ライフサイエンスコーパス: be directed against

1 he major cytolytic activity of the donor CTL was directed against 2 HLA-A11-restricted epitopes in th

2 that physiologic anti-HCMV T cell responses are directed against a broad range of antigens.

3 c challenge, MHC-restricted T cell responses are directed against a few dominant antigenic epitopes.

4 nding CD8+ T cells use Vbeta10 or Vbeta8 and are directed against a single glycoprotein B (gB498-505)

5 hat spontaneous TRAG-3-specific CD4+ T cells are directed against a single immunodominant epitope and

6 ospholipid antibodies found in this syndrome are directed against a variety of phospholipid binding p

7 es to mitochondria, the hallmark of disease, are directed against a very conserved site of pyruvate d

8 a prominent lymphoproliferative response to be directed against a 62-kDa component.

9 alizing humoral responses that, in part, may be directed against a novel epitope(s) found on the HIV-

10 TB patients show significant homogeneity in being directed against a well-defined subset of antigens

11 Whether this oligoclonal and polyclonal IgG is directed against a disease-relevant antigen remains u

12 The CF antibody response is directed against a heat-labile antigen that has chiti

13 a monoclonal chimeric antibody fragment that is directed against a protein expressed on the surface o

14 e effect upon the immune response because it is directed against a single epitope.

15 tract epithelial cells, and a response that is directed against a virus that continuously undergoes

16 rom schistosome-infected C57BL/6 (BL/6) mice was directed against a 62-kDa component of SEA.

17 from one of the two responder rhesus monkeys was directed against a 9-residue peptide, GELMTLATW, at

18 tivity in supernatants of stimulated B cells was directed against a broad range of CNS antigens.

19 Immunoblots revealed that the blocking IgG was directed against a meningococcal Ag called H.8.

20 The antibody was directed against a recombinant fusion protein consis

21 One was directed against a recombinant molecule containing a

22 This screen was directed against a variety of coregulators, transcri

23 The vaccine-induced T-cell reactivities were directed against a broad set of renal tumor-associa

24 e xenograft was present in the recipient and were directed against a large number of pig proteins.

25 i-HIV-1 NAbs produced between weeks 7 and 13 were directed against a neutralization-sensitive virus s

26 arkably, up to one fourth of the CD8 T cells were directed against a single minor antigen, H60.

27 oped a novel targeted fibrinolytic drug that is directed against activated platelets.

28 e CoV-2-specific CD4+ T helper cell response is directed against all 3 proteins with comparable magni

29 ns, and computer decision support order sets was directed against all antibiotic prescribing.

30 ons and computer decision support order sets was directed against all antibiotic prescribing.

31 Responses were directed against all 10 peptides tested and were re

32 odies to peptides designated PR-15 and DK-12 were directed against amino acid residues 103-117 and 12

33 1996 elicited pH1N1 antibody responses that are directed against an epitope near the HA receptor-bin

34 ain of BPAg2 and that the IgA autoantibodies are directed against an epitope within or adjacent to a

35 antiidiotypic approach which was designed to be directed against an amiloride binding domain on the e

36 The dominant NAb specificity is directed against an epitope at or close to the trimer

37 utoimmune thrombocytopenia in which antibody is directed against an immunodominant epitope of the bet

38 and that a subset of autoantibodies in IDDM is directed against an integral membrane protein of insu

39 In BALB/c (H-2d) mice, the dominant response is directed against an Ld-restricted peptide in the nucl

40 m3D6, which is directed against an N-terminal domain of Abeta (amino

41 he paradigms of allergy as allergic response is directed against an oligosaccharide and the reactions

42 The immunodominant response was directed against an epitope present in the viral M p

43 t was believed earlier that these antibodies were directed against anionic phospholipids.

44 e data suggest that allogeneic responses can be directed against antigenic determinants of low abunda

45 we found that the majority of these T cells were directed against antigenic peptides residing within

46 ANCA are directed against antigens expressed on the surface o

47 edominant immune responses stimulated by BCG were directed against antigens present in mycobacterial

48 Many antibiotics are directed against bacterial ribosomes, and mutations

49 Most pathogenic APLAs are directed against beta2-glycoprotein I (beta2GPI), a

50 Therefore, in many cases treatment must be directed against both the tumor and the hormone-exces

51 d efficacy of the dual nanobioconjugate that is directed against both CK2 and EGFR.

