ライフサイエンスコーパス: be positioned to

1 y suggest that in normal cell division, FtsZ is positioned to a single nucleation site on the inner m

2 erminal domain, conserved in all "enolases", is positioned to abstract the 1-proS proton.

3 xchange even though E164, the glutamate that is positioned to abstract the alpha-proton, is intact in

4 Second, the conserved residue, D22, is positioned to accept a hydrogen bond from the C2-OH g

5 The pyridyl moiety was positioned to accept a hydrogen bond from Asn297, an

6 Glu-234 and Tyr-294 are positioned to act as a general base and general acid

7 We show that these complementarities are positioned to act as intron identity elements, bring

8 n this conformation, the amphipathic helices are positioned to act as molecular wedges that induce me

9 ive site to increase the residue's basicity) is positioned to act as a general base, abstracting the

10 Tyrosine 126 is positioned to act as the general acid that donates a

11 Lysine 199 is positioned to act as the general base that accepts a

12 A conserved guanine residue is positioned to act as the general base, and is assiste

13 alized at the nuclear pore complexes, hGle1p is positioned to act at a terminal step in the export of

14 With this architecture, FKBP51 is positioned to act on specific client residues present

15 ed structural data predicted that serine 229 was positioned to act as a proton donor to the developin

16 His278 and Asp280, which are positioned to activate the water nucleophile in the

17 its pre-cleaved state, showing that cytidine is positioned to activate the 2'-OH nucleophile in the p

18 The side chain of Asp-273 is positioned to activate the hydrolytic water molecule

19 MST in which an Asp-His-Ser catalytic triad is positioned to activate the nucleophilic cysteine resi

20 ed through an initiative, and each crop will be positioned to advance with cost-effective parallels,

21 of the mutations that cause motor disorders are positioned to affect enzyme activity directly, the r

22 hin the alphavirus particle, these mutations are positioned to affect the E2-capsid interaction or th

23 tergic pathway from layer VI, whereas mGluR5 is positioned to affect retinogeniculate activation of r

24 o-terminal and carboxy-terminal domains that are positioned to allosterically modulate cytoplasmic Ca

25 Both the D297G and I19F substitutions are positioned to alter the substrate specificity so tha

26 ulate brain-wide serotonin neuron firing and are positioned to assert large-scale effects on negative

27 s available for screening, virtual screening is positioned to assume a more prominent role in early d

28 which are depleted of TFIID, a +1 nucleosome was positioned to be in competition with the PIC, which

29 technologies, whole-genome sequencing (WGS) is positioned to become an essential tool in the control

30 Furthermore, the ATPase Prp16 is positioned to bind and translocate the intron downstr

31 ydrophobic pocket in the active site chamber is positioned to bind long acyl chains, as suggested by

32 the melted template DNA in the open complex is positioned to bind the +2 NTP.

33 hen a city's hubs (such as shopping centres) are positioned to bridge diverse neighbourhoods and ther

34 the water molecule in-line with the P-O bond is positioned to bring about the change in bond angle.

35 (Glu-343), located at the subunit interface, is positioned to catalyze a nucleophilic attack on the g

36 pore through the S4-S5 linker helices, which are positioned to constrict or dilate the S6 inner helic

37 ement, which can be as short as one residue, is positioned to contact pore loops near the "bottom" of

38 ized subsets of B cells and macrophages that are positioned to continuously monitor the blood-stream

39 amide nitrogen of glutamine in the GGQ motif is positioned to contribute directly to catalysis of pep

40 niversally conserved GGQ motif of the factor is positioned to contribute directly to peptidyl-tRNA hy

41 Q230 of the universally conserved GGQ motif is positioned to contribute directly to the catalysis of

42 ansiently in early postnatal hippocampus and is positioned to contribute to the establishment of hipp

43 ion on cholangiocyte secretion suggest EBP50 is positioned to contribute to the organization and regu

44 roperties and the matrin-3-lamin A interface is positioned to contribute to these defects.

45 The microenvironment of the medullary cords is positioned to control these key processes.

46 This pathway is positioned to control tumor metabolism and promote tu

47 At the same time, these circuits are positioned to convey signals from pathologic events

48 ified subpopulations of LHA Nts neurons that are positioned to coordinate either feeding or drinking.

