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1 l' oligonucleotide in which nucleobase pairs are replaced by .
3 Since 2013, (131)I-related PSMA therapy has been replaced by (177)Lu-labeled ligands, such as PSMA-6
5 h individual Tyr residues in the active site are replaced by 3-chlorotyrosine via amber suppression.
6 Ct values <= 35 for unamplified cDNA) had to be replaced by (3) proofing linear pre-amplification for
8 These macrophages disappear after birth and are replaced by a dynamic mixture of macrophage subtypes
10 ppler, evidence demonstrates that CVR should be replaced by a combination of a resistance-area produc
11 ed by a single bond, which could potentially be replaced by a fused aromatic ring to enhance the rigi
13 ed recovery coefficient lookup tables should be replaced by a more geometry-specific alternative.
14 work that currently characterizes DoC should be replaced by a multidimensional framework that better
15 was unnecessary to prevent errors and could be replaced by a rejection comment specifying clinical s
16 mending that our current emphasis on novelty be replaced by a renewed emphasis on predictive power as
17 In the simpler young wine model, V1 could be replaced by a vector containing just 3 odorants (ethy
20 logues in which one of the benzene rings has been replaced by a different (4n + 2) pai-electron syste
22 itical oxidative addition (OA) mechanism has been replaced by a halogen abstraction-radical capture (
23 one disease" paradigm of oral infections has been replaced by a holistic concept of a microbial commu
24 ate and end-stage kidney disease (ESKD), has been replaced by a more nuanced understanding of the com
25 owing well-studied biological structures has been replaced by a need for quantitative, reliable data
26 d South Asia, an older H9N2 virus strain has been replaced by a new reassortant strain with greater f
27 e phages lack an integration cassette, which is replaced by a 1.4 kbp segment with predicted partitio
28 hich the seven-membered nitrogen heterocycle is replaced by a 9-12-membered ring, were made by an una
29 ne-like motif bridging the two thienyl units is replaced by a benzene motif, and show that this compo
30 and an analog in which the oxazinone oxygen is replaced by a carbon stimulated XBP1 splicing in huma
31 used to elute the NAs off the magnetic beads is replaced by a carefully selected PCR solution, enabli
33 s of molecules in which a CH unit in benzene is replaced by a functionalized transition-metal atom.
35 expressed, if the prepared habitual response is replaced by a goal-directed alternative before it can
36 in which fermionic time-reversal invariance is replaced by a hidden symmetry emerging at the self-du
41 nal penta-symmetron formed by the capsomeres is replaced by a large vertex complex in the pseudo T =
42 struction, the normal polarity of MT current is replaced by a mechanically sensitive current evoked b
44 ion, whereby the dimethylbenzimidazole group is replaced by a non-nitrogenous ligand, which is likely
47 e SNAP25Delta3 mutant, in which residue G204 is replaced by a stop codon, features a partial reductio
50 The initial imidazo-thiadiazole scaffold was replaced by a 3-methyl-1H-pyrazolo[3,4-b]-pyridine w
53 1 knock-out neurons or when endogenous Nlgn1 was replaced by a non-phosphorylatable mutant (Y782F).
57 ibition with an ISI of 40 ms (but not 18 ms) was replaced by a time-specific facilitation (P < 0.001)
60 surrounded by polymorphonuclear cells, which were replaced by a notable number of IL-6-positive cells
62 s originated from yolk sac hematopoiesis and were replaced by a postnatal wave of bone marrow (BM)-de
63 nance imaging revealed that caudal vertebrae were replaced by a ventrally-positioned, unsegmented end
64 turnover across the early warming phase and were replaced by a virtually monotypic assemblage of a s
69 nce the nonpolymerizing fetal hemoglobin has been replaced by adult hemoglobin S at about 1 y after b
74 utant MTA3, in which the 2 cysteine residues are replaced by alanine residues, impairs the generation
76 metal-binding site of the polymerase domain were replaced by alanine is highly toxic to E. coli cell
85 ding interactions with the ribosomal target, is replaced by an apramycin-like dioxabicyclo[4.4.0]octa
87 ed that the amino acid asparagine 285, which is replaced by an aspartate residue in type P(O) SadP, w
88 canonical, negatively charged phosphodiester is replaced by an uncharged P-alkyl phosphonodiester bac
90 cid (in which the methyl group of R-naproxen was replaced by an ethyl group) acts as a potent AKR1C3
91 he ancient X Chromosome, but the ancestral Y was replaced by an X Chromosome carrying a new male dete
92 where the complex borohydride anion, BH4(-), is replaced by another anion, i.e. a halide or amide ion
95 y cell receptors; moreover, the aptamers can be replaced by any other ligands when developing a PAM.
