ライフサイエンスコーパス: be beginning to

1 ' resources and high-throughput based assays are beginning to accelerate antiviral drug discovery and

2 Whereas nutrigenomics research is beginning to account for resident microbiota, the nee

3 In this review, we discuss how studies are beginning to address the nature of these niches as w

4 Policymakers are beginning to address the risk of ecological impact,

5 Here we synthesize studies that are beginning to address this question by investigating

6 Research on the human microbiome is beginning to address factors associated with between-

7 stem cell biology and regenerative medicine are beginning to advance and refine our understanding of

8 archers build on this early foundation, they are beginning to advance the field towards more fine-gra

9 dy of atherosclerosis, and our new knowledge is beginning to affect how we treat this ubiquitous dise

10 cellular mechanisms, novel treatment options are beginning to appear for a number of specific conditi

11 Main group examples are beginning to appear, although here it is mainly by c

12 However, integrative models are beginning to appear.

13 While we are beginning to appreciate the cellular roles played by

14 We are beginning to appreciate the surprising versatility o

15 Early phase trials are beginning to assess the activity of small-molecule i

16 , the climate science and policy communities are beginning to assess the feasibility and potential be

17 orthologous phenotypes and cell types, which are beginning to be addressed by emerging technologies.

18 eview, we discuss analytical approaches that are beginning to be applied to help synthesize the vast

19 teomic analyses, newer non-gel-based methods are beginning to be applied to overcome throughput and c

20 rited platelet disorders, and these findings are beginning to be applied to the genetic diagnosis of

21 ole in intercellular communication, exosomes are beginning to be appreciated as agents of immunoregul

22 The implications of the 80-h work week are beginning to be appreciated.

23 on and action of these two cytokine families are beginning to be appreciated.

24 ways responsible for alpha-granule formation are beginning to be assembled as a result of the charact

25 ll as of invertebrate tricellular junctions, are beginning to be characterized, many questions remain

26 High zinc homeostasis mechanisms are beginning to be defined in animals, but low zinc hom

27 s (DUBs) that function in the nervous system are beginning to be defined, but the mechanisms that con

28 eptor (NLR) family member NLRP3 inflammasome are beginning to be defined, little is known about the m

29 e phenomena such as neutrophil migration and are beginning to be developed for diagnostic application

30 hanisms that govern glia-mediated regulation are beginning to be discovered, but much remains unknown

31 n localized, and some aspects of their roles are beginning to be discovered.

32 of Wnts and Wnt amplifers such as R-spondins are beginning to be elucidated as well as their function

33 Cellular events monitored by this checkpoint are beginning to be elucidated, yet signaling pathways u

34 the development of the olfactory sensory map are beginning to be elucidated.

35 ces as global cues that bias PCP orientation are beginning to be elucidated.

36 or interaction and specificity determination are beginning to be elucidated.

37 in and gene expression, but importantly they are beginning to be essential players in genome organiza

38 rapies based on knowledge of viral functions are beginning to be evaluated, mostly in preclinical mod

39 Metallosupramolecular architectures are beginning to be exploited for a range of application

40 ghly stable, so it is unsurprising that they are beginning to be exploited industrially.

41 Disease-relevant aquaporin polymorphisms are beginning to be explored.

42 pounds, scaffolds, and biological activities are beginning to be globally explored, beyond individual

43 mponents underlying this rapid communication are beginning to be identified, such as the ROS producin

44 sh and maintain themselves in this ecosystem are beginning to be identified.

45 tion of nuclear domains requires forces that are beginning to be identified.

46 r mechanisms of external genital development are beginning to be identified; however, the origin of c

47 pathologies, and microbiome-based approaches are beginning to be implemented in the clinic for diagno

48 As ncRNAs are beginning to be imprecisely classified into function

49 ough these sources of experimental artefacts are beginning to be recognized and managed(11,12), conce

50 thways underlying islet cell differentiation are beginning to be resolved, the cellular basis of isle

51 nsequences of individual m(6)A modifications are beginning to be revealed, but the effects of m(5)C a

52 Muller glia-derived progenitor cells (MGPCs) are beginning to be revealed.

53 f primary disorders of erythrocyte hydration are beginning to be revealed.

