ライフサイエンスコーパス: be guided by

1 d in a single multidomain protein, Cas9, and are guided by a co-processed dual-tracrRNA:crRNA molecul

2 During directed migration, cells are guided by a combination of mechanical and chemical c

3 axons navigate in a complex environment and are guided by a concerted action of attractive and repul

4 In episodic sampling, decisions are guided by a few episodic memories of past choices.

5 Simulations are guided by a phylogenetic tree and incorporate differ

6 ses in which inflammation is involved should be guided by a clear understanding of the immunotherapeu

7 ne networks and stress that such design must be guided by a combination of heuristic models and mecha

8 Antithrombotic therapy should be guided by a comprehensive assessment of intrinsic ris

9 ernating between invoking them is thought to be guided by a conscious decision.

10 Implementation of interventions can be guided by a greater understanding of social-ecologica

11 on nanomaterials for LIBs and PEMFCs should be guided by a life-cycle perspective.

12 scientific discovery in motor BMIs that have been guided by a closed-loop control view.

13 n of this sound increased the probability of being guided by a honeyguide from about 33 to 66% and th

14 The assembly of TAD models is guided by a complete low-resolution chromosome model.

15 of an inherently disordered amorphous silica is guided by a highly ordered proteinaceous scaffold, th

16 oth plant and animal morphological variation is guided by a mid-development period of transcriptome d

17 odel, which assumes that synaptic plasticity is guided by a novel surprise detection system, captures

18 The formation of new daughter centrioles is guided by a pre-existing, mother centriole.

19 e novel objects, so performance on this task is guided by a sense of familiarity for the constant neg

20 The immune system is guided by a series of checks and balances, a major co

21 n vitro biochemical analysis shows that C2c2 is guided by a single CRISPR RNA and can be programmed t

22 differentiation of follicular keratinocytes is guided by a specialized mesenchymal population, the d

23 ion of a human breast cancer xenograft model was guided by a bi-phasic host cytokine response that pe

24 The selection of to-be-fixated locations was guided by a different feature (luminance contrast).

25 Data extraction was guided by a merged and modified version of a Best Ev

26 Dose selection was guided by a preclinical model in mice and nonhuman p

27 days of therapy, open-label warfarin dosing was guided by a web application.

28 ng studies of the PNPase-RNase Y interaction were guided by a homology model ofB. subtilisPNPase base

29 and maximum tolerated dose (MTD) estimation were guided by a modified Bayesian continuous reassessme

30 nt would be considerably better if therapies were guided by a tumor's genomic alterations.

31 ment could be markedly improved if therapies were guided by a tumour's genomic alterations.

32 he maturation of auditory brainstem circuits is guided by action potentials (APs) arising from the in

33 Ablation was guided by activation/entrainment mapping for tolerat

34 Catheter ablation was guided by activation/entrainment mapping for tolerat

35 It has been suggested that eye movements may be guided by activity in the lateral intraparietal area

36 he development of cancer immunotherapies has been guided by advances in our understanding of the dyna

37 Hemodynamic management was guided by algorithms including upper limits for flui

38 Dissemination and implementation efforts may be guided by an environmental scan to detail readiness f

39 ensus, management of such emergencies should be guided by an understanding of the underlying pathophy

40 hway assessment and data interpretation have been guided by an historical conceptual model in which v

41 Being guided by an RNA to cleave double-stranded (ds) DN

42 t models of visual search assume that search is guided by an active visual working memory representat

43 we show that the emergence of these patterns is guided by an effective Peclet number.

44 formation, suggesting that prion conversion is guided by an environment of proconversion and anticon

45 The design of the cross-links was guided by an analysis of the conformational properti

46 Purification of the enzyme was guided by an assay that used a quenched fluorogenic

47 In this study, we were guided by an emerging systems-based conceptualizati

48 Our strategy was guided by analysis of previous radialene syntheses,

49 with stable coronary artery disease, but PCI was guided by angiography alone.

