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1 es isomerized by light to the all-trans form be replaced with 11-cis retinal to regenerate the visual
3 hich expert knowledge and parameter tweaking are replaced with a probability-based hypothesis test.
5 bulk method, sorting and cDNA library steps are replaced with a reverse-transcriptase (RT) reaction
6 ty of bacterial ribonuclease P-can sometimes be replaced with a highly divergent homolog, the cellula
8 able for generic recruitment, since it could be replaced with a nonviral membrane-binding domain with
9 en semantic and environmental context should be replaced with a novel conceptualization of hippocampu
10 The interacting methyl group of Aib could be replaced with a range of alkyl and aryl substituents
13 in which the beta,gamma-bridging oxygen has been replaced with a CXY group are useful chemical probe
14 s from the conventional azobenzene class has been replaced with a five-membered heteroaromatic ring.
16 However, the ancestral Zinderia symbiont has been replaced with a novel symbiont closely related to S
17 Now, we report that B cells in which Sgamma1 is replaced with a 28 I-SceI target array, designed to i
19 nation product, in which the AcN(NO)-C5 bond is replaced with a AcO-C5 bond with the retention of con
21 y as a single point on a free energy surface is replaced with a bithermal property that is derived fr
23 ect BRE and is abolished when the pf1089 BRE is replaced with a BRE from a strong archaeal promoter.
24 knockin mouse model in which endogenous p35 is replaced with a calpain-resistant mutant p35 (Deltap3
25 x spp.) in which the traditional oil droplet is replaced with a complex of electron-dense megamitocho
27 an be stabilized if one of the pyrrole rings is replaced with a furan ring to afford stable oxasmarag
28 In this strategy a null mutation in any gene is replaced with a genetically stable transgene that con
31 is not observed when the oxygen of 5-O-CH(3) is replaced with a larger atom (selenium or sulfur).
33 the apolar moiety of sulfonamide inhibitors is replaced with a more open, hydrophilic pocket in Hpal
35 upling between H(+) and sugar translocation, is replaced with a neutral side chain, the pH effect is
36 t S(2)/S(1)/triplet pathways for spheroidene is replaced with a new pathway for spheroidenone involvi
37 atable version of IDH2(R172K), in which K172 is replaced with a photocaged lysine (PCK), via genetic
38 lic hydroxyl and the keto oxygen in pyruvate is replaced with a potentially stronger hydrophobic inte
39 a-helix of the consensus 455 face in Sma0114 is replaced with a segment that shows high flexibility o
42 e, the normal left-right alternating pattern is replaced with a synchronized hopping gait, and the co
43 in which one of the three disulfide bridges is replaced with a thioether linkage, and evaluate the b
44 n, which requires an A/T-rich (W-box) motif, is replaced with a zygotic TSS selection grammar charact
45 the terminal phenyl group of the dibemethin was replaced with a 2-pyridyl group and in which the 4-a
46 frameshifting also occurred when the C-chord was replaced with a canonical slippery sequence from HIV
47 hemically labile oxindole hydrazide scaffold was replaced with a chemically and metabolically stable
48 spensable thymidine T2.1 in the 8-17 DNAzyme was replaced with a deoxyuridine, resulting in minimal c
50 a new mouse model in which endogenous MerTK was replaced with a genetically engineered variant that
52 which at least one alpha-amino acid residue was replaced with a homologous beta-amino acid residue.
53 , and the chimera Dap2alpha, in which the SA was replaced with a hydrophilic segment, with the propen
55 d efficiently to the VCCs when the NC domain was replaced with a leucine zipper dimerization motif th
57 n (KI) mice in which endogenous cPLA(2)alpha was replaced with a mutant form having an ablated C1P in
59 21F variant in which the proximal tryptophan was replaced with a non-oxidizable phenylalanine exhibit
60 e question on technical skill of endoscopist was replaced with a question on patient comfort during e
61 re produced in which the epsilon-globin gene was replaced with a second marked beta-globin gene (beta
62 llite sequence; cells in which this sequence was replaced with a synonymous nonmicrosatellite sequenc
63 ological sensor, the fibrin clot end-product was replaced with a synthetic material under the biologi
66 E-cYFP-TM, where GPI anchor addition domains were replaced with a single-pass transmembrane domain, f
68 ease in which the current expectant approach is replaced with active attempts to uncover MRD before e
69 Lys residue at P3' of Pro-sigma(K) could not be replaced with Ala unless a Lys was provided farther C
70 utant in which an inverted Cys-Pro motif had been replaced with Ala residues fails to bind hemin with
72 , the Y15A and Y15G variants in which Tyr-15 is replaced with Ala or Gly, respectively, are monomeric
75 en the serine and acidic residues of the SRT were replaced with Ala, Leu, and Gly, trans-activation a
76 s from mice in which the beta93 cysteine had been replaced with alanine (beta93A) in a number of ex v
78 ression of an H3.3 mutant in which serine 31 is replaced with alanine, the equivalent residue in H3.2
80 eE but not NleE(49AAAA52) where each of GITR was replaced with alanine restored the ability of an nle
81 art of the predicted binding pocket (Phe342) was replaced with alanine, the apparent affinity of the
82 residues (Cys 85, Cys 101) within this motif were replaced with alanine, and the effects of these rep
83 ant in which three Lys residues (KKK191-193) were replaced with alanine, and/or its other mutants wit
84 proposed to bind to the incoming duplex DNA were replaced with alanines, resulting in apparent loss
86 energy, and CO2 emissions reduction if they were replaced with alternatives that consume less energy
88 lization that the arylglycine cap of 2 could be replaced with an alkylglycine derivative and still ma
92 in which the native metal of a metalloenzyme is replaced with an abiological metal with reactivity di
93 Of these, an analog in which the EFV alkyne is replaced with an alkene and an analog in which the ox
94 the typical B-D-E immunoglobulin beta-sheet is replaced with an alpha-helix further confirms the ext
97 ignificantly reduced when the mp-Al2 O3 film is replaced with an mp-TiO2 electron extraction and tran
98 cadherin through a flexible linker or if it was replaced with an actin-binding domain of utrophin.
