ライフサイエンスコーパス: be thought to

1 ubstrate-induced conformational changes that are thought to account for high replication fidelity, bu

2 s on rare variants of large effect size that are thought to account for the observed phenotypes.

3 In the absence of Dna2, 5'-flaps are thought to accumulate on the lagging strand, resulti

4 All normal somatic cells are thought to acquire mutations, but understanding of t

5 nd retraction fibers in mitosis [1-6], which are thought to act as local cues that pattern cortical G

6 These compounds are thought to act by cysteine modification to alter the

7 While EBV SM has been thought to act posttranscriptionally, we provide ev

8 These aggregates were thought to act by templating the formation of an as

9 inked to pubertal development in adolescence are thought to affect multiple aspects of brain developm

10 Global warming is thought to affect phytoplankton production both direc

11 f neural oscillations (oscillation-based FC) is thought to afford dynamic information exchange across

12 The modification of habitats in urban areas is thought to alter patterns of species interactions, by

13 The cognitive issues are thought to arise from increased release of the neuro

14 dividuals who have implanted cardiac devices are thought to arise from the interaction between the im

15 that in SLE and Sjogren's syndrome has long been thought to arise from alleles of the human leukocyt

16 model proposed by Bastin et al., familiarity is thought to arise from attribution of fluency signals.

17 r 2/3 for stimulus orientation and direction is thought to arise from intracortical inputs that are s

18 Fragile site damage is thought to arise from the aberrant repair of spontane

19 lso results in gradual cognitive decline and is thought to arise, in part, because of a chronic pro-i

20 NT Interictal epileptiform discharges (IEDs) are thought to be a cause of memory deficits in chronic

21 Phenotypes such as height and intelligence, are thought to be a product of the collective effects of

22 Wilt symptoms are thought to be caused by systemic bacterial colonizat

23 er 5 pyramidal neurons (L5PNs) in particular are thought to be central to cortical computation becaus

24 unctional consequences of focal brain injury are thought to be contingent on neuronal alterations ext

25 evant in young animals, as early life stages are thought to be critical with respect to animal life-h

26 e, present-day patterns of genetic structure are thought to be dictated by repeated expansion and con

27 Declines in pollinator populations are thought to be due to multiple factors including habi

28 often omitted in recombinant spidroins, but are thought to be essential for the spiders' natural spi

29 In contrast, prokaryotes are thought to be evolving under much stronger selective

30 These psychological effects are thought to be highly sensitive to context, but robus

31 Feedback inhibitory motifs are thought to be important for pattern separation acros

32 Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence.

33 ssue-damaging and immunothrombotic responses are thought to be major causes of respiratory failure an

34 Inflammation and vascular permeability are thought to be major contributors to the development

35 ially in their role in the visual cycle, and are thought to be one of the first cell classes affected

36 Patients with thoracic malignancies are thought to be particularly susceptible to COVID-19 g

37 The sensory consequences of our actions are thought to be predicted via sensorimotor integration

38 cene pattern, when South Pacific dust fluxes are thought to be primarily supported by Australian sour

39 More realistic preclinical cancer models are thought to be provided by transplantable, patient-de

40 cumulate in haematopoietic stem cells (HSCs) are thought to be responsible for age-related changes in

41 ism by which those channels in smooth muscle are thought to be targets of endothelium-derived nitric

42 These functional microstates are thought to be the building blocks of spontaneous con

43 Although immune and epithelial cells are thought to be the canonical orchestrators of this co

44 Compulsive patterns of drug use are thought to be the consequence of drug-induced adapta

45 imordial progenitors of the foregut endoderm are thought to be the developmental precursors to all ad

46 These are thought to be the first results showing that magneti

47 ligomers of the beta-amyloid peptide, Abeta, are thought to be the synaptotoxic species responsible f

48 Vertebrate striated muscle thin filaments are thought to be thermodynamically activated in respons

49 onstitute a key oncogenic pathway, which has been thought to be functionally connected to estrogen re

50 n, ecological niche differentiation has long been thought to be important for polyploid success.