52 Peptide-specific IFN-gamma responses were directed against both the class I and class II MHC-

53 esults showed that some patients' antibodies were directed against both the domain containing the gam

54 Therefore, adaptive immunity can be directed against Burkitt's lymphoma, and perhaps this

55 3) of hemophiliacs treated with plasma fVIII were directed against C2 and another LCh epitope within

56 ent to which tumor-infiltrated T lymphocytes are directed against cancer cells, but how the immune in

57 Much of the immunity to the parasite is directed against carbohydrate determinants in both gl

58 he rD-mPGPtide in this transplantation model was directed against CD4+ T cells and was exclusively sp

59 Myositis-specific autoantibodies (MSAs) are directed against cell machinery proteins such as ami

60 All the antibodies identified were directed against class I antigens.

61 und in high titers in most patients, seem to be directed against conformational forms of GAD.

62 hannel activation by DeltaP when the Deltapi was directed against DeltaP.

63 PF autoantibodies are directed against desmoglein (Dsg) 1; PV autoantibodi

64 chniques to determine whether the antibodies were directed against donor mismatches.

65 -bovine reassortant rotavirus vaccine (HBRV) is directed against each of the most prevalent rotavirus

66 Bulk T-cell responses were directed against either Hantaan virus nucleocapsid

67 c T cell responses, elicited by all vectors, were directed against Env, rather than Gag, determinants

68 amers can function as anticoagulants if they are directed against enzymes of the coagulation cascade.

69 nfirming the VirB9-specific T-cell responses are directed against epitopes in the native protein.

70 Most human antibodies against HA and NA are directed against epitopes that are hypervariable and

71 Most of the inhibitory activity is directed against epitopes in the A2 and C2 domains.

72 e viral M protein, and subdominant responses were directed against epitopes present in the P, F, and

73 The most frequent and robust responses were directed against epitopes within the Gag and Nef pr

74 known transgenerational silencing responses are directed against foreign DNA introduced into the org

75 broside sulfate (sulfatide); and RMAb, which is directed against galactocerebroside (GC).

76 ned with monoclonal antibodies: MAbO4, which is directed against galactocerebroside sulfate (sulfatid

77 ned which HSV entry glycoproteins these PAbs were directed against: glycoproteins gB, gD, and gC were

78 odies elicited during natural infection that are directed against gp120 epitopes that overlap the bin

79 neither these autoAbs nor the receptor they are directed against have been convincingly implicated i

80 induce the expression of defense genes that are directed against herbivores, as found in tobacco and

81 mental design of vaccine candidates that may be directed against HIV-1 subtype C.

82 Current malaria vaccine candidates are directed against human and mosquito stages of the pa

83 a different antiviral activity of ZAPL that is directed against influenza A virus.

84 Responses appeared to be directed against intracellular proteins involved in c

85 mobility shift assays using antibodies that are directed against known RNA-binding proteins.

86 l antibodies (bnMAbs), 2F5, 4E10, and Z13e1, are directed against linear epitopes mapped to the MPER,

87 rase activity in vivo and that this activity is directed against Lys(9) of histone H3.

88 eutrophil cytoplasmic autoantibodies (ANCAs) are directed against lysosomal components of neutrophils

89 se mAbs, like those from a previous patient, were directed against mature Dsg1 (matDsg1) on the cell

90 d model of alopecia areata in which immunity is directed against melanogenesis-associated proteins in

91 The GVL effect is directed against minor histocompatibility antigens sh

92 e rejection of a transplanted kidney if they are directed against mismatched donor HLA antigens.

93 Most dnDSA are directed against mismatched donor HLA-DQ antigens.

94 T cells were directed against modifications of a chemically domi

95 ts may be a serious problem when CTL therapy is directed against more unstable tumor cell-derived tar

96 es it to be a host enzyme whose activity can be directed against multiple intracellular bacterial pat

97 that new, nonantibiotic therapeutics need to be directed against multiple targets.

98 ating HIV-1, the CTL response is polyclonal, is directed against multiple HIV-1 proteins, including h

99 The Abs were directed against multiple FH epitopes located at th

100 markably, immunodominant T cell reactivities were directed against mutated neoantigens or a cancer ge

101 tivity of some "histone deacetylase" enzymes is directed against non-histone substrates.

102 ve epitopes, since only 2-5% of these titers were directed against nonprotective de-O-acetylated GXM

103 ective bactericidal antibodies and appear to be directed against nonsialylated bacterial epitopes.

