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1 rgets in Liver-RE mice, circadian expression is restricted to ~10% of normally rhythmic transcripts.
2  when compared to non-conserved epitopes and were restricted to 13 HLA class I genotypes, hence provi
3 r, since treatment duration with these drugs is restricted to 18-24 months, treatment should be conti
4 lcohol intake among men with prostate cancer was restricted to 5,182 men diagnosed with nonmetastatic
5 urrent studies of DNA synthesis through STRs are restricted to a handful of selected sequences, limit
6                  However, their applications are restricted to a limited number of metal ions owing t
7 ty is highly dynamic but that these dynamics are restricted to a low-dimensional set of motifs, poten
8 ce are currently limited in availability and are restricted to a single genetic background.
9  Control analyses revealed these findings to be restricted to a multivariate compared with a univaria
10    The active CNV mutation shower appears to be restricted to a transient perizygotic period.
11       In this paradigm, daily caloric intake is restricted to a consistent window of 8-12 h.
12 transcriptomically-defined populations, eGFP is restricted to a discrete subset of cells in the GRP::
13 ontrast, in the mature brain, its expression is restricted to a few presynaptic terminals and scatter
14 However, our understanding of these patterns is restricted to a few taxonomic groups.
15 presents an intriguing case study because it is restricted to a single 'contact zone' population, inv
16 laria gibba, the upper leaf (adaxial) domain is restricted to a small region of the primordium that g
17         In this paper the use of SAT solvers is restricted to a smaller task related to factoring: fi
18 tural' and 'non-natural' rates, this finding is restricted to a subgroup of the population with quant
19                            Tumor development is restricted to a subset of alveolar type II cells expr
20 e approved cancer therapeutics, but efficacy is restricted to a subset of tumors and resistance often
21 emonstrate that Lgr5 expression in the liver is restricted to a unique subset of hepatocytes most adj
22 cell immunity in peripheral blood and tumors was restricted to a few clonal neoantigens featuring an
23  (PBMCs), the propagation of the two viruses was restricted to a similar level when Nef was not expre
24     Increased production of leukotriene E(4) was restricted to a subgroup of patients with eosinophil
25  of uncoupling protein 1 after cold exposure was restricted to a subpopulation of MCT1-expressing adi
26 ring induced migration, whereas alpha6beta4E was restricted to a subset of cells with increased kinet
27 itochondrial genomes from Order Thysanoptera were restricted to a single family, the Thripidae, resul
28 up is still challenging because most studies were restricted to adult subjects.
29 e (5-15 years and 45-60 years), whereas PCPs are restricted to adults mainly in the fifth and sixth d
30 ly, the requirement for MYO7B in endocytosis is restricted to alpha-Syn PFFs and other polycation-bea
31 c vertebrates and that epiblast pluripotency is restricted to an intermediate cellular state residing
32 onceivably because most studies to date have been restricted to analyses of circulating CD8+ T cells.
33 atial vision can "see." Conventionally, this was restricted to animals possessing discrete visual org
34 ssed in inflamed tissues, whereas the latter is restricted to antigen-presenting cells.
35 ins belong to a clade of P-type ATPases that are restricted to apicomplexans and their closest relati
36                    Benefit/harm calculations were restricted to aspirin-naive participants <70 years
37 uction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marginal zones
38                  The experimental conditions are restricted to be categorical in their work.
39                          One of these clades was restricted to Beringia while the other was prevalent
40                        During eTRF, daily EI was restricted to between 08:00 and 16:00, which prolong
41 approvals (24/35, 69%), all clinical studies were restricted to biomarker-positive patients (enriched
42                       Drosophila cortex glia are restricted to brain regions devoid of synapses, prov
43 pothesised that such human activity may have been restricted to brief periods of climatic warming wit
44 l models, high-resolution kinematic tracking is restricted to brief sessions in constrained environme
45 y related SARS-CoV-1 and MERS coronaviruses, is restricted to BSL-3 facilities.
46 s were substantially magnified when analyses were restricted to cases attributed to serovars commonly
47          Ag-reactive CD4 cytokine production was restricted to CD4 cells with an effector memory phen
48                              Initial studies were restricted to cell peripheries and typically focuse
49 re ubiquitously expressed, SPTLC3 expression is restricted to certain tissues only.
