ライフサイエンスコーパス: be compromised by

1 The barrier function was shown to be compromised by 24 hours of exposure to high doses (17

2 were similar to flight TA muscles, yet power was compromised by 40% following flight.

3 cular epidemiological mapping of cholera has been compromised by a reliance on sub-genomic regions su

4 In diabetes, HIF-1alpha function is compromised by a high glucose-induced and reactive ox

5 of live-attenuated oral poliovirus vaccines is compromised by a high prevalence of diarrhoea and oth

6 trans-SNARE-regulating function of Munc18-1 is compromised by a mutation associated with Ohtahara Sy

7 In over half of human cancers, p53 function is compromised by a mutation in its gene.

8 onuclease activity on ssDNA but not on dsDNA is compromised by a NEIL3 Zf-GRF repeat, whereas one Zf-

9 d cervical dystonia, but therapeutic success is compromised by a non-responder rate of up to 25%, eve

10 tion or orientation of the C-terminal domain is compromised by a proline residue at position 572 or 5

11 GK1 upregulation and cell survival functions were compromised by a pharmacological SGK1 inhibitor.

12 The effectiveness in birth weight of IPTp-SP is compromised by A581G-bearing parasites, but there was

13 Thus, neuromuscular transmission is compromised by AChR deficiency, fast channel kinetics

14 ll-cell lung cancers, but their efficacy can be compromised by acquired drug resistance conferred by

15 nst the T790M mutant, but their efficacy can be compromised by acquired mutation of C797, the cystein

16 e found that the induction of endogenous p21 is compromised by AD1-deficient p53 (p53(AD1(-))), AD2-d

17 activity of BET protein inhibitors (BETi's) is compromised by adaptive or innate resistance in acute

18 In cells where AGT function was compromised by addition of the AGT inhibitor O(6)-be

19 hether the expression or function of PLCzeta is compromised by advancing male age.

20 iotics, which target the bacterial ribosome, is compromised by adverse effects related to limited dru

21 enetically determined drive for fetal growth is compromised by adverse intrauterine conditions.

22 that protects against daptomycin, which can be compromised by Agr-triggered toxin production or an e

23 e with surgery or radiation does not seem to be compromised by an initial trial of surveillance.

24 cern if the quality of an infant's milk diet is compromised by an inadequate or lack of supplemented

25 an initial period, when LNCaP cell survival was compromised by an arising population of neuroendocri

26 cause disease only when the commensal flora is compromised by antibiotic therapy.

27 cted group of patients whose quality of life is compromised by atrial fibrillation, the recommended p

28 In other areas of Pakistan, SIAs have been compromised by attacks targeting polio workers, whi

29 ith conditions where healing of hard tissues is compromised by bacterial contamination.

30 However, the activity of DP can be compromised by binding to the acute phase serum prote

31 osis, unless its ceramide-induced activation is compromised by binding to PAR-4.

32 Reproducibility in research can be compromised by both biological and technical variatio

33 len from thermophilous taxa like Betula, can be compromised by both exotic pollen fluxes and vegetati

34 The stability of the vaccine was compromised by both high temperatures and dilution.

35 However, measurements of neural activity are compromised by brain movement in behaving animals.

36 observation that the BRCA2/APRIN interaction is compromised by BRCA2 missense variants of previously

37 ause the digestive system of infected snails is compromised by C. lingua infection.

38 se polysaccharide biosynthetic machinery had been compromised (by carbon starvation, respiratory inhi

39 If caregivers' well-being is compromised by caregiving, it may bode poorly for tra

40 Many innovative studies have been compromised by challenges in recruiting sufficient

41 apacity to survive future climate change may be compromised by changes in the fire regime.

42 However, therapeutic consistency was compromised by chromosomal position effects on vecto

43 the proliferation of cultured diploid cells is compromised by chromosome missegregation.

44 t, long-term survival of the allograft might be compromised by chronic antibody-mediated rejection (C

45 ter hematopoietic cell transplantation (HCT) is compromised by chronic GVHD.

