified due to simultaneous disappearance of cont

149 rferon (IFN) and IFN-stimulated genes (ISGs) are amplified during HCV infection but fail to eliminate

150 this resource to characterize the DNAs that are amplified during MdBV replication using a combinatio

151 differences among trivalent lanthanides can be amplified during the crystallization of borates, prov

152 y sensory, EEG component amplitudes that are being amplified during rapid audiovisual decision-making

153 of genes with basal/stem-like/EMT properties is amplified during metastatic progression.

154 ntromeres of nine chromosomes, indicating it was amplified during the evolution of modern humans.

155 Trends were amplified during a 2015-2016 severe El Nino drought

156 Negative conspecific effects were amplified during rainy years and at dry sites, wher

157 ncluding responses to one mutant neoantigen, were amplified effectively with therapy and generated du

158 anels of LISH probes ('LISH-seq'), which can be amplified efficiently and with negligible bias.

159 first time, that mechanically gated currents are amplified following in vivo tissue inflammation, and

160 ses and whether tumor-resident T cell clones are amplified following treatment.

161 d from children, and extracted bacterial DNA was amplified for the V4 region of the 16S rRNA gene.

162 le/gene for most genes) of full-length cDNAs are amplified, fragmented and short-read-sequenced.

163 Although Lrrc32 is amplified frequently in breast cancer, the expression

164 e organisms, small-interfering RNAs (siRNAs) are amplified from target mRNAs by RNA-dependent RNA pol

165 sal plant barcode is chosen as the target to be amplified from dairy samples.

166 estigated whether envelope (env) genes could be amplified from proviral DNA or RNA derived from brain

167 ing a specific exon are duplicates that have been amplified from the PCR step.

168 ZIKV envelope was amplified from 4 samples.

169 Two gene variants, Ppal15kDaA and Ppal15kDaB were amplified from a P. palmivora papaya isolate.

170 No PCR products were amplified from all nontarget control samples.

171 fragments covering these regulatory elements were amplified from B2 and C2 isolates to generate lucif

172 HIV env and pol genomes were amplified from DS.

173 enomic sequences flanking the 3'-side of L1s were amplified from neuronal DNA, and neuronal L1 librar

174 uid were similar to those of aggregates that were amplified from the brain.

175 found that the properties of aggregates that were amplified from the cerebrospinal fluid were similar

176 pervariable sites, the V4 and V8-V9 regions, were amplified from the total of eight lagoon samples an

177 man serum albumin (HSA), the r(1) relaxivity is amplified further up to 270%.

178 igher than that of DNA polymerase and errors are amplified >1000-fold due to translation.

179 after a small displacement, the displacement is amplified, ideally with no added quantum noise.

180 over time and that on plant water use would be amplified if N deposition persists.

181 T-1), were recently highlighted because they are amplified in a significant subset of human tumors, a

182 lular inhibitors of apoptosis (cIAP) 1 and 2 are amplified in about 3% of cancers and have been ident

183 Additionally, we found that centrioles are amplified in immediate neuronal precursors (INPs) co

184 some extent these pharmacoeconomic concerns are amplified in myeloma due to the need for multidrug r

185 lear whether and how these ionotropic inputs are amplified in olfactory receptor neurons (ORNs).

186 WL) is an important approach, as its effects are amplified in the liver, with 10% TBWL resulting in a

187 sm by which the signals evoked by pheromones are amplified in the ORNs that selectively promote court

188 Notably, these advantages of diazo groups are amplified in water.

189 silico analysis revealed the PTP4A3 gene to be amplified in 29% of basal-like breast cancers, and hi

190 In cancer, however, genes can be amplified in chromosomes or in circular extrachromoso

191 ng that disruptions at the HSC/MPP level may be amplified in downstream cells.

192 uations in transcription factor activity may be amplified in homozygotes, whereas it is buffered in h

193 alized in the 17q25 locus, which is known to be amplified in human cancers, but its role in tumorigen

194 re the only urinary cell population that can be amplified in long-term culture.

195 9 gene FGF19 has previously been reported to be amplified in several cancer types and encodes for a k

196 lineage history and that the barcode RNA can be amplified in situ, a prerequisite for in situ sequenc

197 We finally show that market trends tend to be amplified in the portfolios identified by the algorit

198 kinase (FAK) gene protein tyrosine kinase 2 is amplified in 16.4% of The Cancer Genome Atlas HCC spe

199 The MYCN proto-oncogene is amplified in a number of advanced-stage human tumors,

200 d in breast cancer cell lines, and its locus is amplified in about half of primary breast cancers.

201 an epidermal growth factor receptor 2 (HER2) is amplified in approximately 15-20% of human breast can

202 king interneurons and hilar mossy cells, and is amplified in CA3 pyramidal cells.

203 explains why this classical tumor suppressor is amplified in colon tumors and suggests a rationale fo

204 ctivity exhibits respiratory modulation that is amplified in hypertensive rats.

205 e importance of drivers of genetic diversity is amplified in island populations that tend to have mor

206 ic basis by which HIF target gene expression is amplified in kidney cancer and a new mechanism by whi

207 The CCNE1 locus, which encodes cyclin E1, is amplified in many types of cancer cells and is activa

208 Emperipolesis is amplified in models of murine inflammation associated

209 The STING-dependent antiviral signaling is amplified in neighboring cells through gap junctions.

210 reported that p21-activated kinase 4 (PAK4) is amplified in pancreatic cancer tissue.

211 ormal cells, and that this function of Tgifs is amplified in some cancers.

212 leads to a decoupling between RE and RG that is amplified in the absence of denaturants.

213 It has a strong climate warming effect that is amplified in the Arctic.

214 Importantly, this subset is amplified in the FL context, unlike in other B-cell l

215 due to association-signal-annotation weights is amplified in the integration process.

216 reatment, signaling from inflammatory niches is amplified in the presence of MAPK inhibitors.

217 ator for the standard IV estimator; the bias is amplified in the treatment effect estimate.

218 ndothelium-dependent vasodilatory signalling is amplified in the vasculature of contracting skeletal

219 cochlea, even though reticular lamina motion is amplified in this region, which indicates that reticu

220 g steps, as sensitivity to sequencing errors is amplified in this type of analysis.

221 Angiogenesis is amplified in wound healing and cornea models in albin

222 We found that MYST3 was amplified in 11% and/or overexpressed in 15% of brea

223 vince of Caceres, where viral RNA from ticks was amplified in 2010.

224 This IL-4/CXCL12 axis was amplified in activated lymphoid stromal cells as sho

225 IL-17-related cytokines expression was amplified in bronchial/nasal mucosa of neutrophilic

226 This difference was amplified in obese subjects and reduced to normal af

227 SFK family member YES1 was amplified in osimertinib-resistant EGFR-mutant tumor

228 with elevated painful TMD risk, and the risk was amplified in subjects who had enhanced sensitivity t

229 ging as compared to controls, which increase was amplified in the presence of bacteria (all P-val < 0

230 e of multiplexed PCR, the two mutation types were amplified in a single reaction.

231 function, migration and glycolytic responses were amplified in LXA(4)-deficient mice, which correlate

232 P and mortality from all-causes, CVD and CHD were amplified in magnitude when using offspring BP as a

233 nsulin, and glucose tolerance; these effects were amplified in mice given lipopolysaccharide but redu

234 tDNA damage, and apoptosis in wild-type mice were amplified in Sirt3(-/-) animals.

235 ference in the dicarboxylate building blocks is amplified into distinct photophysical properties of t

236 g through a CD11b-Syk-PKCdelta-CARD9 pathway was amplified, leading to increased TLR-induced producti

237 Driver oncogenes were amplified most commonly in ecDNA, thereby increasin

238 econstituted with wild-type, and this defect is amplified near body-temperature.

239 Signal was amplified nearly 25-fold for DON, 90-fold for ZEA an

240 ffective marker for diagnosing the BK virus, was amplified on an on-chip device in less than 60 min.

241 , we found that directional movement signals were amplified on STOP trials before completion of the r

242 bal warming due to anthropogenic factors can be amplified or dampened by natural climate oscillations

243 nhancers (SE), the LIN9 gene lacks an SE but was amplified or overexpressed in the majority of TNBCs.

244 all calcium signatures have the potential to be amplified, or (2) how a given calcium signature maint

245 e organ of Corti, the reticular lamina (RL), are amplified over a much broader region.

246 theory suggests that such instabilities can be amplified over vast distances from the sites of nutri

247 can occur, and where specific genotypes can be amplified, perhaps initially by cellular proliferatio

248 rapidly degraded, and SFK-mediated signaling is amplified relative to macrophages.

249 which a single stereoisomer out of seven can be amplified selectively.