51 s has remained somewhat of a mystery but has been thought to be in part mediated by the release of my

52 ling petroleum-derived compounds, which have been thought to be relatively inert (unreactive) and thu

53 the expression of sex-specific behavior and is thought to be a critical mediator of many psychiatric

54 Although CVID is thought to be a disorder of the peripheral B-cell com

55 The cell cycle, in particular, is thought to be a key driver of cell-to-cell heterogene

56 transformation from sensation to perception is thought to be a major function of the mammalian corte

57 ns it regulates synaptic transmission, which is thought to be a major mechanism through which altered

58 ction, information storage and structure and is thought to be a prerequisite for the origin or early

59 The near-Earth asteroid (162173) Ryugu is thought to be a primitive carbonaceous object that co

60 y a complex network of muscular strands that is thought to be a remnant of embryonic development(1,2)

61 The hippocampal CA2/CA3 region is thought to be able to rapidly store incoming informat

62 ost recent glacial and deglacial periods and is thought to be absent during warmer climate conditions

63 Intuitively, cognitive control is thought to be affected by the state of alertness; for

64 Atomic interface regulation is thought to be an efficient method to adjust the perfo

65 to dampen the antitumor immune response and is thought to be an important driver in tumor immune eva

66 Hypoxia in solid tumors is thought to be an important factor in resistance to th

67 sion of C(19) androgens into C(18) estrogens is thought to be an irreversible reaction.

68 ough not fully understood, diabetes mellitus is thought to be associated with cardiac fibrosis and st

69 vidually differentiated social relationships is thought to be cognitively challenging.

70 cells and the local immunogenic environment is thought to be critical for long term repair and regen

71 and normalization of this aberrant function is thought to be critical for successful treatment.

72 e selective removal of damaged mitochondria, is thought to be critical to maintain neuronal homeostas

73 The M (main) group of HIV-1 is thought to be derived from SIVcpz, which utilizes Nef

74 ile antibody-dependent enhancement of dengue is thought to be driven by viral load, this has not been

75 Memory is thought to be encoded by sparsely distributed neurona

76 growth and stabilization of dendritic spines is thought to be essential for maintaining long-term mem

77 This evolutionary innovation is thought to be facilitated by the pervasive translatio

78 The PLC effect is thought to be fundamentally caused by the dynamic int

79 Establishing lung lymphatic drainage is thought to be important for successful lung transplan

80 In cases where habitat connectivity is thought to be influenced or guided by multiple object

81 Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise

82 ns and tumours in the central nervous system is thought to be limited owing to the lack of lymphatic

83 The ATPase of this machinery, PscN (SctN), is thought to be localized at the base of the secretion

84 Anaphase chromosome movement is thought to be mediated by pulling forces generated by

85 ased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experie

86 Regulation of oxidative status is thought to be one major physiological mechanism under

87 of excitatory synapses in key brain regions is thought to be one of the major mechanisms underlying

88 rcadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality.

89 tracellular release of Ca(2+) through TRPML1 is thought to be pivotal for maintenance of intravesicul

90 A crucial role in ejaculation is thought to be played by a population of lumbar spino-

91 Specifically, the healthy intima is thought to be populated by vascular dendritic cells (

92 IL-35 is an anti-inflammatory cytokine and is thought to be produced by regulatory T (Treg) cells.

93 the helicase activity of XPD during NER, p62 is thought to be purely structural.

94 nanoscale magnetic tunneling junction (MTJ), is thought to be radiation hard, making it attractive fo

95 Type I IFN (IFN-I) is thought to be rapidly internalized and degraded follo

96 Accumulation of lipid in skeletal muscle is thought to be related to the development of insulin r

97 ene emission, we show that this trait, which is thought to be required for the tolerance of abiotic s

98 i, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe

99 Ribosome dimerization is thought to be reversible, with the dissociation of th

100 Masting is thought to be selectively beneficial because interann

101 ted sediment deposition in reservoirs, which is thought to be starving the coast of sediment and decr

102 Conventionally, IFE differentiation is thought to be stepwise as reflected in sharp boundari

103 Community assembly of crop-associated fungi is thought to be strongly influenced by deterministic se

104 itochondrial Calcium Uniporter (MCU) complex is thought to be the primary pathway for Ca(2+) entry in

105 Enhanced basal melting of the ice shelves is thought to be the ultimate driver of change(2,3), mot

106 The injury was thought to be caused by inadvertent ocular exposure

107 Myelin structure, including thickness, was thought to be extraordinarily stable in adults.

108 and the major contributor to organic sulfate was thought to be hydroxymethanesulfonate (HMS).

109 uch higher energy over shorter distances but was thought to be inappropriate for the treatment of sol

110 Mycobacterium leprae was thought to be the exclusive causative agent of lepro

111 t code, the 'Blue-ON' small bistratified RGC was thought to be the only pathway necessary for compari

112 T(H)2 cells were thought to be a pivotal factor for initiation of th

113 Initially, children were thought to be spared from disease caused by severe

114 Although chemical cues were thought to be sufficient, live imaging, genetics, m

115 RP has KH0, KH1, KH2, and RGG domains, which are thought to bind to specific RNA recognition elements

116 The immune response is thought to both contribute to the pathogenesis of dis

117 The model is thought to capture the essential physics of high-temp

118 peutic.IMPORTANCE Human astroviruses (HAstV) are thought to cause between 2 and 9% of acute, nonbacte

119 ated in vertebrate genomes, and when active, are thought to cause genome instability with potential b

120 Ca(2+) dysregulation is thought to cause rod and cone photoreceptor cell deat

121 ents to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions betw

122 mal behavior-from locomotion to human speech-is thought to consist of different hierarchical levels,

123 n (CBP)20 and its binding partner CBP80 have been thought to constitute the cap-binding complex (CBC)

124 ytic site with the local protein environment are thought to contribute to differences in catalytic re

125 vity that can exist when multiple objectives are thought to contribute to movement decisions and that

126 levels of beta-amyloid (Abeta) in the brain are thought to contribute to the cognitive impairments o

127 Two forms of DGAT, DGAT1 and DGAT2, are thought to contribute to the formation of seed oil,

128 BPD remain uncertain, exposure to hyperoxia is thought to contribute to disease pathogenesis.Objecti

129 cluster in the nucleus; a conformation that is thought to contribute to gene silencing.

130 ene Mecp2 Misexpression of the protein MECP2 is thought to contribute to neuropathology by causing dy

131 e oxygen species (ROS), and oxidative stress is thought to contribute to pathology in sickle cell dis

132 dysregulation in arachidonic acid metabolism is thought to contribute to the enhanced sinonasal infla

133 riability during multijoint movements, which is thought to contribute to their motor deficits.

134 Racism-related stress is thought to contribute to widespread race/ethnic healt

135 Microglia, resident immune cells of the CNS, are thought to defend against infections.

136 en into account, aspects of memory that have been thought to demonstrate a fixed working memory capac

137 Their electrical properties are thought to depend critically on the covalency of the

138 The cognitive alterations in DS are thought to depend on brain regions critical for lear

139 Predictions of forthcoming CCD are thought to depend on learning and memory in two ways

140 Stable representations of past experience are thought to depend on processes that unfold after eve

141 f newly synthesized polypeptides, and so has been thought to depend on ongoing protein synthesis.

142 he hippocampal circuitry, detection fidelity is thought to depend on the GABAergic synaptic input thr

143 They are thought to derive from intraluminal vesicles formed

144 between HSP70s and co-chaperone recruitment is thought to determine substrate fate, yet it has been

145 IBD is thought to develop as a result of interactions betwee

146 IGNIFICANCE STATEMENT Hippocampal subregions are thought to differentially contribute to memory.

147 Parallel processing circuits are thought to dramatically expand the network capabilit

148 Prediction errors are thought to drive the extinction learning process, an

149 Enhanced blood vessel (BV) formation is thought to drive tumor growth through elevated nutrie

150 This diversity is thought to enable both local and global computations.

151 Tyrosine proximity within TG is thought to enable the coupling reaction but hormonoge

152 s, offering complementary perspectives, that is thought to enable the identification of patient subgr

153 This is thought to enhance efficiency in the population code

154 foundly decreased in pregnant mothers, which is thought to ensure adequate iron availability for tran

155 ent of cholesterol-rich membrane nanodomains is thought to exclude many transmembrane (TM) proteins.

156 used into patients infected with SARS-CoV-2, are thought to exert an antiviral effect, suppressing vi

157 anism of SSRI action is still unknown, SSRIs are thought to exert therapeutic effects by elevating ex

158 ional objects, in reality magnetic skyrmions are thought to exist as elongated, tube-like objects ext

159 Kidney transplant recipients are thought to experience a high risk of stroke; however

160 ancy resulting from whole genome duplication is thought to facilitate evolutionary change through sub

161 In Vibrio cholerae, a type IVa pilus (T4aP) is thought to facilitate natural transformation by exten

162 st, a positive density-dependent growth rate is thought to favor species exclusion by inhibiting the

163 Vascular structures in the developing brain are thought to form via angiogenesis from preformed bloo

164 of antigen-specific T helper 1-type T cells is thought to fuel plaque inflammation.