50   Furthermore, NO reduction by both pathways is restricted to chlorophytes, organisms particularly ab
51  L. asiaticus cannot be cultured; its growth is restricted to citrus phloem and the psyllid insect.
52                                   The search was restricted to clinical studies and relevant grey lit
53 odimeric receptors and will therefore likely be restricted to closely related homodimeric GPCRs.
54                   Nevertheless, the analyses are restricted to coarse-scale signals and should be con
55                               Available data is restricted to cohorts acquired over several decades a
56 sediment models, their scopes have generally been restricted to comparing the individual model perfor
57 ar coordination environment is known, but it is restricted to condensed metallic phases(8), the hexag
58 DP-43 pathological signature of sporadic ALS is restricted to cortical areas as well as to subcortica
59 s methods of heptamethine chain modification are restricted to coupling reactions and nucleophilic su
60 humans and in knock-in mice, and this effect was restricted to D3 selective brain regions (limbic str
61 chaperone activity and whether this function is restricted to de novo protein synthesis is unknown.
62  suggesting that semaphorin function may not be restricted to dimers.
63 d grouped failure time, where times or doses are restricted to discrete increments.
64 lar signal-regulated kinase (ERK) activation is restricted to distinct cell types in different RASopa
65 ve a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance
66 ut how exactly cone photoreceptor production is restricted to early stages remains unclear.
67               Many higher level avian clades are restricted to Earth's lower latitudes, leading to hi
68 ase, and the AlmEFG tripartite system, which is restricted to EI Tor biotype of Vibrio cholerae O1.
69 beta-cells postnatally, while its expression is restricted to embryonic and neo-natal beta-cells in m
70 into amino acid code, the extant biopolymers are restricted to encoding amino acid or nucleotide sequ
71 on strategies vulnerable if their production is restricted to environments, which may be too costly t
72 is supposedly ancient lineage of amoebozoans are restricted to extant taxa.
73           However, almost all of the changes were restricted to extreme treatments that led to carbon
74 m that, in the CY spigot clade, such spigots are restricted to female spiders.
75 study reveals a CpG methylation pattern that is restricted to female animals that had borne offspring
76 tudies that corrected for gestational age or were restricted to full-term infants to separate effects
77                      Mutations of Mecp2 that are restricted to GABAergic cell types largely replicate
78  C18 polyunsaturated fatty acids (FAs), 18:5 being restricted to galactolipids.
79 brane spherules (DMSs) previously thought to be restricted to gamma- and delta-CoV infections and pro
80                        Its normal expression is restricted to germ cells and attenuation of its activ
81 t HIF-1alpha deletion in NTS-HIF-1alpha(-/-) was restricted to glutamatergic neurons.
82                  CI symptoms at 12 degrees C were restricted to green fruit peel sectors but at 2 deg
83                Since hepatic RhBG expression is restricted to GS-expressing hepatocytes, the findings
84  analyses included both cohorts (pooled) and were restricted to heavy ever smokers (>=20 pack-years).
85          Plasmodium parasites are thought to be restricted to hepatocytes throughout this obligate li
86 ion elicited localized Ca(2+) increases that were restricted to hepatocytes in the periportal zone.
87       Amorphous analogs for MHPs have so far been restricted to high pressures, limiting detailed stu
88     Replication of RV in the small intestine is restricted to homologous host species, and host range
89 that arginine-GlcNAcylation, once thought to be restricted to host cell compartments, also plays an i
90           As the mechanism of action of ABMA is restricted to host-endosomal compartments, it reduces
91                                  Eligibility was restricted to human participants and studies written
92 unodeficiency virus type 1 (HIV-1) infection is restricted to humans and some nonhuman primates (e.g.
93 cens with a metabolism previously thought to be restricted to (hyper)thermophiles and acidophiles.
94 hether the perceptual impairments seen in DP are restricted to identity information, or also affect t
95 rudimentary, because most human studies have been restricted to immunological analyses of blood and v
96 ogenetic non-independence (e.g., [13-16]) or been restricted to individual clades (e.g., [11, 12, 16]
97 unts and thus access to these treatments can be restricted to individuals with normal levels of white
98 da from administrative databases; the sample was restricted to individuals at average risk of colorec
99 -mediated inhibition of type I IFN signaling was restricted to infected cells.
