ライフサイエンスコーパス: be precluded by

1 homogeneous gas with attractive interactions is precluded by a conventional phase transition into eit

2 rve as informative indicators of Alzheimer's is precluded by a lack of knowledge regarding why the di

3 a rat pharmacodynamic model, but advancement was precluded by a low therapeutic window to QTc prolong

4 urther subjects into the 1,000-mg dose group was precluded by adverse skin events (rash).

5 senile plaques in Alzheimer's disease (AD), is precluded by alpha-secretase cleavage within the Abet

6 Currently, access to the database is precluded by an urgent need for tools that allow the

7 AD, or that if such a relationship exists it is precluded by another, as yet unknown factor.

8 timulation of Ca(2+) influx in the podocytes is precluded by blocking either AT1 or AT2 receptors (AT

9 which the interaction between CD70 and CD27 was precluded by blocking Abs.

10 en, but further insights into this symbiosis are precluded by both UCYN-A and its host being uncultur

11 iance after any therapeutic intervention may be precluded by changes in tracheal tube leak during the

12 cognition by the human TRIM5alpha orthologue is precluded by CypA.

13 ta across population scale cohorts, however, is precluded by day-to-day nonlinear signal drifts in LC

14 e of pU(L)25, or when pU(L)25 capsid binding was precluded by deletion of its first 50 amino acids, p

15 el of EAE-immunized WT mice, an outcome that was precluded by depleting DC-HIL(+) cells from the infu

16 tion of GABAB receptors in these two regions is precluded by differences in the diffusion and concent

17 that eventual tree dominance through shading is precluded by ecohydrological constraints in dry savan

18 ne inhibition of Ca(v)3.2 whole cell current is precluded by Gbetagamma-scavenger proteins or a pepti

19 90 inhibitors as antifungal therapeutics has been precluded by human host toxicities and suppression

20 ults in a cellular senescence phenotype that is precluded by inactivation of p16.

21 Although further dose escalation was precluded by infusate volume constraints, this SU101

22 Subgroup analyses for BA were precluded by insufficient data.

23 ence, unequivocal study of Hrd3 function has been precluded by its central role in Hrd1 stability.

24 ulfur-containing amino acid, methionine, has been precluded by its intrinsically weaker nucleophilici

25 f lovastatin as a chemotherapeutic agent has been precluded by its significant cytotoxic effects.

26 of functional enhancer-promoter interactions is precluded by its effective resolution that is determi

27 Clinical development of KCP, however, is precluded by its size and complexity.

28 Testing this hypothesis has been precluded by lack of an assay to measure random mut

29 is formed spontaneously when enzyme turnover is precluded by lack of substrates, is a Na(+)/H(+) anti

30 However, this is precluded by limitations of current cell-based system

31 s; however, further biophysical studies have been precluded by limited access to this promising antiv

32 bolism in a cell, tissue or intact organisms is precluded by multiple unknowns, including in vivo enz

33 uence background in which the wild-type fold is precluded by negative design.

34 However, the expansion of NRP is precluded by obstacles of an organizational, legal, a

35 m selective labeling of R71 and Q101 in D75H was precluded by overlap of the (15)N lines with the muc

36 on is not mediated by the CTD of RNAPII, but is precluded by phosphorylation of the CTD.

37 ns in ENaC that depress open probability and was precluded by proteolytic cleavage that increases ope

38 Coimmunoprecipitation of pU(L)6 was precluded by pU(L)26 mutations Y451A, P452A, and E45

39 eptor activation, which in the case of CXCR2 is precluded by rapid receptor phosphorylation and inter

40 ng from both native and recombinant channels was precluded by 'run-down', i.e. channel activity could

41 plantation of a single organ transplantation is precluded by severe disease in the other organ system

42 ccumulation following HCV protein expression was precluded by silencing the expression of PI4KA, but

43 Multivariate confirmation was precluded by small sample size.

44 -mediated transcriptional activation in mice is precluded by species-specific structural differences

45 Unfortunately, the utility of CPE is precluded by systemic toxicity because its receptors

46 ds through known replication roadblocks, has been precluded by technical limitations.

47 Possibility of cross-amplification was precluded by testing as many as 24 animal species (m

48 because direct tumor recognition and killing are precluded by the absence of MHC class I and II molec

49 ppositional behaviors, but causal inferences are precluded by the correlational nature of the data an

50 ing that some avenues for further adaptation are precluded by the IS150-mediated mutations.

51 c studies, measurements of DNA adducts often are precluded by the unavailability of fresh tissue.

52 c inputs to the primate DB1 bipolar cell has been precluded by the absence of a suitable immunohistoc

53 gations of resting human CD4(+) T cells have been precluded by the absence of efficient approaches fo

54 ne enzyme, a model for human complex I, have been precluded by the difficulty of preparing complex I

55 elopment but its function in this tissue has been precluded by the fact that in the Six3-deficient em

56 ation in the human structural connectome has been precluded by the inability of non-invasive neuroima

57 the catalytic mechanism of the enzyme, have been precluded by the instability of 5-hydroxyisourate.

58 However, significant advances have been precluded by the lack of mechanistic explanations f

59 le(s) of high affinity L-proline uptake have been precluded by the lack of specific uptake inhibitors

60 pithelialization is unknown and analysis has been precluded by the lethal phenotype of integrin alpha

61 oxyglucose (2DG) as a cancer therapeutic has been precluded by the need for high systemic concentrati

62 application of many complex natural products is precluded by the impracticality of their chemical syn

63 However, effective use of these data is precluded by the limitations of pattern-matching stra

64 However, rational therapy optimization is precluded by the poor understanding of the mechanism(

65 egation occurs even when disulfide formation is precluded by the presence of dithiothreitol (10 mM).

66 lation on the culprit regions, even when MRI is precluded by the presence of implanted devices.

67 Thus, aerobic growth is precluded by the vulnerability of these iron-sulphur

68 t a satisfactory refinement of the structure was precluded by the contamination of monomeric Ar'HgH b

69 ence of patterning, but detailed examination was precluded by the increased length and entanglement o

70 Further analysis, however, was precluded by the presence of mixing (shear) artifact

71 This effect was precluded by the selective TRPV4 antagonist HC-06704

72 ose escalation of SU101 above 443 mg/m(2)/wk was precluded by the total volume of infusate required,

73 er the course of environmental perturbations were precluded by the traditional preparation of bacteri

74 development of NTSR1 agonists has, however, been precluded by their severe side effects.

75 tylase inhibitor (HDACi) drugs for treatment is precluded by their weak blood-brain barrier (BBB) per

76 s impact on global biogeochemical cycles has been precluded by uncertainty concerning the relationshi