ライフサイエンスコーパス: be downregulated by

1 miR-133a expression was downregulated by 0.7- and 0.5-fold at 2 and 4 weeks

2 -infection of macrophages but the expression was downregulated by 12 h post-infection.

3 t receptor in HCE cells up to 30 minutes and was downregulated by 2 hours.

4 Podocalyxin was downregulated by 20% in newborn kidneys but not in k

5 pressed from birth through 8years of age and is downregulated by 20years of age to low levels that ar

6 ong which maternally expressed gene 3 (MEG3) was downregulated by 210-fold relative to expression in

7 study to experimentally identify genes that are downregulated by 25 miRNAs.

8 phosphatases, we found that calcineurin/PP2B was downregulated by 30% in pre-symptomatic and 50% in s

9 mRNA expression of interleukin (IL)-1beta was downregulated by 42.5 +/- 4.7% (p < .05) and transfo

10 in several malignancies, including melanoma, was downregulated by 5.6-fold following MUC18 silencing.

11 cell-cycle regulatory activity, was shown to be downregulated by 50% following androgen stimulation.

12 f total), and (b) in heart failure alpha-MHC was downregulated (by 67-84%) and beta-MHC gene expressi

13 nificantly upregulated miRNAs and three that were downregulated by 6hpi of infection of CD34+ cells w

14 DAPK1 expression of the CLL allele is downregulated by 75% in germline cells due to increas

15 y contrast, partially complementary messages are downregulated by a combination of translational repr

16 ion of the kinetochore complex subunit Ndc80 is downregulated by a 5' extended long undecoded NDC80 t

17 Ammonium uptake by AMT1 transporters is downregulated by a CIPK23 protein kinase whose expres

18 We show that hepatocyte tPA is downregulated by a pathway in which the corepressor D

19 enes, 1088 genes were induced and 3828 genes were downregulated by a log(2) factor of 2.

20 adomain-associated genes MYC, CCAT1 and TP63 were downregulated by A-485.

21 Sclerostin (Sost) expression was downregulated by about 90% and SOST protein was unde

22 tic and eukaryotic cells alike, Acs activity is downregulated by acetylation and reactivated by deace

23 alkalinizing SC pH, whereas this antiporter was downregulated by acidifying SC pH, independent of ch

24 models of NSCLC, we found that Cyp2c44 could be downregulated by activating the transcription factor

25 Sprouty2 is downregulated by acute inflammation; this appears to

26 evolutionary conserved lncRNA Sarrah, which is downregulated by aging, as a regulator of cardiomyocy

27 alent in human disease, where PTEN and FOXA1 are downregulated by allelic loss and site-specific DNA

28 An IL-1beta-induced set of 27 genes was downregulated by an NF-kappaB inhibitor, leading to

29 ding 4-coumarate:coenzyme A ligase (4CL) has been downregulated by antisense inhibition.

30 Cardiac Kv4.3 channel gene expression was downregulated by approximately 3- to 5-fold, both at

31 (HAT1), which catalyzes H4K5ac and H4K12ac, was downregulated by ascorbate mainly via the TET-mediat

32 n (CLU) gene, which is related to apoptosis, was downregulated by ascorbate.

33 phosphatase, protein phosphatase 2A (PP2A), is downregulated by ATM-mediated phosphorylation.

34 s a key regulator of anabolic metabolism and is downregulated by axotomy.

35 Using CML mouse model, we show that Msr1 is downregulated by BCR-ABL and this down-regulation is

36 in which the SpSoxB1 transcription regulator is downregulated by beta-catenin-dependent gene products

37 rgest functional group (n = 45) all of which were downregulated by bile exposure.

38 of the translation initiation complex eIF4F, is downregulated by binding the negative-acting factor 4

39 Whereas SlFAD2-1 and SlFAD2-2 are downregulated by biotic stress, the majority of dive

40 vealed previously unidentified pathways that are downregulated by BKV.

41 Subunits of the Arp2/3 complex were downregulated by BLOC-1 loss of function, thus affe

42 c genes (for example, BCL2, BCL-XL and DAD1) was downregulated by BTK short hairpin RNA.