100 ing long-range spin-spin coupling has so far been restricted to interactions between individual spins
101                     The karyokinesis defects were restricted to intestinal cells and required close p
102 llows more options for further manipulation, are restricted to intrinsically slow printing methods su
103        However, mechanosensors of this class are restricted to ion channels.
104                                 Our analyses were restricted to IPV leading to arrest, suggesting tha
105  ultraviolet radiation (UVR) exposure, which is restricted to iris UM.
106  FBXO31 during normal cell-cycle progression is restricted to its functions during the G(2)/M phase.
107 on wheat, suggesting that the ancestral Pm41 was restricted to its place of origin and was not incorp
108                      Until recently, studies were restricted to keratinocyte-derived cell lines immor
109                In contrast, the Sec-7 domain was restricted to L. pneumophila and seven other species
110                  Specifically, these species are restricted to large body sizes, diets consisting of
111            The protective effect appeared to be restricted to large polyps located in the proximal co
112                             How FGF activity is restricted to leading cells in this system is, howeve
113 mechanisms of this phenomenon and whether it is restricted to legume plants are not known.
114 rrence in cell walls, PRX oxidative activity was restricted to lignifying regions during development,
115                 In most cases, these species are restricted to limited locations, and the relative li
116 passively traveling photosynthetic organisms are restricted to live.
117 tention, but not endogenous attention, would be restricted to locations within the so-called oculomot
118 spontaneous visual improvements in subacutes were restricted to luminance detection; discrimination a
119 edge of associated immune system adjustments is restricted to mammals.
120                        Initially believed to be restricted to marine animals, fluorescent colours are
121 ons for above-belowground community assembly is restricted to mathematical and conceptual model proje
122 he host diversity in the enrichment cultures was restricted to members of the order Sulfolobales.
123  would continue to increase if DTG-based ART was restricted to men.
124 croglia of different phenotypes, rather than being restricted to microglia which express classical pr
125                 However, until now they have been restricted to micrometer-scale areas, reducing thei
126  and bundled microtubules, severing activity is restricted to microtubule cross-over and nucleation s
127 ls throughout pregnancy, but this difference was restricted to monoinfected participants.
128                                 The analysis was restricted to mothers with estimated daily total fol
129                     Even when TRA expression is restricted to mTECs, DCs still present self-antigens
130 se results were reinforced when the analysis was restricted to municipalities with more than 5 radon
131                   Here we report that MS4A4A was restricted to murine and human mononuclear phagocyte
132                       However, these results were restricted to mutations which did not change the ne
133 w Fluorescent Protein (YFP) in these animals is restricted to myeloid lineage allowing the identifica
134 +) model, the earliest epileptiform activity is restricted to neocortical and entorhinal networks.
135 monstrate that enteric CDNF immunoreactivity is restricted to neurons (submucosal > myenteric) and is
136                Imprinted expression of UBE3A is restricted to neurons by expression of UBE3A antisens
137  we also find that GC-biased gene conversion is restricted to non-crossover tracts containing only on
138                      Hoxa11 expression in BM is restricted to nonhematopoietic cells.
139 genes involved in Wnt secretion and response was restricted to nonoverlapping cells.
140 ogic gated operations and amplifications but is restricted to nucleic acid output.
141 cause or CVD mortality, but the associations were restricted to nutrient intake from foods.
142  results were even stronger when the outcome was restricted to obesity-associated cancers (HR 0.59, 9
143 oyo virus, we show that these rearrangements are restricted to Old World arenaviruses and are not ind
144 c compartments, with the majority of changes being restricted to one location and not the other.
145                             Cpne4 expression is restricted to one amacrine cell population of the INL
146 g hetDNA formed during mitotic recombination were restricted to one locus.
147  infecting humans were rare and when present were restricted to one or two viral families.
148 s, but existing ab initio simulation methods are restricted to only the smallest proteins due to seve
149                             However, its use is restricted to only those people who are confident wit
150 es (such as genome-wide association studies) is restricted to only trusted individuals.
151 x of Orai1+ CD4 T cells and IL-17 expression was restricted to Orai1+ cells.
