ライフサイエンスコーパス: be implicated in

1 f sudden cardiac death in early life and has been implicated in ~10% of sudden infant deaths and unex

2 Hypervalent Fe(V) =O species are implicated in a multitude of oxidative reactions of

3 The basal ganglia are implicated in a range of perceptual functions [1], i

4 Hydrogen sulfide has been implicated in a large number of physiological proce

5 Disruption of Th17-Treg cell balance is implicated in a number of immune-mediated diseases, m

6 Dysregulated cholesterol metabolism is implicated in a number of neurological disorders.

7 Dense granule protein 12 (GRA12) is implicated in a range of processes related to the est

8 ciding to act, the neurotransmitter dopamine is implicated in a valuation of prospective effort and r

9 t incorporation into cell-surface structures is implicated in a variety of bacteria-host interactions

10 ell as synaptic physiology in adult life and is implicated in a variety of neural disorders.

11 P2J2 silencing; these master regulators have been implicated in aberrant cardiac remodeling, heart fa

12 Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers,

13 Autophagy has been implicated in acute kidney injury, which can arise

14 Members of this MMP family were implicated in AD neuropathology.

15 CK-mediated actin cytoskeleton dynamics have been implicated in adipogenesis.

16 ty and phospholipid metabolism and have also been implicated in adult BD.

17 n PCa initiation, a chromatin regulator that is implicated in aggressive PCa.

18 ondrial DNA (mtDNA) sequence and copy number are implicated in aging and organ dysfunction in diverse

19 f mtDNA can cause mitochondrial diseases and are implicated in aging.

20 highlighted several surface loops that have been implicated in allosteric networks in related coagul

21 Amyloid-beta (Abeta) oligomers are implicated in Alzheimer disease (AD).

22 amental to learning and memory in health and are implicated in Alzheimer's pathogenesis.

23 ACAT1 has also been implicated in Alzheimer's disease(4), atheroscleros

24 The accumulation of amyloid Tau aggregates is implicated in Alzheimer's disease (AD) and other tauo

25 of gamma-glutamyl transpeptidase (GGT1) has been implicated in an array of human diseases including

26 essential regulators of gene expression have been implicated in ASD.

27 The hippocampus is implicated in associative memory and spatial navigati

28 ytokines, such as IFN-gamma and IL-17A, have been implicated in asthma pathogenesis, particularly in

29 Noise-induced neuroinflammation is implicated in auditory processing deficits such as im

30 ric acid (GABA) neurotransmission system has been implicated in autism spectrum disorder (ASD).

31 Aberrant OX40 cosignaling has been implicated in autoimmune and inflammatory disorders

32 roduced by EAEC, the Pic serine protease has been implicated in bacterial colonization by virtue of i

33 nt roles in bioenergetics and metabolism and is implicated in biochemical pathways underlying angioge

34 is a versatile transcription factor and has been implicated in both gene-specific regulation and tra

35 isoform of the L-type calcium channel, have been implicated in both PTSD and highly comorbid neurops

36 Polo kinase has been implicated in both stabilizing and destabilizing ki

37 cortex and support that NRG1/ErbB4 signaling is implicated in both critical period and adult visual c

38 amples engage a robust group of regions that are implicated in bottom-up and top-down emotional respo

39 NAT1 has also been implicated in breast cancer progression however the

40 eria and altered intestinal homeostasis have been implicated in CA pathogenesis, and pilot study had

41 tosine dioxygenase family of enzymes and has been implicated in cancer and aging because of its role

42 ntral to the ubiquitination cascade and have been implicated in cancer and other diseases.

43 Human regulatory T cells (Tregs) have been implicated in cancer immunotherapy and are also an

44 s underlying normal tissue regeneration have been implicated in cancer, but the degree of their enact

45 Dysregulation of miRNA expression has been implicated in cancer.

46 Conversely, ATXN1 loss-of-function is implicated in cancer development and Alzheimer's dise

47 central in meiotic HR, and its misregulation is implicated in cancer development.

48 associated with multiple cancers but has not been implicated in CaP thus far.

