ライフサイエンスコーパス: be important in

1 irus (KSHV) are human gammaherpesviruses and are important in a variety of malignancies.

2 They are important in a wide range of biologic processes, inc

3 icrowave properties of nano-scale structures are important in a wide variety of applications in quant

4 We believe that this method and results will be important in a diversity of areas including mechanica

5 breast cancer cells and that the kinase TTK is important in acute myeloid leukemia.

6 nstream of p110alpha in the trophoblast that are important in adapting placental phenotype.

7 nitor cells and the glymphatic system, which are important in Alzheimer disease pathogenesis, may als

8 Neuroinflammation is important in amyotrophic lateral sclerosis (ALS).

9 clinical and neurophysiological examination is important in antibody-negative patients.

10 Detection of diverse paramagnetic species is important in applications ranging from quantum comput

11 iche specialization in microbial communities is important in assessing consequences of environmental

12 vironmental compartments of the Arctic Ocean is important in assessing the potential threats posed by

13 nt manner and further suggest this mechanism is important in attenuating hypoxic injury.

14 lian homologs of yeast Atg8 protein (mAtg8s) are important in autophagy, but their exact mode of acti

15 ng in immune cells, such as monocytes, which is important in bacteria-driven inflammation, shares a s

16 tions of the cell wall, driven by SCAR/WAVE, are important in balancing cell wall developmental funct

17 Areas of endemism are important in biogeography because they capture facet

18 Enzyme chemotaxis and EED may be important in biology and could have practical applica

19 Photochemical ligation is important in biomaterials engineering for spatiotempo

20 this provides pathways to new materials that are important in biomedical research, energy generation

21 endogenous EPO-Epor signaling in osteoblasts is important in bone remodeling, particularly trabecular

22 Alginate lyases, which are important in both basic and applied sciences, fall i

23 onds within collagen have been recognized as being important in both crosslink formation and collagen

24 The giant sarcomere protein titin is important in both heart health and disease.

25 Although it is important in cancer, Tn modified glycoproteins are no

26 addition to antihemagglutinin antibodies may be important in capturing the true influenza infection r

27 n on the effective surfaces of solid samples is important in catalyst studies.

28 ination of themselves and other proteins and are important in cell growth and differentiation.

29 challenging for beta-barrel proteins, which are important in cellular transport.

30 ilized for dissecting molecular targets that are important in certain cellular phenotypes.

31 Other pathogens were important in certain age groups or sites.

32 Finally, the driver regulators are shown to be important in clarifying the relations between modules

33 he virological evaluation of the results can be important in clinical settings.

34 ting immediate and subsequent graft function is important in clinical decision-making around kidney t

35 ts will fail and the likely cause of failure is important in clinical trial design to either enrich p

36 ly less stable isomers of [4]-helicene might be important in combustion flames as well.

37 ffective nicotine delivery from e-cigarettes is important in consumer acceptance.

38 e social environments over time in ways that are important in contributing to risk and resilience.

39 Evidence abounds that effector functions are important in controlling infections by influenza, Eb

40 osttranslational modifications of NLRP3 that are important in controlling its activation.

41 iding an account of early responses that may be important in controlling infection.

42 his innate immune signaling pathway may also be important in controlling other RNA virus infections.

43 a putative long noncoding RNA (lncRNAs) that is important in controlling innate immunity.