43 t the majority of these genes carried by pCD were downregulated by Ca2+.

44 The PrgX protein, prgX RNA, and the Qa RNA were downregulated by cCF10 induction; however, prgX gen

45 In turn, CD2-stimulated adhesion is downregulated by CD2BP1, apparently through coupling

46 Cdk2/CyclinE acts downstream of ATM and is downregulated by Cdk2 phosphorylation on tyrosine 15.

47 d on these results, it appears that the SERT is downregulated by chronic administration of SSRIs but

48 psychotic actions by neuroleptic treatments, was downregulated by chronic treatment with the two pote

49 R2A encodes the serotonin 2A receptor, which is downregulated by citalopram.

50 core components of the beta-catenin pathway, is downregulated by clofibrate.

51 e brain, and has been previously reported to be downregulated by cocaine.

52 a matrix stiffness-repressed transcript that is downregulated by collagen density and reduced in the

53 that about 70% of the genes induced by Wnt3a were downregulated by combined FGF treatment.

54 responses to bacterial challenge or TNFalpha are downregulated by CsA.

55 mely miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further

56 Ct-Rac1 expression is downregulated by DARas under limiting nutrition.

57 sion, a time at which many maternal proteins are downregulated by deadenylation and destabilization o

58 nstead, at E17.5, fatty acid oxidation genes were downregulated by dexamethasone, as was GR itself.

59 We show that Cpe expression is downregulated by diet-induced obesity and that FoxO1

60 omologous recombination protein RAD51, which was downregulated by disruption of the E2F1/DP1 complex.

61 is a p53-targeting E3 ubiquitin ligase that is downregulated by DNA damage through mechanisms that r

62 In colorectal cancer cells, AP4 was downregulated by DNA damage in a p53-dependent manne

63 T-type Ca(2+) channels were downregulated by dopamine receptor activation actin

64 iverse HDACs, and lamina-associated proteins were downregulated by dsRNA.

65 boule expression is downregulated by ecdysone in MB neurons at the onset

66 d actin binding activity of FSGS mutants can be downregulated by EGF-mediated phosphorylation, to dis

67 d rabbit model, FasL expression was shown to be downregulated by elevations in serum cholesterol, whi

68 n and gap junction between pericytes and ECs are downregulated by EP-4 and EP-1-dependent mechanisms,

69 at angiogenic factor and proliferation genes were downregulated by ERRalpha knockdown in proliferatin

70 ectant that decreases with advancing age and is downregulated by estrogen treatment.

71 METTL14 is downregulated by exercise, both at the level of RNA m

72 of both the EXO-GUS and the native EXO genes is downregulated by exogenous cytokinin.

73 AtMYB4 expression is downregulated by exposure to UV-B light, indicating t

74 ity; (c) PPAR gamma 1 and gamma 2 expression is downregulated by fasting and insulin-deficient diabet

75 ed that neural activity in other systems may be downregulated by food deprivation.

76 Expression of all 14 genes was downregulated by GA and upregulated by DELLA.

77 m level and anaphylactic activity of IgE may be downregulated by glycan-specific IgG anti-IgE autoant

78 enin, a member of the Wnt signaling pathway, is downregulated by glycogen synthase kinase-3beta (GSK-

79 s was upregulated and expression of 61 genes was downregulated by >1.5-fold at both E12.5 and E13.5 i

80 and spy remained unchanged while pbp2 levels were downregulated by > 25%.

81 were consistently upregulated, and 14 genes were downregulated, by >50%.