49 ty is clearly not beneficial, considering it is implicated in certain interferonopathies, in which he

50 LY, an RNA-binding protein recently found to be implicated in cholesterol homeostasis.

51 sis thaliana) clathrin adaptor EPSIN1 (EPS1) is implicated in clathrin-coated vesicle formation at th

52 rmation flow between cortical areas, and has been implicated in cognitive tasks like directing visual

53 al function, and importantly its dysfunction is implicated in cognitive impairment in humans.

54 nslocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis.

55 and tunneling nanotubes, some of which have been implicated in communication defects associated with

56 , including the regions that have previously been implicated in compass-based navigation.

57 [expression quantitative trait loci (eQTLs)] are implicated in complex diseases through unknown molec

58 Because dopamine has been implicated in contextual fear memory, and Ca(v)1.2

59 contributes to vascular development, and has been implicated in coronary artery disease risk.

60 Noncoding RNA molecules have been implicated in critical roles covering a broad range

61 The latter has been implicated in cross-linking the protofilaments.

62 ain, express TREM2, and microglial responses are implicated in dementia pathways.

63 Human isoform 2 GFAT (hGFAT2) has been implicated in diabetes and cancer; however, there i

64 diates diurnal rhythmicity in metabolism and is implicated in diet-induced obesity.

65 RACK1 in a human cell line, as both proteins are implicated in direct translational control.

66 rified ATP13A2, whereas ATP13A2 mutants that are implicated in disease are functionally impaired to a

67 a wide array of physiological processes and are implicated in disease.

68 Th17-mediated immunity has been implicated in disease protection correlates of immu

69 ltiple protein isoforms and mis-splicing has been implicated in disease.

70 of glutathione in liver extracts, which has been implicated in diseases and pathological conditions

71 les in human health, and their misregulation is implicated in disorders ranging from neurodegenerativ

72 The neurotransmitter dopamine is implicated in diverse functions, including reward pro

73 The DNA glycosylase NEIL3 has been implicated in DNA repair pathways including the bas

74 Previously, XRN2 was implicated in DNA double strand break (DSB) repair a

75 l functions, including taste processing, and is implicated in drug craving and relapse.

76 ogenetic mutations in 16 distinct genes have been implicated in EB, encoding proteins influencing cel

77 e PR N88S and RT K103N mutations, which have been implicated in elevated resistance to antiretroviral

78 and alterations in temperature regimes have been implicated in emergent disease outbreaks, making it

79 This recruitment has been implicated in enhanced intact sensory function.

80 Anthropogenic environments have been implicated in enrichment and exchange of antibiotic

81 involved in protein synthesis and DNA damage were implicated in etoposide susceptibility.

82 , and their recruitment to inflamed arteries is implicated in events leading to mortality following M

83 However, viruses have not been implicated in giant cell myocarditis (GCM).

84 Type 2 Innate lymphoid cells (ILC2s) are implicated in helminth infections and asthma where t

85 t-derived bacterial lipopolysaccharide (LPS) are implicated in hepatic fibrogenesis.

86 Though LSD1 is implicated in heterochromatin regulation, its functio

87 luN2B-containing NMDARs have both previously been implicated in hippocampal synaptic plasticity.

88 3(-) T cells, including some genes that have been implicated in HIV expression.

89 Group 2 innate lymphoid cells (ILC2s) are implicated in host defense and inflammatory disease,

90 The blood-clotting protein fibrinogen has been implicated in host defense following Staphylococcus

91 eukaryotes and genes that tune PI signaling are implicated in human disease mechanisms.

92 oRNAs have been described in humans and many are implicated in human pathologies including tissue fib

93 cused exomes, targeting ~5,000 genes know to be implicated in human disease.

94 nia, alterations in brain pathways that have been implicated in human bipolar disorder, and changes i

95 es leads to malignant transformation and has been implicated in human cancers.

96 Dysregulated Notch signaling has also been implicated in human disease, including multiple for

97 Mutations in these critical proteins have been implicated in human diseases including Brugada synd

98 Autophagy of the ER (ER-phagy) is implicated in human neuropathy but is poorly understo

99 tidylcholine, choline transporter deficiency was implicated in impaired membrane homeostasis of other

100 NE proteins are implicated in important cellular processes ranging f

101 ne acetate (DMPA) and vaginal dysbiosis have been implicated in increased risk of human immunodeficie

102 osis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease, modulating

103 Galectins have been implicated in inhibiting BCR signaling in mature B

104 d reemerge in tumors and the TME, where they are implicated in invasion, metastasis, and angiogenesis

105 nflammation and psychologic dysfunction have been implicated in irritable bowel syndrome (IBS).

