ライフサイエンスコーパス: be introduced by

1 in the diet of 55 patients; the remaining 12 were introduced by 10 patients at least in traces.

2 Human platelet FVIII expression was introduced by 2bF8LV-mediated transduction of human

3 to their relative frequency and new variants are introduced by a process of random mutation.

4 the germline, where DNA double-strand breaks are introduced by a regulated program and repaired by cr

5 These cross-links are introduced by a single graspetide synthetase, the AT

6 Ig somatic mutations would be introduced by a polymerase (pol) while repairing DNA

7 We first met on a Boston streetcar in 1940, being introduced by a mutual friend.

8 netics of motors at the protrusion tip which is introduced by a boundary condition.

9 For serotonin, a link to the indole core is introduced by a Claisen rearrangement from the allyla

10 Bending is introduced by a strong (i, i + 8) hydrophobic interac

11 ne in 2,2'-positions of the 4,4'-bipyridines was introduced by a copper-catalyzed Finkelstein reactio

12 pment in NOD/Lt mice, a disrupted Casp1 gene was introduced by a speed congenic technique.

13 ed with lines where endogenous PsGA3ox1 (LE) was introduced, by a series of backcrosses, into the sam

14 and assembly of ribosomes, operon variations were introduced by a plasmid into an Escherichia coli st

15 Insertions were introduced by a two-step mutagenesis procedure into

16 attice-spring lattice-Boltzmann model (GLLM) is introduced by adding a three-body force in the tradit

17 A hydrogen bond or hydrophobic interaction was introduced by adding a single functional group to th

18 48 segment of the eventual triene side chain was introduced by addition of a functionalized Grignard

19 ed by electrolyte gating or oxygen vacancies are introduced by adjusting growth conditions.

20 Out-of-plane curvature is introduced by adjusting the particular position and p

21 OVA-specific CD8(+) T cells were introduced by adoptive transfer and then activated

22 ve generated much interest since the concept was introduced by Aleksandr Oparin in the 1920s, and the

23 eletion of 727 bp in the 5' end of the gene, was introduced by allelic replacement into S. aureus Rey

24 incorporating a 6-hydroxy group proposed to be introduced by alpha-hydroxylation of the thioester of

25 The first two stereocenters are introduced by an asymmetric allylic alkylation react

26 Immortal time bias is introduced by an "anytime-in-pregnancy" exposure defi

27 Specificity of the immunoassay was introduced by an anti-immune complex (IC) antibody b

28 n in educational attainment among women that was introduced by an educational policy (a school-entry

29 disease in which the 79A murine prion strain was introduced by an intraperitoneal route into BALB/cJ(

30 red strategy, and the tertiary hydroxy group was introduced by an NBS-mediated bromination-nucleophil

31 The C23 hydroxyl of oridamycin B was introduced by an sp(3) C-H bond oxidation at a late

32 Moreover, the pyro-phototronic effect can be introduced by applying a -0.45% compressive strain to

33 es suggest two acceptors and one donor level were introduced by As doping with activation energies at

34 The absolute stereochemistry was introduced by asymmetric Noyori reduction of furfury

35 naturally occurring hypermodified nucleoside was introduced by automated chemical synthesis.

36 the second in that the nitrogen atom at C-9 is introduced by azidation of the C-9/C-10 olefin, follo

37 The propionyl-lysine modification is introduced by bacterial Gcn-5-related N-acetyltransfe

38 led low numbers of off-target mutations that were introduced by base editing, located predominantly i

39 by fungi; antimicrobials and acaricides that are introduced by beekeepers; and fungicides, herbicides

40 This question was introduced by Ben-Eliezer et al. ["Is this correct?

41 the concept has attracted much debate after being introduced by C.

42 Additionally, an aldehyde group was introduced by C-H amidation, enabling oxime ligation

43 e HPV vaccines are highly effective and have been introduced by Cameroon's Ministry of Health (MOH),

44 c organic matter on the early Earth may have been introduced by carbonaceous asteroids and comets.

