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1 into four functional categories: those that are necessary for (1) glycosylase activity (C146 and C25
2 ave access to sufficient and nutritious food is necessary for a healthy life and the core tenet of fo
3 g neurons and visual projection neurons, and is necessary for a male to pursue a female during courts
5 nd optogenetic activation, we show that LC11 is necessary for a visual object-induced stopping behavi
7 and kallikrein by soybean trypsin inhibitor was necessary for abolishing RBC-MV-induced TG in normal
9 chanisms exhibit clear daily variation which is necessary for achieving the homeostatic osmolality.
10 d that glycosylation of Asn-471 and Asn-1030 is necessary for ACLP secretion and identified a specifi
11 These data indicate that the primate ACC is necessary for acquisition of prosocial preferences fr
12 s IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcript
13 mploying highly reactive intermediates which are necessary for activations of most stable chemical bo
14 show that activity of the NAc to VTA pathway is necessary for adaptive inhibition of food intake in r
15 o investigate whether the presence of a cost is necessary for adaptive therapy to extend the time to
17 y bulb to the posterior medial amygdala-that is necessary for all behavioural responses to darcin.
19 se findings confirm that attentional control is necessary for an association between attentional bias
21 y provides direct genetic evidence that Sox2 is necessary for androgen ablation-induced neuroendocrin
23 cemia through hepatic gluconeogenesis, which is necessary for anticipating and fueling "fight or flig
24 not support the conclusion that dissociation is necessary for antidepressant response to ketamine.
25 ses (HATs) and histone deacetylases (HDACs), is necessary for appropriate gene expression and neurona
26 e demonstrate that reactivation-induced hPAC is necessary for avoidance memory destabilization, and t
29 ammation triggered by pneumococcal infection is necessary for bacterial clearance but must be spatial
30 The beta(ps)-integrin Myospheroid, which is necessary for basal cell adhesion, is mislocalized in
33 HELLS is recruited to hot spots by PRDM9 and is necessary for both histone modifications and DNA acce
35 associated with monocyte recruitment, IRAK-M was necessary for CCR2 upregulation following bleomycin
37 on in swimming direction, mediated by CheY3, is necessary for cells to escape from the porous biofilm
40 5b functions as a dopamine-induced gene that is necessary for cocaine reward memory and DRD1-mediated
41 g matrix detachment, and both SIRT3 and SOD2 are necessary for colonization of the peritoneal cavity
42 chosen stimulus, and reward outcomes, which are necessary for computing the value of novel and famil
45 cation between the VH and PL during training is necessary for contextual fear memory, but not for tra
46 receptor complex CLAVATA2/CORYNE (CLV2/CRN) is necessary for continuous flower outgrowth during infl
47 ANCE STATEMENT The transcription factor Gli3 is necessary for correct development of the olfactory sy
49 dition, formation of microtubule (MT) arrays was necessary for cytolysis and was accompanied by chang
50 iron which co-localizes with DA vesicles and is necessary for DA synthesis, was assessed across the s
52 Precise assessment of the corneal condition is necessary for deciding which type of keratoplasty (i.
53 r receptor protein NR5A1 (also known as SF1) are necessary for defensive responses to predators in mi
54 Consequently, rapid ABHD4 downregulation is necessary for delaminated daughter neuroblasts to esc
56 xidation and mitochondrial uncoupling, which are necessary for development of functional beige adipoc
58 of whether local neuronal inhibition in NAc is necessary for DNQX microinjections to produce either
60 to knock out CD21, we demonstrated that CD21 is necessary for EBV entry into the Jurkat T-cell line.