44 Climate is important in controlling the optimal balance of H(2)

45 id-body coupling, with LptF's coupling helix being important in coordinating cavity collapse with Lpt

46 ding and twisting constraints, both of which are important in defining the mechanics of DNA supercoil

47 tal stressor-mediated microscopic injury may be important in delaying tumor initiation from foregut b

48 alisation of mandibular canals in lower jaws is important in dental implantology, in which the implan

49 ng the behaviour of deep-sea sediment plumes is important in designing mining operations that are eco

50 atial patterns of damage that it creates can be important in determining effects on plant fitness and

51 the nasal mucosa in allergic individuals may be important in determining the outcome of viral exposur

52 Genetic factors are likely to be important in determining the risk of stroke but are p

53 mma plays a role in VZV gene programming may be important in determining the tissue restriction of VZ

54 s are associated with transmission risk will be important in determining whether they can directly en

55 The number of vacancies on the nodes is important in determining a tradeoff between the catal

56 The composition of plant cell walls is important in determining cereal end uses.

57 Size is a fundamental cellular trait that is important in determining phytoplankton physiological

58 d the monomeric composition of native lignin are important in developing a fundamental understanding

59 Tissue microarchitecture and mechanics are important in development and pathologies of the Cent

60 on against human influenza A virus infection is important in development of broadly protective ("univ

61 ggesting that different biological processes are important in different groups of tooth surfaces and

62 th the aim to target bacterial proteins that are important in disease causation and progression but d

63 l risk may highlight metabolic pathways that are important in disease development.

64 of cell memory and fold change detection may be important in diverse signaling cascades and multiple

65 n of solutes in two-dimensional random media is important in diverse physical situations including th

66 ne responses that regulate viral replication is important in diversifying the resources available to

67 are known regulators of adult metabolism and are important in driving several aspects of fetal develo

68 stinct phenotypes and effector functions may be important in driving inflammation in experimental CrG

69 on in the acinar cells are now recognized to be important in driving the profound systemic inflammato

70 velopmental processes in metazoans, where it is important in driving cell fate and directing differen

71 eins or arrestins-known as biased agonism(3)-is important in drug development, because the therapeuti

72 njugates (ADCs) using mass spectrometry (MS) is important in drug discovery and formulation developme

73 Chirality is important in drug discovery because stereoselective d

74 ive, fast, and accurate is inevitable, as it is important in drug quality control, point-of-care diag

75 r-a-go-go-Related Gene (hERG) channel, which is important in drug safety assessment and commonly scre

76 TNK2, WASL, and NCK1 were important in early stages of the viral lifecycle, a

77 and order constraints for species invasions are important in ecology.

78 around the receptor binding site (RBS) that were important in elicitation of these broadly reactive

79 cess and functional changes of rare taxa may be important in elucidating the ecosystem stability and

80 uding lectins, in the late secretory pathway is important in embryonic and tissue contexts where cell

81 ivity to environmental conditions, which may be important in enabling rapid cytoskeletal structural r

82 cid cycle, while in anaerobic bacteria, they are important in energy-conserving fermentation and resp

83 in the moss Physcomitrella patens, PpMACRO2, is important in epigenetic modification, stem cell funct

84 in any cancer type; as such, these findings are important in ESCC as well as in other cancer types.

85 4 to surmount their IgE counterpart seems to be important in established peanut tolerance.

86 wing the concentration of bilirubin in serum is important in evaluating the health of the liver, and

87 ubstantial RSV disease burden in adults will be important in evaluation and use of urgently needed in

88 Bias assessments are important in evidence synthesis, but we argue they c

89 ivers beyond our tested lake characteristics are important in explaining long-term trends in thermal

90 Both biotic community and abiotic conditions are important in explaining variation of flower colour t

91 This type of nonredundancy may be important in facilitating social plasticity in A. bur

92 as a feedback inhibitor of RELA/p65 and may be important in facilitating the resolution of inflammat

93 arabrachial nucleus, a brain region known to be important in feeding behaviors, conditioned taste ave

94 We further characterized genes that may be important in future studies of genetically modified c

95 NX1 in conjunction with anti-VEGF agents may be important in future treatments for the management of

96 s ligand vasoactive intestinal peptide (VIP) are important in gastrointestinal physiology, their invo

97 heat flux and wind stress related processes are important in generating precursor positive SSTAs and

98 nt of mitochondrial fatty acid biosynthesis, is important in generating the fatty acid precursor of l

99 lore a role for 2'-OH of GTP and show how it is important in generating the nucleophile.