45 This distance was introduced by Cardona and his co-authors, building o

46 Vascular injury was introduced by carotid air-dry endothelium denudation

47 The results are consistent with the disease being introduced by cattle infected with T b rhodesiense

48 mple cell we can detect 3-A-sized steps that are introduced by cell translations at rates of 10 Hz, w

49 Typically, anisotropy has been introduced by changing the shape of the inorganic n

50 The term was introduced by Charles Sherrington in 1897.

51 genesis refers to atom-specific changes that are introduced by chemical synthesis, such as the replac

52 n, hydrophobic and hydrophilic moieties have been introduced by chemical and mutagenic methods to the

53 These have been introduced by chemical synthesis at central sites w

54 Unnatural amino acids were introduced by chemical synthesis at the N- and C-ca

55 pH-switchable ion-transport selectivity was introduced by chemisorbing L-cysteine to the inside

56 The term "autophagy" was introduced by Christian de Duve in part based on ult

57 etically modified plants when R genes cannot be introduced by classical breeding.

58 s and the reactants for the modification can be introduced by coating them onto the AFM tip.

59 initiate movement only if surface asymmetry is introduced by coating the beads on one hemisphere.

60 ontaining BR96 V region sequences, mutations were introduced by codon-based mutagenesis at single pos

61 proposed process, mutations in the Ig locus are introduced by copying short segments from other Ig g

62 rectly investigate the consequences of virus being introduced by DCs or T cells, we reinjected ex viv

63 egments, increased junctional diversity that was introduced by differential TdT activities, and somat

64 sMMO hydroxylase into which product alcohols were introduced by diffusion represent the structures in

65 We speculate that the tandem mutations are introduced by direct sequential misinsertions and th

66 ion, and the halogens in the aromatic ring A were introduced by direct halogenation of protected comp

67 nger pertains, provided additional mutations are introduced by directed evolution.

68 +/- 0.4 mug of MC and 1.0 +/- 0.5 mug of DC were introduced by downstream sample preparation (drying

69 ya, dehydroamino acids in signaling proteins are introduced by effector proteins produced by pathogen

70 were observed in both LTRs, which could have been introduced by either RT or RNA pol II, whereas the

71 Those hydrazide groups are introduced by electrografting of diazonium salts or

72 DNA substrates generated by recombinant PCR are introduced by electroporation into strains containin

73 re linked to a luciferase reporter gene have been introduced by electroporation into the retinoblasto

74 The best inhibitor of the Shc domain was introduced by electroporation into Rat1 fibroblasts

75 ry system, nanoparticles and protein species are introduced by electrospray injection from the fluid

76 ently, dual viral transneuronal labeling has been introduced by employing recombinant strains of PRV-

77 A transient membrane permeability switch was introduced by employing the well-known pH-increasing

78 complementarity determining regions that had been introduced by engineering these segments next to hu

79 paradigm called the 'exposome' has recently been introduced by epidemiologists in order to define th

80 Mutations can be introduced by error-prone polymerases such as polymer

81 the intended substitutions, novel mutations were introduced by errors that occurred during PCR.

82 A design rule is introduced by establishing and proving the theoretica

83 Phe37 might be introduced by evolution generating a catalytic advant

84 Selection bias was introduced by exclusion criteria relating to comorbi

85 Female speakers were more likely to be introduced by first name only (17% v 3%; P < .001).

86 ve a professional address and more likely to be introduced by first name only compared with their mal

87 rved between mismatched cytosine base pairs, was introduced by first incorporating a cross-linked pho

88 etate in 20% and 50% H(2)O-CH(3)OH solutions were introduced by flow injection to the interface to IR

89 TAU-Net is introduced by fusion of dense Scale-Invariant Feature

90 ions 71-72, which is shared with KIR3DL2 and was introduced by gene conversion before separation of t

91 In this model, depigmentation was introduced by gene gun vaccination with eukaryotic e

92 ion of the GATA-1 locus in which GATA-3 cDNA was introduced by gene targeting.