82 required for OIS in primary fibroblasts but is downregulated by H-Ras(V12) in immortalized NIH 3T3 c

83 positive regulator of E-cadherin expression, was downregulated by HBx in HepG2X cells and tissue sect

84 We showed that ApoE was downregulated by HCMV to facilitate latent infection

85 as an HCV entry host dependence factor that is downregulated by HCV infection in a cell culture mode

86 ster chromatids during mitosis and how Rad51 is downregulated by Hed1 upon entry into meiosis such th

87 PK2, NFkappaB, and angiogenic factors, which were downregulated by HI.

88 and insulin- stimulable GS and PP1 activity are downregulated by high glucose in fibroblasts and thi

89 1 and cdc25A as direct miR-503 targets which are downregulated by high glucose/low growth factors in

90 HLA-E protein expression on cell surface is downregulated by high-risk HPV16 and HPV18 E7 express

91 CITED2 was the target of miR-200b and was downregulated by high glucose.

92 re is a growing number of genes known, which are downregulated by histone deacetylase (HDAC) inhibito

93 Meiotic recombination 11 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDAC

94 in PBMCs from HIV-1-infected individuals and was downregulated by HIV-1 infection of healthy donor ce

95 ER and PR in LAM cells appear to be downregulated by hormonal therapy.

96 tring profiling identified 14 microRNAs that are downregulated by hPMR1, including all five members o

97 We discover that microRNA-203 is downregulated by Hras(G12V).

98 s, the yeast alpha-factor pheromone receptor is downregulated by hyperphosphorylation, ubiquitination

99 ases in key IgE signaling molecules known to be downregulated by IL-10.

100 t of airway epithelial barrier function that is downregulated by IL-13 and that claudin-18 deficiency

101 ased IL-13Ra2 transcription levels, and this were downregulated by IL-13Ra1KD.

102 fic genes, Sox9 and collagen type IIa, which were downregulated by IL-1beta.

103 trating that miR-23b cluster and miR-125a-5p are downregulated by increased expression of PDGFR-alpha

104 Protein kinase C (PKC) was downregulated by incubating acini overnight, with or

105 Hepatitis B virus (HBV) RNA is downregulated by inflammatory cytokines induced in th

106 However, all four prosurvival proteins were downregulated by inhibition of NF-kappaB in MCF-7/E

107 e-induced luciferase activity in macrophages was downregulated by inhibitors of NF-kappaB pathway, as

108 growth regulators in the retina and RPE that are downregulated by injury, to allow tissue repair.

109 Our novel findings reveal that omentin-1 is downregulated by insulin and glucose.

110 LK-1, a conserved regulator of regeneration, is downregulated by insulin/IGF1 signaling, bound by DAF

111 x 1 (Pdx1), an insulin transcription factor, is downregulated by interaction with SPOP.

112 specifically expressed within these domains are downregulated by interference with SoxB1 expression,

113 olved in P. gingivalis invasion of GECs, may be downregulated by internalized P. gingivalis.

114 e homologs of Drosophila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated

115 s, iron, and bone morphogenetic proteins and is downregulated by iron deficiency, ineffective erythro

116 is highly sensitive to stress conditions and is downregulated by iron depletion and gamma-irradiation

117 phenomenon in which the expression of a gene is downregulated by its protein product.

118 Interestingly, SnoN itself is downregulated by Lats2 that is activated by the Scrib

119 Namely, expression of UDA is downregulated by let-7 microRNA, whereas the predomin

120 dent, and Snn3-D1 transcriptional expression was downregulated by light and upregulated by darkness.

121 However, expression is downregulated by lipopolysaccharide and rIL-1beta in

122 the regulation of smooth muscle contraction, was downregulated by lipopolysaccharide (LPS) in mesente

123 that the basic helix-loop-helix factor Ascl1 is downregulated by loss of Smad4 and that Ascl1 regulat

124 ssed the expression of eight genes that also were downregulated by low temperature, indicating that i

125 es demonstrate that murine GHR transcription is downregulated by LPS, primarily via TNF-alpha-depende

126 that show constitutive macropinocytosis that was downregulated by LPS treatment.

127 Exopolysaccharide production is downregulated by Ltp1 through transcriptional regulat

128 Similarly, CA9 promoter activity was downregulated by MC in HCT 116 p53(+/+) but not the

129 BIG transcription is downregulated by methyl JA (MeJA), necrotrophic infec

130 g pathway, including mTOR, eIF4A, and eIF4E, are downregulated by mf, suggesting that mf target this

131 ient and that Fgf2 and its receptor, Fgfr-1, are downregulated by mid to late stages of neurogenesis.