61 gative regulator of Ras signaling in EC that is necessary for EC export of collagen IV, thus permitti
67 a relatively stable HA protein (pH 5.5-5.6) was necessary for efficient replication and airborne tra
69 Drainage of exudative retinal detachment may be necessary for either therapeutic or diagnostic purpos
70 -1-dependent microglia-endothelia cross talk is necessary for eliciting this spinal cord microglia ph
79 ed growth factor A (Adgf-A) from enterocytes is necessary for extracellular adenosine to activate Ado
80 xperience with faces nor fovea-biased inputs is necessary for face-selectivity to arise in the latera
88 The posterior dorsomedial striatum (pDMS) is necessary for goal-directed action; however, the role
89 e beta-glucoside salicin; however, only bglP was necessary for growth in other non-beta-glucoside PTS
91 E Transition from latency to the lytic phase is necessary for herpesvirus-mediated pathology as well
92 signaling is high in tracheoblasts and this is necessary for high levels of activated (phosphorylate
93 ortholog to the yeast HMP-P synthase (Thi5) was necessary for HMP synthesis in Legionella pneumophil
94 te balance among primate prefrontal networks is necessary for homeostasis and behavioral flexibility.
95 We present evidence that the SAGA complex is necessary for homeostatic plasticity, demonstrating i
97 tin receptor expression in Nav1.8(+) neurons was necessary for hyperalgesic priming in female, but no
99 1 (HSV-1) immediate early (IE) promoters and is necessary for IE gene expression, viral DNA replicati
101 ence map of all cell types in the human body is necessary for improving our understanding of fundamen
102 ods, technologies, and analytical approaches are necessary for in situ plastic-type identification an
103 racts with the p22phox subunit of NOX, which is necessary for increased ROS-mediated RA pathogenesis.
108 t binds beclin1 and controls neurovirulence, are necessary for interactions with PGAM5, KEAP1, and ot
109 ays that result in elevated serum PCT levels is necessary for interpretation and subsequent clinical
110 Results suggest five areas of understanding are necessary for interpreting spectra, and progress in
111 downstream of the Toll and Imd pathways and is necessary for iron relocation from the hemolymph to t
112 whether ketamine's dissociative side effects are necessary for its antidepressant effects remains unc
114 the C-terminal edge of the second DCX domain is necessary for KLHL15-mediated ubiquitination of DCX a
118 mmadeltaT cells up-regulate both CD1d, which is necessary for lipid-based antigens presentation, and
119 nscriptional sites in the MMT1 promoter that are necessary for low-iron- or oxidant-mediated MMT1 exp
123 e alpha-chymotrypsin-based cleavage reaction is necessary for manufacturing peptides using rDNA techn
127 Selective depletion demonstrated that Tregs were necessary for maximal apoptotic cell-directed enhan
129 on of DNA methylation in postmitotic neurons is necessary for memory formation and other adaptive beh
132 d wet) and a maximum of 4km(2) spatial scale is necessary for minimizing uncertainties (<10%) in regi
133 atalyzed by dynamin-related protein 1 (Drp1) is necessary for mitochondrial biogenesis and maintenanc
135 strated that expression of BM-derived IRAK-M was necessary for monocyte trafficking into the lung and
137 he hypothesis that VitE, not just alpha-TTP, is necessary for nervous system development, adult 5D st
139 tion of nitric oxide (NO) with the P450 heme are necessary for NO to trigger ubiquitination and prote
142 demonstrate that orbitofrontal cortex (OFC) is necessary for normal behavior in this task, but a cau
143 ate that Adar adenosine deamination activity is necessary for normal locomotion and prevents age-depe
145 show that embryonic photosynthetic activity is necessary for normal skoto- and photomorphogenesis in
148 re, the intact structure of the retinal ring is necessary for obtaining the excitonic interaction.
149 type transition, signaling through PPARdelta is necessary for obtaining the M2-biased phenotype.