100 insert of an anthropomorphic cardiac phantom was replaced with an aortic aneurysm model containing a
101 The normal Faraday plate collector electrode was replaced with an electrode "needle" used to concentr
102 he middle Pro residue within the tripeptides was replaced with analogues of varying ring sizes (azeti
103 The decomposition in the manual pipeline can be replaced with any NMF algorithm, for further generali
104 in which the 8 lysine amino acids of p5 have been replaced with arginine residues predisposing the pe
105 equivalent residue to K305 in human NHA2 has been replaced with arginine, which is a mutation that ma
108 in which the largest RFC subunit, RFC1, has been replaced with ATAD5 (ELG1 in Saccharomyces cerevisi
113 ferase from Bacillus subtilis (MazF-bs(arg)) were replaced with Can by using the single-protein produ
119 back was eliminated when extracellular Na(+) was replaced with choline and significantly reduced by a
120 Protocolized POD 1 laboratory testing should be replaced with clinically-based criteria to trigger se
123 position in the M2 membrane-spanning segment was replaced with Cys in dupalpha7 or dupDeltaalpha7, an
129 mnia where the traditional analgesics in PCA were replaced with dexmedetomidine (Dex), an alpha-2 ago
130 he myeloid lineage in which XIAP alleles can be replaced with disease-associated XIAP variants expres
131 replaced by O(6)-Bn-dG and cytosine C(9) has been replaced with dPer to form the modified O(6)-Bn-dG:
132 ified DDD in which cytosine at position C(9) is replaced with dPer to form the dG:dPer (DDD-GY) [5'-d
133 erve terminals in which dynamin 1 and 3 have been replaced with dynamin 1 harboring dephospho- or pho
135 rated that a recombinant VSV where G protein is replaced with EBOV GP (rVSV-EBOV) is safe and highly
137 the P. berghei csp gene coding sequence has been replaced with either full-length P. vivax VK210 or
138 sensitivity of strains in which YvcK Thr-304 was replaced with either an alanine or a glutamic acid r
139 residue involved in the depsi (ester) bond, was replaced with either diaminopropionic acid (DAPA), (
140 in mdx mice in which the Cx43 serine-triplet was replaced with either phospho-mimicking glutamic acid
142 dels in which the three PKA sites in cMyBP-C were replaced with either phospho-mimic (DDD) or phospho
143 approach where the mouse PrP coding sequence was replaced with elk or deer PrP, we show that the resu
144 binding motif ESEV (which affects virulence) was replaced with ESKV, and NS1-138F (which is highly co
145 ng and suckling deficits in infants with PWS are replaced with excessive feeding and obesity in child
148 3) to 12-20 mug/m(3), when synthetic filters were replaced with fiberglass filtration media in the HV
150 at chimeric rhabdoviruses in which G protein is replaced with filovirus GP, widely used as surrogate
151 y abiotic assay where antibodies and enzymes are replaced with fluorescent molecularly imprinted poly
152 e useful in deciding whether orchiectomy can be replaced with follow-up or less invasive organ-sparin
153 which components of undefined activity have been replaced with fully defined culture conditions.