104 odies consisted of classes IgA and/or IgM or were directed against NR1a/NR2b (not against NR1a alone)

105 of pathogenic autoantibodies, many of which are directed against nuclear antigens, in particular dou

106 apies for non-small-cell lung cancer (NSCLC) are directed against oncogenic drivers that are more pre

107 ate a CD8(+) T-cell response in the CNS that is directed against one dominant (VP3(159-166)) and two

108 nd suggest that future brain therapies might be directed against paracrine factors produced by cells

109 s of HDM-allergic and nonsensitized subjects were directed against peptide epitopes and higher allerg

110 but immune surveillance can, in some cases, be directed against peptides presented by nonclassical M

111 o acid 57 and amino acid 113 but no antibody was directed against peptides representing the hypervari

112 The majority of APLAs are directed against phospholipid-binding proteins, part

113 art by allele-specific immune responses that are directed against polymorphic epitopes on blood-stage

114 ups, the majority of antibodies against AMA1 were directed against polymorphic epitopes.

115 ggesting that responses against both vectors were directed against preformed components of the viral

116 tion of the MHC class II-restricted response was directed against proteasome-dependent epitopes.

117 In patients with GN or vasculitis, ANCAs are directed against proteinase 3 (PR3) or myeloperoxida

118 litis seen in Wegener's granulomatosis (WG), are directed against proteinase-3 (PR-3), a serine prote

119 atory assays for antiphospholipid antibodies are directed against prothrombin and beta2-glycoprotein

120 Antibody to peptide KD-14 was directed against residues 206-219 of the first extra

121 ting method for targeted removal of O-GlcNAc was directed against retrotransposon promoters.

122 suggested that the negative function of SOG is directed against SCW, we present data that suggests t

123 elpful or wanted when therapeutic antibodies are directed against self-antigens, and can sometimes ca

124 d in almost all convalescent individuals and were directed against several structural and nonstructur

125 didate, PorB induces antibody responses that are directed against six variable surface-exposed loops

126 ic for fluorescein isothiocyanate (FITC) can be directed against solid tumours via the intratumoural

127 The IgE response is directed against specific components from an allergen

128 led plasma IgE from DOCK8-deficient patients is directed against staple food antigens but not house d

129 Correspondingly, vaccines may be directed against "stealth" epitopes, overriding viral

130 Treatment of uncomplicated cellulitis should be directed against Streptococcus and methicillin-sensit

131 e target the inflammatory process and others are directed against structural cells.

132 A from multiple strains of S. pneumoniae and were directed against surface-exposed epitopes.

133 that a proportion of neutralizing antibodies are directed against the Ad5 fiber.

134 ments in development for Alzheimer's disease are directed against the amyloid-beta (Abeta) peptide.

135 ayed allergic reactions where IgE antibodies are directed against the carbohydrate alpha-Gal epitope.

136 he 375 S/W mutant by CD4BS antibodies, which are directed against the CD4-binding region of gp120, wa

137 s an autoimmune disorder in which antibodies are directed against the desmosomal adhesion molecule Ds

138 tering disease in which autoantibodies (IgG) are directed against the desmosomal cadherin desmoglein

139 The associated autoantibodies are directed against the extracellular domains of cell-s

140 All seven mAbs are directed against the first Ig-like domain (D1) of hL

141 n the detection of antibodies, most of which are directed against the immunodominant regions (IDR) of

142 Several specific therapies are directed against the influx of inflammatory cells in

143 A group of specific therapies are directed against the influx of inflammatory cells in

144 gated humanized antiTac Fab fragments, which are directed against the interleukin-2 receptor, with gl

145 gical hallmark of primary biliary cirrhosis, are directed against the lipoyl domain of the E2 subunit

146 hould devise empiric treatment regimens that are directed against the most common local pathogens.

147 ies, members of four distinct B cell clones, are directed against the Mtb phosphate transporter subun

148 Most monoclonal antibodies that are directed against the receptor-binding motif lost in

149 g monoclonal antibodies, 7A12 and 2G4, which are directed against the SA-binding site within VP8* and

150 Campath-1 antibodies are directed against the surface antigen CD52 that is ex

151 ls for growth, and many new cancer therapies are directed against the tumor vasculature.

152 ls, and that CTL immunotherapy of JMML could be directed against the gamma-globin-derived epitope g10

153 tection induced by these peptides appears to be directed against the infected hepatocytes.

154 the pathologic auto-antibodies are shown to be directed against the plasma protein beta(2)-glycoprot

155 Two of these mAbs appeared to be directed against the same epitope site within this re

156 that diverse immune responses in humans can be directed against the same protein.

