ライフサイエンスコーパス: be sensed by

1 ed to be mediated by peptide pheromones that are sensed by a class of G protein-coupled receptors, vo

2 Furthermore, we find that secreted ACLs are sensed by a dedicated transcription factor, AclR, re

3 the appetitive phase, both hunger and thirst are sensed by a nearly identical population of individua

4 These DAMPs are sensed by a pattern recognition receptor called NLRP

5 Changes in ligand concentrations are sensed by a protein assembly consisting of transmemb

6 In the nematode C. elegans, these cues are sensed by a small number of olfactory neurons, each

7 l pathogen-associated molecular patterns can be sensed by a growing number of host cell cytosolic pro

8 ct evidence suggests that oxygen tension may be sensed by a hemoprotein.

9 he effect of peptide anchor modification can be sensed by a TCR at regions distant from the site of m

10 Matrix stiffness that is sensed by a cell or measured by a purely physical pro

11 Proliferation-associated DNA damage is sensed by a complex comprising caspase-8, FADD, c-FLI

12 Hcy is sensed by a constitutive protein complex composed of

13 We conclude that lumenal glucose is sensed by a glucose sensor, distinct from SGLT1, resi

14 Oxygen, an essential nutrient, is sensed by a multiple of cellular pathways that facili

15 CO2 is sensed by a population of olfactory sensory neurons i

16 Attenuated elongation is sensed by a ribosome-coupled mechanism that triggers

17 that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that co

18 ry, in which a binding event in one protomer is sensed by a second symmetric protomer.

19 We find that spindle position is sensed by a system composed of MEN-inhibitory and -ac

20 One peptide, known as CSP, is sensed by a two-component signal transduction system

21 Virus infection is sensed by a variety of cellular pattern-recognition r

22 nerates microdomains of elevated Ca(2+) that are sensed by adjacent mitochondria.

23 provide evidence that elevated CO(2) levels are sensed by AECs and that AMPK mediates CO(2)-induced

24 Cytosolic DNA is sensed by AIM2-like receptors (ALRs) during bacterial

25 data suggest that chromatin assembly defects are sensed by an ATM-dependent intra-S phase chromatin q

26 the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase pr

27 arginine, glutamine, lysine, and methionine) are sensed by an indirect mechanism.

28 These viral DNAs are sensed by an unidentified host sensor that triggers

29 mary translation product ComS, is thought to be sensed by an intracellular receptor, ComR, after upta

30 ze recent findings about how enteric viruses are sensed by and, in turn, modulate host immune respons

31 Our study shows how polyamine odorants can be sensed by animals as proxies for microbe identity and

32 A small subset of these compounds is sensed by animals and humans, and the volatile profil

33 identify the molecules from one species that are sensed by another.

34 r results show that components of food (fat) are sensed by antral cilia on endocrine cells, which mod

35 The IR radiation is sensed by applying a dc bias voltage to each antenna

36 hibition of Cu(II) reduction, responses that are sensed by ArcBA and CusRS respectively.

37 t the concentration of L-arginine in the LCV is sensed by ArgR to produce an intracellular transcript

38 together, our results indicate that Brucella is sensed by ASC inflammasomes that collectively orchest

39 The persisting complexes are sensed by ataxia telangiectasia mutated (ATM), a pro

40 ecular mechanisms by which stress conditions are sensed by bacteria, how related signals are discrimi

41 als, involved in interkingdom communication, are sensed by bacterial sensor kinases.

42 This change of resistance is sensed by biasing each antenna with a constant DC vol

43 e hypothesized that anabolic nutrients would be sensed by both AMPK and mTOR, resulting in an acute a

44 g-like feedback loop where the produced IL-2 is sensed by both the activated CD4(+) T cell pool and b

45 Poly I:C is sensed by both TLR3 in the endosomes and melanoma dif

46 ciated gene 5 (MDA5) inside cells, rotavirus was sensed by both RIG-I and MDA5, alone and in combinat

47 The level of stored Ca2+ is sensed by Ca(2+)-permeant channels in the plasma memb

48 These calcium signals are sensed by calcium binding proteins such as calmoduli

49 nges in intracellular calcium concentrations are sensed by calmodulin, a signal transduction protein

50 pothesis that adenosine and nitric oxide can be sensed by capillaries and are implicated in the remot

51 Thus, muscle contraction can be sensed by capillaries and the signalling mechanism fo

52 11 phages harbour both trigger proteins that are sensed by CapRel(SJ46) during infection, and we demo

53 gical responses, indicating that eNAD(+) may be sensed by cell-surface receptors.