154 and analgesia when water for injection (WFI) was replaced with glucose 5% (G5) for (90)Y-resin micros
155 tein (Cp183-EEE), in which three CTD serines are replaced with glutamate to mimic phosphorylated prot
156 the S segment and one in which the NSs gene was replaced with green fluorescent protein (GFP), allow
157 tone gene array in which all H3-H4 promoters were replaced with H2a-H2b promoters (12x(PR)) does not
158 ously described a mouse model in which mDPP4 was replaced with hDPP4 such that hDPP4 is expressed und
159 and the intracellular transcriptional module are replaced with heterologous protein domains, can serv
160 ackage the newly replicated genome, they can be replaced with histone variants that alter nucleosome
162 e of transmission until April 2014 (60%) and was replaced with hospital exposure in June 2014-July 20
164 del in which the endogenous mouse Fgfr3 gene was replaced with human FGFR3(G380R) (FGFR3(ACH)) cDNA,
167 sential for antimicrobial activity and could be replaced with hydrophobic aliphatic or aromatic group
168 ovirus vaccine (OPV) will eventually need to be replaced with inactivated poliovirus vaccines (IPV).
169 HMGB-1 is sufficient to prime microglia, IS was replaced with intracerebral administration of disulf
170 In two of the 18 systems, Pb valve weights were replaced with iron, which decreased the observed Pb
172 P-A1 in which the threonine residue in P-A1 was replaced with l-2,3-diaminopropionic acid (P-A1-Dapa
174 Expensive, ineffective membrane materials are replaced with laminar flow and a nonselective, porou
175 sembly remained defective when D231 and K178 were replaced with larger charged residues or when their
176 s of the eastern Pacific Ocean, amphibactins were replaced with lower concentrations (1-2 pM) of hydr
177 % deionized water of polysulfide electrolyte was replaced with methanol to improve the wettability an
178 cally altered when one of the cytosine bases is replaced with methyl-, hydroxymethyl-, formyl-, or ca
179 exyl) phthalate (DEHP), are now increasingly being replaced with more environmentally friendly altern
180 ors were inactive when the plasmid substrate was replaced with mRNA, suggesting they interfered with
181 If magnetocaloric working bodies were to be replaced with multilayer capacitors of PbSc(0.5)Ta(0.
182 alogues in which the intracyclic Trp residue was replaced with natural, unnatural, and constrained am
183 xperiment, and then two members of the group are replaced with new participants, and the newly formed
184 pounds, where the tetramethylpiperidine ring was replaced with new scaffolds, led to improved antivir
186 of an internally tagged Cse4 reveals that it is replaced with newly synthesized molecules in S phase,
187 ins almost unchanged when CH meta to B and N is replaced with nitrogen, and becomes slightly weaker w
190 MP-13 active site, the Zn(2+) chelating unit was replaced with nonchelating polar residues that bridg
193 ions, in which three hydrophilic amino acids are replaced with nonpolar residues, that leads to dewet
195 4) mice, in which the coding region for BDNF is replaced with NT4, we examined whether the different
197 SST) means and annual cycles in all the GCMs are replaced with observed data from the ~4-km NOAA Path
198 site of a minimal type I hammerhead ribozyme were replaced with oligo-U loops, severely crippling or
201 R study indicated that the allyl group could be replaced with other substituents, with the most activ
202 lication in commercial products is gradually being replaced with other related compounds, such as bis
204 ) mice in which the entire T-cell repertoire was replaced with ovalbumin (OVA)-specific CD8(+) or CD4
205 ocodone, in which the N-methyl functionality was replaced with oxygen, sulfur, sulfoxide, and sulfone
206 ral phenylcyclopropyl amide side chain of 2a was replaced with p-fluorophenylisoxazole-carbonyl moiet
207 enerated in which Tyr(99) or Tyr(138) of CaM was replaced with Phe, generating mutant CaM, Phe(99)-Ca
208 a Syn5 RNA polymerase in which tyrosine 564 is replaced with phenylalanine (Y564F) that further decr
209 ylation site, Tyr(399), in endogenous PTPROt was replaced with phenylalanine had increased bone mass
211 empirical parameters in existing models must be replaced with physics- and biology-based terms anchor
212 ice in which the weakest S region, Sepsilon, is replaced with prominent recombination hotspot Smu.
214 n from beef consumption in the United States was replaced with protein from oysters, the GHG savings
215 Recently fish meal and oil have increasingly been replaced with proteins and oils from vegetable sour
218 In the second cohort, when body mass index was replaced with radiologic anthropometric measurements
220 ctivity of another nucleophile when His(nuc) is replaced with residues containing a small side chain
221 d increased to 5.1% and 7.3% when rice flour was replaced with retrograded and retrograded debranched
224 ated mice in which either IGCR1 CBE1 or CBE2 was replaced with scrambled sequences that do not bind C
226 midine (DB75) in which the central furan has been replaced with selenophene and/or one or both of the
227 whose Cys axial ligand to the heme iron has been replaced with Ser) generated variants that selectiv
228 FixK2(C183S)-His6) was used in which Cys-183 was replaced with serine and the C terminus was fused wi
230 he two intracellular regions of the receptor were replaced with serines using site-directed mutagenes
231 he extracellular domains of the TCR and pMHC were replaced with short hybridizing strands of DNA.
