ライフサイエンスコーパス: be overcome by

1 As shown here, such difficulties can be overcome by (13)C-(13)C and for the first time (15)N-

2 stance of Saccharomyces cerevisiae to copper is overcome by 2-(6-benzyl-2-pyridyl)quinazoline (BPQ),

3 This ubiquitin binding inhibition can be overcome by a longer chain of linear, but not K63-lin

4 Here, we show that this limitation can be overcome by a method, termed midfield powering, to cr

5 proach showed that the barriers that need to be overcome by a species to successfully establish or sp

6 e activation, although this inhibition could be overcome by a stronger stimulus.

7 For lasers, losses need to be overcome by a sufficient amount of gain to reach the

8 This stalling at C:8-oxo-G can be overcome by a switch from pol delta to pols lambda, b

9 Here we show that this limitation can be overcome by a transition of a matrix of densely packe

10 which was previously the biggest constraint, was overcome by a novel application of convolution and F

11 n increase in RUNX1 expression; the blockade was overcome by a RUNX1 inhibitor.

12 These ERM limitations were overcome by a dedicated proteomic procedure based o

13 ma, many are redundant, so targeting one can be overcome by activating another.

14 tion of BTIC growth by EGFR inhibitors could be overcome by activation of neurotrophin signaling, and

15 xisting inhalational antigen tolerance could be overcome by activation of the transcription factor NF

16 L-21 to establish CD8 TE/TEM and TRM subsets was overcome by acute lymphocytic choriomeningitis virus

17 level of viral entry and that this block can be overcome by adaptation of the virus in tissue-culture

18 These limitations might be overcome by adding multiphase PMCT angiography.

19 alue in CS but has some limitations that may be overcome by adding newer cardiovascular magnetic reso

20 These defects often can be overcome by adding the Epstein-Barr virus (EBV) parti

21 ence defect of the SMU.1147 mutant could not be overcome by addition of sigX-inducing peptide (XIP) i

22 It is thought that this may be overcome by allowing some 20 ppb of sodium to be alwa

23 time, such assays have limitations that can be overcome by alternative approaches.

24 led-coil domain (CCD) and the autoinhibition is overcome by alternative splicing regulation.

25 ellular blocks limiting replication that can be overcome by an avian-like pH of activation for nuclea

26 induction of RpoS and OspC; this repression was overcome by an excess of Zn(2+).

27 Here we show that these limitations may be overcome by angular momentum-biased metamaterials, in

28 CXCR4 signaling in IgD-deficient B cells can be overcome by anti-CD19 antibody stimulation that also

29 prostate tumor resistance to cabazitaxel can be overcome by antiandrogen-mediated EMT-MET cycling in

30 Poor outcome in high-risk patients cannot be overcome by any of the applied treatment strategies.

31 riction conferred by MCPIP1 does not seem to be overcome by any viral protein, it is removed during c

32 Here we show that these limitations can be overcome by applying high-resolution mass spectrometr

33 ng that neutralization resistance of HCV can be overcome by applying recombinant antibodies.

34 ve isothiourea/Ir catalyzed alpha-alkylation was overcome by appropriate substituent choice, leading

35 faulty checkpoints for central tolerance can be overcome by autoantigen-specific immunomodulatory the

36 In fact, these deficiencies can be overcome by balancing NCC intrinsic processes of prol

37 cytotoxicity depends on DNA binding, but can be overcome by BCL2 overexpression, suggesting that apop

38 Permanent arrest can be overcome by blocking autophagy, by deleting the vacuo

39 ic liabilities of the piperazine oxadiazoles were overcome by blocking predicted sites of metabolism,

40 Here we show that this material obstacle is overcome by bulk crystals of lightly Sn-doped Bi1.1Sb

41 arrier develops during the budding that must be overcome by capsid proteins diffusing along the membr

42 n transmembrane and cytoplasmic domains must be overcome by cellular energy input to stabilize extens

43 Although major challenges remain, these can be overcome by cementing our resolve, raising advocacy,

44 rganization cannot be detected and which can be overcome by choosing suitable experimental parameters

45 pha-induced hyperexcitability by minocycline was overcome by coadministration of sIL-6R, showing that

46 elicit a boosted PPS14-specific IgG response was overcome by coimmunization with unencapsulated GBS-I