46 d other marine organisms whose habitats have been compromised by climate change and other anthropogen

47 However, benefits of HIV PIs are compromised by clinically important adverse effects,

48 dent spindle assembly using mitotic extracts was compromised by cohesin depletion, and it was rescued

49 buprenorphine-induced antinociception might be compromised by concomitant activation of ORL-1 recept

50 olerability of some prostacyclin analogs may be compromised by concomitant activation of the E-prosta

51 stage intermediate en route to kealiiquinone was compromised by concomitant O-demethylation upon trea

52 es essential when activity of these subunits is compromised by conditional mutations.

53 ementation of such a multimodal approach can be compromised by conflicting requirements to optimize e

54 nd engineered auxotrophies, these approaches are compromised by cross-feeding of essential metabolite

55 bserved when the peroxidase activity of Prx1 is compromised by Cys52 overoxidation or in the presence

56 on, repetitive DNA stability, and DNA repair are compromised by decreasing cohesin levels to 30% of w

57 However, p53 function could be compromised by defective signaling in the p53 pathway

58 kemia, the BACH2-mediated checkpoint control is compromised by deletions, rare somatic mutations and

59 iven boost in net primary productivity (NPP) was compromised by DeltaT-driven stress and mortality as

60 oximal region of cilia, and cilium formation was compromised by depletion of either Inturned or Fuzzy

61 irectly influenced by Emx2 and that polarity is compromised by developmental defects in the sensory p

62 e and level differences (ITDs and ILDs), can be compromised by device processing.

63 nstrate that muscle mitochondrial efficiency is compromised by diet-induced obesity and is subsequent

64 erall performance of protein microarrays can be compromised by diffusion-limited kinetics.

65 or from degenerating SER whose function has been compromised by dilation.

66 ays, as well as their efferent counterparts, are compromised by disease or injury resulting in signif

67 ent-control protein modules (CCPs 1-20), may be compromised by disease-linked mutations.

68 ng in protoplast transient expression assays is compromised by disruption of F-actin.

69 its function in controlling growth polarity was compromised by disruption of ROP1-dependent F-actin

70 maintenance in proliferating cells that may be compromised by diverse genetic, environmental, and xe

71 est that the protective function of DJ-1 can be compromised by diverse perturbations in its structura

72 evels and restored fetal growth in mice that was compromised by DL-propargylglycine treatment, demons

73 ting that prevention efficacy is unlikely to be compromised by DMPA use.

74 Genomic integrity is compromised by DNA polymerase replication errors, whi

75 tions of mature GABAergic interneurons which are compromised by early-life injury have yet to be iden

76 Computers can be compromised by encoding malware in DNA sequences, and

77 r step toward realizing a world where no one is compromised by epilepsy.

78 Predicted solutions were compromised by excessively underdetermined systems,

79 Both steps might be compromised by excluded volume conditions that would

80 ty in fish to nC60 based on methods shown to be compromised by experimental artifacts.

81 Recreational opportunities are compromised by extreme weather, and children may suf

82 critical virulence factor, listeriolysin O, was compromised by FA modulation, suggesting that FAs pl

83 pplication of layered black phosphorus (LBP) is compromised by fast decomposition in the presence of

84 gens, which have greater B cell involvement, is compromised by fetal growth retardation.

85 yzed inhibition of factor Xa by antithrombin is compromised by fibrinogen to a greater extent when Zn

86 One-carbon metabolism is compromised by folate deficiency and common genetic p

87 nction and that the function of beta-catenin is compromised by fusion to a transcriptional repressor

88 promise in colorectal cancer (CRC), but they are compromised by gastrotoxicity.

89 o LTA-treated human aortic endothelial cells was compromised by gelsolin.

90 forms whose internalization properties have been compromised by genetic perturbations within the car

91 mina propria once the mucosal barrier mucosa is compromised by GVHD.

92 hypothesize that the bona fide pattern might be compromised by heterogeneity of multiple structural d

93 In situ levels of levodopa are compromised by high abundance of gut bacterial tyros

94 zing genomic analysis, but this analysis can be compromised by high rates of missing true variants.

95 he province of the private sector, have long been compromised by high rates of attrition (failure dur

96 sively drug-resistant tuberculosis HIV might be compromised by HIV viral failure, and emergent antire

97 lts suggest that the normal function of MLK3 is compromised by HIV-1 neurotoxins (Tat, gp120), result

98 raft survival after intraportal implantation is compromised by host innate immune responses and the p

99 ic treatments of micrometastatic disease may be compromised by hypoxic resistance.