100 show that subcortical motivational circuits are important in guiding explore-exploit decisions.

101 Motion vision is important in guiding animal behavior.

102 aracteristics of dormant bacteria that might be important in H. pylori infections refractory to treat

103 studies suggest neuronal-glial interactions are important in HD and fl-mHTT is expressed in astrocyt

104 conserved sequence motifs that are known to be important in helix packing.

105 Vitamin D (VD) is important in hepatic fibrogenesis in animal models an

106 than prognostic utility, the latter of which is important in high-risk diseases like IE.

107 Vaccines are important in HPAIV control both for poultry and in p

108 bsequent verification confirmed that CgSTE11 is important in hyperthermal tolerance and the observed

109 ith high-dimensional DNA methylation markers is important in identifying epigenetic pathways between

110 to gene locus, as well as chromatin context is important in identifying implicated TFs from GWAS SNP

111 or harmonic oscillator thermal contributions are important in improving the accuracy of computed Gibb

112 Autophagy is important in inducing cell death or survival in cance

113 plicated virion RNA and host protein factors are important in infection and immunity.

114 Acetate availability was important in influencing bacterial diversity, microb

115 These findings are important in informing policymakers considering furt

116 oglobin in the lung and serum, both of which are important in iron sequestration.

117 um, parasubiculum and the entorhinal cortex, is important in learning, memory, and navigation.

118 diographic-derived index of LV stiffness may be important in LF AS.

119 ACKR2 is important in limiting persistent inflammation, tubula

120 CD4 T cells to endothelium and may therefore be important in linking these cells to cardiovascular co

121 salivary glands which suggests these factors are important in maintaining normal commensals in the mo

122 Constitutive TGFbeta signaling is important in maintaining retinal neurons and blood ve

123 so found that wave and mean flow interaction is important in maintaining the robust spectral structur

124 of structures with submicrometer resolution are important in many areas of science and technology su

125 Gene circuits are important in many aspects of biology, and perform a

126 Excitatory amino acid transporters (EAATs) are important in many physiological processes and crucia

127 lization, mass, and dynamics of microtubules are important in many processes.

128 They are important in many scientific and engineering applica

129 Cell type composition of tissues is important in many biological processes.

130 metabotropic glutamate 5 (mGlu(5)) receptor is important in many brain functions and implicated in s

131 g of such relativistic effects on NMR shifts is important in many branches of chemical and physical s

132 on, lubrication, friction and corrosion, and is important in many processes used by microelectronics,

133 ffects at the smallest scale possible, which is important in many realistic situations.

134 lls protrudes out of the plasma membrane and is important in many signaling processes related to cell

135 fusion for multiple brain regions thought to be important in MDD, and (2) highlight the potential rol

136 Monocytes and macrophages are important in mediating CrGN, but little work has bee

137 Floral traits and rewards are important in mediating interactions between plants a

138 influences on UF microstructure, which could be important in mediating the nonheritable components of

139 IFN-gamma is important in mediating the protection, as IFN-gamma k

140 est that the RNA-binding protein (RBP) ZMAT3 is important in mediating the tumor-suppressive effects

141 pecific quantification of protein biomarkers is important in medical diagnostics, academic research,

142 Cyclobutane rings are important in medicinal chemistry, yet few enantiosel

143 or a hybrid epithelial-mesenchymal phenotype are important in metastasis.