233 evels of fish meal (FM) protein in aquafeeds being replaced with soybean meal (SBM) protein, understa
235 ventional three dimensional MR scalar images are replaced with spatially resolved multidimensional sp
236 ng of other noncanonical bases, RNase H2 can be replaced with specific nicking endonucleases in this
237 e of sperm development during which histones are replaced with sperm-specific protamines to repackage
239 riazolopyrimidines wherein the p-SF5-aniline was replaced with substituted 1,2,3,4-tetrahydro-2-napht
240 e termed codon optimization, in which codons are replaced with synonymous ones in order to increase p
241 n which all 62,214 instances of seven codons were replaced with synonymous alternatives across all pr
243 phenyl derivatives in which the central ring is replaced with tetrafluoro-, tetramethyl-, or di-tert-
244 RNA constructs in which specific G residues are replaced with (th) G, an emissive isomorphic G surro
245 ric virus in which the ULb' region of TB40/E was replaced with that of AD169 showed reduced effects o
246 Ad5/3 vector in which the knob region of Ad5 was replaced with that of Ad3, conferring partial resist
248 ne hepatitis virus (MHV) in which the N gene was replaced with that of its close relative, bovine cor
249 ch the gH transmembrane and cytoplasmic tail were replaced with that of human CD4 protein permitted c
250 ich large genomic regions of S. lycopersicum are replaced with the corresponding segments from S. pen
251 is-acting form of K28, each nucleotide could be replaced with the corresponding 2F analog without los
253 V-1 MONITOR Test, version 1.5 (Amplicor) has been replaced with the COBAS AmpliPrep/COBAS TaqMan HIV-
255 muscle excitation-contraction coupling, has been replaced with the corresponding but nonfunctional l
256 nal sequence downstream of the kinase domain being replaced with the corresponding CRAF sequence.
257 conserved N terminus of the mature PilA1His is replaced with the corresponding N domain of FlgA1 is
259 mice (AKBI), in which the IkappaBalpha gene is replaced with the IkappaBbeta cDNA, we show that Ikap
260 r partially labile systems whenever the time is replaced with the product lability degree times t.
261 ) of the N170K/K297G double mutant of hRPE65 was replaced with the corresponding cRPE65 fragment, the
262 coding sequence from the start to stop codon was replaced with the corresponding human genomic region
263 23-21c, where the C-terminal domain of FGF23 was replaced with the corresponding regions from FGF21.
264 residues N-terminal to the acetylation site was replaced with the corresponding sequences from other
266 histocompatibility complex class II antigen was replaced with the human leukocyte antigen DR4 (HLA-D
267 e IL-15Ralpha intracellular signaling domain was replaced with the intracellular portion of the IL-2R
268 drift tube for an ion mobility spectrometer was replaced with the IonCCD providing images of ion pro
269 which the ospA open reading frame, on lp54, was replaced with the ospC gene or the ospB gene, encodi
272 ich the N-terminal transmembrane domain of S was replaced with the transmembrane domain of the HCV en
273 ch the ectodomains of envelope glycoproteins were replaced with the corresponding ectodomains from av
274 ubstitution where all non-exchangeable atoms were replaced with the corresponding heavy isotope ((13)
275 Experiments in which regions of Far1 or Far2 were replaced with the corresponding region of the other
276 utative DNA binding loop regions of APOBEC3G were replaced with the corresponding regions from APOBEC
278 sive to neurounina-1 when both alpha-repeats were replaced with the corresponding regions of NCX1.
279 1b laboratory (lab) strains (H77c and Con1) were replaced with the corresponding regions of specimen
280 second extracellular loops of CD81 and OCLN were replaced with the respective human sequences, which
281 C911 because bases 9 through 11 of the siRNA are replaced with their complement, was able to complete
282 ariant exchange, in which canonical histones are replaced with their variant counterparts, is an enti
285 Conserved sequence motifs within the TMD were replaced with those from the established trans-Golg
288 anef were constructed in which env sequences were replaced with those of the heterologous strain E543
289 membrane and cytoplasmic tail (TMCT) domains were replaced with those of the HPIV1 F protein in an ef
290 moval was needed due to stent migration, and was replaced with three stents telescopically aligned to
293 g is observed when the benzamide derivatives are replaced with trifluoroacetamide, causing an additio
294 the Ala residues at different positions have been replaced with Trp residues, has been investigated.
295 ng faces of the outward-facing cavity walls, are replaced with Tyr or Phe, and reduced quenching is o
297 st that the triazolone/side chain region can be replaced with various functionalities (hydrazine carb
298 polymers where one of the four normal bases is replaced with various cationic, anionic or neutral an
300 In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnost