ライフサイエンスコーパス: be significantly downregulated

1 3-beta-Hydroxy-5-cholestenoate were found to be significantly downregulated.

2 continue to be expressed, but ACY expression is significantly downregulated.

3 novo acute myeloid leukaemia (AML) where it is significantly downregulated.

4 K signaling, while invasion-associated genes are significantly downregulated.

5 e cell types, only a limited number of genes were significantly downregulated.

6 TGF-beta1 and several collagen genes were significantly downregulated.

7 lipid biosynthesis/metabolism (ACOT2, LOXL2) were significantly downregulated.

8 cRFXa mutants, ciliogenesis genes and foxJ1 were significantly downregulated.

9 tors, calcium signalling and fibrosis genes) were significantly downregulated.

10 Notably, Dmd, Actc1, Col6a1, and Mmp2 were significantly downregulated.

11 st and cell contractility-related molecules, were significantly downregulated.

12 gene MEFV was upregulated, CD40LG and PYDC1 were significantly downregulated.

13 Runx2 and its downstream genes Odam and Amtn were significantly downregulated.

14 osomal genes, and lysosomal gene expression, were significantly downregulated.

15 Specific colonocyte genes were significantly downregulated.

16 ficantly upregulated in SO, but 27 microRNAs were significantly downregulated.

17 were unaltered, and other astrocytic markers were significantly downregulated.

18 lion (DRG) of CHF rats whereas VR1 receptors were significantly downregulated.

19 on of the T helper 1-related biomarker CXCL9 was significantly downregulated (-3.10; P < .05), wherea

20 OCN was significantly downregulated (70%) at the lowest dose

21 d respiratory electron transport pathways to be significantly downregulated after RK-33 or DDX3 knock

22 tudies have identified gene transcripts that are significantly downregulated and upregulated in the e

23 sociated with cell cycle and DNA replication were significantly downregulated and genes linked to apo

24 In Keap1MuKO mice, blood glucose levels were significantly downregulated and the levels of the g

25 henotypes: extracytoplasmic stress responses are significantly downregulated, and the production of o

26 In human endometriosis, CFP1 was significantly downregulated, and expression levels b

27 miR-224 was significantly downregulated as ameloblasts different

28 f DFNA5 in four of five colon cancer tissues was significantly downregulated as compared to normal ti

29 as an inhibitor of myelination, p38gammaMAPK was significantly downregulated as oligodendrocyte precu

30 the control, the expression of Vg and mrjp1 was significantly downregulated at 26 degrees C and 38 d

31 BDNF itself was significantly downregulated at the RNA and protein l

32 r results showed that dendritic HCN channels were significantly downregulated at an acute time point

33 were significantly upregulated, and 29 genes were significantly downregulated at one or more time poi

34 metabolism (PCK2, PFKL, IDH2, ACY1, and ADA) are significantly downregulated because of the accumulat

35 scripts for TLR7, RelA, IFN-gamma, and IP-10 were significantly downregulated between 2- and 3-fold i

36 ding small RNA miR-188-3p that targets BACE1 was significantly downregulated both in the brains of AD

37 One of those genes (AtRALF23) is significantly downregulated by brassinolide (BL) trea

38 pression of the homeostatic chemokine CXCL14 is significantly downregulated by the HPV oncoprotein E7

39 multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pent

40 as significantly upregulated and hsa-miR-30c was significantly downregulated by Onconase treatment in

41 We found that OGG1 expression was significantly downregulated by the RUNX1-ETO fusion

42 7, lipidated LC3-II, and LC3-II/LC3-I ratio) were significantly downregulated by at least one of thes

43 ssion profiling identified seven miRNAs that were significantly downregulated by IL-6 overexpression

44 cribed non-canonical integrin beta3 pathway, were significantly downregulated by LSD1 silencing.

45 I interferon and interferon stimulated genes were significantly downregulated by PKR activation.

46 enes (CYP340K4, CXE18, GSTe, and GSTe1) that were significantly downregulated by the phenolics.

47 xisome profilerator-activated receptor gamma were significantly downregulated by TNF-alpha treatment.

