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1 ar localization studies have shown that TILs are targeted to a variety of cell membranes and organell
2 nal, multifunctional chemical probe that can be targeted to a genetically encoded protein of interest
5 point regions of the hGLUT proteins that can be targeted to achieve isoform selectivity, and show tha
6 have identified potential pathways that can be targeted to activate cancer immunogenicity via TEs in
7 plex is the major form of kinase in vivo and is targeted to active genes and telomeric transposons vi
9 ine the precise microbial functions that can be targeted to address specific pathophysiological proce
12 e availability of Cas9 endonuclease that can be targeted to almost any genomic locus using so called
15 in, and highlight a trophic pathway that can be targeted to ameliorate dendrite loss in pathological
16 it that gates avoidance responses, which can be targeted to ameliorate maladaptive avoidance in psych
21 elements within the ANDV N protein that can be targeted to attenuate ANDV and suggest targeting cell
23 CD19(+) cells and CD19(-) precursors should be targeted to avoid CD19(-) relapses in patients with B
24 sialylated N-glycan (Neu5Ac/Neu5Gc-terminal) is targeted to be used as a novel biomarker of sickness/
25 transgenic mouse model in which p53 deletion is targeted to biliary epithelia and CC induced using th
26 the epigenetic activator of ERalpha that can be targeted to block ERalpha gene expression is a critic
27 (Y382-384) within the P2X7 receptor that can be targeted to blunt the development of morphine analges
29 to produce specific output projections that are targeted to both similar and different target areas.
31 We found that Kir2.1 and Kir2.2 channels were targeted to both the surface and the transverse tub
33 oped a modular drug delivery system that can be targeted to cell types of therapeutic interest in the
36 fusion of Tn5 transposase to Protein A that is targeted to chromatin by a specific antibody, allowin
37 l SMT of Cbx7 mutants demonstrates that Cbx7 is targeted to chromatin by co-recognizing of H3K27me3 a
38 ort the exciting possibility that miRNAs can be targeted to combat seizures after spontaneous seizure
40 require distinct metabolic programs that can be targeted to control specific T cell populations in au
41 covery identifies novel molecules that might be targeted to correct defective repair during cirrhosis
44 sociate with PBs in the cytoplasm but rather is targeted to cytosolic insoluble protein deposits (IPO
46 cluding declining hemoglobin and anemia, may be targeted to delay the effects of aging in a compellin
48 distinct pharmacological profile, and, thus, be targeted to develop innovative pharmacological therap
50 n heart muscle, enabling those structures to be targeted to develop new therapies for heart disease.
51 ia and the active nature of resilience could be targeted to develop new treatments for stress-related
57 TN in S phase removal of DPCs, but how SPRTN is targeted to DPCs during DNA replication is unknown.
58 or proteins, many of which are glycosylated, are targeted to each type of granule according to their
59 indicate that Arabidopsis uL18-Like proteins are targeted to either mitochondria or chloroplasts.
60 esis and osteogenesis in bone, and Cxcl9 can be targeted to elevate bone angiogenesis and prevent bon
63 XCR3 in CTL migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunothera
64 D31 acts as a checkpoint receptor that could be targeted to enhance FcgammaR functions in Ab-mediated
65 epigenetic, and inflammatory pathways could be targeted to enhance old HSC fitness and prevent leuke
66 uman hematolymphoid cell development and may be targeted to enhance production of specific cell popul
67 among major cell stress pathways that could be targeted to enhance proliferation of CMs in ischemia
69 gest that the purinergic checkpoint P2X7 may be targeted to enhance T-cell-mediated cancer immunother
70 stem cell (CSC)-like populations that could be targeted to enhance the antitumor action of these dru
71 identified molecules and pathways that could be targeted to enhance the efficacy of an EBV-specific v
72 hromosome upon the upregulation of Xist, and is targeted to enhancers and promoters of active genes.
78 The enzymes and transporters they encode may be targeted to further construe the nature of NMDAR coag
81 CoV E has a single hydrophobic domain (HD), is targeted to Golgi complex membranes, and has cation c
82 CoV E has a single hydrophobic domain (HD), is targeted to Golgi membranes, and has cation channel a
85 insights into the control of Arc that could be targeted to harness neuroplasticity for clinical appl
87 n drugs for breast cancer prevention, should be targeted to high-risk groups to maintain a favourable
90 strategies among these high-risk individuals are targeted to identify precursor lesions and PDAC at a
91 hifts, leading to beneficial traits that can be targeted to improve animal health and production.
98 tabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care che
99 ngs uncover a purinergic checkpoint that can be targeted to improve the efficacy of cancer immunother
100 vidence suggesting that the microbiota could be targeted to improve therapy while attenuating adverse
102 naling pathways such as JAK-STAT3 that could be targeted to improve treatment of aggressive disease.