93 While specific mutations can be introduced by genome engineering, we still lack scala

94 pha-linked 2,6-dideoxyglycoside l-oleandrose was introduced by gold-catalyzed activation of an o-alky

95 The 8-phenyl group was introduced by Grignard addition to ketone 6 or nucle

96 l hallmark of actively transcribed genes and is introduced by histone methyltransferase (HMT) and its

97 is a corner stone of polyfold theory, which was introduced by Hofer, Wysocki, and Zehnder as a broad

98 d (CAG)(76) and (CAG)(84) repeat motifs have been introduced by homologous recombination.

99 first step, a loxP recombination target site is introduced by homologous recombination into a predete

100 gene encoding the C-terminal McpG-GFP fusion was introduced by homologous recombination into the chro

101 arginine (R454)) within the catalytic domain was introduced by homologous recombination.

102 The problem was introduced by Hubbell et al.

103 biotic fungi were detected, which might have been introduced by human activities, transported by bird

104 Stimuli of potential interest could be introduced by humans, such as an otherwise benign vir

105 itoes transmit pathogens which have recently been introduced by humans and the larvae of the fly suck

106 the overlap complexity of a pattern set that was introduced by Ilie and Ilie is closely related to th

107 inhibited when the RNA replication template was introduced by in vivo transcription from DNA or by t

108 nesis." Meta-substituted analogs of Tyr(274) were introduced by in vitro translation in the presence

109 Instead, competition can be introduced by including a separate mechanism that sca

110 nonlinear threshold response required in VAM is introduced by incorporating 2,2,6,6-tetramethyl-1-pip

111 The salt bridges were introduced by incorporating arginine and glutamic a

112 operators, whereas their unusual properties are introduced by incorporation of gain and loss.

113 ation confirmed an added mechanism of action was introduced by incorporation of the trimethylammonium

114 The Hispaniolan Parrot also likely was introduced by Indigenous people to Grand Turk and Mo

115 t occur naturally in breeding populations or are introduced by induced-mutagenesis methods.

116 Second, response interference was introduced by infrequently changing the location of

117 tified a single "hotspot" at which variation is introduced by insertion of peptide segments.

118 ut closed bipolar electrode (BPE) system has been introduced by integration of hydrogen evolution rea

119 otransmitter release, the Ca(2+) sensitivity is introduced by interactions between the Ca(2+) sensor

120 An antibody to mouse GM-CSF was introduced by intracerebroventricular (ICV) injectio

121 The vector was introduced by intracerebroventricular injections int

122 ntical to those of animals in which leukemia was introduced by intravenous transplantation of the sam

123 ecause the chemical changes in these sludges are introduced by irradiation only, we have a genuinely

124 gy when a micrometer scale-length pre-plasma is introduced by irradiation with a low energy femtoseco

125 to an explicit theoretical concept that had been introduced by Janet-as the basis for classification

126 a vibrant area of research since this field was introduced by Joseph Barcroft, a century ago.

127 empirical equation which its constant, K(r), was introduced by Koohyar in 2011.

128 new version of the motif search problem has been introduced by Kuksa and Pavlovic.

129 X-independent decondensation when DNA damage is introduced by laser microirradiation.

130 Allergen immunotherapy was introduced by Leonard Noon 100 years ago and is the

131 acterial genomes, large proportions of genes are introduced by LGT, as indicated by their composition

132 or biotinylated (-S-PEG-biotin) ligands had been introduced by ligand exchange.