97 1 where the normal glutamine at position 369 is replaced by arginine (Q369R), lysine (Q369K) or histi
99 ce, in which Ser(48), Ser(226), and Ser(227) were replaced by aspartic acid (designated as D-Tg) or a
100 endent on its MAP subunit EDE1, which cannot be replaced by AUG8, and that the cell-cycle-dependent f
102 initial decoding strategy, we suggest it may be replaced by better methods following visual experienc
105 yphenylenes, in which one or more aryl units are replaced by borazine rings, is reported for the firs
106 a healthy Lactobacillus-dominant microflora is replaced by BV-associated bacteria (BVAB), can signif
108 parental strain in which the wild-type cagY was replaced by cagY with DFMO-induced rearrangements.
110 ing which areas of subtropical native forest were replaced by Chinese fir, we show by direct measurem
112 ch the squamous epithelium of the oesophagus is replaced by columnar epithelium as an adaptive respon
113 The hydrogen atoms in these clusters can be replaced by convenient groups that open the way to a
117 PGHS-2 variants in which Pro-127 and Ser-541 are replaced by cysteines spontaneously forms Cys-127 to
118 o not persist in anthropogenic habitats, but are replaced by different native species and phylogeneti
121 faE-CTA2/CTB) in which the CTA1 domain of CT was replaced by dsc(19)CfaE that was strongly immunogeni
123 nerating knockin mice in which the native AR is replaced by either a polyQ AR or a polyQ AR lacking t
124 protein kinase A in the m-domain of cMyBP-C were replaced by either alanine or aspartic acid, mimick
126 s in the genome scanning of linkage analysis was replaced by estimating polygenic variance in a genom
129 ation-based P -value estimation methods have been replaced by exact methods, providing faster and mor
132 Reduced iron, an ineffective fortificant, was replaced by ferrous fumarate in wheat flour in 2002,
133 ape characterized by small chromatin domains is replaced by fewer but larger domains in mitosis.
134 one-third of the left ventricular myocardium was replaced by fibrosis, mainly of replacement type.
135 s, the dominant bacteria in healthy piglets, were replaced by Firmicutes in asymptomatic and diarrhea
136 tion observed when the four positive charges are replaced by four negative charges borne by sulfonate
139 titumor Vgamma5(+) gammadelta T cells, which were replaced by gammadelta T-cell subsets (mainly Vgamm
144 isotopomers in which carbon and hydrogen can be replaced by heavier nuclei at nearly every position.
146 n atoms in the graphitic carbon skeleton can be replaced by heteroatoms with different electronegativ
147 , we can show that NHR2 and NHR4 domains can be replaced by heterologous protein domains conferring t
149 ease burden in 1990, such as undernutrition, were replaced by high fasting plasma glucose and high bo
150 t model, the scaffolds degrade gradually and are replaced by highly matured new bone tissues, as asse
151 use of drugs on a compassionate basis should be replaced by highly powered, multi-centre, multi-arm c
152 when cytosine within an UNCG tetraloop motif was replaced by hm(5)rC, the thermodynamic stability of
153 s began to resolve, and eventually this area was replaced by hyperreflective, irregular, knobbly elev
156 Until now, the question if podocytes can be replaced by immigration of cells along the glomerular
157 suggesting that the effects of viral RNA can be replaced by increased Gag concentration in cells.
158 mensional system, observed before transition is replaced by intense localized spots after transition.