47 esistance to macrophage-mediated killing can be overcome by combination regimens involving therapeuti

48 nhibitors in SPOP-mutant prostate cancer can be overcome by combination with AKT inhibitors and furth

49 o Braf(V600E) inhibitor PLX4720, which could be overcome by combined treatment of PI3K inhibitor LY29

50 induces senescence and growth arrest, which is overcome by combined CAR activation, resulting in unc

51 GFR-mutant tumor cells, the effects of which were overcome by combined treatment with osimertinib and

52 These limitations can be overcome by combining NP-centered strategies with fra

53 uring treatment in many cancer types and may be overcome by combining PARP inhibitors with other ther

54 Here we show that this restriction can be overcome by combining several well-established quantu

55 istance to RAF-MEK-ERK inhibition, which may be overcome by combining signalling- and chromatin-direc

56 Resistance was overcome by combining ER-directed therapy with the i

57 These challenges can be overcome by comparing electron density volumes direct

58 This has been overcome by comparing historic plankton tows from t

59 Mutual gametophytic sterility was overcome by complementation with a genomic construct

60 This drawback could be overcome by complexation in cyclodextrins (CD) or cos

61 sign presents a major challenge that has not been overcome by computational approaches.

62 alpha inhibition; yet such limitations could be overcome by concomitant blockade of one or more of th

63 Early problems with their use have been overcome by conjugation with N-acetylgalactosamine,

64 Whereas the thermal motion can be overcome by cooling a mechanical oscillator to its mo

65 in the absence of RNA and that this barrier is overcome by correct placement of appropriately orient

66 Here, we show that this limitation is overcome by correcting the geometric distortion induc

67 resistance to EGFR inhibitors in TNBC might be overcome by cotargeting Mcl-1.

68 amuscular transplantation, but that this can be overcome by cotransplantation of an oxygen carrier, t

69 This bottleneck was overcome by coupling Raman spectroscopy with chemome

70 adoption as standard of care, which can only be overcome by data sharing and standardization of evalu

71 triage capable of finding progressible hits were overcome by data-driven optimization.

72 g hydrophobic character of the dipolarophile is overcome by decreasing water solubility causing chang

73 upport of this, we found that the defect can be overcome by deleting the regulatory gene lcrQ.

74 Limitations that may be overcome by delivery include, but are not limited to,

75 Here we show that these limitations can be overcome by designing the piezoelectric strain tensor

76 This problem could be overcome by developing stable hydrophobic MOFs whose

77 These problems have been overcome by developing a novel blend technique wher

78 and microstructure control in complex oxides is overcome by developing a general two-step synthetic a

79 The quiescent period was overcome by dispersal pheromone extracts of their ow

80 triction of infection via apical inoculation was overcome by disruption of intercellular junctions.

81 by the same antigen-presenting cell and may be overcome by distributing these sequences among severa

82 During S-phase, minor DNA damage may be overcome by DNA damage tolerance (DDT) pathways that

83 red resistance to PI3K inhibition that could be overcome by downstream AKT or mTORC1/2 inhibitors.

84 s suggest that resistance to fulvestrant can be overcome by drugs targeting the PI3K pathway.

85 Nonetheless, these defects could be overcome by early or prolonged exposure to IL-2, or b

86 ndicating that limits on diversification can be overcome by ecological or evolutionary change.

87 major limiting factor in translation, which is overcome by eIF4A activity.

88 This block was overcome by either increasing occludin expression, c

89 The defects are overcome by eliminating sensitivity of cells to INK4

90 e with high power lasers: this liability can be overcome by employing materials with high melting poi

91 e ions with unique histidine residues, which were overcome by employing ETD fragmentation.

92 d that epigenetic barriers to conversion can be overcome by endowing cells with the ability to mitiga

93 This obstacle has been overcome by energy-dispersive Laue diffraction.

94 resistance of KRAS(*)-expressing tumors can be overcome by enforced IRF2 expression or by inhibition

95 his study shows that genetic constraints can be overcome by environmental change and that cross-envir

96 expand during viral infection, and this can be overcome by exogenous IL-2 administration.

97 ian statistical theory, a priori beliefs can be overcome by experience.