48 ve voltage-gated fibroblast current (IKv,fb) was significantly downregulated (by ?44%), whereas the B

49 fold) with PCN treatment, and that 834 genes were significantly downregulated (by at least 1.5-fold)

50 e AMP genes (DEFB1, DEFA5, DEFA6, and CAMP), was significantly downregulated compared to that of TNFA

51 RP2), a key factor for vascular development, was significantly downregulated during EC differentiatio

52 structures at and near the nodes of Ranvier were significantly downregulated during ZIKV-induced par

53 he structural neurofilament NF-H is found to be significantly downregulated following injury in both

54 hannels, and Kv4.3 expression in these cells was significantly downregulated following ION-CCI.

55 fection; however, BEC production of versican was significantly downregulated following RSV infection.

56 In humans, LRP6 and Wnt signaling are significantly downregulated in AD brains, likely by

57 ed 5 miRNAs (29a/b, 27a, 130b and 148a) that are significantly downregulated in conjunction with conc

58 sis shows that expression of T-bet and Eomes are significantly downregulated in COVID-19 patient non-

59 es in Notch and retinoic acid (RA) signaling are significantly downregulated in Nkx2-5-null endocardi

60 After two treatments IL-9 and TNF-alpha are significantly downregulated in patient serum.

61 nes associated with each of these phenotypes are significantly downregulated in response to Dmel\Kdm4

62 NR1D1 protein and mRNA expression are significantly downregulated in the spinal cord of sy

63 evels of ISLR2 and STRA6 and that both genes are significantly downregulated in tissues of PEX patien

64 or of apoptosis protein family, was found to be significantly downregulated in an inverse relationshi

65 We found FOXP1 to be significantly downregulated in both EZH2- and MEF2B-m

66 lon cancer, we found claudin-7 expression to be significantly downregulated in cancer samples.

67 iRNAs in blood in PTSD&Dep reveals miRNAs to be significantly downregulated in cases versus controls.

68 ed in healthy human ventricle and appears to be significantly downregulated in failing hearts.

69 OID CLEAVAGE DIOXYGENASE 8 gene was found to be significantly downregulated in SPL13 RNAi silencing p

70 00 calcium-binding protein A11 (S100/A11) to be significantly downregulated in the presence of IL-4 a

71 n-coupled receptor (GPCR) signaling pathway, is significantly downregulated in both human AD patients

72 cells from DCIS tumors revealed that miR-140 is significantly downregulated in cancer stem-like cells

73 d in hematopoietic cells, and its expression is significantly downregulated in chronic lymphocytic le

74 protein of the CCN (CYR61/CTGF/NOV) family, is significantly downregulated in clinical samples of hu

75 or tight control of local RA concentrations, is significantly downregulated in embryos of diabetic mi

76 el regulatory system are shown as miR-515-5p is significantly downregulated in ER-positive (n = 146)

77 at a conserved family of microRNAs, miR-181, is significantly downregulated in IECs from patients wit

78 )-dependent protein kinase kinase 2 (CAMKK2) is significantly downregulated in individuals with schiz

79 induces an upregulation of p53; (ii) miR-124 is significantly downregulated in malignant prostatic ce

80 Here we show that miR-153 is significantly downregulated in maturation ameloblasts

81 We next show that RAB26 and RAB3D expression is significantly downregulated in Mist1(-)(/)(-) ZCs, su

82 nnel 2), a gene within the genomic interval, is significantly downregulated in Motley embryonic skin.

83 The long noncoding RNA (lncRNA) MEG3 is significantly downregulated in pancreatic neuroendocr

84 Here we determined that 14-3-3o expression is significantly downregulated in primary human colorect

85 Expression analysis indicated that KLF4 is significantly downregulated in prostate cancer cell l

86 Importantly, Sorbs2 expression is significantly downregulated in the coronary arteries

87 sion of the Bmp4, Fgf10, Msx1 and Osr2 genes is significantly downregulated in the developing palatal

88 ox9 are significantly upregulated while Pax3 is significantly downregulated in the muscle progenitor

89 SMCs of the vascular wall and its expression is significantly downregulated in the vascular walls wit

90 tudy demonstrated that miRNA hsa-miR-6510-3p is significantly downregulated in tumor tissue compared

91 e in vivo phosphorylation of Thr-89 in MBD10 was significantly downregulated in a quadruple mutant of

92 In contrast, epidermal growth factor (EGF) was significantly downregulated in a subgroup of DOCK8-d

93 L-6 and matrix metalloproteinase 3 secretion was significantly downregulated in activated FLS transfe

94 synthesis of fructose-2,6-bisphosphate that was significantly downregulated in aged mice.

