ライフサイエンスコーパス: be solved by

1 ix (TMH) to residue 20 of the first TMH, has been solved by (15)N,(1)H NMR in a monophasic chloroform

2 The dilemmas were solved by (18)F-FES PET in 87 of 100 scans (87%).

3 g equations for the electrokinetic transport are solved by a high-efficiency lattice Poisson-Boltzman

4 et article, we expect that this dilemma will be solved by a fixed individual strategy rather than a c

5 dual patient-level extrapolation may need to be solved by a future randomized controlled trial.

6 Here, we propose that this dilemma can be solved by a new diagnostic concept: liquid biopsy, th

7 pharmaceutical challenges, some of which can be solved by a prodrug approach.

8 non-homologous end-joining pathway, may have been solved by a greater tolerance to deletion errors.

9 We find that this dilemma is solved by a "collision release" process in which pol

10 constructed based on the new IP3R model and is solved by a hybrid Gillespie method with adaptive tim

11 inverse kinematics problem of such a system is solved by a Jacobin based algorithm.

12 The citation side challenge is solved by a new deep semantic representation, D2V-TFI

13 Optimal partitioning is solved by a numerically efficient analytical solution

14 m the 6-deoxyerythronolide B synthase (DEBS) was solved by a combination of multiple isomorphous repl

15 The solution structure, which was solved by a combined NMR and intensity-refined compu

16 rate constants for the two-compartment model were solved by a simple graphic approach and a more comp

17 The crystal structure has been solved by ab initio procedures from powder XRD data

18 Analyte carryover problem encountered was solved by adding 20% acetonitrile to the solvent of

19 d spatial responses to the same gradient can be solved by additional inputs from complementary gradie

20 ifying an appropriate control treatment, can be solved by adhering to 2 principles: the control treat

21 This and other unexpected problems were solved by adjustments in pH and temperature during

22 al hypothesis asserts that this core problem is solved by adult brains through two connected mechanis

23 s for two-nucleon spin-triplet states, which are solved by an iterative method.

24 The structure was solved by an ab initio approach that took advantage

25 The structures of 3-7 were solved by analysis of spectroscopic data including

26 ptimization problems so that the problem can be solved by any standard optimization algorithm.

27 tical problem of insufficient ion fluxes has been solved by applying a direct plasma injection scheme

28 The inconsistencies are solved by assuming an equilibrium between antiparall

29 Crucially, this task could not be solved by attending low-level features, but only by p

30 nical problem that, at the farm level, is to be solved by better shrimp and management of ponds and b

31 sidues of Bacillus stearothermophilus S4 has been solved by both X-ray crystallography and NMR, that

32 The model is solved by both analytic theory and stochastic-growth

33 The structure was solved by both the traditional 3-D crystallographic

34 eath protein 1 (PD-1) blockade therapies can be solved by combining with anti-cancer vaccines and CpG

35 -synthesized borosilicate zeolite SSZ-87 has been solved by combining high-resolution X-ray powder di

36 nstrate that this inefficiency can sometimes be solved by confining the liquid to an optical cavity u

37 from tetracycline-responsive promoters have been solved by constructing tetracycline-sensitive trans

38 f the resulting catalytic domain, CelB2, has been solved by conventional multiple isomorphous replace

39 exed with H16.U4 fragments of antibody (Fab) was solved by cryo-electron microscopy (cryo-EM) image r

40 ated state of Artemis in complex with DNA-PK was solved by cryo-EM recently, which showed Artemis bou

41 Recently the structure of human CST was solved by cryo-EM, allowing the design of mutant pro

42 The homo-tetrameric structure has been solved by cryoelectron microscopy.

43 d in an acidic solution, and their structure was solved by cryogenic electron microscopy with a resol

44 This problem was solved by crystallization of an engineered heterodim

45 generated, and the structures of the mutants were solved by crystallography.

46 The genomic structure of CYP4F11 was solved by database searching and computer analysis.

47 Nevertheless, this problem was solved by decreasing the azide dosage as long as it

48 This issue is solved by demonstrating the capability to electricall

49 derstand how similar biological problems may be solved by different molecular mechanisms of signal tr

50 improve the accuracy of the conformation and is solved by differential evolution algorithm.