103 for identifying regulatory routes that could be targeted to improve treatment response. We conducted
104 gic signaling in differentiating T cells can be targeted to improve vaccine responses, in particular
105 suggest that parkin activation by Mdm2 could be targeted to increase its neuroprotective functions, w
106 e middle/outer active sites rim, which could be targeted to increase the CAI isoform selectivity.
107 as observed when two CRISPR-Cas12a complexes were targeted to independent sites on the phage genome,
108 that MCL-1 is a mitophagy receptor that can be targeted to induce mitophagy, and identify MCL-1 as a
109 These data suggest that multiple lipids can be targeted to induce oligomerization of defensins durin
110 novel TCR-CXCR4-signaling pathway that could be targeted to inhibit the aberrant cytokine secretion t
111 racterize a novel signaling pathway that can be targeted to inhibit the secretion of cytokines by mod
113 other activity of senescent cells that might be targeted to limit the spread of cancer.See related ar
116 Thus, NpHR-mCherry or mCherry expression was targeted to lOFC neurons that project to the BLA or
118 providing a regulatory mechanism that could be targeted to manage acid-related gastric diseases.
120 by suppressing NKRF production, which might be targeted to manage viral-induced neuroinflammation.
121 iral interferon regulatory factor 1 (vIRF-1) is targeted to mDRM during virus replication and negativ
123 indicators, R-CEPIA3mt and R-CEPIA4mt, which are targeted to mitochondria and their Ca(2+) affinities
127 riants (types II and III) revealed that they were targeted to mitochondria independently of exon 1 sp
130 , only allergen-specific immunotherapy (AIT) is targeted to modify the natural history of allergic di
131 eutrophils and suggest that therapies should be targeted to modulate autophagy and phagocytosis in ne
133 f the VSMC differentiation programs that can be targeted to modulate VSMC phenotype during vascular d
134 d-mediated capture/release strategy, HyCCAPP is targeted to multiple genomic loci in parallel, and th
137 In autoimmunity, these same pathways can be targeted to opposite effect: to curb the over-exubera
140 sulated in 100 nm pegylated liposomes, which are targeted to organs with a monoclonal antibody agains
144 actors identified could allow the therapy to be targeted to patients most likely to benefit and not e
146 seizures, but additional mechanisms need to be targeted to permanently prevent epilepsy development.
147 ies demonstrated that the Sf-RV nucleocapsid was targeted to plasmodesmata, while two forms of the ac
148 l-targeted to plastids and mitochondria; two are targeted to plastids, and five are targeted to mitoc
149 precursors containing Hsp70-binding elements were targeted to plastids, whereas none of the chimeric
150 underlying fibroblast homeostasis that could be targeted to potentially prevent fibroblast activation
151 ing transcriptional remodeling during stress are targeted to PQC sites to influence gene expression c
156 may contribute to disease, and how it might be targeted to prevent damage to the aging choriocapilla
157 rictal global network dysfunction that could be targeted to prevent disruption of normal neural activ
158 bset of VEGFR2 mediated responses that could be targeted to prevent excessive sprouting angiogenesis
160 Finally, we demonstrate that Car enzymes can be targeted to prevent human mast cell development.
161 sic and new cell signaling pathways that may be targeted to prevent senescence, a significant barrier
164 erial transporter for drug uptake that might be targeted to promote greater antibiotic influx to incr
166 mmunoregulatory circuits in B cells that may be targeted to promote long-lived humoral immunity and r
169 point, redox dysregulation has successfully been targeted to protect PVIs with antioxidants/redox re
171 es, these new agents are selective, and many are targeted to proteins which are mutated or translocat
172 iRNA regulators of ANP production that could be targeted to raise ANP levels, which may have applicat
173 ay inhibit immune surveillance, and it could be targeted to reactivate CIITA expression in SWI/SNF de
174 present in late endosomes/lysosomes, ClC-3c is targeted to recycling endosomes via a novel N-termina
176 mation and injury in mice with AP, and might be targeted to reduce pancreatic tissue damage and infla
177 ventions and epidemiological research should be targeted to reduce the burden of human cystic echinoc
178 ydroxy-2-naphthoate prenyltransferase (MenA) was targeted to reduce methicillin-resistant Staphylococ
179 -in-class protein cage nanoparticle that can be targeted to renal proximal tubules through glomerular
182 and implicate additional pathways that could be targeted to restrain Th2 trans-differentiated Treg ce
184 y hydrophobic sequences (e.g., 5Leu + 11Ala) are targeted to SecYEG by SecA and inserted, but subsequ
186 l and proliferation of cancer cells, and can be targeted to selectively trigger cancer cell apoptosis
188 cytosis, and demonstrate whether a toxin can be targeted to Siglec-8-bearing cells to kill these cell
190 the preparation of protein micelles that can be targeted to sites of activated platelets with broad p
193 the vertebrate CNS, afferent sensory inputs are targeted to specific depths or layers of their targe
194 ns express multiple neuroligin isoforms that are targeted to specific synapses, but their synaptic fu
195 ity through the use of microbubbles that can be targeted to specific biological processes is explored
198 may be a vehicle by which RNA therapy could be targeted to specific cells for the treatment of kidne
199 dicate a mechanism by which TET1 protein may be targeted to specific sites of action at enhancers by
201 mRNA, and some noncoding RNAs (ncRNAs), can be targeted to stress granules, the targeting efficiency
202 ng interneurons, the alpha5-GABA(A)R subunit is targeted to synapses formed by the VIP- and calretini
204 The paraoxon-induced beta1 integrin response was targeted to synapses, and the two-fold increase in b
210 ryotes, up to one-third of cellular proteins are targeted to the endoplasmic reticulum, where they un
211 which mitochondrial-derived vesicles (MDVs) are targeted to the endosomal compartment has remained u
212 decades has determined how membrane proteins are targeted to the ER and how individual transmembrane
215 oteins destined for the mitochondrial matrix are targeted to the inner membrane Tim17/23 translocon b
218 m which newly synthesized lysosomal proteins are targeted to the late endosomes and the ATP7A copper
219 the VHHs with a GPI attachment signal, VHHs are targeted to the lipid rafts of the plasma membranes.
220 the VHHs with a GPI attachment signal, VHHs are targeted to the lipid rafts of the plasma membranes.
229 there are multiple means by which substrates are targeted to the proteasome, and these differences co
230 e immunomodulation and immunosuppression and are targeted to the specific organ manifestation, with t
232 ls that allow precursors of such proteins to be targeted to the mycomembrane remain uncharacterized.
235 with the ubiquitin receptor protein DSK2 and is targeted to the autophagy pathway during stress via t
236 N1 is expressed selectively in rods where it is targeted to the axonal terminals by the synaptic rele
239 teins, the HIV-1 envelope glycoprotein gp160 is targeted to the endoplasmic reticulum (ER) by its sig
245 a bona fide Ser/Thr protein phosphatase that is targeted to the mitochondrial intermembrane space (IM
246 ogenase Fe protein when the NifH polypeptide is targeted to the mitochondrial matrix together with th
247 ves mitotic remodeling; here we show that it is targeted to the nuclear pore complex (NPC) by binding
248 and immunocytochemistry, we found that Liat1 is targeted to the nucleolus by a low-complexity poly-K
249 -815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for removing SUMO from spec
255 P1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteasome for degradation (the canon
256 igned a modified form of nNOSmu (NOS-M) that is targeted to the sarcolemma by palmitoylation, even in
258 cular mechanism by which the G9a/GLP complex is targeted to the specific gene loci for H3K9 methylati
260 m nucleotide sequence-an RNA 'barcode'-which is targeted to the synapse using engineered proteins.
261 cent of some other ion-channel subunits, and is targeted to the tips of the stereocilia in the sensor
263 proton-translocating subunit a: Vph1p, which is targeted to the vacuole, and Stv1p, which is targeted
264 which a membrane anchored MinC/MinD complex is targeted to the Z ring through the conserved carboxy
266 approach where PHOT1-GFP (P1-GFP) expression was targeted to the hypocotyl apex of the phot-deficient
267 petent model in which anti-insulin Vkappa125 was targeted to the Igkappa locus and paired with anti-i
268 ing import into isolated chloroplasts, Plsp1 was targeted to the membrane via a soluble intermediate
270 We found that ectopically expressed LpdA was targeted to the plasma membrane and Rab4- and Rab14-
272 pea genome and expression of the transporter was targeted to the sieve element-companion cell complex
273 overexpressed or antisense oligonucleotides were targeted to the C9orf72 hexanucleotide repeat expan
274 presence of AChR subunits, rapsyn molecules were targeted to the cell surface and formed aggregates
275 ically, acyl-CoA/acyl-ACP processing enzymes were targeted to the cytoplasm, peroxisome, or endoplasm
277 hat PS1-containing gamma-secretase complexes were targeted to the plasma membrane, whereas PS2-contai
281 tions of Cre-dependent adenoviral constructs were targeted to the ventrolateral hypothalamus of Foxb1
282 identified in structural images and stimuli were targeted to these locations using real-time retinal
285 omatin modifications such as DNA methylation are targeted to transposable elements by small RNAs in a
286 a specific receptor of the gut-lung axis can be targeted to treat airflow obstruction in asthma.
287 ul in understanding how these pathways could be targeted to treat diseases associated with type 2 inf
289 ation and suggest that EC Kir channels could be targeted to treat endothelial dysfunction, which is a
294 lminating in Kv1.1 overfunction, which could be targeted to treat striatal-related monogenic disorder
296 biosocial, household-level interventions to be targeted to tuberculosis-affected households that are
299 nally repressive DNA and histone methylation are targeted to viruses, transposable elements, and some
300 e (FLEX)-Channelrhodopsin2 (ChR2) expression was targeted to VTA DA neurons in DA transporter (DAT)-c