54 which can be used to augment rehabilitation, are beginning to be studied in the context of their effe

55 In turn, the results of scientific studies are beginning to be translated back to the bedside to im

56 ce to other neurodegenerative conditions and are beginning to be translated into clinical trials.

57 h fibroblasts and promote tissue remodelling are beginning to be understood and will be an important

58 rimary cilium formation and ciliary motility are beginning to be understood, but little is known abou

59 mitochondrial movement toward axon terminals are beginning to be understood, the frequency and functi

60 gh many aspects of optic pathway development are beginning to be understood, the mechanisms promoting

61 at initially orient the left-right body axis are beginning to be understood, the mechanisms that shap

62 chanisms underlying aphid-plant interactions are beginning to be understood.

63 s that control formation of such asymmetries are beginning to be understood.

64 Molecular mechanisms underlying T-cell aging are beginning to be understood.

65 epair, but lead to disease when overwhelmed, are beginning to be understood.

66 t and the relevant mechanistic underpinnings are beginning to be understood.

67 late tooth eruption and tooth root formation are beginning to be unraveled.

68 underpinning vertebrate body plan evolution are beginning to be unravelled.

69 tion of post-transcriptional gene expression are beginning to be unveiled, the precise roles of m(6)A

70 n cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and d

71 rognosing the associated outcomes, its value is beginning to be appreciated, and the genomics revolut

72 ical elements to cell polarity and migration is beginning to be appreciated, underlying mechanisms ar

73 tion capabilities, in therapeutic resistance is beginning to be better understood, the significance o

74 feasibility of implementing such strategies is beginning to be confirmed.

75 nd reconstitution after lymphocyte depletion is beginning to be defined.

76 Forecasting is beginning to be integrated into decision-making proce

77 by the World Health Organization in 2017 and is beginning to be introduced in countries around the wo

78 lar counting is the method of the future and is beginning to be performed today.

79 tween RNA splicing and histone modifications is beginning to be recognized, a lack of knowledge exist

80 fect of particulate matter (PM) on the brain is beginning to be recognized.

81 As the landscape of TIMCs is beginning to be understood, it opens up questions abo

82 ing, although the basis for these challenges is beginning to be understood.

83 urnover through a degradation mechanism that is beginning to be understood.

84 genetic architecture of quantitative traits is beginning to be understood.

85 ling functions to actively modulate lifespan is beginning to be unraveled.

86 And its life outside the laboratory is beginning to be unveiled.

87 ed and massively parallel genomic sequencing is beginning to be used in clinical practice to determin

88 r large-scale genome sequencing projects and is beginning to be used in the clinical diagnostic testi

89 NA-seq) technology is hitting its stride and is beginning to be widely adopted.

90 onists - which drive the intrinsic pathway - are beginning to bear clinical fruit.

91 these pathways function to specify cell fate is beginning to become clear.

92 epigenetic enzymes in specific brain regions are beginning to build causal links between these epigen

93 Sea-level rise is beginning to cause increased inundation of many low-l

94 goal; however, advances in stem cell science are beginning to challenge this assumption.

95 Recent finds of early ceremonial complexes are beginning to challenge this model.

96 and allele discovery for various conditions, is beginning to challenge classic definitions of genetic

97 ation and damage limitation during infection is beginning to change perspectives on infectious diseas

98 This is beginning to change thanks to vibrant growth in the d

99 This is beginning to change.

100 area have accumulated, new areas of emphasis are beginning to characterize the determinants of variab

101 gineering by endothelializing these networks is beginning to close the gap between in-vitro and in-vi

102 g Genetics through Meta Analysis) consortium are beginning to collect data in large quantity and to c

103 kingdom, transkingdom, and immune cross talk are beginning to come into focus, setting the stage for

104 ion and metastatic outgrowth of cancer cells are beginning to come into view.