152  mammalian oocytes and embryos has generally been restricted to overall uptake and detailed understan
153                 Robust RAG-mediated cleavage is restricted to paired V(D)J segments flanked by comple
154 r bla(CTX-M) genes, as their bacterial hosts were restricted to particular genetic lineages, includin
155 , aberrant production of LIF in the pancreas is restricted to pathological conditions and correlates
156 um of targeted organisms, FA-M/E testing may be restricted to patients with abnormal CSF findings.
157 ore, this curative approach should no longer be restricted to patients with HLA-matched donors.
158 wever, to date, PARP inhibitor treatment has been restricted to patients with BRCA1/2 mutation-associ
159 n (FDA) for r/r ALL (CD19CAR T-cell approval is restricted to patients <=25 years old).
160 , 95% CI 1.02-2.33), including when analysis was restricted to patients aged 18 years or younger (1.8
161 sults remained significant when the analysis was restricted to patients who had not consumed fluoroqu
162                                   The cohort was restricted to patients who received LT, resection, o
163                           The primary cohort was restricted to patients who were newly prescribed bac
164                                      Testing was restricted to patients with cerebrospinal fluid (CSF
165 -1.45) which remained true when the analysis was restricted to patients with fulminant CDI (aOR 1.17,
166 1.45), which remained true when the analysis was restricted to patients with fulminant CDI (aOR, 1.17
167 nteraction analyses showed that this benefit was restricted to patients with node-positive disease: N
168               The impact of serum creatinine was restricted to patients with pre-LT cardiovascular di
169                                     Analyses were restricted to patients with an initial diagnosis on
170  typical symptoms is minimal; its use should be restricted to people aged 55 years and older, or to t
171 e incremental cost was similar when analysis was restricted to persons with CD4 count <100 cells/muL.
172 ink repair leads to genetic instability that is restricted to PGCs within the genital ridge during a
173 l aerobic oxidation of ferrous iron (Fe(II)) is restricted to pH-circumneutral environments character
174                                However, they were restricted to planar geometries.
175 ession of BTB-BACK Kelch-like (BBK) proteins is restricted to poxviruses and conserved within them, i
176 te II on both the pre-F and post-F proteins, is restricted to prophylaxis in neonates at high risk of
177 m and fiber intake (P for trend = 0.03), and were restricted to proximal colon cancer.
178  these findings, we report pSmad3 expression is restricted to quiescent MG and suppressed in injury-r
179 y increase the risk of thrombosis and should be restricted to rare patients with hypofibrinogenemia-i
180 nt filtering procedure, analysis of WES data was restricted to rare, predicted pathogenic variants in
181                    We find that mPing bursts are restricted to recent domestication and is likely due
182 ar (fire return interval of 4-6 yr), seeders were restricted to regions with more frequent fire than
183         This is largely because the germline is restricted to relatively few cells buried deep within
184      These data indicate that MAPK signaling is restricted to relatively undifferentiated cancer cell
185            To complicate this, these viruses are restricted to replication in human cells and tissues
186 re available for routine diagnosis, and many are restricted to research laboratories.
187 h can invade all aged erythrocytes, P. vivax is restricted to reticulocytes.
188 w that responses reflecting target detection are restricted to secondary somatosensory cortex, wherea
189 ly on sexual reproduction and are thought to be restricted to sexual organisms.
190 , current diamond quantum optics experiments are restricted to single devices and few quantum emitter
191 ms supporting these interactions has largely been restricted to situations of social observation - th
192 cterisation of side-chain motions has so far been restricted to small proteins and methyl-bearing sid
193  and, generally, NMR structure determination is restricted to small (<30 kDa) proteins.
194 rification was recently achieved, the method is restricted to small sample volumes, thereby limiting
195 arger-sized LDs, whereas lipophagic vesicles were restricted to small LDs as revealed by immunofluore
196 nd controls in smoking cessation when trials were restricted to smokers (9 trials, n = 2516; 80.7% vs
197 hnologies that enable the effect of drugs to be restricted to specific cell types, thereby allowing a
198 eas TbD1-intact "ancestral" lineages tend to be restricted to specific geographical areas, such as So
199 train but providing dynamic symmetry control is restricted to specific materials under intense laser
200        Simulational studies of D(omega) have been restricted to studying poorly annealed glasses that
201  conservation, while biosynthesis and growth are restricted to sulfide-respiring cells.