54 th diseases is how the loss of cell polarity is sensed by cell death machinery.

55 we reasoned that their metabolic by-products are sensed by cells of the immune system and affect the

56 rom strain, pressure, and fluid shear stress are sensed by cells through an unidentified mechanorecep

57 Carbon dioxide (CO(2)) is sensed by cells and can trigger signals to modify gen

58 How physical force is sensed by cells and transduced into cellular signalin

59 generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin.

60 echanism through which collagen biosynthesis is sensed by cells internally and directly regulates cle

61 Little is known, however, about how sulfate is sensed by cells.

62 ulp had low concentrations of S1P, while S1P was sensed by cells inside the white pulp near the margi

63 beta following ligand binding; changes which are sensed by cellular factors (coactivators) required f

64 Although several DNA viruses are sensed by cGAS, viral strategies targeting cGAS are

65 n and cytosolic telomeric DNA fragments that are sensed by cGAS.

66 DNA and consequent sequestration of DNA from being sensed by cGAS, explaining its role in restricting

67 occurring changes in APS concentrations may be sensed by changes in the conformation of PAPSS2.

68 Hypoxia is sensed by changes in mitochondrial-derived reactive o

69 presence of recombination intermediates that are sensed by checkpoints.

70 The latter is sensed by components of the extracellular matrix like

71 with stark increases in succinate, which can be sensed by Cra.

72 According to the canonical view, temperature is sensed by cutaneous thermoreceptors and nerve impulse

73 During infection, foreign DNA is sensed by cyclic GMP-AMP synthase (cGAS) leading to t

74 nstrate that the DNA of Plasmodium parasites is sensed by cytosolic AIM2 (absent in melanoma 2) recep

75 that several gut microbial-derived products are sensed by dedicated host receptor systems to alter c

76 ualities (sweet, bitter, salty, sour, umami) are sensed by dedicated taste cells (TCs) that relay qua

77 causes telomere-associated DNA damages that are sensed by dendritic cells (DCs) and activates the ho

78 Amino acid starvation is sensed by depletion of the aminoacylated tRNA pools,

79 it is well established that nutrient status is sensed by different internal organs, which in turn re

80 that periderm integrity in Arabidopsis roots is sensed by diffusion of the gases ethylene and oxygen.

81 vidence indicates that environmental signals are sensed by discrete neuro-immune cell units (NICUs),

82 Injury to a target organ is sensed by distant stem cells, which migrate to the si

83 fects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factor

84 These stresses are sensed by diverse cellular signaling processes, lead

85 tal stimuli such as temperature and pressure are sensed by dorsal root ganglion (DRG) neurons.

86 We found that IL-33 could be sensed by EC cells, inducing release of 5-HT.

87 Body size is sensed by either stretch receptors or oxygen restrict

88 ARS-CoV-2, revealed that HCoV infections can be sensed by endosomal toll-like receptors and/or cytopl

89 In Bacillus subtilis, this labile pool is sensed by equilibration with the metalloregulator Zur

90 primary product of oxidative metabolism, can be sensed by eukaryotic cells eliciting specific respons

91 In Arabidopsis, the hormone ethylene is sensed by five related receptors, all of the 'two-com

92 tors, and their intracellular concentrations are sensed by gene-regulatory mRNA domains (riboswitches

93 anscription, a variety of input signals must be sensed by genetic regulatory proteins.

94 lting in increased lactate production, which is sensed by GPCR132 on macrophages to stimulate protumo

95 on, innate lymphoid cell (ILC)-derived IL-13 is sensed by gut neurons, which in turn secretes CGRP to

96 How cell-cell contact is sensed by Hippo signaling is poorly understood.

97 a diverse repertoire of small molecules that are sensed by host cells.