105 ough exome- and genome-sequencing approaches are beginning to compete, disease-targeted testing retai

106 ype (e.g., feeding, pollination), ecologists are beginning to consider networks which combine multipl

107 aging gene x environment interaction (iGxE), is beginning to contribute to our understanding of the n

108 eks to eliminate trachoma by 2020, countries are beginning to control the transmission of trachomatou

109 and activity-dependent modes of myelination are beginning to crystallize in a model of myelin plasti

110 Together, these findings are beginning to define an engram as the basic unit of m

111 Clinical studies are beginning to define these factors as immune profiles

112 ystem to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of o

113 Recent chemical biology developments are beginning to demonstrate how the incorporation of an

114 Transcriptomic studies are beginning to demonstrate important sex differences a

115 Recent efforts are beginning to demonstrate the potential to build on t

116 Metagenomics is beginning to demonstrate the role of the oral resisto

117 role in hair or feather bud development, we are beginning to discover that multiple mechanisms may,

118 as more bacterial genomes are sequenced, we are beginning to discover their prevalence and their dif

119 Although case-control approaches are beginning to disentangle schizophrenia's complex pol

120 have led to a renaissance in this field and are beginning to dissect circuit mechanisms in the basal

121 Recent studies are beginning to dissect the mechanisms that make these

122 ation; hence even the earliest mammaliaforms were beginning to diversify--morphologically, functional

123 Systems-level, integrative pathway analyses are beginning to elucidate the additive, polygenic contr

124 developments in RNA sequencing technologies are beginning to elucidate the cellular diversity presen

125 We discuss recent advances that are beginning to elucidate the complex relations between

126 composition of dorsal-horn networks, studies are beginning to elucidate the intricate computational l

127 of miRNA biogenesis and modes of action, and are beginning to elucidate the mechanisms of miRNA degra

128 The underlying genetic determinants are beginning to emerge and are interpreted in the conte

129 nce, it is not surprising that disease links are beginning to emerge and that interference with sumoy

130 in particular, the areas of convergence that are beginning to emerge from multiple study designs.

131 cy on fetal programming of brain development are beginning to emerge in the literature.

132 nd NF2 genes, molecularly targeted therapies are beginning to emerge, as a result of a deeper underst

133 indings from genome-wide association studies are beginning to emerge, as are discoveries of large-eff

134 ssically cytoplasmic proteins in the nucleus are beginning to emerge, in particular, as participants

135 differentiation in normal tissue homeostasis are beginning to emerge, it is still unclear whether can

136 h intriguing roles for plant linker histones are beginning to emerge, much of our current understandi

137 Massive behavioral datasets are beginning to emerge, particularly from zebrafish lab

138 ation is still lacking, but important themes are beginning to emerge, primarily in budding yeast.

139 both high permeability and high selectivity are beginning to emerge.

140 new research areas and treatment strategies are beginning to emerge.

141 unravel mechanisms of symmetry establishment are beginning to emerge.

142 mporal dementia improves, rational therapies are beginning to emerge.

143 anisms of unconventional secretory processes are beginning to emerge.

144 acids under transition-metal-free conditions are beginning to emerge.

145 s of both convergent and divergent evolution are beginning to emerge.

146 its of low calorie and low cholesterol diets are beginning to emerge.

147 bules control FA turnover in migrating cells are beginning to emerge.

148 K2, PRKN, and VPS35 in the regulation of SVE are beginning to emerge.

149 consequences of such changes for ecosystems are beginning to emerge.