133 ient used in the analysis of microarray data was introduced by M. B. Eisen, P. T. Spellman, P. O. Bro

134 array (SGA) method, wherein a query mutation is introduced by mating to mutant arrays, selection of d

135 , a transgene encoding the BCL2 gene product was introduced by mating into the mutant background, and

136 The 13C8 atom is introduced by means of a ring closure of the exocycli

137 Asymmetry is introduced by means of an enantioselective conjugate

138 The protecting group is introduced by means of the readily prepared benzyl br

139 rization of the biofunctionalization process is introduced by measuring interfacial capacitance which

140 Pay for performance programs being introduced by Medicare and other insurers will lin

141 For 1 and 2, the (18)O atom was found not to be introduced by moisture or by singlet oxygen [(18)((1)

142 copper-coordinating thiolate sulfur of Cys92 is introduced by movement of the amide nitrogens of Phe9

143 more likely from global properties that can be introduced by multiple somatic mutations.

144 We found that phenotypic diversity can be introduced by mutagenesis of the principal sigma fact

145 In this study, carboxylate residues were introduced by mutagenesis into highly oxidizing rea

146 Single Cys residues were introduced by mutation in several consecutive posit

147 The (3)H label is introduced by NaB(3)H(4) reduction and the resulting

148 The RTS,S/AS01(E) malaria vaccine (RTS,S) was introduced by national immunisation programmes in Gh

149 s that a steric hindrance at the active site was introduced by Nbs but removed by cyanide.

150 rhabditis elegans and showed that they could be introduced by nematode CARNMT in vitro.

151 However, pathological mutations can also be introduced by nonreciprocal recombination events betw

152 f lymph nodes in healthy mice has previously been introduced by our group.

153 and nonconservative amino acid substitutions were introduced by overlap extension PCR.

154 Asymmetry was introduced by partial, outside-only exchange of anio

155 stimulating factor (GM-CSF) or globin mRNAs were introduced by particle-mediated gene transfer into

156 the MICU during the study period, four (18%) were introduced by patients admitted directly from the c

157 ed directly from the community and ten (45%) were introduced by patients admitted from other hospital

158 sample preparation thus no biases and errors are introduced by PCR reaction.

159 The L2 sequence was introduced by PCR (by replacing 13 codons) into sequ

160 uced by anesthetics, and the extrinsic input is introduced by periodic stimulation of vibrissae.

161 These isotopic shifts were introduced by permethylating carbohydrates with eit

162 All subsequent modifications of that gene are introduced by phiC31-mediated integration of plasmid

163 cancies in the device in which the vacancies are introduced by placing MgO atomic layers between pris

164 dgap in a graphene layer where the asymmetry was introduced by placing a graphene layer on a hexagona

165 er, the large deletions were absent when cre was introduced by pollination.

166 The mechanochromic functionality was introduced by polymerization of dihydroxyspiropyran

167 mers are inherently limited by stresses that are introduced by post-gelation volume changes during po

168 These atypical amino acids are introduced by post-translational modification of a r

169 ynthesis, and then, the Rh catalytic complex is introduced by postsynthetic linker exchange.

170 f neuronal activity and anticorrelations can be introduced by preprocessing steps, such as global sig

171 A small amount of the substance of interest was introduced by pressure injection and transport to th

172 Alternate donor substrates were introduced by priming apo AT(4)E with synthetically

173 ure-sensitive) and non-ts (host range), that were introduced by prolonged passage in cell culture or

174 10 years ago, the proportional recovery rule was introduced by promising that high-fidelity predictio

175 cal, the pair of hydroxyl groups in 37 could be introduced by proper recourse to the oxidation of 36

176 -phenyl-2-(phenylsulfanyl)ethyl moiety could be introduced by reaction of a sugar alcohol with acetic

177 The (13)C labels were introduced by reaction of KS(13)CN with allyl bromi

178 Subsequently, these were introduced by recombination into the C. glabrata ge

179 tion of linearly independent restraints, can be introduced by reducing the negative charge of DNA nan

180 Two mutations were introduced by replacing the essential Arg in each c

181 Both beta-xylosidases and the transporter were introduced by replacing two endogenous genes, GRE3

182 When a functional alphaGT gene was introduced by retroviral gene transfer into bone mar

183 73 identical sensing elements (DNA hairpins) were introduced by rolling circle amplification.