98 QS molecules can also be sensed by hosts, although the respective receptors an

99 that binding to SAalpha2,3 by H5N1 HPAIV may be sensed by human cells differently than binding to SAa

100 cells, whereby released endogenous adjuvants are sensed by immune cells to direct adaptive immune res

101 he intestine, diverse environmental cues can be sensed by immune cells, which must balance resistance

102 tudy, we explored whether acidic environment is sensed by immune cells as an inflammasome-activating

103 Thus, centromere tension can be sensed by increased spatial separation of Aurora B fr

104 Dying cells are sensed by innate immune cells using specialized rece

105 Pathogens are sensed by innate immune receptors that initiate an e

106 s (damage-associated molecular patterns) can be sensed by innate cells, which drives type I interfero

107 Excessive nutrients can be sensed by innate pattern recognition receptors as dan

108 However, the mechanisms by which heme is sensed by innate immune cells contributing to these d

109 ditions and stimuli from the surrounding ECM are sensed by integrin proteins and transduced by submem

110 away from a directional light source, which is sensed by intracellular photoreceptors and mediated b

111 ER stress is sensed by Ire1, a transmembrane kinase/endoribonuclea

112 back mechanism in which the secreted hormone is "sensed" by its respective receptor and initiates syn

113 ry pathway is described in which excess iron is sensed by its ability to catalyze site-specific oxida

114 ither by creating condensate structures that are sensed by kinases or by direct LLPS of kinases, cofa

115 Gases are sensed by lung cells and can activate specific intra

116 is known about the signaling molecules that are sensed by LuxR solos.

117 cing enzyme heme oxygenase (HO1) and that CO is sensed by M. tuberculosis to initiate a dormancy prog

118 This second messenger is sensed by macromolecular targets inside the cell, bot

119 e cell-autonomous signals delivered by agrin are sensed by macrophages through the alpha-DC (DG) rece

120 Mate contact is sensed by male-specific sensilla of the tail, the ray

121 S. aureus is sensed by many pattern recognition receptors, includi

122 demonstrate that HIV-1 encoding Nef F/R191A is sensed by MDA5 after proviral integration in an R12C-

123 ith encephalomyocarditis virus (EMCV), which is sensed by MDA5, Trim13(-/-) mice produce increased am

124 which synthesizes double-stranded RNAs that are sensed by melanoma differentiation-associated protei

125 Environmental arsenic is sensed by members of the ArsR/SmtB family.

126 nsduced into common metabolomic changes that are "sensed" by metabolite-responsive regulators, such a

127 ded by ligands of the semaphorin family that are sensed by migrating neuronal growth cones through pl

128 Calcium signals are sensed by mitochondria acting in concert with mitoch

129 rs of innate antiviral immune responses that are sensed by multiple classes of sensors, but other ind

130 hypocotyl photomorphogenesis, light signals are sensed by multiple photoreceptors, among which the r

131 w a vast array of extracellular signals that are sensed by multiple sensory transduction pathways whi

132 Proprioception is sensed by muscle spindles for precise locomotion and

133 er the local submembrane [Ca]i ([Ca]sm) that is sensed by NCX dynamically during the action potential

134 ds functioning as diffusive signals that can be sensed by neighboring protocells and trigger the acti

135 This glutamatergic gliotransmission is sensed by neurons of the dorsal SCN via specific pre-

136 xplains how circulatory neurogenic mediators are 'sensed' by NSCs.

137 ection, wherein pathogen-derived RNA and DNA are sensed by nucleic acid sensing receptors.

138 However, translocated bacterial products are sensed by nucleotide binding domain and leucine-rich

139 However, these perturbations can be sensed by nucleotide-binding leucine-rich-repeat (NLR

140 cing a re-evaluation of how external signals are sensed by, or communicated to, the germline epigenom

141 d multiple S. aureus secreted molecules that are sensed by P. aeruginosa and affect its physiology, d

142 onclude that outer membrane perturbation can be sensed by P. aeruginosa to activate the T6SS even whe

143 he concept that ribonucleotide depletion can be sensed by p53, resulting in a G(1) cell cycle block.

144 Viral infection of cells is sensed by pathogen recognition receptors that trigger

145 icrobe-associated molecular patterns (MAMPs) are sensed by pattern recognition receptors (PRRs) on ce

146 en- and damage-associated molecular patterns are sensed by pattern recognition receptors, including m

147 How poxviruses are sensed by pDCs to induce type I IFN production is no

148 However, how self-derived factors are sensed by phagocytes and impact the immune response

149 released from necrotic cells are thought to be sensed by phagocytes leading to secretion of IL-1alph

150 oncentrations of magnesium, the ion known to be sensed by PhoQ.

151 -activated genes is induced by Fe(3+), which is sensed by PmrA cognate sensor PmrB, and by low Mg(2+)

152 Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which reg

153 produces double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of d

154 erases and a subclass of sirtuins (writers), is sensed by proteins that contain binding modules (read

155 The change in pH is sensed by protonation of the allosteric pH sensor his

156 Modifications to RhoA are sensed by pyrin, which, once activated, assembles a

157 Diet-derived cytosolic amino acids are sensed by Rag GTPases through the GTPase-activating

158 These cues are sensed by receptors at the surface that trigger intr

159 Natural sugars and artificial sweeteners are sensed by receptors in taste buds.

160 extracellular signal of the TGF-beta ligand is sensed by receptors and transmitted into the nucleus

161 ral cases, the pK(a) of a particular residue was sensed by resonances not only in that residue but al

162 t by the release of neurotransmitters, which are sensed by responding neurons through cognate recepto

163 is driven by an aversion to blue light that is sensed by Rhodopsin 7 outside of the eyes.

164 Previously, it was unclear which signals are sensed by salmonellae to promote PhoQ-mediated virul

165 through label-free self-internalization and were sensed by SERS.

166 How pHi fluctuations are sensed by signaling proteins and translated into cel

167 ditis elegans, gentle touch to the body wall is sensed by six mechanosensory neurons that express two

168 ts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and have been impli

169 Temperature is sensed by specific neurons, in turn eliciting both be

170 Streptomyces secrete dodecanoic acid, which is sensed by SRB-6.

171 emptying of IP(3)-sensitive ER Ca(2+) stores are sensed by STIM1 molecules which aggregate and move c

172 oplasmic reticulum (ER) Ca(2+) stores, which is sensed by stromal interaction molecule 1 (STIM1).

173 Cues from the external environment are sensed by surface receptors, and complex signaling m

174 y surface-anchoring proteins, and they could be sensed by synthetic receptors.

175 A surprising discovery was that L-leucine is sensed by Tar as an attractant at low concentrations

176 hat guide termite construction, and how they are sensed by termites.

177 tion of the cytosolic leaflet, both of which are sensed by the +ALPS motif.

178 ges in the luminal concentrations of alphaKG are sensed by the alphaKG receptor OXGR1 expressed in th

179 We demonstrate that HAAs are sensed by the bulb-type lectin receptor kinase LIPOO

180 Here we review how viruses are sensed by the cGAS-STING signaling pathway as well a

181 Temporal changes in solute concentration are sensed by the chemotaxis system in Escherichia coli,

182 othesised that changes in pectin composition are sensed by the CpGRP1-CpWAK1 complex therefore leadin

183 DNA viruses are sensed by the cytosolic pattern recognition receptor

184 These environmental stimuli, which are sensed by the DosS heme group, result in autophospho

185 c and membrane bilayer stress, both of which are sensed by the ER protein Ire1.

186 These ligands are sensed by the heme domain of sGC, which belongs to t

187 apeutic settings, viral infections like VSIV are sensed by the host, and as a result the host cells m

188 Here, we ask what properties of CFTR are sensed by the Hsp27-Ubc9 pathway by examining the ab

189 en- and damage-associated molecular patterns are sensed by the immune system's pattern recognition re

190 the effects of chemotherapy and radiotherapy are sensed by the immune system, their combination with

191 Infections with RNA viruses are sensed by the innate immune system through membrane-

192 the mechanism by which cyclic dinucleotides are sensed by the innate immune system.