49 Thus, Barrington's nucleus is positioned to coordinate brain noradrenergic activity

50 rane localization of MondoA suggests that it is positioned to coordinate the adaptive transcriptional

51 These developing axonemes were positioned to coordinate trafficking into the furro

52 different trains of radioactive 192Ir seeds was positioned to cover the treated site, and a dose of

53 ifferent trains of radioactive (192)Ir seeds was positioned to cover the treated site, and a dose of

54 The resident peroxisomal protease LON2 is positioned to degrade obsolete or damaged peroxisomal

55 protein connects the tube and baseplate and is positioned to degrade peptidoglycan during penetratio

56 An active site glutamate (Glubeta(117)) is positioned to deprotonate bound acyl-CoA and initiate

57 We show that these cells are positioned to detect external settlement cues and hy

58 Ser-107 is positioned to donate a hydrogen bond to the leaving g

59 dimer surface; and illustrating that His-98 is positioned to donate a hydrogen bond to the scissile

60 tory and inhibitory descending pathways that are positioned to drive the interneurons in a context-sp

61 Thus, axonal GABA(B)Rs are positioned to efficiently control the input and outp

62 ional structures reveal how C1s polypeptides are positioned to enable activation by C1r and interacti

63 Tetherless sensors have long been positioned to enable next generation applications i

64 T) neurons of the dorsal raphe nucleus (DRN) are positioned to enact coordinated modulation of circui

65 a multidisciplinary team, which intensivists are positioned to engage and lead.

66 heir entry into the islets so they could not be positioned to engage, kill, and thus remove insulin-p

67 tion of an Asn residue from each strand that is positioned to engage in a buried polar interaction.

68 C) and dorsomedial prefrontal cortex (dmPFC) are positioned to exert top-down control over subcortica

69 eurons form synaptic contacts that appear to be positioned to exert inhibitory control near sites of

70 The ventral midline thalamus is positioned to exert significant control over fairly w

71 The large PEG loops are positioned to extend out of the peptide binding site

72 is 212, at the end of the third beta-strand, are positioned to facilitate both syn-dehydration and ke

73 and four low-spin, bis-his coordinated hemes are positioned to facilitate intra- and intermolecular e

74 two tyrosine residues, Tyr-108 and Tyr-503, are positioned to facilitate this deprotonation.

75 nclude that E106 residues in wild-type ORAI1 are positioned to form a Ca(2+) binding site in the chan

76 , the two cysteine residues in the extension are positioned to form an interdomain disulfide cross-li

77 sor protein, the side chains of H74 and D278 are positioned to form an ion pair between monomers that

78 buted by both subunits of the dimeric enzyme are positioned to form hydrogen bonds with the 2'- and 3

79 These water molecules are positioned to form multiple hydrogen bonds, as well

80 Within the active site of Fms1, His67 is positioned to form hydrogen bonds with the polyamine

81 ne inhibitors, and the terminal 5'-phosphate is positioned to form medium-range Coulombic interaction

82 ng specificity is provided by Asp-196, which is positioned to form two hydrogen bonds to the guanine

83 The FAPY formyl group was positioned to form a hydrogen bond with A6 N6Ha.

84 determined here indicates that Arg93 in NucA is positioned to fulfill this role.

85 Lys(133) and Lys(235) are positioned to function as acid/base catalysts in the

86 Pro-1 is positioned to function as a catalytic base.

87 Glu370 is positioned to function as the catalytic base, and pre

88 Our system is positioned to generate 11,270,771 kWh/year with a res

89 These data indicate that TGF alpha and EGF-R are positioned to have a role in the genesis, differenti

90 stal intestine-projecting vagal neurons that are positioned to have an afferent role in microbiota-me

91 es may coexist in common axon terminals that are positioned to have an impact on the LC.

92 Although the human population was positioned to have strong effects, arrival and prese

93 cent to the target base, and a conserved Arg is positioned to help flip the target base out of the st

94 His-143 is positioned to help polarize the carbonyl group of the

95 Each gene pair was positioned to homeologous regions of the genome usin

96 Active site residue Asn(297) is positioned to hydrogen bond with an adventitious liga

97 88 imidazole still stacked with the heme and was positioned to hydrogen bond with the heme thiolate.

98 d disease modeling and drug development, and are positioned to impact regenerative medicine but have

99 vers of the co-occurrence of these disorders is positioned to improve women's health.

100 Mechanistically, 5-HT2CRs are positioned to influence both homeostatic feeding cir

101 es of cortical pyramidal neurons, where they are positioned to influence both synaptic and dendritic

102 We propose that cortical nNOS neurons are positioned to influence neuronal activity across wid

103 CRF-enriched CEA-DA projections are positioned to influence outputs to the 'limbic-assoc

104 inputs to the midbrain dopamine (DA) system are positioned to influence striatal functions through m

105 y contact the substrate during catalysis but are positioned to influence the packing of substrate bin

106 This classification system is positioned to inform patient monitoring and care and,

107 )-5 and IL-13, group 2 innate lymphoid cells are positioned to initiate and maintain homeostatic type

108 Arg 147 at the end of the second beta-strand are positioned to initiate the reaction by abstraction o

109 have been identified in which His159-ImH(+) is positioned to initiate a general acid-catalyzed addit

110 e formation of macromolecular scaffolds that are positioned to integrate biochemical processes in cel