50 t alternatives we have never experienced can be guided by associations between current choice options

51 a heterohexameric ring of AAA-ATPases, which is guided by at least four RP assembly chaperones in mam

52 tablished that social judgments and behavior are guided by attitudes and stereotypes of which the act

53 Model selection was guided by backward stepwise selection conducted on t

54 kocytes from blood vessels to inflamed zones is guided by biochemical and mechanical stimuli, with th

55 ed approaches in childhood cancers, few have been guided by biomarkers or clinical-grade assays devel

56 This highly concise route was guided by biosynthetic logic and enabled by an unusu

57 Covert and overt spatial selection behaviors are guided by both visual saliency maps derived from ear

58 general mechanism allows for development to be guided by both the genetic blueprint as well as the e

59 Therefore, relative responding is guided by both internal and external cue sources.

60 rate that human glioma cells whose migration is guided by bradykinin generate bleb-like protrusions.

61 Embryogenesis is guided by cell-cell and cell-matrix interactions, but

62 during anterior-posterior axis specification is guided by centrosomes, resulting in anterior-directed

63 While most synthetic developments are guided by changes in ensemble properties, certain ap

64 Most importantly, measurements are guided by chemical responses, which make LIBS-based

65 e migratory and functional behavior of which is guided by chemokine or cytokine gradients.

66 ell proliferation in response to lymphopenia was guided by classical homeostatic resources, such as I

67 alysis (APD) is increasing worldwide and may be guided by clinical characteristics, financial issues

68 suggests immunotherapy administration should be guided by clinical features of encephalitis, rather t

69 For now, optimal treatment will need to be guided by clinical trials.

70 and textile properties of the surgical mesh was guided by clinical feedback from hernia repair proce

71 Management strategy was guided by clinical status, splanchnic organ function

72 th moderate/complex congenital heart disease be guided by clinicians trained in ACHD.

73 motherapy in patients with breast cancer may be guided by clinicopathological factors and a score bas

74 y of new solid-state electrolytes (SSEs) can be guided by computation for next-generation Li batterie

75 Our experiments were guided by computational studies that revealed struc

76 Our approach is guided by concepts and theory from the field of "mono

77 novel computational model in which learning is guided by confidence-based reinforcement signals, we

78 therapy for PDR, treatment decisions should be guided by consideration of the relative advantages of

79 ngate along one side wall of the channel and are guided by contact with the wall to the contiguous br

80 Clinicians were guided by continuous glucose monitoring and explici

81 n and morphogenesis of many non-muscle cells are guided by contractile actomyosin bundles called vent

82 Treatment was guided by controlling intracranial pressure and cere

83 rphogenesis occurs in 3D space over time and is guided by coordinated gene expression programs.

84 uided by local density gradients, our method is guided by correspondences between the alpha-helices i

85 a membrane, and the orientation of synthesis is guided by cortical microtubules; however, the guiding

86 mbination in the Cre-loxP system has largely been guided by crystallographic structures of tetrameric

87 l compared with participants whose treatment was guided by CT.

88 Much climate policy discourse has been guided by "current knowledge" of the DeltaTs uncert

89 at can occur when antihypertensive treatment is guided by CVD risk.

90 In Arabidopsis, pollen tubes are guided by cysteine-rich chemoattractants to target t

91 T cell responses are guided by cytokines that induce transcriptional regu

92 epted model that vesicles at the plasmalemma are guided by cytoskeletal tracks to specific sites on t

93 The initial model development in this study was guided by data and hypothesized processes from a pre

94 Optimization was guided by density functional theory computations, su

95 enetic and process factors, so that both can be guided by design of experiments (DOE).

96 ication is needed to improve care and should be guided by direct pathophysiologic markers of arrhythm

97 ) loops 1 and 2, whereas peptide selectivity is guided by direct interactions with the TCR CDR3 loops

98 The differentiation of each subset is guided by distinct regulatory requirements, including

99 zes reward and minimizes cost/punishment and is guided by dopamine (DA).