150 gomers suggest structural rearrangement that is necessary for oligomers with an antiparallel beta-she
151 Several of the 11 classical HDAC enzymes are necessary for optimal Treg function while others are
154 positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA and protein levels in
156 enes, in their proper genomic context, which is necessary for overlapping expression data with other
159 Knockdown of DHHC5 showed that this enzyme is necessary for palmitoylation of Galphas, Galphai, and
161 ies, we show that PI3K recruitment of ZC3H14 is necessary for PDGF-induced neuroprotection and that t
165 y of natural metal-(hydr)oxide nanoparticles is necessary for predicting ion adsorption phenomena in
170 LXR alpha/beta, expressed in sensory neurons are necessary for proper peripheral nerve function.
172 Correspondingly, deletion of Ccr2 in MPs is necessary for proper fusion into regenerating aged mu
175 Lastly, we demonstrate that the alarmones are necessary for protecting GTP homeostasis against exc
177 ly, FGF21 signaling in glutamatergic neurons is necessary for protection against body weight gain and
178 ly showed that the autophagy protein ATG16L1 is necessary for protection against MRSA strains encodin
179 Further, we demonstrate that Sox2 3'UTR AREs are necessary for RBM24-based elevation of Sox2 mRNA hal
180 tain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acetylated lysine resid
181 thaliana) cyclin-dependent kinase G1 (CDKG1) is necessary for recombination and synapsis during male
182 o protein-coding genes (Hnrnph1, Rufy1) that was necessary for reduced methamphetamine-induced locomo
184 e evolution of intraspecific trait variation is necessary for reliable, long-term species and climate
185 bolic strategies in consumer-resource models is necessary for reproducing experimental growth curves
186 nding of (18)F-FGln pharmacokinetics and may be necessary for response assessment to targeted therapi
188 idence that the mushroom body vertical lobes are necessary for retrieving visual memories for success
190 fically, the separation of plasma from blood is necessary for routine health assessments such as comp
191 single-cell RNA-sequencing (scRNA-seq) data are necessary for samples containing a mixture of genoty
196 tion of both growth and cell-division timing is necessary for size control in animal cells, and this
197 lamic spindles, an interregional dialog that is necessary for sleep-dependent memory consolidation.
199 actor tyrosine kinase substrate (HRS), which was necessary for sorting surface receptors to intralumi
204 he neuroeffector junction (NEJ) is likely to be necessary for terminating inhibitory neurotransmissio
205 her, these data indicate that forebrain DORs are necessary for the action of DOR agonists in relievin
206 ishing human-origin and swine-origin viruses are necessary for the continued surveillance of influenz
207 To test whether fast-spiking interneurons are necessary for the development of compulsive ethanol
208 actions posited to occur during neurogenesis are necessary for the formation of the characteristic la
209 1 DNA-binding activity and BRG1 reexpression are necessary for the gene and protein expression of epi
210 o on to identify cell envelope proteins that are necessary for the import of PyoG and its killing act
211 y and specific geometry of GM1 binding sites are necessary for the induction of membrane curvature.
212 n of matrix metalloproteinases (MMPs), which are necessary for the invasive and metastatic phenotype.
213 y whether visual inputs to the intact retina are necessary for the LPZ responses, here, we measured B
214 ors, which interact in the late endosome(9), are necessary for the membrane fusion and delivery of RN
215 hy adult mouse brain, we show that microglia are necessary for the normal functional development of a
217 h experimental features or model assumptions are necessary for the observed continual evolution to em
218 manner and demonstrate that ovarian hormones are necessary for the prophylactic efficacy of (R,S)-ket
219 ting that factors such as adhesion molecules are necessary for the stabilization of the CAR-Env inter
221 rite-free electrodeposition of lithium metal is necessary for the adoption of high energy-density rec
223 MT5 expression in recently activated T cells is necessary for the cholesterol biosynthesis metabolic
224 at the integrity of CA activity in the brain is necessary for the consolidation of fear extinction me
225 While early experience with moving stimuli is necessary for the development of direction selectivit
226 The homeobox transcription factor PROX1 is necessary for the development of lymphatic vessels, l
227 ated in development and DNA damage 1 (REDD1) is necessary for the development of oxidative stress in
228 2 interfered with TGF-beta1 signaling, which is necessary for the development of T(H)17 and regulator
229 e results suggest that optimization of MP135 is necessary for the development of therapeutics that su
230 han SRPX2(-/Y) mice, which indicates that C3 is necessary for the effect of SRPX2 on synapse eliminat
231 itro, and observed that membrane association is necessary for the efficient transfer of acyl-phosphat
232 estion that maintenance of critical dynamics is necessary for the emergence of consciousness and comp
233 utaryl reductase degradation protein 1), and is necessary for the ERAD activity of the Sel1L-Hrd1 com
234 e hypothalamic paraventricular nucleus (PVN) is necessary for the expression of binge-eating behavior
235 during and shortly after the critical period is necessary for the expression of LTP at PV-IN output s
236 gulator, and it is well-described that KIF11 is necessary for the formation and maintenance of the bi
237 in brain nuclei in response to an experience is necessary for the formation of long-term memories.