106 ron-dependent phospholipid peroxidation, has been implicated in ischemic events.

107 gulating endothelin-1 (ET-1) production, has been implicated in IUGR.

108 king memory and cognitive control, have long been implicated in language comprehension, including in

109 ation during brain development and they have been implicated in learning and memory.

110 tions of the local field potential have long been implicated in learning and memory.

111 ssed as a diverse array of spliceoforms, has been implicated in linking the AJ and TJ complex to the

112 th the template base, and the V557L mutation is implicated in low-level resistance to RDV.

113 mitochondrial oxidative phosphorylation has been implicated in macrophage polarization.

114 Wiskott Aldrich syndrome protein (WASp) has been implicated in maintenance of the autophagy-inflamma

115 ptors in medial prefrontal cortex (mPFC) has been implicated in major depressive disorder.

116 Sphingolipids have been implicated in mammalian placental development and f

117 Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasi

118 Amyloids are implicated in many protein misfolding diseases.

119 (mRNAs) to reduce protein synthesis and have been implicated in many diseases, including OA.

120 are highly vulnerable to stressors and have been implicated in many neuro-psychiatric diseases such

121 ent accumulation of damaged mitochondria has been implicated in many neurodegenerative diseases.

122 Their dysfunction has been implicated in many psychiatric disorders, including

123 leads to pathological calcium signaling and is implicated in many common diseases, including cancer

124 eeds by plant populations, known as masting, is implicated in many ecological processes, but how it a

125 eeds by plant populations, known as masting, is implicated in many important ecological processes, bu

126 xyeicosatrienoic acids, which, in turn, have been implicated in mediating several cardiovascular cond

127 ved and variable structural hot spots, which were implicated in mediating functional diversity.

128 Epigenetic mechanisms of tumorigenesis have been implicated in mesenchymal tumours ranging from chon

129 stasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneratio

130 ctivation of type I IFN pathways, which have been implicated in microglial-associated neuroinflammati

131 ssociated with lipid metabolism are known to be implicated in MNDs, there remains a lack of clarity r

132 Genetic variation in CR1 and CR2 have been implicated in modifying disease states but the mech

133 lar biological fluids in PD patients and has been implicated in modulating immune responses in the ce

134 isease-causing mutations in known genes that are implicated in monogenic PID occurred in 10.3% of the

135 A dysfunctional dopamine system is implicated in most psychiatric disorders, and genetic

136 Although CD4+ T cells are implicated in MS pathogenesis and have been the main

137 occurrence or defects in repair enzymes, has been implicated in multiple diseases.

138 on of matrix metalloproteinase-9 (MMP-9) has been implicated in multiple essential roles in the devel

139 nome and the nuclear pore complex (NPC) have been implicated in multiple gene regulatory processes, b

140 stinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative diseases a

141 in various neuronal functions and have also been implicated in multiple neuropsychiatric disorders l

142 Its dysregulation is implicated in muscle wasting diseases.

143 Chronic inflammation has been implicated in myelodysplastic syndrome (MDS); howev

144 -function mechanisms to induce pathways that are implicated in neural degeneration(3-9).

145 Aggregation of tau has been implicated in neurodegeneration, cellular toxicity

146 ging(2), and impaired neurovascular coupling is implicated in neurodegeneration(1).

147 ies indicate that deficits in these pathways are implicated in neurodegenerative diseases, including

148 rupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesi

149 The human Msp1 homologue has been implicated in neurodegenerative diseases, and we sh

150 Dysregulation of TrkB signaling is implicated in neurodegenerative disorders and cancers

151 A large number of genes have been implicated in neurodevelopmental disorders (NDDs),

152 n in excitatory synapses, and its disruption is implicated in neurodevelopmental disorders such as Ph

153 While other HDAC complexes have been implicated in neurogenesis, the physiological role

154 Microglia are implicated in neurological diseases and modulated by

155 teins control nervous system development and are implicated in neurological disorders.