100 that sculpt the emerging tissue architecture are guided by dynamic basement membranes.

101 using membrane-anchored PG synthases, which are guided by dynamic cytoskeletal elements.

102 We adopt a complementary approach that is guided by ecological interactions, whereby cyclical p

103 artial caloric compensation may consistently be guided by ED.

104 chanistically, superficial revascularization is guided by epicardial Cxcl12-Cxcr4 signaling and intra

105 Cytotoxic T cell differentiation is guided by epigenome adaptations, but how epigenetic m

106 These decisions should be guided by ethical principles and values, should not b

107 U, and emphasizing that NGU treatment should be guided by etiologic diagnosis.

108 Human behavior is guided by evolutionarily shaped brain mechanisms that

109 disease is an enormous challenge, and should be guided by evolutionary principles.

110 Spectral interpretations were guided by examination of the calculated transition

111 nfirm that the perception of others' actions is guided by expectations of efficient actions, which ar

112 values to guide choice, more so when actions were guided by experienced than by predicted values.

113 Development of G-OnRamp was guided by extensive user feedback.

114 Reward-seeking actions can be guided by external cues that signal reward availabili

115 s abolished in these brain areas when travel was guided by external cues.

116 rocesses during normal embryonic development are guided by extracellular soluble factors such as morp

117 that covert and overt attentional orienting are guided by feedback projections of visual and visuomo

118 of additional EH risk-outcome pairs need to be guided by findings of systematic reviews, the size of

119 To obtain this structure, we were guided by findings from single-molecule fluorescenc

120 Our understanding of the PI3Ks in immunity is guided by fundamental discoveries made in simpler mod

121 bital with a sigma orbital or a p/pi orbital is guided by geometrical aspects present in the starting

122 We detected 68 Psis on rRNA, which are guided by H/ACA small nucleolar RNAs (snoRNA).

123 larger proportions of clinical practice can be guided by high-quality evidence; clinicians and their

124 The atoms are guided by horizontal red-detuned laser beams which c

125 A rational design of a catalyst can be guided by identifying descriptors that determine its

126 ther fixation selection in real-world scenes is guided by image salience or by objects has been a mat

127 Research prioritization should be guided by impact of disease.

128 The synthesis was guided by in situ X-ray powder diffraction studies,

129 Optimization of CL(u) within the series was guided by in vitro metabolite identification, and th

130 umab treatment regimen (q12-week or q8-week) was guided by individual disease activity assessment usi

131 triggers for intervention but decisions can be guided by information from histology, prostate-specif

132 selection during cell line development must be guided by information on potential chain mispairing t

133 f the preceding step, and (2) foot placement is guided by information about the position of the targe

134 ation did not affect choice behavior when it was guided by innate taste aversion.

135 protocols for tolerance induction that will be guided by innovative immune monitoring tools.

136 ate CD4(+) T cell help for cellular immunity is guided by instructive signals received during DC matu

137 The first step is guided by interactions between the catalytic HECT dom

138 Such behaviors are guided by internal representations of choice values

139 s with targeted properties has traditionally been guided by intuition, and trial and error.

140 a task where the rhythmic tapping of monkeys was guided by isochronous stimuli separated by a fixed d

141 The transitions were guided by key electrostatic interactions between sp

142 hyroidectomy in hereditary cases of MTMC may be guided by knowledge of specific exon mutations and ca

143 searching real-world scenes, human attention is guided by knowledge of the plausible size of target o

144 studies of such intermediate representations are guided by linguistically defined concepts, such as p

145 The content of the OPAS was guided by literature review, a body of experts, and

146 Unlike existing methods that are guided by local density gradients, our method is gui

147 The initial choice of antibiotic is guided by local microbiological knowledge and by subs

148 y at specific sites, such as tumors, and can be guided by magnetic resonance imaging.

149 moshadow domain but not its chromodomain and was guided by maternally provided signals.