160 ic choices based on drug availability should be replaced by investments in modular (pro)drug and nano
161 sex) evoked by steady depolarization at rest is replaced by irregular firing during functional networ
162 Hnt's role in regulating Mmp2 and Oamb can be replaced by its human homolog Ras-responsive element-
163 ession and follicle cell differentiation can be replaced by its mouse homolog steroidogenic factor 1
164 nscription factor TATA binding protein (TBP) is replaced by its paralogue, TBPL2 (TBP2 or TRF3), whic
165 ptide segment (e.g., an alpha-helix, a loop) is replaced by its unnatural counterpart, with the expec
166 (MHV) in which all or part of the M protein was replaced by its phylogenetically divergent counterpa
169 untries where extensive farming systems will be replaced by large-scale intensive farming operations
171 electrodes', the phrase "anhydrous LiBr/LiCl was replaced by LiBr.H(2)O (99.95%; Sigma-Aldrich) and L
172 a-Aldrich)" should read "anhydrous LiBr/LiCl was replaced by LiBr.H(2)O (99.95%; Sigma-Aldrich) and L
173 Arachidic acid was selectively reduced and was replaced by linoleic acid from the seventh day of fe
174 mbrane cytochrome, one natural histidine has been replaced by lysine without loss of the native low s
175 ment, the oxyntic gastric glands atrophy and are replaced by metaplastic cells in response to chronic
177 gas in spin-exchange optical pumping (SEOP), was replaced by molecular hydrogen without penalty for t
179 at a very early stage in development, it may be replaced by more accurate methods as the animal gains
181 he changes involving uninformative relations being replaced by more specific and informative ones, wh
182 yer species with small geographic ranges are being replaced by more widely distributed species, and o
190 te could be decreased by 25% if coal were to be replaced by natural gas in the power generation and i
191 ntration would reduce 42% overall if biofuel were replaced by natural gas in the residential sector.
192 aradigm of anthracycline cardiotoxic effects is replaced by new insights that anthracycline targets t
195 which either all 68 sites or subsets of them were replaced by nonphosphorylatable or phospho-mimickin
197 revealed that the pyridinyl ring of 2 could be replaced by other aromatic rings and the pyrrolidinyl
198 in (residues 1379-1518) in Hsl1 but that can be replaced by other, heterologous phosphatidylserine-bi
199 es with potential adverse health effects are being replaced by other phthalates or phthalate alternat
200 asticity in that in some biotin operons bioH is replaced by other alpha/ss hydrolases of diverse sequ
202 bstitution matrix in the Psi-blast algorithm is replaced by our structure-based matrices, the structu
203 lenes, in which peripheral carbon atoms have been replaced by oxygen atoms, has been achieved for the
204 um satisfiability problems where the clauses are replaced by parity checks over potentially large num
207 lel measurement of absorbance of samples can be replaced by photometers based on inexpensive and ubiq
209 opionibacterium) at the surgical site, which were replaced by potential pathogens and intestinal anae
210 type ligands, in which the PPh2 substituents are replaced by PR2 (R = alkyl, benzyl) groups, are also
211 normally exist in elaborated networks, which were replaced by predominately individual punctuate mito
212 tes, the canonical anti-inflammatory program was replaced by pro-inflammatory and oxidative-stress-as
214 closely resemble Gaussian deviates, and can be replaced by quantiles from a Gaussian with negligible
218 tocin augmentation following misoprostol can be replaced by regular doses of oral misoprostol tablets
224 plantation development at these elements and is replaced by secondary imprinted DNA methylation on th
225 ry-lymph-node dissection for staging has now been replaced by sentinel-lymph-node biopsy for patients
226 ine in which a portion of Col-0 chromosome 4 was replaced by sequences of another ecotype, we show th
227 or a redox-insensitive mutant in which C674 is replaced by serine (C674S) were exposed to H(2)O(2) (
228 e and thus costly experimental studies could be replaced by simulations for movement analysis and vir
230 -dominant species in savanna ecosystems - to be replaced by smaller, less water-dependent species.
232 Pegylated interferon plus ribavirin has been replaced by sofosbuvir plus pegylated interferon an
233 aits (low specific leaf area, short stature) were replaced by species with resource-acquisitive funct
234 l stem cells (ISCs) in the Drosophila midgut are replaced by spindle-independent ploidy reduction of
235 cherichia coli strains in which wildtype SSB is replaced by SSB-IDL fusions are viable and display no
237 rofiling of MRSA began in the mid-1980s, has been replaced by ST22 isolates belonging to EMRSA-15, a
238 ted during a dense cyanobacterial bloom, but were replaced by strains with only the high-flux bicA ge
240 nsional mammographic images are increasingly being replaced by synthetic mammograms in DBT screening
241 iciency remained equally potent when helices were replaced by synthetic membrane-binding motifs.