144 Plasmids are important in microbial evolution and adaptation to n

145 Our results suggest that storage method is important in microbiota studies and that the stabiliz

146 Because PRKN is important in mitochondrial quality control and protec

147 appa opioid receptors that are considered to be important in modulating pruritus in conditions such a

148 Parkinson's disease (PD) argue that the GPe is important in motor control.

149 Lung macrophages are important in mounting an inflammatory response to in

150 Macrophages are important in mounting an innate immune response to i

151 sistent colonization of this niche, and many are important in mucosal immunity and vaccine developmen

152 y creates a conundrum because this E2 enzyme is important in multiple signaling pathways, including s

153 roadly defined as any amorphous solid, which are important in nature and have significant societal va

154 Both the element and the species are important in new-born nutrition.

155 as well as intratumoral oHSV gene expression are important in oHSV-mediated GBM therapy.

156 Although genetics are important in opioid use disorder, younger age, male

157 Thoughtful management of irAEs is important in optimizing quality of life and long-term

158 igh risk of experiencing these complications is important in order to prevent disease progression.

159 ts the possibility that this interaction may be important in other eukaryotic systems.

160 al timescale, but related phenomena may also be important in other processes, such as cellular differ

161 ng lifespan and other fitness-related traits is important in our understanding of the selective force

162 understanding these physiological processes is important in overcoming some of the challenges that c

163 The PRRX1 isoforms have been demonstrated to be important in pancreatic cancer, especially in the reg

164 ession occurring in the lung environment may be important in pathogenesis.

165 Optimal fluid management is important in patients with acute brain injury, includ

166 Smoking cessation is important in patients with tuberculosis because it ca

167 ave identified various amino acids likely to be important in peptidoglycan binding and catalytic acti

168 ay diseases, clock biology is also likely to be important in perinatal lung development, where it has

169 ariation in plant-herbivore interactions can be important in pest systems, particularly when insect h

170 signals and their downstream effectors that are important in PH onset and development.

171 erience various complex modes of forces that are important in physiology and disease.

172 ng dead cells and associated cellular debris is important in physiology.

173 ults suggest that kin selection and conflict are important in plants, that the conflict includes not

174 autophagy receptor NBR1 was demonstrated to be important in polyubiquitinated AGR2 clearance in resp

175 Therefore, the diagnosis is important in population with extreme risk of diabetes

176 species that have not been trained on, which is important in practical applications but is often unte

177 MRI is important in pre-treatment evaluation of neuroblastom

178 ne artery blood flow in pregnancy, which may be important in pregnancy disorders characterized by ute

179 In contrast, both Mrc1 functions are important in preventing repeat length instability.

180 tion, additional antibody functions may also be important in preventing infection.

181 1) provides greater maneuverability that may be important in prey capture efficacy, (2) does not prov

182 lized effect of bending-induced stresses may be important in processes like cellular extravasation, w

183 7-committed gammadelta T cells in the dermis is important in promoting tissue immunity.

184 anscriptional programs and epigenomic events are important in providing the necessary metabolic netwo

185 dentification of paths or corridors that may be important in providing connectivity among habitat.

186 e piece, we discuss why a developmental view is important in Psychiatry and how recent genetic-epidem

187 The paper is important in raising 3 issues of continued relevance:

188 The paper is important in raising three issues of continued releva

189 e referral of CKD by primary care clinicians are important in reducing the burden of CKD worldwide.

190 dysfunction, we therefore posit that this G4 is important in regulated local expression of Task3 leak

191 gene expression of neurotrophic factors that are important in regulating cell survival, synaptic remo

192 phisms were identified in or near genes that are important in regulating ciliogenesis through the exo

193 ators and products of the IFN-I pathway that are important in regulating WNV replication are incomple

194 The IL-36 subclass of cytokines may be important in regulating mucosal inflammation and home

195 We also show that PIEZO1 is important in regulating cell number during CNS develo

196 CD38 is important in regulating several Ca(2+)-dependent path

197 These effects are important in relation to nutritional value, health b

198 icro-pore architecture and strong acid sites are important in relevant heterogeneous catalysis suffer

199 ace GRP78 (sGRP78) is expressed on iPSCs and is important in reprogramming, (2) sGRP78 promotes cellu

200 Predicting mortality risk in patients is important in research settings.

201 Although genetic testing is important in research, it is not recommended for pred

202 Handling uncertainty reasoning is important in researching ontology.

203 damage, and the regulation of NTH1 activity is important in resisting oxidative stress and in suppre

204 ced protein 44-like (IFI44L), as potentially being important in respiratory syncytial virus (RSV) inf

205 rmation is the nucleoprotein, NP, which also is important in RNA encapsidation and synthesis.