202 small-molecule modulators of V-ATPase either are restricted to targeting one membranous subunit of V-
203 e as evidence against our claim that animals are restricted to temporal updating and cannot engage in
204 rs has strongly suggested that these animals were restricted to terrestrial environments(1).
205  both experiment and simulation studies have been restricted to testing only a few compounds at a tim
206 lation and alternative splicing, events that are restricted to the cell nucleus.
207                   These include T cells that are restricted to the cluster of differentiation 1 (CD1)
208 verity of obesity, and whether these effects are restricted to the extremes of maternal body mass ind
209 e I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule
210 sociated invariant T cells (MAIT cells) that are restricted to the MHC-related protein 1 (MR1).
211            Why the disease-causing mutations are restricted to the N terminus and how they cause huma
212 DAergic neurotransmission in RGS12-null mice are restricted to the nucleus accumbens.
213          We find no evidence that stem cells are restricted to the regeneration-competent neck.
214 sexes (heterochiasmy); in male meiosis, they are restricted to the termini of all four chromosomes st
215          However, while most R. mucilaginosa are restricted to the tongue as expected, two genomes re
216 d temperate regions assume that whole clades are restricted to the tropics.
217 g nuclear pre-40S particles, Tsr4 appears to be restricted to the cytoplasm.
218        HSPC generation via EHT is thought to be restricted to the early stages of development.
219     The proposition that dietary SFAs should be restricted to the maximal extent possible (e.g., to a
220 NAs; however, this process too is thought to be restricted to the nucleus.
221 e repair, the activity of the drugs needs to be restricted to the region of damage.
222 ined protein-dependent function of BHLF1 may be restricted to the replication cycle.IMPORTANCE Epstei
223                         Initially thought to be restricted to the respiratory system, we now understa
224     The "veraguensis" phenotype was found to be restricted to the Western end of the Isthmus and the
225 eatment effect, the overall survival benefit being restricted to the hyperfractionated group (HR 0.83
226 s process starts during development or if it is restricted to the aging period has not yet been studi
227 ere, we show that Snai2 expression in the BM is restricted to the BM stromal compartment where it reg
228 rogress in this direction in Weyl semimetals is restricted to the DC regime.
229                                   This study is restricted to the early phase of the pandemic, when C
230 innervation in the male reproductive complex is restricted to the epididymis and vas deferens and nev
231 in any warm-blooded mammal, the sexual cycle is restricted to the feline intestine.
232 anslocated to an IG partner, and this effect is restricted to the first 2 years after diagnosis.
233 at acts mainly on gram-positive bacteria and is restricted to the gut, potentiated the RT-induced ant
234 factory bulbs to the hindbrain, while vglut3 is restricted to the hypothalamus and hindbrain.
235 in the setting of a coexisting RP diagnosis, is restricted to the infratemporal retina, can affect bo
236 eveal that beta-catenin nuclear accumulation is restricted to the late stage of the disease.
237             VZV transcription during latency is restricted to the latency-associated transcript (VLT)
238                             While cell death is restricted to the limb margin in amphibians with aqua
239                       The expression of DUO1 is restricted to the male germline and is first detected
240 nferred when either Cyp6 gene overexpression is restricted to the midgut or oenocytes, indicating tha
241 rial accommodation inside living plant cells is restricted to the nitrogen-fixing root nodule symbios
242 t the proline-deleted recombinant MHV strain is restricted to the optic nerve, is unable to transloca
243 SPOCD1 is a nuclear protein whose expression is restricted to the period of de novo genome methylatio
244 ted to Vitis species - and because the virus is restricted to the phloem, most GLRaV-3 research has c
245 on displays a strong polarized signal, as it is restricted to the plasma membrane domain between rece
246                       Internally tagged Rho3 is restricted to the plasma membrane in a gradient corre
247                              Cln7 expression is restricted to the post-synaptic cell and the protein
248                        Maurolicus mucronatus is restricted to the Red Sea.
249           HR supresses tumorigenesis(1), but is restricted to the S and G2 phases of the cell cycle w
250 lls to form the primordial germ cells (PGCs) is restricted to the second through the fourth abdominal
251            Expression of H2-T3/TL and H2-Q10 is restricted to the small intestine and liver, respecti
252                                         Pum2 is restricted to the soma of developing neurons, and Pum
253                                      Kv 3.1b is restricted to the soma, the primary neurite and the a
254 synaptically triggered action potential that is restricted to the spine head.