132 factor-kappaB (NF-kappaB), was identified to be downregulated by miR-7 using quantitative proteomic a

133 tin-interacting protein 1-related (HIP1R) as being downregulated by miR-23b/-27b.

134 We also identified MAFA as a target that is downregulated by miR-204.

135 truct containing the 3'-UTR of PKCvarepsilon was downregulated by miR-107 and mutations in the three

136 ture experiments showed that AIB1 expression was downregulated by Mir-17-5p, primarily through transl

137 ersely correlated with NEDD4 expression that was downregulated by miR-30 family, suggesting post-tran

138 Accordingly, global H3K27me3 levels were downregulated by miR combo treatment.

139 3'UTR and coding sequence and for genes that were downregulated by miR-200c overexpression.

140 pression of OBFC2A, a DNA-damage factor that is downregulated by miR17 and miR21 in HTLV-1-infected C

141 harmacologically or genetically impaired but is downregulated by mitoROS signaling.

142 Key regulators of adipogenesis/lipogenesis were downregulated by MNSB treatment, mainly resulting f

143 H4 gene transcription during differentiation is downregulated by modulating protein interaction at th

144 Only ESR1 was downregulated by more than two-fold in ER-positive c

145 We find that HLA-C is downregulated by most primary HIV-1 clones, including

146 In our model, the hedgehog pathway was downregulated by Mtb-stimulation, but Shh levels in

147 in cells in which the RhoA signaling pathway was downregulated by multiple experimental approaches.

148 In addition, the expression of Na(V)1.5 mRNA is downregulated by muscle activity, both at the NMJ and

149 rt that the tumor suppressor microRNA let-7i is downregulated by mutant p53 in multiple cell lines ex

150 Pump activity is downregulated by natriuretic hormones, such as dopami

151 g mediated by phospho-JNK and p38 expression was downregulated by NBP treatment in vitro and in vivo.

152 ich play critical roles for NCC development, was downregulated by NCC disruption of Smad4.

153 The NgR family is downregulated by neuronal activity, a response that m

154 The induction was downregulated by neutralizing IL-22.

155 epatic lipin 1beta and PGC-1alpha expression are downregulated by obesity and obesity-related metabol

156 lated protein 9 (CTRP9) is an adipokine that is downregulated by obesity.

157 hen compared to healthy donors and that PLK1 is downregulated by on average 50% using RNAi prodrugs w

158 ue of human Gravin/AKAP12), whose expression is downregulated by oncogenic Src and in many human canc

159 , and many ribosome biogenesis-related genes were downregulated by osmotic stress, implying a negativ

160 pression of transthyretin, which is known to be downregulated by oxidative stress.

161 The discovery that macrophage COX-2 is downregulated by oxidized low-density lipoprotein and

162 on, suggesting that PRC1 transcription could be downregulated by p53.

163 EAM pathway and describe a set of genes that is downregulated by p53 independent of LIN37/DREAM.

164 iption factors MYB and MYBL1, but not MYBL2, were downregulated by p95HER2 and by miR-503 or miR-221/

165 Similar to FOXM1, KIF20A expression is downregulated by paclitaxel in the sensitive MCF-7 br

166 ny key host genes including cyclins and IL-6 were downregulated by pacritinib, while KSHV genes were

167 Smpd3 expression in ATDC5 chondrogenic cells is downregulated by parathyroid hormone-related peptide

168 In addition, TGM-2 induced by CsA is downregulated by PD98059, LY294002, NAC, curcumin, EG

169 embers of the protein kinase C family, which are downregulated by phorbol esters, because it was stil

170 AID activity and its oncogenic potential can be downregulated by phosphorylation of serine 3 and that

171 on have suggested that c-Src kinase activity is downregulated by phosphorylation of a critical carbox

172 s steady state level during the light period are downregulated by phototropin, whereas the level of c

173 The level of ambient TNF is known to be downregulated by physical activity, exercise and adap

174 This mitochondrial activity of ATR is downregulated by Pin1 that isomerizes ATR from cis-is

175 or (NPR-C) expression in rat mesangial cells is downregulated by platelet-derived growth factor (PDGF