51 cture-directing agent, and its structure has been solved by direct methods applied to the powder X-ra

52 The structure was solved by direct methods and showed significant diff

53 Disagreements were solved by discussion within the study team.

54 hese data establish that telomere protection is solved by distinct mechanisms in pluripotent and soma

55 on in the parallel conformation is likely to be solved by distributing the stress over the helices th

56 sion cytotoxicity at the highest dose, which was solved by dose reduction.

57 This complex task has been solved by dragonflies, who intercept their prey in

58 were trained on a cross maze task that could be solved by either a place or a response strategy, and

59 ynthase from the fungus, Pichia angusta, has been solved by electron cryo-microscopy.

60 h the alpha,beta-tubulin dimer structure has been solved by electron crystallography, the 3.7 A resol

61 However, the problem was solved by equipping the sensor with a heating unit t

62 For small models, the problem can be solved by exhaustive enumeration of all state transit

63 The system is solved by expanding the wavefunction in terms of the

64 lems for deployment in agriculture but could be solved by expressing genes for the biosynthesis of ph

65 This regiochemical control problem was solved by extension of a method we recently develope

66 A two-domain decomposition problem is solved by finding a bottleneck (or a minimum cut) of

67 The issue is solved by formulating the quantum dynamics in the Hei

68 ctures of the major product in each reaction were solved by GCEIMS and one- and two-dimensional (1H a

69 However, the specific computational problem being solved by grid cells has remained elusive.

70 ucture of the central EH domain of Eps15 has been solved by heteronuclear magnetic resonance spectros

71 e 19-nortestosterone hemisuccinate (19-NTHS) was solved by heteronuclear multidimensional NMR methods

72 Several basic olfactory tasks must be solved by highly olfactory animals, including backgro

73 not all object and spatial recognition tasks are solved by hippocampal-dependent memory processes.

74 classification model but this situation can be solved by implementing standardization methods such a

75 urs during visually guided eye movements and is solved by implementing Listing's law and the half-ang

76 tion bias and information bias, which cannot be solved by increasing the sample size, and the precisi

77 The structure was solved by integrated analysis of MS and 1D and 2D NM

78 reover, anion interference problem at low pH was solved by integration of all-solid-state ISE and int

79 The structure was solved by interpretation of NMR data obtained at 600

80 The structure was solved by interpreting NMR and MS data, and the rela

81 The problem can be solved by introducing new sensing mechanism based on

82 The crystal structure was solved by isomorphous replacement with the correspon

83 es of a mammalian protein structure that has been solved by isotopic labeling of the protein in a euk

84 The tasks he could perform can all be solved by learning the value of actions, while those

85 s, while those he could not perform can only be solved by learning the value of stimuli.

86 s of the whiskers revealed that the task can be solved by linearly integrating multiple whisker conta

87 Here we study these effects and how they can be solved by loading into nanoscale drug carriers.

88 Protein structures are being solved by Machine Learning based on human-derived

89 The homotetrameric structure of ES* was solved by MAD phasing with 52 Se-Met sites in an ort

90 iculty of luciferin diffusion into the cells was solved by making use of cell membrane leakage during

91 The structure of III was solved by maximum entropy analysis of XRD data coupl

92 The maximal clique problem has been solved by means of molecular biology techniques.

93 structure of a bacterial K+ channel pore has been solved by means of X-ray crystallography.

94 tructure in the tetragonal space group I4 2m was solved by means of single crystal X-ray diffraction

95 The problem of gliadin insolubility was solved by mild acid treatment, which renders an acid

96 The structure has been solved by molecular replacement and refined at 1.8

97 erase (CPDase) from Arabidopsis thaliana has been solved by molecular replacement and refined at the

98 le 5 domain of human plasminogen (K5HPg) has been solved by molecular replacement methods using K1HPg

99 UMT), which is encoded by the cobA gene, has been solved by molecular replacement to 2.7A resolution.

100 The OIH-1 structure was solved by molecular replacement and refined at 1.25

101 The structure was solved by molecular replacement and refined at 2.0 A

102 MMP-10cd at 1.9 A resolution; the structure was solved by molecular replacement and refined with an

103 e S-(2-oxo)pentadecyl-CoA, and its structure was solved by molecular replacement at 1.4 A resolution.