206 extensively studied multifunctional miRNAs, is important in several human malignancies such as diffu

207 Long term stability is important in several of the recent applicative develo

208 ent fashion.SIGNIFICANCE STATEMENT This work is important in several ways.

209 been discovered in the past several years to be important in shaping the cellular immune response.

210 The inflammatory component may be important in shaping the clinical and neuropathologic

211 uding eradication of invasive predators, may be important in shaping the response of ecological commu

212 The eyes are important in signalling emotions, with the act of na

213 iation of Mk from HSCs may coexist and could be important in situations of increased physiological re

214 sitive to social signals and their valuation is important in social learning.

215 arating integrated from unintegrated HIV DNA is important in some clinical settings to properly study

216 regulatory factor 2 (SMURF2) ligase activity is important in stabilizing EGFR.

217 Homeostasis of neural firing properties is important in stabilizing neuronal circuitry, but how

218 echanisms such as interspecific associations are important in structuring free-living communities, bu

219 Precise measurement of temperature is important in studies of chemical and biological syste

220 and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors.

221 This long duration of efficacy is important in support of active immunization protocols

222 Nevertheless, ongoing safety assessments are important in sustaining vaccine uptake.

223 The pig whipworm Trichuris suis is important in swine production because of its negative

224 These motifs are important in synthesis, particularly for the formati

225 The construction of C(sp(3))-Si bonds is important in synthetic, medicinal, and materials chem

226 The strand escape problem is important in that it predicts the time a dynamic syst

227 , glutaredoxins (GRX) and thioredoxins (TRX) are important in the control of growth mediated by phyto

228 ding oxygen concentrations that suggest both are important in the effects of hypoxia and hyperoxia on

229 Chemical reactions are important in the evolution of low-temperature inters

230 onale: Neutrophil extracellular traps (NETs) are important in the host defense against infection, but

231 IFNs that are induced by virus infection and are important in the host's innate antiviral response.

232 Natural killer (NK) cells are important in the immune defense against tumor cells

233 ur results indicate epigenetic modifications are important in the pathogenesis of CAD and identifying

234 B cells are important in the pathogenesis of many, and perhaps a

235 While protic ancillary groups are important in the performance of iron porphyrin ORR c

236 r studies have shown that aquatic reservoirs are important in the persistence of the disease on the I

237 deposition in the diseased liver and as such are important in the progression of liver fibrosis.

238 superoxide radicals to hydrogen peroxide and are important in the protection against oxidative stress

239 eceptors expressed in the gut and brain, and are important in the regulation of gastrointestinal phys

240 P2X7 receptors are important in the regulation of inflammatory response

241 Mechanical forces are important in the regulation of physiological homeost

242 Seeding effects are hypothesized to be important in the "infectivity" of amyloids and are li

243 periments implicate specific zinc binding to be important in the antimicrobial activity of Hst-5.

244 expression with anti-cytokine therapy might be important in the context of severe acute respiratory

245 tion of innate immune cells is considered to be important in the disease pathogenesis.

246 The FMO modularity revealed here may be important in the evolutionary changes between species

247 teral VPFC regions and their connections may be important in the excessive negative and blunted posit

248 Shifting to the open state is thought to be important in the formation of a proton relay network

249 alence in remote societies, this gesture may be important in the maintenance of long-term pair bonds

250 at treating VRF and cessation of smoking may be important in the management of MS.

251 eoarthropathy indicate their formation could be important in the pathogenesis of OA and AKU.