150 Chemical modifications were guided by measuring interactions between the compou

151 while collective forces on longer timescales are guided by mechanical feedback from the extracellular

152 behaviors, in two tasks: one where attention was guided by memory and another in which attention was

153 the performance of sequential movements that were guided by memory.

154 the performance of sequential movements that were guided by memory.

155 to select an optimal synthetic sequence that is guided by metrics including efficiency, quality and y

156 This effect is guided by microchannel size-specific regenerative mac

157 Thus, CENP-E-driven chromosome congression is guided by microtubule detyrosination.

158 ion within human fronto-parietal cortex that is guided by momentary attentional demands.

159 d activity relies upon afferent feedback and is guided by motor output remains unclear.

160 ressed agreement to several types shows they are guided by multiple and partly conflicting ideals whe

161 This simple, yet intricate, process is guided by multiple initiation factors.

162 centered practice in long-term care settings is guided by multiple person-centered care models.

163 n reaction on contact with adventitious O(2) are guided by nature's design of hydrogenase active site

164 s that cerebellar contributions to cognition are guided by neural oscillations with function-specific

165 Behavior can be guided by neuronal activity in visual, auditory, or s

166 ng experiences trigger escape responses that are guided by nociceptive neuronal circuitry.

167 e deployment of the surge capacity personnel was guided by operational and technical requirement anal

168 now, it has been unclear how the origin DNA is guided by ORC-Cdc6 and inserted into the Mcm2-7 hexam

169 Release is guided by organized charged/hydrophilic surfaces.

170 Evidence-based medicine is guided by our interpretation of randomized controlled

171 Mutagenesis studies on the IA and ECL were guided by our refined model of the ectodomain/TMD i

172 ion of new terminology for resistance should be guided by outcomes data from clinical trials in progr

173 will require many logistic innovations that are guided by overarching conceptual advances in tumor g

174 thus far do not meet this objective as they are guided by pairwise scores that do not utilize the en

175 nsupervised functional impact predictor that is guided by parsimony.

176 with stage 5 CKD who want to avoid dialysis, is guided by patient values, preferences, and goals, wit

177 tion of preclinical findings into the clinic is guided by PET and receptor occupancy studies, particu

178 on-Hodgkin lymphoma whose first-line therapy was guided by PET/CT had significantly better survival c

179 ile single-celled freshwater green alga that is guided by photosensory, mechanosensory, and chemosens

180 inated from small molecules whose reactivity was guided by physico-chemical processes.

181 cumented rationale for additional treatments was guided by physiologic abnormalities (physiology-cent

182 fluid therapy has led to IVF administration being guided by physiological principles with a new cons

183 Piwi was reported by Huang et al. (2013) to be guided by piRNAs to piRNA-complementary sites in the

184 n the core lexicon of a language-word choice is guided by positive frequency-dependent selection-a bi

185 Perception and behavior can be guided by predictions, which are often based on learn

186 Surveillance should be guided by presumed risk of recurrence and functional

187 escribing the new population and context and was guided by principles for cultural adaptation drawn f

188 ory and inhibitory inputs, model fitting can be guided by prior knowledge about the inputs to a given

189 ns for patients with cancer are increasingly being guided by prognostic and predictive markers.

190 The design of 3D-printed living materials is guided by quantitative models that account for the re

191 imidazole-based organo-hydride, whose choice was guided by quantum chemical calculations.

192 Further, many molecular diagnoses are guided by recent gene-disease association discoverie

193 Mapping and successful ablation sites can be guided by recording potentials within or near the CS

194 ngoing use of preexposure prophylaxis should be guided by regular risk assessment.

195 This process is guided by representing the uncertainty in the model t

196 ng or rapid dispersion, some migratory cells are guided by repulsive collisions with their neighbors.

