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1 f HMPA in more complex systems are likely to be fraught with a high degree of uncertainty.
2 layed over the helical scaffold such that it is fraught with a huge steric strain to undergo required
3 lity to cross-couple secondary alkyl centers is fraught with a number of problems, including difficul
4  with the most efficient regimens available, is fraught with a substantial proportion of failures to
5 pheral percutaneous transluminal angioplasty is fraught with a substantial risk of restenosis and rei
6                           Bacterial survival is fraught with antagonism, including that deriving from
7 isting reprogramming methodologies, however, are fraught with caveats, including a heavy reliance on
8  the management of anophthalmia in the child is fraught with challenges and nuances, the principal ai
9         Predictive modeling of clinical data is fraught with challenges arising from the manner in wh
10                         Biomedical discovery is fraught with challenges stemming from diverse data ty
11 onal solvothermal approach, while prevalent, is fraught with challenges such as complicated processes
12     Learning their structure and intricacies is fraught with challenges, and often side-stepped in fa
13                       However, measuring Phi is fraught with challenges, as current quantification me
14 r, the transition to biodegradable packaging is fraught with challenges, including scalability, cost-
15 analytic model in a new clinical environment is fraught with challenges.
16 peratures exceed the bounds of observed data is fraught with challenges.
17 fter for nanoparticle assembly research, but is fraught with challenges.
18 ically ill coronavirus disease 2019 patients was fraught with challenges and generated a strong feeli
19 relationships after termination of treatment are fraught with complexities and are the subject of ong
20 ous interpretation of the measured C/O ratio is fraught with complexity(4).
21 healing following third-degree burn injuries are fraught with complications, often resulting in long-
22 main the mainstay of care for IOI, their use is fraught with complications and side-effects, suggesti
23  permanent extended-length tracheostomy that is fraught with complications including mucus plugging a
24  vitro evaluation of colistin susceptibility is fraught with complications, due in part to the inhere
25 clarified the nature of PTLD, the literature is fraught with conflicting experience and outcomes with
26    For membrane proteins, the extrapolations are fraught with considerable uncertainty as the denatur
27                     Data sharing in research is fraught with controversy.
28        Inferring the size of extinct animals is fraught with danger, especially when they were much l
29 c target genes, particularly in cancer, have been fraught with dead ends and context-specific functio
30 id lichens, particularly the genus Lecanora, are fraught with difficulties arising from hidden divers
31 the inference of their parameters from data, are fraught with difficulties because the dynamics depen
32    However, all elements of informed consent are fraught with difficulties due to the unique nature o
33 ffective in releasing the drug rapidly, they are fraught with difficulties inherent in processing par
34        However, use of the Tet-On system has been fraught with difficulties, including high backgroun
35 r, attempts at targeting these pathways have been fraught with difficulties.
36 blem, but benchmarking and interpreting them is fraught with difficulties (need to compare them on a
37 ing this pre-biomineralization fossil record is fraught with difficulties, leading to controversial a
38 using RPM might seem straightforward, but it is fraught with difficulties.
39 nodes of the webs and the links between them is fraught with difficulties.
40 election in experimentally derived sequences is fraught with difficulties.
41 termining this location crystallographically is fraught with difficulties.
42  practice or clinical research, however, has been fraught with difficulty.
43 TA induction is extremely important, but has been fraught with difficulty.
44                           Replication of DNA is fraught with difficulty and chromosomes contain many
45                        Predicting the future is fraught with difficulty; nonetheless, it is apparent
46 g direct links across phenotypic hierarchies is fraught with difficulty; we identify issues complicat
47                 Although testing of mAbs has been fraught with failure and confusing results, the exp
48 t strategies for reconstructing bony defects are fraught with inadequacies.
49 ses, the randomized trials used for analysis are fraught with inconsistencies, including the availabi
50                      However, the literature is fraught with inconsistent accounts as to whether vari
51             Yet, such sophisticated analyses are fraught with interpretive difficulties.
52  However, machine learning in the microbiome is fraught with issues of reproducibility, driven in lar
53                                      Staples are fraught with limitations including high-localized ti
54 s, the implementation of these maneuvers has been fraught with limited activity and lack of specifici
55 e modification may be helpful, but even this is fraught with limited efficacy and potential complicat
56          Heart valve replacement in children is fraught with long-term morbidity and mortality rates,
57 st has been colon; however, most series have been fraught with major complications and conduit loss.
58            The history of ALS drug discovery is fraught with many stops and starts.
59 hough studies of trauma system effectiveness are fraught with methodologic difficulties, several type
60 e evidence base is limited, and most studies are fraught with methodologic limitations, including cro
61 tween studies, because quantification of AEA is fraught with methodological difficulties.
62                                The condition is fraught with misconceptions that have slowed progress
63 roup and neighboring phosphoglyceryl complex were fraught with obstacles.
64                 Healthcare work environments are fraught with occupational hazards that can impact nu
65 , eliciting reliable responses from newborns is fraught with operational difficulties, and studies wi
66  characterizing the heterogeneity accurately is fraught with parametric uncertainty.
67                     Commercializing research is fraught with pitfalls, but a thoughtful checklist can
68 nomic characters means that using these data is fraught with potential difficulties, leading to error
69 iagnosis of some infectious diseases and yet is fraught with potential pitfalls.
70 gainst infection, and current drug therapies are fraught with problems, predominantly because of the
71                                Clearly, both are fraught with problems.
72  Emergency airway management in children can be fraught with problems.
73 o map the genes for psychotic illnesses have been fraught with problems.
74 l tool in the armoury against cancer, but it is fraught with problems due to its global systemic toxi
75                      Travel into outer space is fraught with risk of exposure to energetic heavy ion
76 ment of highly performant but "black box" AI is fraught with risk, and high-profile errors could dama
77 nistration of such myeloablative transplants is fraught with risks, some of which are related to the
78 , present methods to measure telomere length are fraught with shortcomings that limit their use.
79 s only target disease motor symptomology and are fraught with side effects.
80 t the road to integration and acceptance has been fraught with skepticism and technical hurdles.
81 stic category guiding translational research is fraught with so many problems that the validity of re
82  African populations, but its implementation is fraught with substantial ethical governance risks tha
83 tandard therapy for Wegener's granulomatosis is fraught with substantial toxicity and not always effe
84                         However, iPSC models are fraught with technical limitations including abnorma
85           The study of human-animal chimeras is fraught with technical and ethical challenges.
86 ion of HCV replication in extrahepatic sites is fraught with technical challenges, and in vitro syste
87 primary tumors, however, the analysis of LOH is fraught with technical problems that have limited its
88 g MYC expression in hepatocellular carcinoma are fraught with the theoretical possibility of injuring
89 tion in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the ag
90                       The study of virulence is fraught with the paradox that virulence, despite bein
91 re many effective choices, but as a class it is fraught with the risk of serious peptic ulcer disease
92              Unfortunately, such predictions are fraught with uncertainty, as sensitivity is extrapol
93  will go functionally extinct in the future, are fraught with uncertainty.
94  A patient's decision to undergo surgery may be fraught with uncertainty and decisional conflict.
95 nce current treatment methods for KS and PEL are fraught with unwanted side effects and low efficienc
96              Handling of neutrophils ex vivo is fraught with unwanted heterogeneity and alterations t
97 eroid treatments for uveitis while effective are fraught with vision threatening side effects.