193 rally diverse phosphoantigen (pAg) molecules are sensed by the intracellular domain of butyrophilin B

194 ted through the VNO, whereas other chemicals are sensed by the MOE, recent evidence suggests that som

195 Here, we show that necrotic cells are sensed by the Nlrp3 inflammasome resulting in the su

196 lting in protein conformational changes that are sensed by the organism.

197 d yeast cells secrete mating pheromones that are sensed by the partner which responds by growing a ma

198 The three signals are sensed by the QseC histidine kinase (HK) sensor.

199 pon translation of the NBD1 and R-domain and are sensed by the RMA-1 ubiquitin ligase complex.

200 Head movements are sensed by the vestibular organs.

201 n after adjustments for emissions that might be sensed by the atmospheric network, but which are not

202 Excessive caloric intake is thought to be sensed by the brain, which then activates thermogenes

203 aling duration and strength were observed to be sensed by the cell and to be critical for its decisio

204 nduced fluid flow results in forces that can be sensed by the cells.

205 The resulting SRK homomer levels would be sensed by the common pollen rejection pathway, allowi

206 Thus, signal input to the Frz system must be sensed by the conserved C-terminal module of FrzCD an

207 plication intermediates that would otherwise be sensed by the host.

208 s resulting from intestinal inflammation can be sensed by the liver, leading to the repression of PED

209 These proteins can also be sensed by the plant immune system, leading to restric

210 ce from the locations where disturbances had been sensed by the moving limb.

211 y concealing a pathogen-induced process from being sensed by the inflammasome.

212 Saccharomyces cerevisiae, extracellular [Pi] is "sensed" by the inositol-hexakisphosphate kinase (IP6

213 omeric pilin reservoir in the inner membrane is sensed by the 17-amino acid transmembrane helix of Pi

214 he methylation status of these two sequences is sensed by the action of two proteins, Lrp and PapI, a

215 In Caenorhabditis elegans, gentle touch is sensed by the anterior (ALM and AVM) and posterior (P

216 The released ASN is sensed by the bacteria, altering the expression of ap

217 ttle is known about how biomechanical stress is sensed by the cardiomyocyte sarcomere to transduce in

218 the addition of nocodazole and this process is sensed by the cell QCM biosensor.

219 ibosomal proteins, suggesting that collision is sensed by the cell to initiate downstream quality con

220 This "error" is sensed by the central nervous system via increases in

221 he channel, increasing the local stress that is sensed by the channels and stabilizing the expanded c

222 ascent exit linker to approximately 15bp, it is sensed by the Chd1 DNA binding domain resulting in co

223 We find that nutrient stress is sensed by the class IV multidendritic cholinergic neu

224 ATP is sensed by the coupling/uncoupling of transcription of

225 lar bacterial DNA into the host cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stim

226 At the instant a change in the color is sensed by the detector, the titrant flow rate FH is h

227 ne but it remains uncertain (1) how pressure is sensed by the endothelium and (2) how the vascular re

228 t in gonadotrophs an oscillatory Ca2+ signal is sensed by the exocytotic apparatus in a modified form

229 DNA damage is sensed by the highly conserved recombination protein

230 eals how a widely used natural plant pigment is sensed by the host receptor AhR, and how the physiopa

231 prevalent in T. vaginalis clinical isolates, is sensed by the human epithelial cells via Toll-like re

232 We examine how Mycobacterium tuberculosis is sensed by the immune system; how the granuloma is ini

233 t inflammasomes are activated, how infection is sensed by the innate immune system and how intracellu

234 Here we examined how bee venom PLA2 is sensed by the innate immune system and induces a type

235 ow UV irradiation of epidermal keratinocytes is sensed by the innate immune system, but also show tha

236 ic groups of streptococci, the pheromone XIP is sensed by the intra-cellular regulator ComR, that in

237 ATP, released during cell damage/activation, is sensed by the ionotropic purinergic receptor P2X7 (P2

238 the Casparian strip-based apoplastic barrier is sensed by the leakage of a small peptide from the ste

239 The defect in the top1 trf4-ts mutant is sensed by the MAD1-dependent spindle assembly checkpo

240 In HCN channels, membrane hyperpolarization is sensed by the membrane-spanning voltage sensor domain

241 hat Comamonas DA1877 generates a signal that is sensed by the nematode.