95 omosomal rearrangement, while its expression was significantly downregulated in another patient with

96 Here, we identified that miR-223 was significantly downregulated in chronically hypoxic m

97 ATP6V0A1 was significantly downregulated in cystinosis and highly

98 miR-573 was significantly downregulated in DENV2-infected HUVEC

99 MiR-146a expression was significantly downregulated in diabetic mouse wounds

100 Here we showed that SOX7 was significantly downregulated in different cancer type

101 NA 142, associated with the TGFbeta pathway, was significantly downregulated in exosomes from IL-2-tr

102 t1, involved in appetite and hunger control, was significantly downregulated in female brains only.

103 further showed that Dkk4, a Wnt antagonist, was significantly downregulated in Fzd6(-/-) mice along

104 We previously reported that STAT1 expression was significantly downregulated in Gata1-knockdown murin

105 In this study, we reported that BMP10 was significantly downregulated in HCC at both mRNA and

106 the aryl hydrocarbon receptor (AhR) pathway was significantly downregulated in HDM-challenged Tet1(-

107 icate that the expression of NOTCH receptors was significantly downregulated in HLHS-iPSC-derived car

108 ations, wild-type (WT) KRAS transcript level was significantly downregulated in human ETP-ALL cells.

109 h normal thyroid tissue and cells, Klhl14-AS was significantly downregulated in human thyroid carcino

110 CLDN8 was significantly downregulated in IBD patients with inf

111 ene that enhances adaptive immune responses, was significantly downregulated in IBV-inoculated FNECs.

112 TLR3 was significantly downregulated in IEC in active CD but

113 miR-23a expression was significantly downregulated in macular RPE cells fro

114 evious miRNAome analysis showed gga-miR-219b was significantly downregulated in MDV-induced lymphoma,

115 expression (at both mRNA and protein levels) was significantly downregulated in neutrophils from seps

116 Plasma miR-181a-5p was significantly downregulated in non-progressive patie

117 CIB2 was significantly downregulated in ovarian cancer and lo

118 In addition, DUOX was significantly downregulated in pancreatic cancer spe

119 LKB1 was significantly downregulated in PGD2/3 sEVs compared

120 On PND1, PPARgamma and Pref-1 expression was significantly downregulated in preadipocytes of both

121 We also found that miR-1296 was significantly downregulated in prostate cancer sampl

122 everse transcription-PCR revealed that WIF-1 was significantly downregulated in RCC samples and RCC c

123 Microarray analysis revealed that RORgammat was significantly downregulated in TCF-1(-/-) thymocytes

124 NRG1 expression was significantly downregulated in terminally differenti

125 itor of AXB outgrowth in many plant species, was significantly downregulated in the AXBs of FaHAN -OE

126 GABA(A) receptor clustering protein gephyrin was significantly downregulated in the BLA after fear ac

127 Interestingly, miR-205 expression was significantly downregulated in the brains of patient

128 e found that endogenous Osr2 mRNA expression was significantly downregulated in the developing tooth

129 for the induction of reactive astrogliosis, was significantly downregulated in the GFAP-ARO-KO hippo

130 lysis revealed that microRNA-193-3p (miR193) was significantly downregulated in the lung tissue and s

131 gulator of inflammation and neuroprotection, was significantly downregulated in the suicide decedent

132 To this end, CCR7 expression by iDCs was significantly downregulated in tolerant mice and thi

133 AsFAR transcription levels were significantly downregulated in A. suturalis feeding

134 ical synaptic transmission and ion transport were significantly downregulated in AD compared to contr

135 Expression levels of all 6 candidate miRNAs were significantly downregulated in blood of TCMVR patie

136 is and metabolism (FA2H and ALOXE3) products were significantly downregulated in both AD and psoriasi

137 ally, mutated driver gene targets in 3' UTRs were significantly downregulated in cancer and functione

138 technology, we identified several miRs that were significantly downregulated in CD133(+) cells compa

139 Collagen III and alpha-smooth muscle actin, were significantly downregulated in CXL HKCs.

140 , and CNN1, and endothelial cell marker CD31 were significantly downregulated in Drosha cKO mice comp

141 zed with glial glutamate transporters, which were significantly downregulated in ephrin-A2 KOs.