98 This limit, however, can be overcome by exploiting quantum entangled states, such

99 oms is an expeimental challenge, which could be overcome by exploiting the versatility of carbon allo

100 ections, but their virus-blocking activities were overcome by expressing excess TEM-associated protea

101 mitochondrial pyrimidine nucleotide carrier, were overcome by expressing SLC25A33 or SLC25A36 in thes

102 ate limiting step is reduced uptake that can be overcome by expression of C. albicans Dur proteins in

103 The negative effect on HGF-mediated growth was overcome by expression of CD44v4-10, but not by CD44

104 The adf3-conferred susceptibility to GPA was overcome by expression of the ADF3 coding sequence f

105 ng quartz fork, the reactor size limit could be overcome by extending the substrate area to a continu

106 by reducing equivalents supply, which could be overcome by externally supplying hydroxylamine (NH(2)

107 in protein aggregation and loss of activity, were overcome by formulating the drug as a dry-powder th

108 ral defenses reliant on type III IFNs, which are overcome by FV3 pathogens.

109 predominated by IFN-lambda responses, which are overcome by FV3.

110 This defect was overcome by gavage with B. fragilis, by immunization

111 The GC-MS component co-elution was overcome by GCxGC-qMS.

112 ion of IFNgamma production by Th17 cells can be overcome by genetic ablation of CD73 or by using IL1b

113 Resistance is overcome by genetic or pharmacological inhibition of

114 This limitation is being overcome by genome-editing technologies, which mar

115 ions are not fundamental and that they might be overcome by growth processes that mimic polymerizatio

116 Interestingly, the lethality can be overcome by growth under elevated temperatures due to

117 t with polypropylene surfaces, but that this was overcome by handling in glass vials and injection us

118 lassification is a significant issue but can be overcome by harmonizing SULs using a proprietary soft

119 roquine resistance is dose dependent and can be overcome by higher, still well-tolerated doses.

120 Replication fork inactivation can be overcome by homologous recombination, but this can ca

121 ating that the IFN-alpha-induced barrier can be overcome by HSIV-vif chimeras in PTM CD4(+) T cells.

122 ast data processing and communication, might be overcome by hybridization with their organic counterp

123 This challenge can be overcome by (i) sampling the large sequence space of

124 necessity of high overpotentials, which can be overcome by identifying novel routes that improve the

125 Treg-/Foxp3-independent, requires IL-10 and is overcome by IL-1beta.

126 sgene in treated male Mecp2 mutant mice that was overcome by immunosuppression.

127 posed by interference effects cannot simply be overcome by improved sampling frequencies or sizes.

128 n obtained from DWI data that is unlikely to be overcome by improvements in data acquisition and anal

129 re limits to their precision, which may only be overcome by improving our knowledge of the fossil rec

130 re-harvest sprouting (PHS) could potentially be overcome by improving seed dormancy.

131 These drawbacks are gradually being overcome by improving our understanding of the imm

132 perfect stereochemical complementarity could be overcome by incorporating an appropriate P1 side chai

133 many protein targets, these bottlenecks can be overcome by incorporating electrophiles into small mo

134 In this work, this stochasticity is overcome by incorporating a solid electrolyte interla

135 This suggests that drug resistance could be overcome by increasing hydrogen bond interactions bet

136 likely via an allosteric mechanism that can be overcome by increasing RET ligand concentration.

137 ssion and in cleavage of tethered substrates was overcome by increasing the stalk length of the NA pr

138 d in complex phenotypes and could ultimately be overcome by infection at high multiplicities.

139 We conclude that this resistance can be overcome by inhibiting eIF4E phosphorylation with Mnk

140 ce and suggest that cisplatin resistance can be overcome by inhibition of autophagy in ovarian cancer

141 emotherapeutic treatment of cancer and might be overcome by inhibition of the transporter.

142 27 macro-re-entrant (perimitral) AT that can be overcome by injecting atrioventricular node blockers

143 anol yields during high-solids fermentations are overcome by integrating newly developed cosolvent-en

144 nt in advanced tumors, which are unlikely to be overcome by intervention at a single signaling checkp

145 velopmental impacts of NMDAR dysfunction can be overcome by interventions in adulthood.