250 mini-metagenomic DNA of the sorted bacteria was amplified, sequenced and analysed.

251 ibosomal RNA gene sequences from each sample were amplified, sequenced, and analyzed with the UPARSE

252 ibosomal RNA gene sequences from each sample were amplified, sequenced, and analyzed.

253 , the small amount of starting material must be amplified significantly.

254 then the effects of peripheral variation can be amplified such that nearly all of the genetic varianc

255 e L-R differences in mammary gene expression are amplified, sustained or inverted in a gene-specific

256 utamatergic phenotype of CCK(+)VGluT3(+)INTs is amplified, they promote paradoxical network hyperexci

257 ) mice, and infectious ERV virions could not be amplified through coculture with permissive cells.

258 h, possible detrimental health effects could be amplified through their widespread use in foods, cosm

259 ations increased protein stability and could be amplified through ThreeFoil's structural symmetry to

260 We propose that expression is amplified through modification of promoter and 3'-UTR

261 sepithelial migration, neutrophil chemotaxis is amplified through neutrophil production of a second e

262 vation via the classical and lectin pathways is amplified through the alternative pathway amplificati

263 nts leads us to propose that the ERBB2 locus is amplified through the mechanism that repeatedly gener

264 t domain motions accompanying ATP hydrolysis are amplified, through changes in electrostatic interact

265 l in which initial inhomogeneities in inputs are amplified to produce robust place field activity, th

266 with externally injected seed pulses, which are amplified to similar levels at the highest pump ener

267 h this strategy, the fluorescence signal can be amplified to as high as 70-fold.

268 at ventral visual neural responses, known to be amplified to attractive faces, represent an attention

269 is known that weak certified randomness can be amplified to nearly ideal randomness using quantum-me

270 The pol gene sequence was amplified to ascertain the HIV-1 subtype.

271 n substrate- and inhibitor-bound ABCB1 sites are amplified toward the nucleotide-binding domains (NBD

272 molecular mechanism by which AMPK activation is amplified under energy stress.

273 Extracted DNA was amplified using barcoded primers targeting the V6 va

274 The HCV E2 hypervariable region-1 was amplified using nested reverse-transcription polymer

275 sandwich immunoassay format, the sensitivity was amplified using rabbit anti-mouse IgG-alkaline phosp

276 The MTHFR gene was amplified using specific primers.

277 BKV whole genomes were amplified using long-range PCR with four inverse pr

278 We show that centrioles are amplified via centriole rosette formation in both em

279 depend on dsRNA receptor activation and then are amplified via IFN-stimulated activation of JAK/STAT

280 mpacts of climate change on biodiversity can be amplified via extinction cascades from plants to anim

281 attributed to "Arctic amplification" - that is, amplified warming in Arctic regions due to sea-ice l

282 These challenges are amplified when more than one biomarker is used to se

283 ed direction enhancement, by which responses are amplified when stimuli move along the preferred dire

284 n compared with valsartan in HFpEF appear to be amplified when initiated in the high-risk window afte

285 t the capability of IFN-beta to induce IL-10 is amplified when B cells are stimulated.

286 subjects on suppressive ART, an effect that is amplified when combined with suberoylanilide hydroxam

287 cation and, that in some cells, value coding is amplified when subjects fixate near the cue.

288 Interaction between orthogonal orbitals is amplified when the energy gap between these orbitals

289 lecules located inside the nanocavity, which is amplified when the size/shape of the aldehyde substra

290 mes more Stx1a than Stx2a was delivered, and was amplified when Stx1a was delivered 3 hours prior to

291 l male and female mice, and such differences were amplified when mice of both sexes were exposed to S

292 ess, inputs from second auditory cortex (A2) are amplified, whereas the number originating in the dor

293 tions from the anterior auditory field (AAF) are amplified, whereas those from the DZ decrease.

294 ch that integration of confirmatory evidence is amplified while disconfirmatory evidence processing i

295 vity and fragility of algae to triclosan can be amplified with time extension.

296 e a contextual role in appetite control that is amplified with hypocaloric conditioning.

297 The DNA was amplified with primer pairs covering hypervariable r

298 se expression pattern of CIDEA and FSP27beta was amplified with the increasing severity of the liver

299 ngly, rhythms in the nucleus accumbens (NAc) were amplified with no changes seen in the prefrontal co

300 (phyllosphere) taxa colonizing a native forb is amplified within leaves affected by insect herbivory.