252 ion of antiangiogenic factors are thought to be important in the pathogenesis of the disease.

253 ant regulator of intestinal barrier that may be important in the pathogenesis of UC.

254 minerals, and bioactive compounds which may be important in the prevention of chronic diseases.

255 d and ammonia nucleation and rapid growth to be important in the relatively clean and cold upper free

256 roposed that introgressive hybridization has been important in the generation of new morphologies and

257 such as survival and recruitment have always been important in the study of population and community

258 ed with GAL in amygdala and hypothalamus, as being important in the protein kinase C (PKC) supported

259 ese data indicate that C3a and C5a signaling is important in the activation and polarization of lymph

260 of specific diagnoses in the medical record is important in the broad context of our existing medica

261 Our data show that metabolic flexibility is important in the CNS in times of bioenergetic stress.

262 ecular structure of acidic aqueous solutions is important in the context of, e.g., atmospheric chemis

263 cesses occurring during species range shifts is important in the current context of global change.

264 lexes, especially of the abundant 3d metals, is important in the design of electrocatalysts and organ

265 d diffusion changes from 0 to 6 years of age is important in the detection of neurodevelopmental diso

266 suggest that decreased HIF-2alpha expression is important in the development of emphysema.Objectives:

267 SECM is important in the development of miniaturized bioanaly

268 , and precise control over T cell activation is important in the development of the next generation T

269 A thorough evaluation of limb perfusion is important in the diagnosis of CLI because it can not

270 he resilience of networked dynamical systems is important in the fields of ecology, economics, critic

271 Detecting bacteria is important in the fields of human health, environmenta

272 Understanding the brain is important in the fields of science, medicine, and eng

273 minent microbiota metabolites such as indole is important in the formation of microbial communities i

274 Store-operated calcium entry (SOCE) is important in the maintenance of calcium homeostasis a

275 curonosyltransferase (UGT) family of enzymes is important in the metabolic elimination of a variety o

276 Early diagnosis is important in the neurologically asymptomatic stage.

277 ent in HDAC7, which is a candidate gene that is important in the parasite's cell cycle.

278 and revived Dirac-like electronic character, is important in the physics of magic-angle graphene, for

279 sympathetic neural control of blood pressure is important in the prevention and/or risk reduction of

280 This is important in the reconstruction of food webs and ener

281 our results suggest that histone methylation is important in the regulation of FXN expression and hig

282 Signaling by the TGF-beta superfamily is important in the regulation of hematopoiesis and is d

283 ke to the sediments and whether illitisation was important in the geological past.

284 r fatty acid fluxes, and perilipin 5 (PLIN5) is important in this process.

285 suggested that stress granule (SG) formation is important in this process.

286 Although Rap1 is important in thrombopoiesis, platelet secretion, and

287 studies demonstrated that PI3K/Akt signaling is important in thyroid hormone receptor beta(PV/PV) kno

288 differed between tendons and across species are important in tissue specification and limb morphogen

289 Sex and psychosocial determinants of health are important in understanding the emerging overlap of M

290 Defining their critical downstream targets is important in understanding Aurora kinase function.

291 complex relationship and understanding them is important in understanding developmental patterning a

292 ral mechanisms underlying space-use patterns is important in understanding how future land-use may im

293 ve timing of GliA and GliR production, which is important in understanding how the duration of Shh si

294 nteraction of avian BST-2 with avian viruses is important in understanding innate antiviral defenses

295 g interactions between bacteria and peptides is important in understanding marine carbon and nitrogen

296 This information is important in view of the increasing proportion of pla

297 However, magnesium and calcium are important in vitamin D metabolism.

298 dders, our analysis demonstrates that sizers are important in vivo and highlights the need to determi

299 Notably, glucose metabolism pathway genes were important in vivo but less so in vitro.

300 and polarisation properties of intense light is important in wide-ranging topics at the forefront of