156 Moreover, disruption of these pathways is implicated in neuromuscular disease, and the recent d

157 hydrase (CA; EC 4.2.1.1) isoforms II and VII are implicated in neuronal excitation, seizures, and neu

158 Cortical GABAergic interneurons (CINs) are implicated in NF1 pathology, but the cellular and mo

159 beta4*nAChRs have been implicated in nicotine withdrawal, aversion, and re

160 his dual phenotype, and nine have previously been implicated in nonalcoholic fatty liver disease.

161 ma (HCC), sex hormone receptor signaling has been implicated in numerous aspects of liver cancer path

162 Alternatively, chronic inflammation is implicated in numerous disease processes.

163 entral serotonergic signaling, a system that is implicated in numerous mental disorders in humans.

164 In humans, NEGR1 is implicated in obesity and mental disorders, while NTM

165 integration 1 (Fli-1) signaling network has been implicated in oncogenesis in GBM, making it an appe

166 An MCE transport system called Mla has been implicated in phospholipid trafficking and outer me

167 Microglia have been implicated in playing a role in amyotrophic lateral

168 ient receptor potential channel 6, which has been implicated in podocyte calcium handling.

169 Because infectious diseases are implicated in pollinator declines worldwide, a bette

170 Misregulated EMT has been implicated in processes associated with cancer aggr

171 own-regulation of genes whose orthologs have been implicated in programmed cell death (PCD) in other

172 -ST2 and the PGD(2)-CRTH2 pathways have both been implicated in promoting ILC2 accumulation during ty

173 developmental programs, accessing sites that are implicated in prostate organogenesis.

174 , and complement activity, all of which have been implicated in protection against influenza, have ye

175 ntial to the endosomal-lysosomal pathway and is implicated in protein secretion and clearance, but it

176 Rather, the RG/RGG domain is implicated in providing essential contributions to RN

177 erleukin-23 (IL-23)/T-helper 17 cell pathway is implicated in psoriatic arthritis pathogenesis.

178 system, the primary target of cannabis, has been implicated in psychosis.

179 growth factor-beta) signaling mutations have been implicated in pulmonary arterial hypertension, wher

180 Reward neurocircuitry has been implicated in QoL, the neural basis of MDD, and the

181 We speculate that the ZC3H5 complex might be implicated in quality control during the translation

182 le in the control of cell migration and have been implicated in Ras-mediated tumorigenicity.

183 many effects on synaptic proteins, STEP has been implicated in regulating excitatory synapses during

184 GAS5 has been implicated in regulating transcriptional activity o

185 gene (rs151177743, p = 2.1 x 10(-7)), which is implicated in regulating excitatory synaptic transmis

186 e compartment within the dorsal striatum has been implicated in reinforcement learning and regulation

187 NCE STATEMENT Orbitofrontal cortex (OFC) has been implicated in representing the expected values of c

188 atibility complex class I (MHC-I), which has been implicated in resistance to immune checkpoint block

189 alized (AHL) transcription factor family has been implicated in restricting rosette growth in respons

190 ine, GABA, and glutamate neurons, which have been implicated in reward and aversion.

191 sion process.SIGNIFICANCE STATEMENT Dopamine is implicated in reward processing, reinforcement learni

192 the RNAP delta subunit and NTPase HelD have been implicated in RNAP recycling.

193 that a large number of host genes that have been implicated in SARS-CoV-2 infection by four genome-w

194 creased glutamate levels in thalamus seem to be implicated in schizophrenia pathophysiology.

195 ditions, and various flagellar proteins have been implicated in sensing roles.

196 lar pathways in the brain reward center that are implicated in sensory and affective manifestations o

197 Dysregulated IL-11 signaling has been implicated in several diseases, including some canc

198 on of SPAK-dependent CCC phosphorylation has been implicated in several neurological diseases.

199 nd disruptions in microbial communities have been implicated in several neurological disorders.

200 SULT4A1 has been implicated in several neuropsychiatric disorders, s

201 ators of cell-to-cell communication and have been implicated in several pathologies including those o

202 Complement is implicated in several inflammatory skin diseases incl

203 the expression level of alpha2delta subunits were implicated in several syndromes and diseases, inclu

204 lthough T-helper type 2 (Th2) cell pathology is implicated in severe disease, the mechanisms underlyi

205 SLN has also been implicated in skeletal muscle thermogenesis.

206 inhabitant of warm-blooded animals and have been implicated in skin diseases and systemic disorders,

207 uniform downscaling on the postsynaptic side is implicated in sleep- and memory-related processes.

208 birth (6.1%) involving seven genes that have been implicated in stillbirth and six disease genes that

209 fferents from the ventral hippocampus (vHIP) are implicated in stress-induced susceptibility, but lit

210 and dopaminergic systems have independently been implicated in substance use disorder and obesity.

211 We conclude that blunted interoception may be implicated in suicidal behavior.

212 numerous large and small gene families have been implicated in target recognition, including members

213 Because multiple factors are implicated in the aetiology of delirium, there are l

214 Histone-modifying enzymes are implicated in the control of diverse DNA-templated p

215 These data suggest that Th17.1 cells are implicated in the earliest pathogenic phases of HD a

216 MicroRNAs (miRNAs) are implicated in the epigenetic regulation of complex b

217 mune responses including reactive phagocytes are implicated in the etiology of age-related macular de

218 isruptions to this key developmental process are implicated in the etiology of complex neurodevelopme

219 risk, suggesting that immunologic mechanisms are implicated in the etiology of this subset of SCCHN.

220 Molecular pathways under redox control are implicated in the etiopathology of schizophrenia and

221 These fluctuations are implicated in the optimization of reaction barriers

222 Th9 cells are implicated in the pathogenesis of numerous autoimmun

223 Aberrant TGF-beta signalling and EMT are implicated in the pathogenesis of renal fibrosis, al

224 s of or reductions in GABAergic interneurons are implicated in the pathology of severe neuropsychiatr

225 Insect OBPs are implicated in the perception, storage and transport

226 which expresses a distinct set of genes that are implicated in the recognition, phagocytosis and/or e

227 Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous physiologic

228 that deregulation of the SPECC1L gene could be implicated in the development of ocular coloboma.

229 KRAS homo-dimerization has been implicated in the activation of RAF kinases, howeve

230 Cardiac autonomic dysregulation has been implicated in the comorbidity of major psychiatric

231 tions in the E3 ubiquitin ligase parkin have been implicated in the death of dopaminergic neurons in

232 ory and migratory neural crest (NC), and has been implicated in the delamination and migration of the

233 In the retina, LRR proteins have been implicated in the development and maintenance of fu

234 Somatic copy number aberrations (CNAs) have been implicated in the development and progression of va

235 Brassinosteroids have been implicated in the differentiation of vascular cell

236 HELLS has been implicated in the DNA damage response, but its mech

237 uidance molecules and neuronal activity have been implicated in the establishment and refinement of n

238 Alpha-synuclein SNCA has been implicated in the etiology of Parkinson's disease (

239 ted serotonergic neurotransmission have both been implicated in the etiology of psychiatric disorders

240 The protease neutrophil elastase (NE) has been implicated in the formation of NETs through proteol

241 he dorsomedial prefrontal cortex (dmPFC) has been implicated in the generation of negative affective

242 rally and functionally diverse proteins have been implicated in the granule initiation process in Ara

243 ated in the tumor microenvironment, CD73 has been implicated in the inhibition of immune function thr

244 differentiation 40 (CD40) in Muller glia has been implicated in the initiation of diabetes-induced re

245 Mitochondrial dysfunction has long been implicated in the neurodegenerative disorder Parkin

246 Mitochondrial dysfunction has been implicated in the pathogenesis of almost all neurol

247 Defective proinsulin processing has been implicated in the pathogenesis of both type 1 and t

248 )-driven inflammatory disorders and has also been implicated in the pathogenesis of gastrointestinal

249 markers of endothelial activation, which has been implicated in the pathogenesis of heart failure (HF

250 IFN-kappa expression has been implicated in the pathogenesis of inflammatory skin

251 P53 has been implicated in the pathogenesis of obesity and diabe

252 of G protein-coupled receptors (GPCRs) have been implicated in the pathogenesis of pulmonary fibrosi

253 Because oxidized lipid mediators have also been implicated in the pathogenesis of rheumatoid arthri

254 sruption of prefrontal cortex maturation has been implicated in the pathophysiology of cognitive defi

255 ons in white matter (WM) microstructure have been implicated in the pathophysiology of major depressi

256 these roles in inflammation, plasminogen has been implicated in the progression of a wide range of di

257 tor of aberrant retinal angiogenesis and has been implicated in the progression of proliferative diab

258 The commensal microbiota has been implicated in the regulation of a diverse array of

259 Oxytocin-like peptides have been implicated in the regulation of a wide range of soc

260 n tumor (OTU) subfamily deubiquitinases have been implicated in the regulation of critical cell-signa

261 While parkin has been implicated in the regulation of mitophagy and prote

262 The antimalarial artemisinins have also been implicated in the regulation of various cellular pa

263 kinase (ERK) 5 signaling, which has recently been implicated in the resistance to BRAF and MAPK/ERK k

264 lthough the hippocampal-amygdala pathway has been implicated in the retrieval of contextual fear memo

265 The extracellular tau has been implicated in the seeding and propagation of tau pa

266 Modified nucleotides have been implicated in the stabilization of RNA structure an

267 Every major immune cell subset has been implicated in the unresolved inflammation of PD, re

268 Deregulated overexpression of MYC is implicated in the development and malignant progressi

269 n-coupled second-messenger systems and RUFY3 is implicated in the establishment of neuronal polarity

270 into highly ordered beta-sheet-rich fibrils is implicated in the pathogenesis of a range of neurodeg

271 ffects of prenatal activation of TLR7, which is implicated in the pathogenesis of autoimmune disease.

272 d prosurvival intracellular signaling, which is implicated in the process of chronic allograft reject

273 (COX-1), a biomarker for neuroinflammation, is implicated in the progression and prognosis of ovaria

274 tory pathway of protein quality control that is implicated in the proteotoxicity-associated neurodege

275 Consistent with this, PNKP is implicated in the repair of both DNA single-strand br

276 case complex and not the MRE11 nuclease that is implicated in the resection of HU-induced stalled rep

277 One mechanism that has been implicated in this cross-linking is glycation throu

278 ites - fumarate, succinate and L-2-HG - have been implicated in this disease process.

279 While six genes have been implicated in this hereditary condition (MFRP, PRSS

280 Ecdysone was implicated in this suppression by a reduction in Bro

281 T-type voltage-gated Ca(2+) channels (VGCCs) were implicated in this pacemaking mechanism, based on t

282 (TSP4) is a pro-angiogenic protein that has been implicated in tissue remodeling and local vascular

283 awing generalized conclusions about how 5hmC is implicated in transcription activity and tissue speci

284 It has been implicated in tumor metastasis, renal tubular acido

285 These enzymes have also been implicated in tumor progression and metastatic dise

286 argest network degrees have been reported to be implicated in tumorigenesis.

287 Dysregulation of this homeostasis is implicated in tumorigenesis and acquired resistance t

288 Retrograde transport of this organelle has been implicated in turnover of aged organelles through l

289 Follicular helper T (T(FH)) cells are implicated in type 1 diabetes (T1D), and their devel

290 hite matter abnormalities of the human brain are implicated in typical aging and neurodegenerative di

291 eonine protein kinase v-AKT homologs (AKTs), are implicated in typical and atypical neurodevelopment.

292 DNA double-strand breaks (DSBs) are implicated in various physiological processes, such

293 These interactions have been implicated in various disease states and, consequen

294 structure of both mRNA and proteins, and has been implicated in various diseases.

295 1, affecting efficient t6A modification, has been implicated in various human diseases.

296 e2 activity and related exosome release have been implicated in various pathological processes, inclu

297 the citric cycle intermediate succinate and is implicated in various pathological conditions such as

298 ome to generate two frameshift products that are implicated in viral immune evasion.

299 eins across the cytoplasmic membrane and has been implicated in virulence in many bacterial pathogens

300 nge domain-containing protein 1 (SMCHD1) has been implicated in X-chromosome inactivation, imprinting