104 t Saccharomyces cerevisiae chorismate mutase was solved by molecular replacement at a resolution of 2

105 the structure of the complex with Mg(2+)*OSB was solved by molecular replacement in space group P2(1)

106 alcium-bound state at 2.03 A resolution that was solved by molecular replacement in the space group P

107 erminal catalytic domain joined by a linker, was solved by molecular replacement methods using indepe

108 The phase problem was solved by molecular replacement using an AlphaFold m

109 The structure was solved by molecular replacement using rat serum mann

110 The structure was solved by molecular replacement using the coordinate

111 The structure was solved by molecular replacement using the crystal st

112 The structure was solved by molecular replacement using the crystal st

113 ynureninase were obtained, and the structure was solved by molecular replacement using the CsdB coord

114 m at pH 5.2 in the presence of 0.1 M Mg(2+), was solved by molecular replacement using the model of c

115 The native structure was solved by molecular replacement using the structure

116 The crystal structure was solved by molecular replacement using the unliganded

117 The structure was solved by molecular replacement with the Pseudomonas

118 The SM3-MUC1 peptide structure was solved by molecular replacement, and the current mod

119 The structure was solved by molecular replacement, using a composite o

120 al grown with Triton X-100 and the structure was solved by molecular replacement.

121 zed in space group P41212, and the structure was solved by molecular replacement.

122 essed to 4.0-A resolution, and the structure was solved by molecular replacement.

123 The structures were solved by molecular replacement and refined to 2.1

124 plex between glycogenin and UDP-glucose/Mn2+ were solved by molecular replacement to 1.9 A using the

125 The structures were solved by molecular replacement using Escherichia c

126 the opposition between these approaches has been solved by more unitary theoretical and experimental

127 ency virus-type 1 (HIV-1) capsid protein has been solved by multidimensional heteronuclear magnetic r

128 n the presence of a specific target RNA, has been solved by multidimensional heteronuclear NMR spectr

129 ligand for the CXCR4 G-coupled receptor, has been solved by multidimensional heteronuclear NMR spectr

130 the full-length holo-1.3S subunit of TC has been solved by multidimensional heteronuclear NMR spectr

131 cherichia coli phosphotransferase system has been solved by multidimensional NMR spectroscopy with ex

132 -helical form resembling PrPC, the structure was solved by multidimensional heteronuclear NMR, reveal

133 re of the human Rap30 DNA-binding domain has been solved by multinuclear NMR spectroscopy.

134 ulolyticus in complex with cellotetraose has been solved by multiple isomorphous replacement and refi

135 mandelate pathway of Pseudomonas putida, has been solved by multiple isomorphous replacement at 1.6 A

136 m the alkalophilic Bacillus agaradherans has been solved by multiple isomorphous replacement at 1.6 A

137 in farnesyltransferase crystal structure has been solved by multiple isomorphous replacement methods

138 The structure was solved by multiple anomalous diffraction phasing met

139 structure of the Erwinia chrysanthemi enzyme was solved by multiple isomorphous replacement and refin

140 The crystal structure was solved by multiple isomorphous replacement and refin

141 nase from Erwinia carotovora ssp. carotovora was solved by multiple isomorphous replacement and refin

142 re of flavin reductase P from Vibrio harveyi was solved by multiple isomorphous replacement and revea

143 The structure was solved by multiple isomorphous replacement at 3.0 A

144 The structure of apo OSBS was solved by multiple isomorphous replacement in space

145 The crystal structure of LpdA was solved by multiple isomorphous replacement with anom

146 3-dimensional structure of the native enzyme was solved by multiple isomorphous replacement, and refi

147 domain of TonB from Escherichia coli has now been solved by multiwavelength anomalous diffraction and

148 hich the structures of trapped intermediates are solved by NMR, indicating that they are well packed

149 a prototypic integrin alpha(IIb)beta(3) has been solved by NMR and reveals multiple hydrophobic and

150 GG(TTAGGG)3, antiparallel and parallel, have been solved by NMR and X-ray crystallography.

151 ich (CR) domain of Escherichia coli DnaJ has been solved by NMR methods.