242 we show that infection with Candida albicans is sensed by the Nlrp3 inflammasome, resulting in the su

243 y the PmrB protein, and in low Mg(2+), which is sensed by the PhoQ protein.

244 ated PI4P and PS membrane lipid organization is sensed by the PIP5K specificity loop.

245 be activated independently by Fe(3+), which is sensed by the PmrB protein, and in low Mg(2+), which

246 We propose that this transition is sensed by the portal that is embedded in the capsid w

247 This depletion is sensed by the protein STIM1 in the endoplasmic reticu

248 Nitrite binding at type 2 Cu is sensed by the proton abstracting group Asp92 and the

249 hat IL-1beta produced by hematopoietic cells is sensed by the radioresistant compartment to promote b

250 We demonstrate that DHMA is sensed by the serine chemoreceptor Tsr and that the c

251 DHMA is sensed by the serine chemoreceptor Tsr, and the attra

252 Lipid II is sensed by the serine/threonine kinase PrkC, which pho

253 se1 during G1 produced a spindle defect that is sensed by the spindle assembly checkpoint.

254 The ssDNA that drives ATR signaling is sensed by the ssDNA-binding protein replication prote

255 n local [Ca(2+)](ER) mediated by IP(3)R that is sensed by the STIM2 N terminus.

256 ansfer imparts a polarity on the target that is sensed by the transposon.

257 During everyday behaviours, head motion is sensed by the vestibular system.

258 ity on the channel's extracellular face that was sensed by the activation gating machinery.

259 The released DNA, in turn, was sensed by the DNA receptor absent in melanoma 2.

260 esulted in the formation of micronuclei that were sensed by the cytosolic DNA sensor cGAS and led to

261 roducts, 2-monoacylglycerol and fatty acids, were sensed by the mice, and self-administration pattern

262 whereby a change in renal perfusion pressure is sensed by these cells and results in a change in reni

263 nt combinations lead to an intermediate that is sensed by these checkpoint functions.

264 suggesting that PS-ASO-protein complexes may be sensed by TLR9.

265 hannels, but little is known about how force is sensed by TMC channels.

266 zed with Staphylococcus aureus (S.a.), which are sensed by Toll-like receptor 2 (TLR2).

267 Pathogens are sensed by Toll-like receptors (TLRs) and a growing n

268 Nucleic acids from microbes are sensed by Toll-like receptors 7/9 (TLR7/9), which ar

269 LPS is sensed by Toll-like receptor 4 (TLR4) in complex with

270 RNA is sensed by Toll-like receptor members TLR3, TLR7 and T

271 Moderate coolness is sensed by TRPM8 ion channels in peripheral sensory ne

272 Subunit misfolding in the absence of PapD was sensed by two parallel pathways: the Cpx two-compone

273 We provide evidence that translation stress is sensed by unbalancing the expression levels of an uns

274 We speculate that urea can potentially be sensed by uropathogenic bacteria to initiate infectio

275 Changes in the intestinal microenvironment are sensed by vagal, spinal, and intrinsic primary affer

276 directly through inducing deformation, which is sensed by various mechanosensitive components of the

277 However, it is not known whether FAs are sensed by ventral tegmental area (VTA) dopamine (DA)

278 scle fiber triggers action potentials, which are sensed by voltage-gated L-type calcium channels (Ca(

279 Depolarization is sensed by VSD-charged residues residing in the membra

280 Environmental signals are sensed by whole organisms or cells and markedly affe

281 eic acids formed following intestinal damage are sensed by ZBP1, leading to caspase-8 activation and

282 llows taxane to induce extensive dsRNAs that are sensed by ZBP1, which in turn activates NLRP3-GSDMD-