111 As striatal cholinergic interneurons (ChIs) are positioned to integrate movement cues with gait, and

112 in the pathophysiology of schizophrenia, and is positioned to integrate information from limbic and c

113 of basic residues lining the nuclease groove are positioned to interact with DNA in the tensed state

114 r surface of the plasma membrane, where they are positioned to interact with membrane-spanning recept

115 residues within an unstructured segment that are positioned to interact with the D2 ring have major p

116 Second-sphere active-site residues that are positioned to interact with the HPCA and/or bound O2

117 rim of the channel entrance that appears to be positioned to interact with the distal primary amine

118 The re face of E4P can be positioned to interact with the si face of PEP with o

119 Lys-39 which is positioned to interact electrostatically with the alp

120 a-hairpin structure when the phosphate group is positioned to interact with a tryptophan residue on t

121 The 50-20K loop is positioned to interact with actin, while the 25-50K l

122 ndothelial and smooth muscle cells, where it is positioned to interact with adiponectin.

123 l prediction that the carboxyl-leaving group is positioned to interact with Phe-397.

124 The 'ratchet helix' is positioned to interact with RNA substrates as they mo

125 hereas the carboxylate side chain of Glu 211 is positioned to interact with the 3-OH of 2-PGA.

126 Tyr212 is positioned to interact with the aldehyde group of the

127 NMR analysis reveals that Asn64 in Ht Q64N is positioned to interact with the axial Met61, whereas

128 urface of helix E within the helicase domain is positioned to interact with the primase domain and th

129 not defined in the electron density map but was positioned to interact with LPL's large basic patch,

130 fied strand-separating "pin" structures that are positioned to intercept incoming dsDNA and promote s

131 loop (BG3) and Asp-500 in the EF loop (EF1) are positioned to interfere with the binding of the P+3

132 The N-terminal helix of OTUB1 is positioned to interfere with UEV1A binding to UBC13,

133 Catheters were positioned to intracardiac targets by use of an MRI

134 s between the anode and cathode this concept is positioned to leverage currently available materials

135 The camera was positioned to look down into a 10-cm-deep water bath

136 ealth information providers, and parents may be positioned to make the largest impact.

137 AFF4 is positioned to make unexpected direct contacts with HI

138 The large V1/V2 loops, previously unmapped, are positioned to mask the coreceptor binding site in an

139 lls are a syncytium in which the many nuclei are positioned to maximize the distance between adjacent

140 .6 demonstrated that FKBP12.6-tagged sensors are positioned to measure local [Ca(2+)]Cleft in adult r

141 gh each endotracheal tube such that it could be positioned to measure pressures proximal and distal t

142 periosteum through the calvarial sutures may be positioned to mediate migraine headache triggered by

143 hibit appetite in response to metabolic cues is positioned to mediate the suppression of food intake

144 /GABAergic limbic forebrain projections that are positioned to modulate multiple nodes of homeostatic

145 n contrast, delta-opioid receptors appear to be positioned to modulate the activity of GABAergic neur

146 racrine factors secreted into the cyst would be positioned to modulate the rate of hepatic cyst growt

147 These findings suggest that presynaptic TrkB is positioned to modulate estradiol-mediated and BDNF-de

148 N-lobe of cardiac troponin C (cTnC) and thus is positioned to modulate myofilament Ca2+-sensitivity.

149 wild-type and CaBP4(-/-) mice and therefore is positioned to modulate native Ca(v)1.3 channels.

150 ATP-driven domain motion is positioned to move double-stranded DNA through the he

151 y 3.1 A away from the heme iron, where Phe14 is positioned to occlude binding of NO as a 6th (distal)

152 e radioactive gas-filled balloon (3.5/45 mm) was positioned to overlap the injured segment with margi

153 nt adhesion site (MIDAS) in the betaA domain is positioned to participate in a ligand-binding interfa

154 mmalian wounds, stromal stem cells appear to be positioned to perform functions similar to those of b

155 His287 is not a Type 2 ligand but is positioned to perturb an axial water or a nitrite of

156 m origins of glutamatergic input to PVH that are positioned to play a role in transducing a diverse r

157 eriod for cortical plasticity, and that they are positioned to play an important role in experience-d

158 trates, seemingly rare atmospheric phenomena are positioned to play disproportionately large regulato

159 o the transcriptional landscape of cells and are positioned to play significant roles in cellular dif

160 Direct air capture (DAC) is positioned to play a critical role in carbon removal,

161 These results also suggest that Ucn III is positioned to play a role in mediating physiological

162 Cytoplasmic MCD is positioned to play a role in the regulation of cytopl

163 The guanidinium of the invariant Arg-170 is positioned to potentially interact with a bound acylp

164 CDR1beta D30, CDR2beta N51, and CDR3beta Q97 were positioned to potentially participate in hydrogen b

165 Thus, chandelier cells are positioned to powerfully regulate the excitatory out

166 lucidate whether cannabinoid (CB1) receptors are positioned to presynaptically modulate norepinephrin