197 The design of such controllers can be guided by results from control theory, including the

198 test the degree to which response selection is guided by reward value and can be adapted when expect

199 projections were not necessary when actions were guided by reward expectations generated based on le

200 This should be guided by risk factors for disengagement and improvin

201 Ablation was guided by RM, but operators could perform entrainmen

202 samples, across multiple sites, that ideally are guided by scientifically credible pathophysiological

203 rly visual processing, visual perception can be guided by second-order stimuli is currently unknown.

204 of synapse development in the CNS, which can be guided by select adhesion molecules such as the Synap

205 atients suspected for pulmonary tuberculosis is guided by serial sputum smears.

206 l axons grow along precise trajectories that are guided by several cues secreted from the ventral mid

207 The conformation is condition-dependent and is guided by several nucleoid-associated proteins (NAPs)

208 Structure-based design was guided by several solved cocrystal structures with M

209 Generation of T lymphocytes in the thymus is guided by signal transduction from the T cell recepto

210 revealed that choices in each sequence type were guided by significantly different patterns of proba

211 snRNA Psis are guided by single hairpin snoRNAs, also implicated in

212 Model selection was guided by single-molecule Forster resonance energy t

213 e, we show that internal Nm modification can be guided by small nucleolar RNAs (snoRNAs), and that th

214 lopmental stages of embryonic patterning and is guided by spatial information provided by complementa

215 be examined is larger than expected but can be guided by specific imaging and clinical features.

216 show that any crystallization from solution is guided by stable or metastable equilibria and thus ca

217 The study was guided by structure-activity-toxicity-property relat

218 The optimization was guided by structure-based design and focused on anti

219 Primary prevention efforts are being guided by study of the exposome (or collective env

220 The tRNA docking orientation appears to be guided by subfamily-specific clusters of amino acids

221 This is observed when foraging behaviors are guided by superior nutritional density or minimized

222 be appropriate, and any intervention should be guided by symptoms and/or disease progression.

223 Synthesis of a compound set was guided by T. gondii SAR with 1r found to be superior

224 daptive execution and inhibition of behavior are guided by the activity of neuronal populations acros

225 nganese metal, while its structural features are guided by the complementary internal packing strains

226 erapeutic strategies for individual patients are guided by the expression status of the estrogen and

227 B-cell responses are guided by the integration of signals through the B-c

228 ice are neither random nor predetermined but are guided by the number of embryos entering the uterine

229 haracteristic photons induced in the samples are guided by the polycapillary to the detector allowing

230 ity suggesting that DNA methylation patterns are guided by the sequence preference of these enzymes.

231 ent technologies and infrastructure and must be guided by the application of green engineering princi

232 ndings suggest that vancomycin dosing should be guided by the AUC and day 2 AUCs should be <=515.

233 a process as specific as protein folding can be guided by the chaperonin machine in a way largely ind

234 Treatment of anemia should be guided by the etiology and may include erythropoietic

235 mes, eukaryotic DNA replication continues to be guided by the fundamental principles and concepts est

236 one chemical, because only one SPP wave can be guided by the interface of a metal and a dielectric m

237 The choice of therapy should be guided by the patient's clinical profile, genomic fea

238 The choice of approach should be guided by the phenotype and localization of the desir

239 on reaction in acid-based electrolyzers must be guided by the proper balance between activity, stabil

240 search suggests that different behaviors may be guided by the same genes and hormones, but that the e

241 Treatment should be guided by the severity of lung impairment, symptoms s

242 Decision making is thought to be guided by the values of alternative options and invol

243 rstanding the regulation of GAC activity has been guided by the development of spectroscopic approach

244 both locally and globally has progressively been guided by the identification of biodiversity 'hotsp

245 ign of adherence interventions has too often been guided by the mistaken assumptions that adherence i

246 Perception is guided by the anticipation of future events.

247 sts that the octasome-to-hexasome transition is guided by the asymmetric unwrapping of the DNA.

248 e expresses the chemokine receptor Cxcr4 and is guided by the chemokine Cxcl12a [20-23].

249 Our derivation is guided by the classical problem of universal approxim

250 Tuning of target transcript levels is guided by the density of homologous small RNAs, whose

251 monitoring by transthoracic echocardiography is guided by the disease severity.