245 rmiogenesis, 90% of the nucleosomal histones are replaced by testis-specific transition proteins, TP1
246 Cdc15 is essential for viability and cannot be replaced by that of Imp2, whereas the F-BAR domain of
247 in which the ligand-binding domain of GluD1 is replaced by that of GluK1, to examine its synaptic tr
248 proteins in which the neck region of DNGR-1 is replaced by that of unrelated C-type lectin receptors
249 h the N-terminal 45 residues of mouse band 3 are replaced by the homologous sequence from human band
250 o intermittent hydrogen-bonded clusters that are replaced by the inhibitor moieties upon ligand bindi
251 n which two inhibitory phosphorylation sites are replaced by the non-phosphorylatable amino acids T14
252 and Met-362 of the reentrant hairpin loop 2 are replaced by the smaller Ala and Thr, respectively.
253 mprecise "one-dose-fits-all" approach should be replaced by the clinically proven MPA target concentr
254 red for its uptake and that none of them can be replaced by the homologous genes of the other mce ope
255 ecules essential for the lipase activity can be replaced by the hydroxyl groups at the GO surface.
256 e function of the original coumarin dyes has been replaced by the cyano(4-nitrophenyl)methylene moiet
257 Trypanosoma brucei the function of Pam18 has been replaced by the non-orthologous euglenozoan-specifi
258 A-based MTTT algorithm, where immunoblotting is replaced by the C6 EIA, performs as well or better th
259 normal; and secondly where the second layer is replaced by the complementary to the original, i.e. a
260 RAG-2 protein in which the mouse PHD finger is replaced by the corresponding domain from the shark C
261 helical subdomain in dimeric bacteria ASADH is replaced by the cover loop in archaeal/fungal ASADHs,
262 phenylbenzothiazole or 2-phenylbenzimidazole is replaced by the cyclopentadienyl tricarbonyl [Cp(99m)
266 x in the likelihood of the Poisson based HMM is replaced by the observed transition probabilities of
267 in which the endogenous H19/Igf2 ICR (mIC1) is replaced by the orthologous human ICR (hIC1) sequence
268 udy mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P0 and desc
269 ER, and MTs in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein, P0 (
270 he phenanthridine ligand of phenanthriplatin is replaced by the smaller pyridine molecule, indicating
271 the case of exchange, the protein on the DNA is replaced by the solution-phase protein through compet
272 program, in which the space of permutations is replaced by the space of doubly stochastic matrices.
273 SS proteins and when one interaction partner was replaced by the corresponding protein from the other
274 c SPE-45 protein in which its Ig-like domain was replaced by the Ig-like domain from mouse IZUMO1.
276 h specific regions of the human DAF molecule were replaced by the corresponding murine sequences.
277 e second, products not meeting the standards were replaced by the most nutritionally similar alternat
278 horiomeningitis virus (rLCMVs), whose S-IGRs were replaced by the S-IGR of Lassa virus (LASV) or an e
279 D) so that the first 40 amino acids of gp120 were replaced by the signal sequence and the first 27 am
280 teins containing the zinc-binding CXXC motif are replaced by their motif-free paralogues, collectivel
282 Thus, on a slow timescale, fast species can be replaced by their quasi-steady state (QSS): their sta
284 ffers from that obtained when quality scores are replaced by those generated by a lossy compressor.
285 ant surface proteins (ompA and pmpEFGH) have been replaced by those characteristic of classical ocula
286 that unknown gut microbes of wild rhinos are being replaced by those found in conventional human-dome
287 ins in which the AR and C-tail from HPV11 E1 were replaced by those of BPV1 indicated that while the
288 the oligomerization domain (OD) and the CTD were replaced by those of VSV P stimulated RABV RdRP act
290 mmonly used "aromatic" resonance form should be replaced by two more accurate resonance structures.
292 eduction in CVD risk can be achieved if SFAs are replaced by unsaturated fats, especially polyunsatur
293 dominance but coral habitats at deeper sites were replaced by unstable substrata such as fine sedimen
295 ginally used P4 benzylsulfonyl residue could be replaced by various sulfonyl- or urethane-like protec
300 a conversion in state where ZEB2 expression is replaced by ZEB1 expression associated with gain of a