167 findings indicate that the GABA(B) receptor is positioned to presynaptically modulate afferent trans

168 These late-binding AFs are positioned to prevent each step in the translation i

169 ch case, the 3' OH created on the cut strand is positioned to prime DNA synthesis towards the intron,

170 tes that the residues of the catalytic triad are positioned to promote each step of both the forward

171 on possibly serving as metal ligands, Lys-39 is positioned to promote departure of the NMP leaving gr

172 Retail clinics are positioned to provide immunizations and care for sim

173 The side chains of Lys 269 and Arg 119 are positioned to provide leaving-group activation in th

174 egions of the two enzymes suggests that RDR2 is positioned to rapidly engage the free 3' ends of Pol

175 ucts since the nucleophile (Asp333-CO(2)(-)) is positioned to react with either carbon center in the

176 es from distinct developmental lineages that are positioned to receive input from proprioceptor subty

177 (RGCs) with similar stratification patterns are positioned to receive similar inputs but often displ

178 Therefore, these neurons were positioned to receive both visual and auditory info

179 ture of mEndoG shows that a cysteine (Cys69) is positioned to recognize 5hmC through a thiol-hydroxyl

180 he catalytic triad, another arginine residue is positioned to recognize the substrate beta-sulfate gr

181 epressive symptoms among orthopedic patients are positioned to reduce complications and positively af

182 disease phenotypes: Residues mutated in XP-G are positioned to reduce local stability and NER activit

183 these results show that lamina I pacemakers are positioned to regulate both the level of activity in

184 Intermingled VTA GABA neurons are positioned to regulate dopamine, but we lack detaile

185 orter transcripts and the longer transcripts are positioned to regulate heart failure (HF).

186 Neural circuits that are positioned to regulate rat distal colon function wer

187 uted downstream targets, while L6 CT neurons are positioned to regulate thalamocortical response gain

188 onjecture that penetrating arterioles, which are positioned to regulate the delivery of blood, are lo

189 ablishes a local negative feedback loop that is positioned to regulate inner hair cell excitability a

190 catalytically distinct from mammalian FAAH, is positioned to regulate levels of a variety of bioacti

191 c factor (BDNF) in the CNS, yet whether BDNF is positioned to regulate the excitatory and/or inhibito

192 These cells are positioned to relay ejaculation-related signals from

193 I, that changes conformation on GTP binding, are positioned to relay the receptor-initiated signal ac

194 These advances are positioned to render difficult analyses routine and

195 and functional genomic resources, T2T-CHM13 is positioned to replace GRCh38 as the prevailing refere

196 Initial targets were positioned to require natural co-contraction in the

197 mory T cells in the respiratory tract, which are positioned to respond rapidly to respiratory virus i

198 t to the LGN and pulvinar nucleus appears to be positioned to selectively influence the response of t

199 The epsilon-amino group of Lys 345 is positioned to serve as the base in the forward reacti

200 by an Asp-274 from the opposing half, which is positioned to serve as the initial proton donor.

201 A fourth cysteine was positioned to serve as the bridging ligand between t

202 (FH2 and WH2, respectively) domains of INF2 are positioned to sever F-actin, whereas DIA1 appears un

203 TOP2B is positioned to solve topological problems at diverse c

204 The third metal is positioned to stabilise the negative charge of the 5'

205 omplex with manganese suggests how the metal is positioned to stabilise the transition state.

206 across the beta- and gammaherpesviruses and is positioned to stabilize a putative syntaxin-like bund

207 cruited to one side of CME sites, where they are positioned to stimulate asymmetric actin assembly an

208 n activation and show intrahepatic platelets are positioned to stimulate fibrotic protein deposition

209 The expanded FDA labeling is positioned to substantially increase the potential HF

210 The finding that APE1 residues are positioned to substitute for Nfo metal ions is suppo

211 binuclear metal center, and the indole ring is positioned to suggest that it could provide a hydroph

212 cy, the laboratory, and information services are positioned to support the complexities of ICU care.

213 minant in the preoptic area-hypothalamus and is positioned to support maternal behavior since this fo

214 When electrodes are positioned to target frontotemporal cortex, ECT is a

215 Such 'wet programming' is positioned to transform a wide and diverse swathe of

216 croenvironments in laminar compartments, A32 is positioned to tune activity in columns of A25.

217 proteins in the developing olfactory system are positioned to underlie the formation of the odorant

218 searchers-there are important audiences that are positioned to use neuroscience findings to affect po

219 of inflammation and other disease activities is positioned to usher in a new era of risk assessment a