252 of the fission yeast LTR retrotransposon Tf1 is guided by the DNA binding protein Sap1 and that the e

253 y to build an aggregate funding pattern that is guided by the epidemiology of HIV, and particularly b

254 ivation have highlighted that human behavior is guided by the hedonic principle, according to which o

255 t that direct RNC transfer to the translocon is guided by the interaction between SRP and translocon-

256 ecialized effector subsets of mature T cells is guided by the iterative action of transcription facto

257 ittle effect on integration targeting, which is guided by the LEDGF/p75-IN interaction.

258 ry disease, the decision between PCI or CABG is guided by the local Heart Team (team of different car

259 One possibility is that this assignment is guided by the location of the "spotlight" of selectio

260 strate that the fabrication of these tissues is guided by the organisms by regulating the chemical an

261 The 3'-AMP-PPi moiety is guided by the positively charged residues located alo

262 X-ray use in the catheterization laboratory is guided by the principle of as low as reasonably achie

263 The regioselectivity is guided by the pyridyl substituent attached to the nit

264 The strict regioselectivity is guided by the pyridyl substituent attached to the nit

265 Our homology detection strategy is guided by the reference sequence, and involves the si

266 rgue that the development of face processing is guided by the same ubiquitous rules that guide the de

267 gineering where the differentiation of cells is guided by the scaffold and signals, a bottom-up metho

268 sure can induce a distinctive reaction which is guided by the structure of the molecular crystal.

269 offset surface regions where the orientation is guided by the underlying gold lattice.

270 Lagged structural equation modeling was guided by the adapted Wilson and Cleary/Brunner and

271 may potentially represent motor output that was guided by the delta phase.

272 The choice of substrates was guided by the design and development of the next gen

273 ies in which the diagnostic management of PE was guided by the dichotomized Wells rule and quantitati

274 for the BET calculations on these materials was guided by the four so-called "consistency criteria".

275 The reaction development was guided by the idea that the productivity of catalyst

276 This was guided by the intuition that groups of neurons whose

277 Lead delivery was guided by the model in matched views to intraprocedu

278 Plaque localization was guided by the Plaque Simulator computer modeling sys

279 que to other studies, the treatment duration was guided by the presence of baseline RASs among genoty

280 Our retrosynthetic planning was guided by the putative biosynthesis of the unprecede

281 The synthesis process was guided by the seven steps of meta-ethnography.

282 velopment from axillary buds, a process that was guided by the size and position of green sectors in

283 vitro engineering of MT7 finger regions that was guided by the structure, we have converted the selec

284 Data collection was guided by the Systems Engineering Initiative for Pat

285 The initial design and optimization was guided by the use of X-ray structures of inhibitors

286 However, the use of such compounds is guided by their short-term efficacy; the indirect and

287 modeling of the Isu1-Jac1 interaction, which was guided by these experimental data and structural/bio

288 we investigated whether alpha-band phase can be guided by top-down control in a temporal cueing task.

289 minimizing blood loss, fluid management can be guided by transesophageal cardiovascular Doppler, and

290 isms and that, across different contexts, it is guided by two central factors: the gains in reward an

291 this process, known as pragmatic reasoning, is guided by two universal forces in human communication

292 In both groups, marking was guided by ultrasound and/or mammography depending on

293 Learning can be guided by unexpected success or failure, signaled via

294 Subsequent retreatment was guided by VA and OCT with the aim of treating to sta

295 Suicide research has primarily been guided by verbal theories containing vague construc

296 Goal-directed reaching movements are guided by visual feedback from both target and hand.

297 e altered by dynamic circuit mechanisms that are guided by visual stimulation.

298 The decision to insert PICCs should be guided by weighing of the risk of thrombosis against

299 Treatment should be guided by what is done for Onchocerca volvulus as the

300 n declines, health system interventions must be guided by whether the management priority is an incre