184 Retinal vascular occlusion was introduced by rose Bengal and laser photocoagulation

185 eplacement (AVR) with homograft aortic valve was introduced by Ross in 1962 and Barratt-Boyes in 1964

186 present in a single LTR and could only have been introduced by RT.

187 olutions in use today.The intravenous "drip" was introduced by Rudolph Matas in 1924.

188 zing multisignal sedimentation velocity data was introduced by Schuck and coworkers.

189 Tracer fluorescent dyes were introduced by scrape-loading or by microinjection,

190 omyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a transg

191 The benzophenone moiety was introduced by selective hydroboration of the double

192 act number called half-sphere exposure (HSE) was introduced by separating the contacts within upper a

193 For this report, selective deletions in V3 were introduced by shortening of the stem of the V3 loop

194 2 method of comparing haplotype frequencies, is introduced by simply adding the chi2 test statistics

195 Furthermore, specific amino acids can be introduced by site-directed mutagenesis within the la

196 itutions with deleterious effects on fitness was introduced by site-directed mutagenesis into the bac

197 Mutations in PAX6 and PAX6(5a) were introduced by site-directed mutagenesis and tested

198 Mutations in the prpB gene were introduced by site-directed mutagenesis based on th

199 The 151L and 151K mutations were introduced by site-directed mutagenesis in RTs from

200 Mutations were introduced by site-directed mutagenesis of amino ac

201 h, respectively, mild and severe OI variants were introduced by site-directed mutagenesis.

202 involved in VEGF165 binding, point mutations were introduced by site-directed mutagenesis.

203 In the greenhouse, a stressor was introduced by soil infestation with western corn roo

204 These are introduced by somatic mutation and are tumor specifi

205 complementarity between QMC partners, which is introduced by specific modifications of the quadruple

206 i in the presence of linkage disequilibrium, was introduced by Spielman et al.

207 Constructions carrying the mutant enhancer were introduced by stable transformation into an avian e

208 uch the same way it has nursing homes: after being introduced by staff or newly arrived residents, it

209 eals that C(4) -symmetry-breaking anisotropy is introduced by strain via pseudospin-lattice coupling,

210 ion at 2 K because a dominant 2-fold barrier is introduced by strong Fe(3d)--> H2(sigma*) pi-backbond

211 ithin the context of a synthetic RNA hairpin was introduced by structural remodeling using a magnesiu

212 ITB may be introduced by study design oversights or mishandled d

213 The additional Lys residue was introduced by substituting residue locating on the s

214 supplemental alcohol dehydrogenase activity was introduced by substituting the adhB ORF from Zymomon

215 The aromatic side chains were introduced by Suzuki-Miyaura cross-coupling or clic

216 experiment demonstrating that artifacts can be introduced by synchronization methods.

217 which differentiates natural HIV-1 isolates, was introduced by synonymous substitutions into a gene s

218 mice in which a premature stop codon (Y245X) was introduced by targeted mutagenesis in the murine Tfr

219 sformation in the domain wall of ferrimagnet is introduced by temperature-induced spin reorientation

220 egions of the lipid bilayer of the particles are introduced by the addition of sphingomyelin.

221 lymerase I suggest that single-stranded gaps are introduced by the hyperactive variants.

222 stem-loop structures in the Snake amplicons are introduced by the unique design of one of the PCR pr

223 While K(L-la) can be introduced by the acetyltransferase p300, histone del

224 concern regarding the possible skew that can be introduced by the inherent bias in the available data

225 ditions, while the endocylic double bond has been introduced by the allylic rearrangement.

226 that a specific interaction for aniline has been introduced by the mutation.

227 The dominant selectable gene, Ecogpt, has been introduced, by the calcium phosphate precipitation

228 ral amplicon sequence variants identified as being introduced by the biological filter.