146 rmine whether the observed alterations could be overcome by intestinal bile acids functioning as FXR

147 infections but this defect is overcome by intranasal installation of a TLR2/6 agoni

148 This can be overcome by introducing a minuscule amount of long fl

149 w that the processing bottleneck of LCEs can be overcome by introducing exchangeable links in place o

150 stability in any binary AuHn at P < 300 GPa was overcome by introducing alkali atoms as reductants.

151 Pol II stalling can be overcome by irradiation involving the epigenetic regu

152 counters many impediments, some of which can be overcome by lesion bypass or replication restart path

153 raints exist, and, even if they do, they may be overcome by long-term natural selection.

154 ersion to baseline is not obligatory and can be overcome by manipulating feedback.

155 NRF2-mutated HCC and if this resistance can be overcome by means of NRF2 inhibition in HCC cell line

156 These problems can be overcome by measurement of FRET in single molecules,

157 on, serving as a mechanical barrier that can be overcome by mechanical force as well as disruption of

158 B signal transduction pathway, and that can be overcome by miR-7 overexpression.

159 centrally located dense permeability barrier is overcome by multivalent interactions, which provide t

160 ve demonstrated that transgene silencing can be overcome by mutations in unknown gene(s), thus produc

161 addition, restriction of PB2 627E polymerase was overcome by mutations specific to the viral RNA temp

162 f HCD on the estradiol-induced GnRH/LH surge were overcome by neuron-specific SOCS3 knock-out.

163 are formed the effects of the substitutions are overcome by new quaternary interactions between subu

164 These deficits may be overcome by next-generation PrEP regimen, including c

165 ations in antigen presentations pathways may be overcome by NK cell-based immunotherapy.

166 ontroversial secondary orbital interactions, are overcome by non-covalent interactions affording to t

167 logistical considerations, though these may be overcome by novel methods to monitor CMV viremia usin

168 This requirement can be overcome by oncogene activation.

169 This requirement for MCL-1 can be overcome by overexpression of other antiapoptotic mol

170 ent for SYD and BRM in flower patterning can be overcome by partial loss of polycomb activity in curl

171 ween memory strength and memory lifetime can be overcome by partitioning the memory system into multi

172 d acrosome reaction and that this inhibition is overcome by pharmacological hyperpolarization.

173 that constraints to domain movement in ERK2 are overcome by phosphorylation at pTyr, which increases

174 This can be overcome by placing the betalains in lecithin nanolip

175 We show here that this challenge is overcome by placing the SC-ISE in series with an elec

176 human leukocyte antigen antibodies (DSA) can be overcome by plasmapheresis-based strategies with some

177 Such social dilemmas can be overcome by positive or negative incentives.

178 Such resistance can be overcome by potent BIM induction and concurrent BCL-X

179 ecific aggregation of AuNPs in urine samples was overcome by pre-treatment of samples with the polyca

180 grown in hypoxic conditions, an effect that is overcome by preinduction of HIF-1alpha.

181 in samples with high salt concentrations can be overcome by preparing samples in this way.

182 uminal cells for virus attachment, which can be overcome by pretreating cells--or virus--with neurami

183 This impairment could be overcome by pretreatment of AMPK-deficient MEFs with

184 of myeloma cells to bortezomib, which could be overcome by PRL-3 silencing.

185 re we demonstrate that these limitations can be overcome by protecting the sample with a chemically i

186 caused by the presence of galacturonic acid were overcome by protecting the acid with a group inert

187 This condition-specific inactivation of Pufs is overcome by Puf overexpression, and Puf4p/Puf5p overe

188 outer membrane complex and assembly platform is overcome by PulC linkers spanning the periplasm, with

189 However, this challenge can be overcome by quantum computers.

190 osition beyond 8-oxoG, but this inefficiency is overcome by rapid extension of HiFi PolB1.

191 These limits can be overcome by reconstructing ancient proteins, experime

192 ereas smc6 sensitivity to chronic stress can be overcome by reducing recombination intermediates.

193 This reaction impedance can be overcome by reducing the magnitude of the barrier thr

194 This can be overcome by reducing the particle dimensions.

195 transport CQ suggests that resistance could be overcome by reoptimizing the CQ dosage.

196 reversible growth arrest is induced that can be overcome by reoxygenation.