150 Sex-specific synaptic connectivity is beginning to emerge as a remarkable, but little explo

151 Structural DNA nanotechnology is beginning to emerge as a widely accessible research t

152 A picture is beginning to emerge of chromatin loops representing a

153 A cross-species consensus is beginning to emerge suggesting that subtle synaptic a

154 erlying ligand-dependent receptor activation is beginning to emerge with the recent expansion in GPCR

155 tural information on ABC sterol transporters is beginning to emerge, with published structures of ABC

156 Although the role of 5-LO in tumor cells is beginning to emerge, with the notion that tumor-promo

157 of course correction, and a clearer picture is beginning to emerge.

158 tophagy in bone remodelling and bone disease is beginning to emerge.

159 impact on their cardioprotective properties is beginning to emerge.

160 neurogenesis and neurotransmitter signaling is beginning to emerge.

161 sfunction and atherosclerosis susceptibility is beginning to emerge.

162 ription rate and mRNA abundance under stress is beginning to emerge.

163 ruses transform cells into a malignant state was beginning to emerge as the first viral genomic seque

164 sms underlying nonclear cell variants of RCC are beginning to engender novel therapeutic strategies d

165 ating regenerative strategies in RPE disease are beginning to enroll subjects, and initial results su

166 as well as novel experimental manipulations, are beginning to erode many of these established concept

167 articles from the peer-reviewed literature, is beginning to erode the trust of both the scientific c

168 ed information from human and animal studies is beginning to expand insights regarding neurobiologica

169 ohormonal, vascular, and coagulation systems are beginning to explain how this haemostatic impairment

170 in hematological and solid malignancies that are beginning to exploit these approaches.

171 oss the globe have large shale resources and are beginning to explore extraction of these resources.

172 asingly becoming more networked, researchers are beginning to explore how social media can be used to

173 omic gas Bose-Einstein condensates, research is beginning to focus on the roles of vortices in quantu

174 harmacological and interventional techniques are beginning to gain momentum once again.

175 Artificial intelligence approaches are beginning to have considerable impact in improving d

176 Three-dimensional (3D) imaging technologies are beginning to have significant impact in the field of

177 In medicine, this is beginning to have an impact at three levels: for clin

178 re are common challenges that nanotechnology is beginning to help address.

179 R and highlight the way in which AHR testing is beginning to highlight distinct abnormalities associa

180 Studies in model organisms are beginning to identify the genes and pathways importa

181 rieties of maize, teosinte and other grasses are beginning to identify the genes responsible for the

182 l (hPSC)-based platforms have emerged, which are beginning to illuminate the current black box state

183 in part by an interest in tumor metabolism, are beginning to illuminate the mechanisms through which

184 gs of Rett syndrome, and to what extent they are beginning to impact our understanding and management

185 cians, as well as public and private payers, are beginning to implement alternative delivery and paym

186 echniques, it is encouraging that guidelines are beginning to include evidence from robust observatio

187 As a small number of dietary guidelines are beginning to incorporate more general environmental

188 However, emerging evidence is beginning to indicate that the seminal microbiome has

189 l treatment, genetic and genomic information is beginning to influence pregnancy management.

190 p and laptop usage, scientists and educators are beginning to integrate mobile devices into their res

191 neering liver-experimental and computational-are beginning to interplay toward greater illumination o

192 amsters to study acute social stress, and we are beginning to investigate the genetic mechanisms subs

193 tion of the effect of frailty and disability is beginning to lead to new management approaches.

194 We are beginning to learn about the mechanisms of progressi

195 space and time, but new multiscale knowledge is beginning to link these relationships.

196 ast few years, however, it appears the field is beginning to make progress.

197 t interlink brain and brain-inspired devices are beginning to materialise.

198 r own unconventional petroleum resources and are beginning to move forward with development, thus cal

199 equivalents that mimic mechanical signaling are beginning to offer exciting new methods for improvin

200 These alternative control measures are beginning to penetrate the market, although many rem

201 Diverse efforts in protein engineering are beginning to produce novel kinds of symmetric self-a

202 cations in different fields of investigation are beginning to prove the relevance and effectiveness o

203 Time-lapse microscopy techniques are beginning to provide a direct view of circuit dynami

204 perturbation and systems-biology approaches are beginning to provide a glimpse of how natural popula

205 metabolomics, particularly in the human gut, are beginning to provide a new route to identify functio

206 Findings emerging from these studies are beginning to provide a picture of how signal-depende

207 Mathematical models are beginning to provide a quantitative framework for in

208 Studies reviewed herein are beginning to provide an explanation for chiasma loca

209 However, larger prospective studies are beginning to provide evidence regarding the potentia

210 Recent studies are beginning to provide evidence that many plant-associ

211 Sensors are beginning to provide individuals and communities the

212 Other studies are beginning to provide insight into how neuronal diver

213 Although genome-wide studies are beginning to provide insight into the molecular mech

214 communities across all aquatic environments are beginning to provide insights into the ecology of mi

215 Such 'systems vaccinology' studies are beginning to provide mechanistic insights about inna

216 These systems-level approaches are beginning to provide novel avenues for drug targetin

217 rvey how the recent developments in genetics are beginning to provide social scientists with a powerf

218 Evidence from multiple animal species is beginning to provide a mechanistic understanding of t

219 of SELEX with novel sequencing technologies is beginning to provide the data that will allow the exa

220 the genetic relationship between T2D and CHD is beginning to provide the promise for improved prevent

221 in chemistry, radiology, and systems biology is beginning to provide useful biomarkers, and the emerg

222 ., folkphysics, folkpsychology, folkbiology) are beginning to query the domains themselves and offer

223 astatic or locally advanced solid tumors who were beginning to receive a course of chemotherapy were

224 I am grateful for the recognition, and I am beginning to recognize that having an atypical backgr

225 We are beginning to recognize the brain's susceptibility to

226 or the direct functionalization of C-H bonds are beginning to reshape the field of retrosynthetic ana

227 strate the ways in which simulation modeling is beginning to reshape our understanding of the domesti

228 Interdisciplinary structure-function studies are beginning to resolve the effect each interaction has

229 Studies with these and other vaccines are beginning to reunite the estranged fields of immunol

230 Together, these insights are beginning to reveal answers to century-old mysteries

231 These findings are beginning to reveal how individual components of cir

232 These new studies are beginning to reveal how macromolecular assemblies of

233 ide approaches for probing the transcriptome are beginning to reveal how RNA structure affects each s

234 dies on the molecular-structural association are beginning to reveal how the spatiotemporal gene expr

235 teractions with their host; new technologies are beginning to reveal important aspects of host-microb

236 deling of upconverting nanoparticles (UCNPs) are beginning to reveal the complex details of their ene

237 Studies are beginning to reveal the function of reconsolidation,

238 of DNA methylation and histone modifications are beginning to reveal the landscape of cancer-specific

239 of high fidelity structural information and are beginning to reveal the macromolecular organization

240 tional, and electrophysiological experiments are beginning to reveal the mechanism of action of parti

241 Although cancer genome sequencing studies are beginning to reveal the mutational patterns of genes

242 organization at unprecedented resolution and are beginning to reveal the ways that cells co-opt the s

243 owever, rapid progress in the last few years is beginning to reveal a surprisingly diverse set of pat

244 Recent research is beginning to reveal how the connectivity of individua

245 ingly computational nature of social science is beginning to reverse this traditional bias against pr

246 We are beginning to see that pathogenic microbes are capabl

247 he recreational use of Ketamine increases we are beginning to see the signs of major renal and bladde

248 reatment, this area of molecular diagnostics is beginning to see an upsurge in biotechnological advan

249 Emerging methods to infer cellular functions are beginning to shed new light on the interplay of comp

250 However, recent work is beginning to shed light on key aspects of chaperonin

251 lly high consumption rates, although impacts are beginning to shift to smaller mobile devices.