100 g-term survival and function of islet grafts is compromised by immune rejection-related factors.

101 eonatal host defense against infection could be compromised by immunosuppressive CD71(+) erythroid sp

102 channel, ClC-1, in Huntington disease muscle was compromised by improper splicing and a corresponding

103 Their expression was compromised by in vivo RNA interference (RNAi) deple

104 examination within 1 year was that the first was compromised by inadequate bowel preparation or incom

105 CFS stability may be compromised by incomplete DNA replication and repair

106 tency against multidrug-resistant cell lines was compromised by increased polarity.

107 The (18)F-SiFA-Z(HER2:2891) conjugate was compromised by increasing bone retention over time (

108 ntation for liver failure or dysfunction but are compromised by inefficient engraftment, cell dispers

109 p51 C terminus in nucleic acid binding that is compromised by inhibitor binding.

110 of the colloidosmotic hypothesis appeared to be compromised by initial conflicts between model volume

111 However, this is compromised by insufficient information about the eff

112 r warning signal that the analytical results are compromised by interferences.

113 ic inheritance of stable gene expression can be compromised by interruption of DNA replication.

114 s, or the enzymatic siderophore pipeline may be compromised by intracellular superoxide stress or dam

115 reversed when the partial occlusion percept was compromised by introducing a small gap between the c

116 The antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mis

117 wever, its use as a nutraceutical ingredient is compromised by its low water solubility, chemical sta

118 brain, and chronic treatment with bumetanide is compromised by its potent diuretic effect.

119 Unexpectedly, the topoisomerase activity is compromised by K391/K436 SUMOylation, and this provid

120 plant sterols (PS) for cholesterol lowering are compromised by large variability in efficacy across

121 ng highly transparent, but this transparency is compromised by light that is scattered and reflected

122 al mediator of immunosurveillance, which can be compromised by locally sustained ligand expression bu

123 rvival of peritoneal Escherichia coli sepsis is compromised by long-chain polyphosphates, and improve

124 However, the interpretation of these results is compromised by long-term compensatory adaptation occu

125 y of multi-subunit coactivator complexes can be compromised by loss of a single subunit, underscoring

126 This impact can be compromised by low quality of probes within arrays, w

127 lp maintain fetal growth when its own growth is compromised by maternal undernutrition.

128 as elevated and blood/brain barrier function was compromised by MCAO in WT mice.

129 e therapeutic efficacy of such compounds may be compromised by MDMX overexpression.

130 tact perirhinal (pRh) cortex function, which is compromised by meth-induced downregulation of GluN2B-

131 te determination of metal concentrations can be compromised by microheterogeneity commonly referred t

132 tion of 1-tert-butyl-2-methylenecyclopentane was compromised by migration of the double bond prior to

133 anoparticles increases as the pore structure is compromised by mild aging in phosphate-buffered solut

134 aser speckle contrast imaging (LSCI) systems is compromised by motion artefacts.

135 Those functions are compromised by mounting pressures on marine biodiver

136 r implicated in BAT thermogenesis that could be compromised by MSG treatment.

137 Therefore, translation of RVFV mRNAs is compromised by multiple mechanisms during infection.

138 lding of a larger protein, Rubisco (51 kDa), was compromised by multiplication, whereas that of a sma

139 Lateral rectus function sometimes is compromised by muscle attachment to the lateral orbit

140 y, positive regulator of DKF-1 activity that is compromised by mutation of Lys(298) or Trp(396).

141 Where gene function is compromised by mutation, the presence of multiple iso

142 While protein stability was compromised by mutation, the specific activities of

143 ation status when the STUbL or Ufd1 pathways are compromised by mutations.

144 t a low rate; the utility of avibactam might be compromised by mutations that increase this deactivat

145 om mammalian cells, ESE function in S. pombe is compromised by mutations and increased distance from

146 The expansion mechanism is compromised by mutations that decrease the processivi

147 consequently promote cellular proliferation, is compromised by mutations within the PWWP domain that

148 However, their therapeutic efficacy can be compromised by NA changes that emerge naturally and/o

149 blocking HIV-1 replication, but its activity was compromised by naturally occurring sequence polymorp

150 of a PIN that functions as a bistable switch is compromised by neglecting enzyme-substrate intermedia

151 thors studied this interaction when 1 system was compromised by neurological disease.

152 described here and specifically how they may be compromised by nonsteroidal anti-inflammatory drugs a

153 on process, and we show that this networking is compromised by off-target, bioenergetic effects of so

154 stimate strengths in excess of salt-bridges, are compromised by omission of the relevant anion in the

155 We also discuss how receptor regulation is compromised by oncogenic mutations and the structural

156 s, because survival of endothelial cells can be compromised by opening of the mitochondrial permeabil

157 Their adaptive responses may however be compromised by other constraints, such as predation r

158 arantee that children's development will not be compromised by other hazards as they grow older.

159 pe p53, the p53 transactivation activity may be compromised by other mechanisms.

160 y cGMP-stimulated signaling events in tubule are compromised by overexpression of PDE5.

161 tion-mediated MEF2 activity and CGN survival are compromised by overexpression of the MEF2 repressor

162 wever, the viability of iron-deficient flies is compromised by overexpression of mitochondrial ferrit

163 SGN survival is compromised by overexpression of the proapoptotic reg

164 us trans-Golgi compartment, a mechanism that was compromised by overexpression of GODZ.

165 from 1 of many mutations, after which cones are compromised by oxidative stress.

166 on the epithelium and that these roles could be compromised by P. aeruginosa proteases.

167 Resistance is compromised by pad3 or coi1 mutations, suggesting tha

168 ntry, but reversal of the S-phase checkpoint is compromised by pairwise cyclin knockdown.

169 rmation integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is

170 with cultured cells show that KIT activation is compromised by point mutations in amino acids critica

171 rt, highly conserved sequence whose activity was compromised by point mutations.

172 Interpretation of many experiments is compromised by possible effects of the 3' structures

173 aser anterior capsulotomy integrity seems to be compromised by postage-stamp perforations and additio

174 Specifically, they were compromised by potentially biased patient recall.

175 We find that bistability is compromised by product rebinding and that unrealistic

176 shortened survival and their quality of life is compromised by progressive anemia, marked hepatosplen

177 Furthermore, the potency of some activators is compromised by proteasome inhibition, leading to the

178 es from ionization of C75, and DM reactivity is compromised by protonation of C41.

179 ndicating that damage-induced S-phase arrest was compromised by Rad1 loss.

180 Effective MPR-mediated delivery may be compromised by rapid clearance of infused enzyme by t

181 erm stability of such biophotoelectrodes has been compromised by reactive species generated under aer

182 Regulation can be compromised by reducing the overall structure by fusi

183 ent when Cdk1-cyclin B activation at the SPB is compromised by reduction of Cut12 function.

184 osure, the defenses of the airway epithelium are compromised by reductions in barrier function, impai

185 glucose-dependent vagal afferent signalling is compromised by relatively short periods of exposure t

186 ave shown that clearance of extracellular K+ is compromised by removal of the perivascular pool of th

187 ity of its activated product, plasmin (hPm), are compromised by replacing these two amino acids by th

188 Stability was compromised by repulsive electrostatic forces origin

189 Yet current drug therapies are compromised by resistance.

190 bal health burden and current drug therapies are compromised by resistance.

191 Malaria vector control may be compromised by resistance to insecticides in vector p

192 erse transcriptase inhibitors (NtRTIs) might be compromised by resistance.

193 oguanil, the clinical efficacy of which have been compromised by resistance arising through mutations

194 ge complexes, but their clinical utility has been compromised by resistance.

195 The use of beta-lactam antibiotics is compromised by resistance, which is provided by beta-

196 s in patients with peripheral artery disease is compromised by restenosis and risk of stent fracture

197 However, its activity in saliva is compromised by salivary protease-mediated degradation

198 ness of the test-and-slaughter policy may be being compromised by selection for cattle that are genet

199 photodynamic therapy, but their utilization is compromised by self-aggregation in aqueous media.

200 In cancer cells, PP2A function can be compromised by several mechanisms, including sporadic

201 The accuracy of these assays is compromised by several issues including substrate ins

202 (PPARgamma), but their therapeutic benefits are compromised by severe side effects.