176 ee pathways which cross talk with each other were downregulated by POX: the cyclooxygenase-2 (COX-2)

177 osphorylated state under control conditions, are downregulated by PP2B upon stimulation, with the maj

178 late apoptotic human polymorphonuclear cells was downregulated by proinflammatory stimuli, including

179 Methods and Results-PKC was downregulated by prolonged (24-hour) treatment with

180 RASSF10 is downregulated by promoter hypermethylation in cancers

181 In cancer, expression of BNIP3 and BNIP3L is downregulated by promoter hypermethylation or by homo

182 the first report documenting that the WIF-1 is downregulated by promoter methylation and functions a

183 rized member of the family is RASSF1A, which is downregulated by promoter methylation in 40-90% of pr

184 miR-192 was downregulated by promoter methylation in both PDAC a

185 Expression of miR-193b in liposarcoma cells was downregulated by promoter methylation, resulting at

186 anine kidney cell taurine transporter (pNCT) is downregulated by protein kinase C (PKC) activation.

187 alpha7-nAChR levels are downregulated by reduced activity, whereas alpha3-nA

188 l transduction mechanisms that are likely to be downregulated by reelin deficiency in the brain of sc

189 cytes, the expression of alpha3(IV) collagen was downregulated by Rho-inhibition.

190 We now report that NbFD1 is downregulated by rice stripe virus (RSV) infection an

191 imulate motility of the cells, in which S6K1 was downregulated by RNAi.

192 ith RREB confirmed that the p16 promoter can be downregulated by RREB, in a Ras- or Mek-dependent man

193 l epithelial cells, and one of them, DUSP10, was downregulated by RV infection.

194 CI-AML3 cells revealed that the miRNA let-7a was downregulated by SDF-1alpha-mediated CXCR4 activatio

195 s evidence that presynaptic calcium channels are downregulated by second messenger pathways involving

196 VEGF was downregulated by SERPINA3K at the transcriptional le

197 We conclude that SHP is downregulated by several steatotic drugs and in advan

198 Fob1-mediated Ter-Ter interactions in trans are downregulated by Sir2.

199 tor Robo1 has proinflammatory properties and is downregulated by Slit2 via targeting of miR-218.

200 ents increased phosphorylation of ERK, which was downregulated by social defeat stress.

201 nd keratinocyte-driven inflammation pathways were downregulated by spesolimab as early as week 1.

202 Apolipoprotein B100 was downregulated by statin therapy, consistent with it

203 e results show that TACE is a target of, and is downregulated by, sTNF-induced AP-2alpha transcriptio

204 have identified several additional RNAs that are downregulated by Su(s).

205 ypsin-like (CT-L) activity of the proteasome is downregulated by substrates of the peptidyl-glutamyl

206 Activity of an agpA::TnphoA fusion was downregulated by SyrA.

207 responses for both foreign and self antigens are downregulated by T cells that are specialised for th

208 g and oxidative phosphorylation genes, which are downregulated by tamoxifen.

209 In human VIC, ALDH1A1 expression is downregulated by TGF-beta in a SMAD2/3-dependent mann

210 llular levels of lumican and keratocan mRNAs were downregulated by TGF-beta1 and FBS.

211 These are downregulated by Th2 cytokines of the allergic respo

212 gely stress induced and TAF independent, and are downregulated by the coordinate action of a variety

213 r induced by androgen: 9 out of the 12 mRNAs are downregulated by the microRNA cluster.

214 enovirus expressing miR-145 (Ad-miR-145) but are downregulated by the miR-145 inhibitor 2'OMe-miR-145

215 roteins are upregulated and surface proteins are downregulated by the regulator, suggesting that mgrA

216 ansforming, we investigated whether it could be downregulated by the Cbl proteins.

217 LB2 transcription cluster have been known to be downregulated by the DNA damage checkpoint for many y

218 ell commitment and that Notch signaling must be downregulated by the double positive stage for proper

219 MYC, HIF1a, MTIF and CDKN1B) are reported to be downregulated by the loss of PRMT5, while their mRNA

220 However, activation of Akt appears to be downregulated by the receptor's carboxy-terminal regi

221 Src kinase activity is downregulated by the carboxy-terminal Src kinase (Csk

222 Robo repulsion is downregulated by the Commissureless (Comm) protein, a

223 upregulated in obstructive cholestasis, and is downregulated by the FXR agonist OCA.