152 The structures of both of these domains have been solved by NMR spectroscopy and x-ray crystallograph

153 cherichia coli phosphotransferase system has been solved by NMR using conjoined rigid body/torsion an

154 cherichia coli phosphotransferase system has been solved by NMR, including the use of conjoined rigid

155 mannose transporter of Escherichia coli have been solved by NMR.

156 cherichia coli phosphotransferase system has been solved by NMR.

157 f the DPBD, the first of a WRN fragment, has been solved by NMR.

158 tation of the active site Cys384 to Ser, has been solved by NMR.

159 Glc) of the glucose transporter IICBGlc, has been solved by NMR.

160 ng the consensus sequence CTA(A/T)(4)TAG has been solved by NMR.

161 the histidine phosphocarrier protein HPr has been solved by NMR.

162 cherichia coli phosphotransferase system has been solved by NMR.

163 ased on protease-activated receptor-1 (PAR1) was solved by NMR and found to closely resemble the i3 l

164 ferric state with intact vinyl substituents was solved by NMR methods.

165 The mutant fusion domain structure was solved by NMR spectroscopy in a lipid environment at

166 n structure of the R347K mutant of TNFR-1 DD was solved by NMR spectroscopy.

167 he structure of the tightest binding peptide was solved by NMR, and its binding site on Cdc42 was det

168 astoris, and the three-dimensional structure was solved by NMR.

169 f of the deposited RNA structures in the PDB were solved by NMR methods, the usefulness of NMR is sti

170 emma, common to most flowering plants, could be solved by not producing nectar and/or scent, thereby

171 The structure of EH(3) has been solved by nuclear magnetic resonance (NMR) spectros

172 nd of eukaryotic 16 S-like ribosomal RNA has been solved by nuclear magnetic resonance spectroscopy i

173 0) and the pre-mRNA bound (b L30) forms have been solved by nuclear magnetic resonance spectroscopy.

174 The structure of the modification was solved by nuclear magnetic resonance and shown to co

175 The solution structure of FSD-1 was solved by nuclear magnetic resonance spectroscopy an

176 op IIB of the Rev response element (RRE) RNA was solved by nuclear magnetic resonance spectroscopy.

177 h a variable-volume double-pool model, which was solved by numerical integration (Runge-Kutta method)

178 s could not be corrected directly, but could be solved by omitting libraries with particularly low yi

179 The phase problem is solved by oversampling and iterative phase retrieval.

180 Such equilibria are solved by pCa Calculator, a computer program designe

181 of two new phases-ZIF-4-cp-II and ZIF-hPT-II-were solved by powder diffraction methods.

182 ine daughter zeolite IPC-20, whose structure was solved by precession-assisted three-dimensional elec

183 This end-protection problem is solved by protein-DNA complexes called telomeres.

184 The puzzle may be solved by quantitative historical evidence that demon

185 The problem of conventional weight is solved by reducing the weight by 70%.

186 ual costs or insufficient monitoring, cannot be solved by reputation alone.

187 as been proposed that this "binding problem" is solved by selective attention to the locations of the

188 The structure was solved by selenomethionine single-wavelength anomalo

189 The paradox is solved by showing that variability operates within a

190 from rat (rGSTK1-1) in complex with GSH has been solved by single isomorphous replacement with anoma

191 erase, cloned from Arabidopsis thaliana, has been solved by single isomorphous replacement with anoma

192 n (P domain) of the Escherichia coli Lon has been solved by single-wavelength anomalous dispersion an

193 The structure of this MOF, termed MOF-688, was solved by single crystal X-ray diffraction and found

194 The structure was solved by single isomorphous replacement, anamalous

195 while the structure of [Pb3(SC6H4S)3(en)2]n was solved by single-crystal X-ray diffraction.

196 The structure of BTA121 was solved by single-wavelength anomalous dispersion (SA

197 The structure was solved by single-wavelength anomalous dispersion usi

198 Both were solved by single crystal X-ray diffraction and the

199 st that complex dynamic routing problems can be solved by small-brained animals using simple learning

200 mensional solution structure of apo NosL has been solved by solution NMR methods.