255  whereas the second extension (up to 236 aa) is restricted to the superorder Protacanthopterygii (con
256 iological properties, and, most importantly, is restricted to the VLS.
257 ar infrared imaging showed that the delivery was restricted to the BM, lungs, liver and spleen, with
258 2019 Antiretroviral Guidelines update, which was restricted to the choice of dolutegravir or efaviren
259                        Interestingly, PDLIM2 was restricted to the cytoplasm/membrane of TNBC cells a
260 ication, we confirmed that the benefit of GO was restricted to the favorable (hazard ratio [HR], 0.54
261 driven size reduction of reproductive organs was restricted to the female sex, suggesting input from
262      In summary, even though R58Q expression was restricted to the heart of mice, functional similari
263  immunosuppressed patients whereas arteritis was restricted to the immunocompetent ones.
264 moprevention group than in the placebo group was restricted to the intervention period (week 3 throug
265 ery, it was dogma that protein glycosylation was restricted to the luminal compartments of the secret
266 t of replication rate on virulence evolution was restricted to the period when host resistance was in
267 HKT1;1), encoding an Na(+)/K(+) transporter, was restricted to the radicles and was not enhanced by N
268                           Likewise, Klb mRNA was restricted to the suprachiasmatic nucleus (SCh) and
269 han 49 years with acute ischemic stroke that was restricted to the territory of a single carotid arte
270               Adelie penguin diving activity was restricted to the upper mixed layer, while gentoo pe
271 ile in the control group these relationships were restricted to the categories with structured sound
272 ed scenarios under which these interventions were restricted to the first year after treatment comple
273                           Voxelwise analyses were restricted to the hippocampus, amygdala, and parahi
274 tide, the main component of amyloid plaques, were restricted to the hippocampus.
275 (H)17/CCL20/DEFB4A, and T(H)22/IL22/S100A's, were restricted to the IL-22-high drug group (P < .05).
276             Neurophysiological abnormalities were restricted to the lower limbs.
277             ELP1-associated medulloblastomas were restricted to the molecular SHHalpha subtype(4) and
278 t of the 1,891 foraging trips by 686 animals were restricted to the Patagonian Shelf and shelf slope,
279         Protective effects of facility birth were restricted to the two earlier policy periods (from
280 abolically expensive trait, whose expression is restricted to thermoneutral mice and is not transfera
281                         Intriguingly, SAG101 is restricted to those genomes also encoding TNL recepto
282 rt carriers via a retromer-dependent process is restricted to those tethered by GCC88 but not golgin-
283 alysis of patients with culture-negative CSF was restricted to those with known HIV infection, WCC (0
284             Refugee and non-refugee migrants were restricted to those from regions with at least 1,00
285                                 False alarms were restricted to times when the glucose concentrations
286 nd homeostasis and that these DDR2 functions are restricted to TMJ fibrocartilage and not seen in the
287 is active against MRSA, but its clinical use is restricted to topical administration because of its l
288 e show that constitutive NIK expression that is restricted to Tregs via a Cre-inducible transgene cau
289 sm, and the described way of control may not be restricted to trypanosomes.
290                          Genetic differences are restricted to two small regulatory regions near gene
291 cosal-homing competent phenotype, while this was restricted to type A IELps in adults.
292                                   This study was restricted to unvaccinated girls from the pre-vaccin
293 s of PN are poorly understood, and therapies are restricted to use of painkillers or other drugs that
294 quencing data analysis, are not automated or are restricted to users with bioinformatics backgrounds.
295 porter mice, we found that Nkx2.3 expression was restricted to VAP-1(+) myofibroblast-like pericrypta
296 We propose that the related physics need not be restricted to wave dynamics, and we consider systems
297  1.05-1.18, I(2) = 50%), but the association was restricted to women (1.15, 95% CI 1.08-1.21, I(2) =
298  CS, whilst the calculation of the VBAC rate was restricted to women with just one previous CS (VBAC-
299 cept in Argentina and Brazil, where analyses were restricted to women who were married or in a union.
300                           Fertility analyses were restricted to women whose age at last birth (ALB) w

 
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