203 We hypothesized that SL would be compromised by severe TBI.

204 are effective drugs, but their clinical use is compromised by severe side effects including hypergly

205 of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the con

206 glucose-dependent vagal afferent signalling is compromised by short periods of exposure to HFD well

207 f age coinfected with HIV or malaria, or who are compromised by sickle cell disease or severe malnutr

208 Unfortunately, their utility is compromised by significant nephrotoxicity and polymyx

209 in "normal" liver tissue, but these studies were compromised by small sample size, limited age range

210 earts, however, existing in utero approaches are compromised by spontaneous fetal motion.

211 plastic deformation of bulk metallic glasses is compromised by strain softening and shear localizatio

212 owever, the efficacy of these approaches may be compromised by suboptimal adherence, decreased drug c

213 sides are potent antibacterials, but therapy is compromised by substantial toxicity causing, in parti

214 results demonstrate that the BER DNA ligases are compromised by subtle changes in all 12 possible non

215 ilament structure and how this stability can be compromised by subtle changes in macrolactone ring co

216 trials, but their therapeutic value seems to be compromised by systemic toxicity.

217 lization and drug-resistant activity of BCRP were compromised by T362A mutation.

218 ble mRNAs in yeast when the decapping enzyme is compromised by temperature-sensitive alleles of eithe

219 While repressive functions of the ICR are compromised by the deletion regardless of tissue typ

220 increases dementia risk are conflicting and are compromised by the difficulty of controlling for con

221 IA methods are sensitive but are compromised by the lack of adequate specificity.

222 mmes and the interpretation of their results are compromised by the lack of knowledge about the effec

223 Scans late in the experiment are compromised by the loss of a defined plateau region

224 The quantification of auxin can be compromised by the breakdown of labile auxin-related

225 ut requires coherent illumination, which can be compromised by the complex high-pressure sample envir

226 T cell diversity may be compromised by the declining thymic output of new T c

227 However, the usefulness of oseltamivir can be compromised by the emergence and spread of drug-resis

228 ell penetrating peptides and bioportides may be compromised by the general capacity of polycationic p

229 inflammatory conditions; its activity might be compromised by the IL-13 decoy receptor (IL-13Ralpha2

230 essed concern that any advantage in CR would be compromised by the observed on-study mortality, and e

231 e in the case of Flp but not Cre, appears to be compromised by the pentad mutations.

232 y neutralizing antibody (bnAb) therapies may be compromised by the preexistence of less susceptible v

233 Such measurements can be compromised by the presence of a significant noninter

234 utics based on mini- or micro-constructs may be compromised by the presence of non-native protein jun

235 stly discriminate chromosomal position might be compromised by the propensity of oocyte kinetochores

236 ductance of an ultrascaled interconnect will be compromised by the thick bilayer.

237 rategy for AIDS chemotherapy that should not be compromised by the unusual genetic diversity of HIV-1

238 The AASK-N repository urine samples have been compromised by the acetic acid preservative.

239 indicate that water column structure has not been compromised by the degassing and local stability is

240 e original randomly assigned groups may have been compromised by the exclusion of 20.7% of women from

241 The single previous human study may have been compromised by the fixation method used and the pos

242 n hepatocytes, research in small animals has been compromised by the frailty of the current mouse xen

243 espread prophylactic use of TLR agonists has been compromised by the need to administer them by paren

244 s, along with certain cancer treatments, has been compromised by the presence of multidrug transporte

245 ainst community Escherichia coli strains has been compromised by the spread of CTX-M beta-lactamase-p

246 their sensitivity and specificity have often been compromised by the use of complex mixtures of undef

247 strate that the adhesive function of BT-R(1) is compromised by the Cry1Ab toxin, which acts as a sele

248 ve mycoses, and the efficacy of these agents is compromised by the development of drug resistance in

249 eptionally effective analgesic whose utility is compromised by the development of tolerance and depen

250 used to treat influenza, but their efficacy is compromised by the emergence of drug-resistant varian

251 However, their effectiveness is compromised by the emergence of intrinsic or acquired

252 iable class of antibiotics, the carbapenems, is compromised by the growth, primarily in intensive car

253 etal-coordinating C4C4 motif in RTEL1, which is compromised by the Hoyeraal-Hreidarsson syndrome (HHS

254 DNAJB6 itself, suggest that DNAJB6 function is compromised by the identified G/F domain mutations.

255 and factors involved in overhang processing is compromised by the inability to easily and accurately

256 e performance of PCR-based assays in general is compromised by the inadequacy of experimental control

257 ment to patients with radiorecurrent disease is compromised by the lack of diagnostic tests with suff

258 delta in preserving genome stability, which is compromised by the loss of WRN in Werner syndrome.