201 ich leads to differential equations that can be solved by standard numerical techniques to obtain mor

202 The structure was solved by substituting seleno-methionine for natural

203 The structure was solved by sulfur and manganese single wavelength ano

204 tures of [Pb2(S2C6H2S2)(en)]n and [Pb3C6S6]n were solved by synchrotron X-ray powder diffraction, whi

205 This problem is solved by taking advantage of the fact that most of t

206 Dimers are solved by the addition of a cross-over at a specific

207 ion that the antibiotic pipeline problem can be solved by the collaboration of global leaders to deve

208 o FE fibers are two clinical issues that may be solved by the identification of specific biomarkers.

209 that the fundamental problem with voids can be solved by the sequential nanoscale bonding of MXEne p

210 in, discovered 60 years ago, is removed, has been solved by the demonstration that the trafficking ch

211 erthermophilic archaeon Aeropyrum pernix has been solved by the multiple anomalous dispersion techniq

212 eins in the M. tuberculosis genome that have been solved by the TBSGC over the past few years.

213 With an increasing number of structures being solved by the structural genomics initiatives, the

214 aryotic systems, this directionality problem is solved by the formation of a loop in the lagging stra

215 aryotic systems studied so far, this problem is solved by the formation of a loop in the lagging stra

216 of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tiss

217 te two-parameter sub-problems, each of which is solved by the measurement of two different experiment

218 How this complex problem is solved by the nervous system remains poorly understoo

219 This conundrum is solved by the redox cycling of iron between Fe(III) a

220 y a second telomere replication problem that is solved by the shelterin component TRF1.

221 The crystal structure of hCBG was solved by the molecular replacement method and refin

222 The structure was solved by the molecular replacement method and refin

223 The structure was solved by the molecular replacement method and refin

224 The structure was solved by the molecular replacement method and refin

225 The structure was solved by the molecular replacement method and subse

226 The structure was solved by the molecular replacement method at 1.9 A

227 The crystal structure was solved by the molecular replacement method, and the

228 The structure was solved by the molecular replacement method, and the

229 The structure was solved by the multiple wavelength anomalous diffract

230 The structure was solved by the multiple-wavelength anomalous dispersi

231 The structure was solved by the multiwavelength anomalous diffraction

232 roxymethyl pyrimidine (HMP) salvage pathway, was solved by the multiwavelength anomalous dispersion (

233 iological roles of a protein whose structure was solved by the structural genomics project.

234 e of the enzyme/4-hydroxybenzoyl-CoA complex was solved by the techniques of multiple isomorphous rep

235 isoguanine ribo- and 2'-deoxyribonucleosides were solved by the action of acetone.

236 Both structures were solved by the molecular replacement method using di

237 The structures were solved by the molecular replacement method.

238 Seventy-six percent of cases were solved by the top-ranked variant.

239 Theory has proposed that this ambiguity is solved by tracking head tilt through multisensory int

240 n, we show that the public goods dilemma may be solved by two very different mechanisms: cells can pr

241 f the Escherichia coli F0F1-ATP synthase has been solved by two-dimensional 1H NMR in a membrane mime

242 on is a challenge in mass spectrometry which is solved by two-dimensional (2D) Fourier transform ion

243 These problems were solved by two approaches.

244 atmospheric water in the optical path, which was solved by use of wavelengths centred within availabl

245 .1.1.-), in complex with cofactor NADPH, has been solved by using x-ray crystallographic data to 2.1-

246 tion center from Rhodobacter sphaeroides has been solved by using x-ray diffraction at a 2.55-A resol

247 The phase problem is solved by using an iterative algorithm with a random

248 The MeSH side challenge is solved by using the 'learning to rank' framework of M

249 The solution structure of the complex was solved by using NMR restraints to guide distance geo

250 These technical difficulties were solved by using clavulanic acid, an irreversible in

251 re of an extradiol ring-cleaving dioxygenase was solved by utilizing the improved operation and chara

252 Graph traversal problems are solved by wave-like activation patterns which travel

253 encoded by the Escherichia coli genome, has been solved by X-ray crystallographic analyses to a reso

254 n carbonic anhydrase II (CAII) variants have been solved by X-ray crystallographic methods to probe t

255 though the structure of the aporepressor has been solved by X-ray crystallographic techniques, no str