241 Staphylococcus aureus fatty acid kinase FakA is necessary for the incorporation of exogenous fatty ac
242 RNAi triggered by mitochondrial dysfunction is necessary for the increase in longevity that is induc
244 LSV ex vivo, demonstrating that this pathway is necessary for the induction of the acute arterial WSS
245 bitory neurons in the centrolateral amygdala is necessary for the inhibition of a conditioned respons
246 bitory neurons in the centrolateral amygdala is necessary for the long-term storage of conditioned-th
247 e with a mutation in MSK1, we show that MSK1 is necessary for the majority of gene expression changes
248 Collectively, our findings suggest that ACC is necessary for the mitigation of competing inputs and
249 NCOA4, the autophagic receptor for ferritin, is necessary for the mobilization of liver iron stores d
250 mewhat unexpectedly, the autophagy machinery is necessary for the normal formation and compartmentali
251 r, our results demonstrate that the mouse SC is necessary for the normal performance of voluntary vis
257 nal evidence that Wnt/beta-catenin signaling is necessary for the specification of dorsal cell fate i
259 is sufficient, and TrkB receptor activation is necessary, for the transsynaptic trophic effect exert
261 hetic polymer coating prevented fibrosis and was necessary for the long-term function of the device.
262 uced translation during the day in vitro and was necessary for the rhythmic synthesis of select prote
263 occurred with Pam(3)CSK(4) stimulation, and were necessary for the early priming events to occur.
264 ed genes influencing the IgE response, eight were necessary for the response, while 12 repressed IgE.
268 we demonstrate that a Thi5-dependent pathway is necessary for thiamine biosynthesis in Legionella pne
271 to date, no study has demonstrated that ACC is necessary for this form of behavioral flexibility, no
278 n in seasonal changes in reproduction, which is necessary for traits to evolve via natural selection.
280 rthermore, we find that a minimum of two 3Bs is necessary for trans replication of FMDV replicons, wh
282 remotor cortex, and the primary motor cortex is necessary for transforming visual information into gr
286 mitochondrial electron transport chain (ETC) is necessary for tumour growth(1-6) and its inhibition h
287 f how effectively these movements shift gaze is necessary for understanding their functions and is he
289 SPN transmodulation across the striatum that is necessary for updating previous goal-directed learnin
290 f OFC to test whether these correlates might be necessary for value inference during later probe test
292 that physiological levels of AMPK activation are necessary for vasodilatation in healthy pregnancy.
293 lpha (HIF-1alpha) in CNS respiratory centres is necessary for ventilatory acclimatization to hypoxia
294 Furthermore, we showed that this induction is necessary for vIL-6-mediated cell adhesion and angiog
295 ude that association of E2 with the Brd4 CTM is necessary for viral genome replication and suggest th
298 rthermore, detailed feedback during training is necessary for VPL of distortion and calcification les
299 naling targets of N-oleoylethanolamide (OEA) were necessary for weight loss, metabolic improvements,