259 iotic function in human spermatogenesis that is compromised by the mutant protein via dominant negati

260 m for such studies is that statistical power is compromised by the need to control the false-positive

261 Diagnosis of MAC-based diseases is compromised by the need to cultivate these fastidious

262 galovirus (HCMV) following natural infection is compromised by the presence of immune modulation gene

263 alein, and their potency against cell growth is compromised by the presence of P-gp 170, suggesting t

264 t PM hERG structural and metabolic stability is compromised by the reduction of extracellular or intr

265 e maintenance of photoreceptor cell polarity is compromised by the rhodopsin mutations causing the hu

266 ted when this fundamental protective barrier is compromised by the specific mechanisms of FUS-BBB ope

267 However, the utility of the SF-AP view is compromised by the variation in x-ray penetration in

268 Moreover, when biosynthesis was compromised by the absence of a fully functional DHP

269 phosphorylation-dependent channel activation was compromised by the introduction of disease-causing m

270 ape macerate, although accuracy for linalool was compromised by the presence of interferences.

271 und that motility in an agar migration assay was compromised by the simultaneous absence of four enzy

272 e antiholin function of the deletion protein was compromised by the substitution of early-lysis misse

273 elivered the THP when it was first evaluated were compromised by the competing responsibilities of co

274 slation and NB-LRR-mediated virus resistance were compromised by the downregulation of Argonaute4-lik

275 sly, the stability and robustness of the ICP were compromised by the entrainment of air, N2, or gas m

276 genic repeat elements and 5' distal VH genes were compromised by the Setd1a-cKO.

277 diseases of some classes of antioxidants may be compromised by their autophagy-blocking properties.

278 RISPR-Cas9 and TALENs for genome editing may be compromised by their off-target activity.

279 , yet the biological potency of many analogs is compromised by their inefficient activation through c

280 als are highly successful, but their utility is compromised by their propensity to aggregate during m

281 T-DNA insertion mutant lines of Arabidopsis is compromised by their propensity to trigger transcript

282 of RTX by measuring the CD19+ cell count may be compromised by this activity.

283 mer, the binding of HD1 and NU172 properties is compromised by thrombin inhibitors alone, as well as

284 on, the identity of those interneurons which are compromised by tissue damage during early life remai

285 Tumor angiogenesis in mouse PCa tissues was compromised by tissue-specific ablation of Frs2alpha

286 ed mechanical allodynia in both sexes, which was compromised by Tlr9 mutation or by treatment with TL

287 DRG tissues in both sexes, but these changes were compromised by Tlr9 mutation in male animals.

288 roviding mycobacterial resistance that could be compromised by TNF neutralization.

289 ediated proximal and distal signaling events were compromised by TRAF3 deficiency.

290 st arterial phases that would otherwise have been compromised by transient motion.

291 a is effective only within a time window and is compromised by tumor-to-tumor variation, supporting o

292 expression of ALP, IGFBP5 and axin2 in bone were compromised by UL.

293 However, the specificity of the test is compromised by vaccination with the Mycobacterium bov

294 Postoperative alignment may be compromised by variability in preoperative measuremen

295 Interim performance of the resource is compromised by variable sequence overlap and modest i

296 xtinctions and postextinction recoveries may be compromised by variations in preservation and samplin

297 ctive APC function and T-cell activation can be compromised by viral immune evasion strategies, inclu

298 Cognition is compromised by white matter (WM) injury but the neuro

299 However, protein crystallography data may be compromised by x-ray photoreduction (XRP).

300 ions of cellular mRNA decay and RNA splicing are compromised by Zika virus infection as well as by sf