157 but the responses in both cases appeared to be directed against the same region of gp120.

158 mster ovary (CHO) cells of 5C12 HuMAb, which is directed against the A subunit of Stx2.

159 The anti-Tac dsFv is directed against the alpha subunit of the interleukin

160 of the autoreactive CD4(+) T cell repertoire is directed against the B:9-23 segment of the insulin B

161 Anti-APP is directed against the beta-amyloid precursor protein a

162 chronic varicella zoster virus vasculopathy is directed against the causative virus.

163 ll resistance to the IgG1b12 antibody, which is directed against the CD4 binding site.

164 However, m266.2, which is directed against the central domain of Abeta (amino a

165 response in primary biliary cirrhosis (PBC) is directed against the E2 component of pyruvate dehydro

166 atients with primary biliary cirrhosis (PBC) is directed against the E2 component of the pyruvate deh

167 nergy landscape, whereby the photonic energy is directed against the E2 loop by the C13-methyl group,

168 mAb 12G3H11, used here as a model, is directed against the human receptor tyrosine kinase E

169 m autoantibodies, the immunodominant epitope is directed against the inner lipoyl domain of PDC-E2.

170 The monoclonal antibody (MAb) 13D6, which is directed against the K1 capsule from A. baumannii, wa

171 nt CD4(+) T-cell response in MSP1 vaccinates is directed against the MSP1a subunit.

172 The principal effect of anti-CTLA4 is directed against the naive, not regulatory, T cell po

173 An antiserum has been derived that is directed against the NH2-terminal 17 amino acids of t

174 evelopment and use of such an antibody which is directed against the optimal phosphorylation motif of

175 This immunity is directed against the Plasmodium spp. parasite develop

176 d the FG-3019 monoclonal antibody (mAb) that is directed against the pleiotropic matricellular signal

177 ence the TipA multidrug resistance mechanism is directed against the same chemical motif that inhibit

178 ing the greatest in vivo protective efficacy was directed against the A chain.

179 ains, a portion of the bactericidal antibody was directed against the highly conserved protein, neiss

180 In three patients, immunoreactivity was directed against the Ig domains of contactin and was

181 Strikingly, very little reactivity was directed against the N-terminal domain (aa 1-213) by

182 tibody-mediated macrophage killing mechanism was directed against the spore itself or the vegetative

183 One arm of the diabody was directed against the target antigen, and the other a

184 significant fraction of the gB AD-5 response was directed against the YNND epitope, further argued th

185 The most active ODNs were directed against the 3'-poly adenylation signal sit

186 E antibodies binding TE in patients with AGS were directed against the alpha-Gal epitope.

187 IgA antibodies in primary infection were directed against the Bam Z Epstein-Barr replication

188 Some of these activities were directed against the CD4 binding site (CD4bs).

189 The responses were directed against the donor HLA-class I antigens.

190 Most specific IgG and IgA responses were directed against the GII.2, GII.3, GII.4, and GII.6

191 Sera isolated from these animals were directed against the HA epitope involving amino aci

192 ses correlated with titres of plasma IgG and were directed against the HPV proteins E2, E6 and E7, wi

193 conjugated monoclonal antibodies (mAbs) that were directed against the IL-2R alpha, IL-2R beta, and g

194 However, these interventions were directed against the initial SARS-CoV-2 virus that

195 rylated, showing that these three antibodies were directed against the phosphate group(s) on Ser23 an

196 CD4(+) T cells that were directed against the type 1 diabetes-associated aut

197 Of the linear binding IgG responses, most were directed against the V3 loop in all immunization gr

198 ls are of antibodies and memory B cells that are directed against these conserved epitopes.

199 onally designed targeted agents that are now being directed against these pathways, with early eviden

200 To examine whether immunity to P. vivax is directed against these polymorphic regions of DBPII,

201 e data demonstrate that an antibody response is directed against these virulence-associated factors d

202 tumor antigen (Tag) in C57BL/6 (H2(b)) mice is directed against three H2-D(b)-restricted epitopes, I

203 nduction of robust immune responses that may be directed against tumor-associated antigens.

204 and chronic skin blistering, autoantibodies are directed against type VII collagen.

205 the greatest frequency of responses (by ORF) being directed against UL39, UL25, UL27, ICP0, UL46, and

206 of human monoclonal antibodies (MAbs), which are directed against various epitopes on human immunodef

207 luated the extent to which Ad5-specific NAbs are directed against various HVRs.