197 e we show that many of these limitations can be overcome by replacing interferometric optics with a t

198 shown that these physiological barriers may be overcome by, respectively, opening the BBB with MR im

199 , we show that this diffusion limitation can be overcome by reversibly creating and destroying confin

200 periment due to short plasma stability; this was overcome by reversing the amide bond and changing th

201 in parallel which enables this limitation to be overcome by running on more powerful hardware.

202 The latter was overcome by selection of BCL-2 overexpressing cells

203 This weakness can be overcome by separating the CO(2)-captured product to

204 tions intrinsic to this approach that cannot be overcome by sequencing more species.

205 of studying a rare disease such as JDM have been overcome by several collaborative studies and have

206 m, we conclude that capacity limitations can be overcome by short-term training.

207 the resistance of solid tumors to CAR-T can be overcome by similar means as those used to reactivate

208 This tradeoff could be overcome by simultaneous introduction of separate mut

209 251 to examine how the mucosal immune system is overcome by SIV during acute infection.

210 estriction factor for poxviruses, but it can be overcome by some poxvirus host-range proteins that sh

211 rbic acid but had slight interference, which was overcome by specific ion selective electrode.

212 iciencies in HDR-mediated DNA DSB repair can be overcome by stabilizing RAD51 filament formation in c

213 e redundant; blockade of any one pathway can be overcome by stimulation of another.

214 res of anxiety or motor impairment and could be overcome by strong motivational drive.

215 and not an activation energy issue that can be overcome by stronger reductants/catalysts.

216 acilitating response to imatinib that cannot be overcome by subsequent intensification of therapy.

217 suggests that this is a rare event that can be overcome by subtle structural modifications of an AMP

218 ata demonstrate that this adverse effect can be overcome by supplementing its substrate, GSNO, or by

219 with viral proteolytic priming in ways that are overcome by surplus proteases.

220 Saturation was overcome by switching from ESI to APCI, and our expe

221 lso unclamped release, but this effect could be overcome by synaptotagmin overexpression, arguing aga

222 es in photosynthetic carbon assimilation can be overcome by synthetic biology strategies.

223 However, this defect was overcome by T-cell receptor engagement.

224 Moreover, this resistance could be overcome by targeting the secondary oncogene in conju

225 mimetic kinase inhibitors, an issue that may be overcome by targeting unique residues or binding pock

226 These obstacles were overcome by Teoc protection of the beta-amino group

227 sed DNA damage and reduced survival that can be overcome by TGF-beta.

228 sample concentration, expensive instrument) are overcome by the enzyme assay that is presented here,

229 effects of primase and rNTPs on processivity are overcome by the extra grip on DNA provided by the la

230 eity and sparseness of raw biodiversity data are overcome by the use of models and remotely sensed co

231 ating a negative iron balance that could not be overcome by the adaptive increase in duodenal iron ab

232 rostatic repulsion between subcomponents can be overcome by the addition of an anionic template, or g

233 A through the TAG biosynthetic network could be overcome by the addition of enzymes from species that

234 han wild-type plants, and this reduction can be overcome by the application of the synthetic SL GR24.

235 iated with matrix and processing effects may be overcome by the choice of extraction buffer and detec

236 ghts into how obstacles to transcription may be overcome by the concerted actions of multiple accesso

237 Although the block imparted by Tbf1 can be overcome by the DNA-binding activity of the single-st

238 sential glycolytic enzyme enolase, which may be overcome by the exchange of intermediates with S. str

239 SypE of SypG-induced biofilm formation could be overcome by the expression of a non-phosphorylatable

240 Importantly, this could be overcome by the introduction of long-acting injectabl

241 stic hypotheses about how each problem might be overcome by the macromolecules involved.

242 ts low processability and degradability, can be overcome by the preparation of its blends and nanocom

243 nactivated by CSPGs, and this inhibition can be overcome by the presence of a beta1-binding integrin

244 This problem can be overcome by the present postcalorimetric ICcE procedu

245 d clinical radiologic problems of today will be overcome by the probes of tomorrow.