256 differences, three CYP158A1 structures have been solved by X-ray crystallography and have been compa

257 The structure of VanX from E. faecium has been solved by X-ray crystallography and reveals a Zn(2+

258 the Bacillus stearothermophilus protein have been solved by X-ray crystallography and the structure o

259 embrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution

260 by its natural regulatory zeta-protein, has been solved by X-ray crystallography at 4.0 A resolution

261 d transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstr

262 cture of the resulting variant, CVB3-RD, has been solved by X-ray crystallography to 2.74 A, and a cr

263 nase, casein kinase I delta (CKI delta), has been solved by X-ray crystallography to a resolution of

264 The structure of VCBC-Cullin5 has recently been solved by X-ray crystallography, and, using molecul

265 the Mycobacterium tuberculosis ortholog has been solved by x-ray crystallography, but details of how

266 l packing by loop-receptor interactions have been solved by X-ray crystallography, but not by NMR.

267 n associated with a portion of the shaft has been solved by X-ray crystallography, the in situ struct

268 leotide-binding (OB)-fold domain of TPP1 has been solved by X-ray crystallography, the molecular inte

269 While the structure of the O-layer has been solved by X-ray crystallography, there is no detail

270 ined, structures of inhibitor complexes have been solved by X-ray crystallography, with data up to 1.

271 main from the human trifunctional enzyme has been solved by X-ray crystallography.

272 elatively few protein-protein complexes have been solved by X-ray crystallography.

273 structures of the most powerful mutants have been solved by X-ray crystallography.

274 tions of (beta-)arrestins that have recently been solved by X-ray crystallography.

275 s gnavus (strain ATCC 29149) [PDB:4HYZ] have been solved by X-ray crystallography.

276 nsional structure of the IRES RNA, which has been solved by X-ray crystallography.

277 cosides, the structures of two of which have been solved by X-ray diffraction.

278 on channel from Synechocystis PCC 6803, have been solved by X-ray diffraction.

279 o the substrate analog UDP-glucose (UDP-Glc) was solved by X-ray crystallographic methods and refined

280 l, the structure of the C5_MG4-CirpT complex was solved by X-ray crystallography (at 2.7 angstrom).

281 The three-dimensional structure of Phl p 3 was solved by X-ray crystallography and compared with th

282 sis protein At5g01750 from the DUF567 family was solved by X-ray crystallography and provides the fir

283 ic assembly of voltage-dependent K+ channels was solved by x-ray crystallography at 2.1 angstrom reso

284 e three-dimensional structure of the protein was solved by X-ray crystallography at 2.2A resolution a

285 The structure of recombinant BcelPL6 was solved by X-ray crystallography to 1.3 angstrom reso

286 e sulfur bacterium Marichromatium purpuratum was solved by X-ray crystallography to 2.75 A resolution

287 the extremely oxygen-sensitive CompA protein was solved by X-ray crystallography to 3 A resolution.

288 the structure of BFDC with the MBP inhibitor was solved by X-ray crystallography to a spatial resolut

289 ly, the high-resolution structure of ClC-ec1 was solved by X-ray crystallography.

290 i-idiotypic monoclonal antibody (mAb) GH1002 was solved by X-ray crystallography.

291 f one fragment and of a more active analogue was solved by X-ray crystallography.

292 E and IgG reactivity to the natural allergen was solved by x-ray crystallography.

293 nd (13)C NMR spectroscopy, and the structure was solved by X-ray crystallography.

294 A complex was crystallized and its structure was solved by X-ray crystallography.

295 to the native COOH terminus at position 319 was solved by x-ray diffraction to a resolution of 1.75A

296 cL homologue from Mycobacterium tuberculosis was solved by x-ray diffraction to a resolution of 3.5 A

297 res of the designed proteins CA01 and DA05R1 were solved by x-ray crystallography (2.2 angstrom resol

298 ctures of the I50Q, V241A, and E211S mutants were solved by X-ray crystallography to resolutions of 2

299 e form and in complex with protospacer DNAs, were solved by X-ray crystallography.

300 d 2,3,4,4'-tetramethoxy-1,1'-biphenyl (TMB), were solved by X-ray diffraction.