142 We found that DNMT1 and 3b levels were significantly downregulated in G(0)/G(1)while DNMT3

143 ic analysis identified four metabolites that were significantly downregulated in germ-free mice and h

144 iptomic analysis revealed that Fgf9 and Igf2 were significantly downregulated in Hdac3 KO mouse epica

145 AKT2 and phospho-AKT levels were significantly downregulated in human thoracic AAD t

146 omoter activities of TGF-beta1 and -beta RII were significantly downregulated in KSFM compared with D

147 l tissue, while keratins (KRT35/KRT83/KRT81) were significantly downregulated in lesional compared to

148 ere, we found that miR-218 expression levels were significantly downregulated in lung cancer tissues

149 We focused on mir-145 whose levels were significantly downregulated in malignant mesothelia

150 d, and a number of its putative mRNA targets were significantly downregulated in motor neurons after

151 iling displayed several important genes that were significantly downregulated in Myo-3M mice compared

152 Messenger RNA levels of SCO2 were significantly downregulated in myopic mouse retinae

153 TOR) genes that protect cells from infection were significantly downregulated in Native Hawaiians.

154 gral transcriptional co-activator Pgc-1alpha were significantly downregulated in Ogg1(-/-) livers.

155 miRNA-21-3p and miRNA-150-5p expression were significantly downregulated in patients with peri-i

156 Dermally expressed genes were significantly downregulated in psoriatic biopsies,

157 proteins, which include p53, CHEK1 and BRCA1 were significantly downregulated in SZ.

158 Genes in metabolic pathways were significantly downregulated in the AVF, whereas sig

159 cytokines such as TNF-alpha, MMP3, and MCP-1 were significantly downregulated in the brain of the dou

160 We found 30 genes that were significantly downregulated in the dorsal horn of P

161 evealed that 18 of the 23 cytokines analyzed were significantly downregulated in the hemisphere contr

162 ransglutaminases (Tgms) and their substrates were significantly downregulated in the knockout mice.

163 mune response and inflammation-related genes were significantly downregulated in the omental adipose

164 d magnetization were enriched for genes that were significantly downregulated in two prior case-contr

165 important in extracellular matrix structure were significantly downregulated, including decorin, fib

166 In dry eye, 46 glycogenes were significantly downregulated, including five members

167 versely, the negative marker for MSCs, CD45, was significantly downregulated (median, -2.7).

168 , we find that two others, Ynl058c and Alk1, are significantly downregulated on DNA damage.

169 Moreover, vascular endothelial growth factor was significantly downregulated on ER alphaKO EPCs compa

170 KRT19, and prostaglandin D2 synthase (PTGDS) were significantly downregulated, potentially reflecting

171 M interaction, and phosphoinositol signaling were significantly downregulated, proteomic analysis ide

172 statin (Fst) and progesterone receptor (Pgr) were significantly downregulated, raising the risk of br

173 ontrast, CDC42 and PAK1 messenger RNA levels were significantly downregulated specifically in deep la

174 eptors was unchanged, whereas P2Y12 receptor was significantly downregulated, suggesting a negative f

175 beta-defensins tested, only beta-defensin 1 was significantly downregulated, suggesting beta-defensi

176 independent studies demonstrate that CYP2C19 is significantly downregulated to 46% in NASH, to 58% in

177 alidation confirmed that ATP6V0D1 and FAM89B were significantly downregulated under both mechanical a

178 paralogs, miR-106a~363 and miR-106b~25, that are significantly downregulated upon syncytiotrophoblast

179 As miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell act

180 stically, we found that apoptotic signalling is significantly downregulated upon RASAL2 expression.

181 Multidrug resistance gene (MDR1) was significantly downregulated upon co-treatment.

182 Moreover, it was significantly downregulated VEGF, survivin and Bcl2

183 n addition, the tumor suppressor P53 pathway was significantly downregulated when exposed to schistos

184 elevated temperature, the expression of LtpA was significantly downregulated when spirochetes were gr

185 omic analysis showed that ribosomal proteins were significantly downregulated whereas EMT-associated

186 Clinically, KLF14 transcription is significantly downregulated, whereas Plk4 transcripti

187 HSP-27 was significantly downregulated, whereas vimentin was up

188 th immune function and response to pathogens was significantly downregulated with the loss of RB.

189 analyses revealed that miR-128a and miR-34a were significantly downregulated within GBM.