224 rom thymus and secondary lymphoid organs and is downregulated by the immunosuppressive drug FTY720.

225 Furthermore, when the expression of nestin is downregulated by the nestin-specific small interferin

226 on of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR prot

227 charide (LPS)-induced monocyte TF expression is downregulated by the nuclear hormone all-trans retino

228 virus saimiri, whereby ORF 50a transcription is downregulated by the ORF 57 gene product, a gene whic

229 this study, we show that Claspin expression is downregulated by the proteasome-mediated degradation

230 In meiosis Rad51 is downregulated by the protein Hed1, which blocks Rad54

231 Dab1 is downregulated by the Reln signal in neurons in the ab

232 d by the SMG1 interactors SMG8 and SMG9, and is downregulated by the so-called SMG1 insertion domain.

233 show for the first time that activated c-Abl is downregulated by the ubiquitin-dependent degradation

234 In summary, ENaC was downregulated by the activation of P2X2, P2X(2/6), P

235 ut factor VIII, in which thrombin generation was downregulated by the addition of protein C and throm

236 RGS4 was downregulated by the master regulator of LEC differe

237 -positive MCC cells, the expression of NDRG1 was downregulated by the MCPyV early gene, as T antigen

238 -) T cells as was mTOR, and their expression was downregulated by the overexpression of miR-15b/16.

239 RA two-component sensory transduction system was downregulated by the presence of FCS.

240 A-DRalpha, a member of the MHC-II molecules, was downregulated by the replication and transcription a

241 The gene was downregulated by the syrA gene product and also by g

242 nd important target of CDC42b and ACK, which is downregulated by their combined actions in promoting

243 mune response and inflammation pathway genes were downregulated by thiazolidinedione treatment, beta-

244 (atypical protein kinase C [aPKC]-PAR6-PAR3) were downregulated by TNF-alpha signaling in intestinal

245 microRNAs (miRs), miR-126 and miR-126*, that are downregulated by TNFalpha and IFNgamma in a human br

246 The expression of survivin was downregulated by TP.

247 The ICAM-1 adhesion response to WSCM was downregulated by transfecting HAECs with ICAM-1 siRN

248 HER2-overexpressing breast cancer cell lines was downregulated by transfection with HER2 small interf

249 y, similar to c-Myc, the expression of Gfi-1 is downregulated by transforming growth factor-beta (TGF

250 itutive expression of NF-kappaB in NHL-B can be downregulated by treatment with antibodies to CD40 or

251 tive pathways regulating cell migration that are downregulated by tumor suppressor PTEN: one involves

252 thelial NO synthase (eNOS), whose expression is downregulated by tumor necrosis factor (TNF)-alpha at

253 d by twofold or greater, and 173 genes (51%) were downregulated by twofold or greater.

254 Here we demonstrate that Smo is downregulated by ubiquitin-mediated endocytosis and d

255 y expressed IL-15 mRNA, and IL-15 expression was downregulated by ultraviolet B radiation in cultured

256 GFP and ONE HELIX PROTEIN1 transcript levels were downregulated by up to 90%, and GFP protein levels

257 , and further show that like MICA*008, MELTF is downregulated by US9 via CLPTM1L during infection.

258 rived growth factor-b, and S100A4 in R-cells were downregulated by valproic acid and suberoylanilide

259 oth muscle cells (VSMCs), and its expression is downregulated by vascular injury or other conditions

260 n additive effect on RUNX1 expression, which was downregulated by VEGF modulation.

261 n additive effect on RUNX1 expression, which was downregulated by VEGF modulation.

262 In proneural GBM, apelin levels were downregulated by VEGFA or VEGFR2 blockade.

263 localized to the nucleus, and its expression was downregulated by water stress.

264 n-inducible, and we also identify genes that are downregulated by ZAP during an innate immune respons