229 factor crucial for BYDV translation, eIF4F, is introduced by the 3' BYDV translational enhancer (BTE

230 tage offset between the quadrupole rod pairs is introduced by the capacitors which is dependent on th

231 ic unsaturated fatty acid (UFA) biosynthesis is introduced by the FabA dehydratase/isomerase of the b

232 of the excitation; rather, angular momentum is introduced by the particle's interaction with the ani

233 Each makes use of filtering that is introduced by the spatial distribution of inputs on d

234 This modification is introduced by the TrmB enzyme, which is conserved in

235 e competencies in graduate medical education was introduced by the Accreditation Council for Graduate

236 Geminal dichloromethane functionality was introduced by the addition of in situ generated dich

237 (U09.9 Post COVID-19 condition, unspecified) was introduced by the Centers for Disease Control and Pr

238 Precautionary allergen labelling (PAL) was introduced by the food industry to help manage and c

239 Precautionary allergen labelling (PAL) was introduced by the food industry to help manage and c

240 with Op-iap3 dsRNA, the Op-IAP3 protein that was introduced by the inoculum virus decreased to almost

241 onal gammopathy of renal significance (MGRS) was introduced by the International Kidney and Monoclona

242 or quaternary structure of the chemoreceptor was introduced by the mutations.

243 The triene system was introduced by the Pd-catalyzed tandem cyclization-Su

244 A reporting domain was introduced by the specific substitution of a single

245 A blockage in the turning gate passageway was introduced by the triple mutant C232V/A251V/A314V.

246 or the molecular quantification of HIV-1 RNA was introduced by the United Kingdom National External Q

247 e speakers were significantly less likely to be introduced by their formal title (OR = 0.55, 95% CI:

248 Deuterium can also be introduced by this method by using D(2) O as the D so

249 and the cytoplasmic tail of human VPAC1 and were introduced by transfection into HEK-293 cells expre

250 Nestin is introduced by transient transfection and is positivel

251 Plasmids expressing either Hsp53 or Map53 were introduced by transient transfection into the p53-n

252 a variety of contexts, including genes that were introduced by transient transfection, carried on ep

253 reduce the threat, artificial processes can be introduced by transmitting very-low-frequency (VLF) w

254 It is introduced by tubulin tyrosine ligase-like enzymes an

255 For the 12->10 circRNA, a start codon can be introduced by two FTLD-Tau mutations, generating a pr

256 ith the interventions, a stewardship measure was introduced by UC leadership into the quality measure

257 Recommendations on the care of women with EH were introduced by United Kingdom-wide guidance (Green-t

258 were done with an axially chiral borane that was introduced by us a few years ago, and the refined me

259 The approach is introduced by use of myoglobin from four meats: beef,

260 s been developed to minimize errors that can be introduced by using starting concentrations far from

261 Chemical complexity is introduced by using a precipitating agent, SCN(-), wh

262 The coupling is introduced by using Hills classical semi-spherical vo

263 yl)ethyl)-4-(phenylsulfonyl)piperidine (12), was introduced by using stability toward rat liver micro

264 7-Substitutions were introduced by using 7-substituted-7-deaza heterocyc

265 reomers of C-nucleoside analogues of Fapy.dA were introduced by using the respective phosphoramidites

266 ect in a novel tetragonal magnetic structure is introduced by vacancies in Mn3 Ga0.95 N0.94 , due to

267 onstraining the coordination sphere geometry was introduced by Vallee and Williams with the concept o

268 Electrostatic energy differences were introduced by varying the distribution of charged o

269 possible in hearts exceeding a critical size was introduced by W.

270 ciple of piezotronics and piezo-phototronics were introduced by Wang in 2007 and 2010, respectively.

271 The original Daisyworld was introduced by Watson & Lovelock to demonstrate how t

272 e multiple thioamides, which are proposed to be introduced by YcaO-TfuA proteins.