252 arostat, despite their technical challenges, are beginning to show promise in clinical practice.

253 Cancer vaccines are beginning to show signs of clinical activity, but ma

254 the brain, and how some recent human trials are beginning to show some promise as to the effectivene

255 arch in animal models of Parkinson's disease is beginning to show exercise-induced neuroplastic effec

256 ffective treatment of multiple diseases, and is beginning to show promise for stroke.

257 Progress in understanding sterolin function is beginning to show that xenosterols can be toxic and a

258 , new applications of ecohydrological models are beginning to simulate small-scale water movement pro

259 y to molecular markers to targeted therapies are beginning to solidify the identification of select m

260 ental requirements and function of MPS cells are beginning to solve this problem in an objective mann

261 Related arenaviruses are beginning to spread in human populations in South Am

262 number of curved and helical Proteobacteria is beginning to suggest possible mechanisms and provide

263 microscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures a

264 Although some vendors are beginning to supply multi-kilobase sequence-verified

265 ing and controlling matter at the microscale are beginning to take hold, suggesting new modular appro

266 ns of these different chemical modifications is beginning to take shape, but it's clear that in both

267 New tools, practices, and partnerships are beginning to transform local fisheries, biodiversity

268 logists in providing high-resolution insight is beginning to transform drug discovery efforts, and th

269 ective therapies for mitochondrial disorders are beginning to translate from bench to bedside along t

270 mediate TLS and describe how this knowledge is beginning to translate into the development of small

271 However, inspired by Nature, chemists are beginning to turn their attention to the development

272 l groups and genome-wide association studies are beginning to uncover the complex genetic architectur

273 iven experiments and new modeling techniques are beginning to uncover the general control principles

274 Using animal models, preliminary work is beginning to uncover differences between young and ag

275 We are beginning to understand better the role of JAK2(V617

276 Based on this information, we are beginning to understand how alterations in autophagy

277 ion and super-resolution imaging studies, we are beginning to understand how the ULK1 and PI3KC3-C1 c

278 005, but after 10 years of investigation, we are beginning to understand how they are organized in th

279 We are beginning to understand the connections between QS a

280 We are beginning to understand the function of 3D genome ar

281 Although we are beginning to understand the late stage of neurodegen

282 BACKGROUND & AIMS: Although we are beginning to understand where, when, and how intesti

283 Advances in genetics and animal models are beginning to unearth an unexpected role of the immun

284 vel investigation of the neonatal microbiome is beginning to unearth substantial information, with a

285 nous viral counterparts, their early history is beginning to unfold.

286 ughs in structural and computational biology are beginning to unravel the mechanistic basis of GPCR a

287 Significant advances in recent years are beginning to unravel the molecular mechanism of this

288 Recent discoveries, however, are beginning to unveil new components of the inflammaso

289 ecent genomic and in-vivo biological studies are beginning to unveil the molecular drivers of follicu

290 However, large-scale sequencing is beginning to unveil other unique mutational spectra i

291 microbiology and public health laboratories are beginning to utilize next-generation sequencing (NGS

292 approaches examining regional neurochemistry are beginning to yield additional insights with regard t

293 velopment and summarize recent findings that are beginning to yield important insights into deuterost

294 nstitution and their homeostatic maintenance are beginning to yield improved mouse strains to create

295 ved cells in vitro, and co-culture platforms are beginning to yield insights into the complex interac

296 to a renaissance in the study of the BF and are beginning to yield new insights about cell-type-spec

297 ompounds against drug-resistant tuberculosis are beginning to yield novel inhibitors.

298 cular networks driving vaccine immunity, and are beginning to yield novel insights about the immune s

299 dies in depressed patients and rodent models are beginning to yield promising insights.

300 Tandem catalysis is a growing field that is beginning to yield important scientific and technolog