246 The effort to simplify diagnosis could be overcome by the risk of undiagnosed HBP.

247 IBG imaging has several limitations that can be overcome by the use of a PET agent.

248 pression of plasma estrogen levels and might be overcome by the use of an increased dose of anastrozo

249 itative workflows, (ii) ratio distortion can be overcome by the use of an SPS-MS3 scan, (iii) interfe

250 This issue could be overcome by the use of less basic amino derivatives l

251 These problems can be overcome by the use of near-infrared light, which has

252 This dilemma has been overcome by the introduction of unprecedented chemi

253 diment of detection of food contaminants has been overcome by the suspect and non-targeted screening.

254 This is overcome by the acquisition of multiple spacers that

255 eficiency viruses (SIVs), SAMHD1 restriction is overcome by the action of viral accessory protein x (

256 opolymers, where unfavorable Shannon entropy is overcome by the catalytic activities of selected gene

257 ion state occurs when this activation strain is overcome by the stabilizing interaction energy.

258 high mortality at the seedling stage, which was overcome by the addition of an exogenous carbon sour

259 The metabolic instability of 5 was overcome by the replacement of the 6-dimethylisoxazo

260 Of interest, this loss of priming was overcome by the type II anti-CD20 antibody obinutuzu

261 In the present paper, this problem was overcome by the use of effective energy approximatio

262 Barriers at the ends of each segment were overcome by the build-up of pressure in the dyke en

263 esistance mutations within each binding site were overcome by the inhibition of the opposite function

264 e (e.g., postsurgical dysfunction) that must be overcome by these therapeutic modalities to achieve c

265 , we show that Allee effects can potentially be overcome by transient hybridization with a resident s

266 We show that these limitations cannot be overcome by transplantation into the microenvironment

267 The problem of low Raman scattering was overcome by trapping particles with 2D optical tweez

268 This effect can be overcome by treating cells with the clinically approv

269 In most cases, this defect can be overcome by treatment with all-trans-retinoic acid (A

270 in gH/gL/UL128-131 but low in gH/gL/gO could be overcome by treatment with the chemical fusogen polye

271 of pluripotency-associated factors that can be overcome by two inhibitors (2i) of the MEK and GSK3 p

272 They can be overcome by understanding the causes and finding the

273 scorbic acid and challenges of chiral purity are overcome by using chiral selective conductive polyme

274 d-effect transistor in which these obstacles are overcome by using two quantum point contacts as spin

275 This limitation can be overcome by using a synthetic system in which Spo0A a

276 ost frequently used motif-mapping tools, can be overcome by using an Ensemble approach, which combine

277 Here we show that this problem can be overcome by using buffer gas cooling to produce conti

278 We suggest that this failure can be overcome by using chemically and geometrically accura

279 This limitation can be overcome by using cold-ion spectroscopy.

280 erials used, but that these difficulties can be overcome by using different additives.

281 We show that this impasse can be overcome by using electrical polarization to generate

282 otein expression in live bacterial cells can be overcome by using fluorescent sensors based on Spinac

283 tudy demonstrates that this limitation could be overcome by using Fourier self-deconvolution of infra

284 This can be overcome by using inducible promoters with extremely

285 This problem may be overcome by using oocytes containing healthy mtDNA, t

286 These limitations can be overcome by using optical communications based on chi

287 These shortcomings could be overcome by using prefabricated allogeneic cell or ti

288 energy gain presented by laser depletion can be overcome by using staged acceleration, suggesting a w

289 e demonstrate that this speed limitation can be overcome by using the faster actomyosin motor system.

290 weak individual protein-carbohydrate binding is overcome by using multivalent interactions.

291 This weakness is overcome by using simple linear models, which give ve

292 In this work, the challenge is overcome by using time-resolved photoemission spectro

293 ydrogenation of the acetylated disaccharides was overcome by using a microfluidic continuous flow rea

294 e repressive effect of FOF2 in flowering can be overcome by vernalization.

295 This effect was overcome by VIP treatment of the early pregnant mice

296 has technical limitations, some of which can be overcome by virtual reality applications.

297 targets the HIV-1 envelope protein Env, but is overcome by Vpr and its interaction with DCAF1.

298 s with altered epigenetic landscapes and can be overcome by wild introgression.

299 ll function stemming from various etiologies are overcome by Wnt ligands, this mechanism is a potenti

300 sents an effective species barrier that must be overcome by zoonotic viruses.