165 Via these interactions, LAR-RPTPs are thought to function as synaptogenic wiring molecules

166 Conceptually, descending neurons are thought to function either as command-type neurons,

167 o treat psoriasis and atopic dermatitis, and is thought to function through regulation of the AhR and

168 Traditionally, this system was thought to function diffusely.

169 Stem cell treatments are thought to functionally regenerate the urethral sphi

170 neuropathological feature of concussion and is thought to greatly contribute to the classical sympto

171 w-dose oral Xa inhibitors are convenient and are thought to have a lower risk of bleeding; they are l

172 strategies to navigate their world, but few are thought to have detailed mental maps of their landsc

173 Many infectious diseases are thought to have emerged in humans after the Neolithi

174 a) are predominantly aerobic halophiles that are thought to have evolved from anaerobic methanogens.

175 While primates are thought to have specialized cortical mechanisms for

176 Background Subdural hemorrhage (SDH) is thought to have a benign course in asymptomatic neona

177 ers.SIGNIFICANCE STATEMENT Neuroinflammation is thought to have a pathogenetic role in epilepsy, a di

178 oxygen transport function of hemoglobin (HB) is thought to have arisen ~500 million years ago, roughl

179 ark asteroid on an Earth-crossing orbit that is thought to have assembled from the fragments of an an

180 The abiotic synthesis of ribonucleotides is thought to have been an essential step toward the eme

181 Like other coronaviruses, SARS-CoV-2 is thought to have been transmitted to humans from wild

182 t this point, a complex history of migration is thought to have begun with the arrival of people shar

183 nse to insolation and greenhouse gas forcing is thought to have caused grounding-line retreat of mari

184 e RNA-based organisms from which modern life is thought to have descended would have depended on an R

185 in the lung(2,4); the same receptor tropism is thought to have determined the pathogenicity-but also

186 plication of the primordial genetic material is thought to have enabled the evolution of early forms

187 Wet-dry cycling on the early Earth is thought to have facilitated production of molecular b

188 f prokaryotic species, but until recently it was thought to have little, if any, effect on the evolut

189 elective enhancement of GABAergic inhibition is thought to impact many vital brain functions and inte

190 The prefrontal cortex (PFC)'s functions are thought to include working memory, as its activity c

191 RNA polymerase variants that are thought to increase or decrease R-loop accumulation

192 time zone than in the western regions, which is thought to induce higher levels of circadian misalign

193 The sequence of the DNA template has long been thought to influence the rate of transcription by D

194 cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosi

195 LL37 in complex with DNA and RNA is thought to initiate disease exacerbation via plasmacy

196 After termination, RNAP is thought to initiate the next round of transcription b

197 ng late onset Alzheimer's disease (LOAD) and is thought to interact adversely with other risk factors

198 kill parasites with first-cycle activity but are thought to involve off-target mechanisms outside the

199 Relocation requires polymerized actin, and is thought to involve actin-mediated vesicle traffic to

200 Adopting another perspective is thought to involve both embodied and nonembodied proc

201 tween oxidative stress and cardiac stiffness is thought to involve modifications to the giant muscle

202 The mechanism of delayed OP toxicity is thought to involve off-target inhibition of serine pr

203 from the mechanism of TCR activation, which is thought to involve steric phosphatase exclusion as we

204 Today, its pathophysiology is thought to involve the cold-induced formation of auto

205 The immune response to this disease is thought to lead to an aberrant inflammatory response

206 ficits in associative and Pavlovian learning are thought to lie at the center of anxiety-related diso

207 , and use of a vascular closure device (VCD) are thought to mitigate percutaneous coronary interventi

208 pographically organized feedforward circuits are thought to modulate multiple behaviors in parallel.

209 The pulvinar is thought to modulate information flow between cortical

210 of homology and saturation of substitutions, are thought to negatively impact phylogenetic inference.

211 Vesicle tethering and fusion are thought to occur sequentially, with tethering mediat

212 antidepressant effects of rapid-acting drugs are thought to occur via inhibition of GABA interneurons

213 g the homocoupling step which had previously been thought to occur via a single-metal Mn aryl species

214 fication of basilar membrane traveling waves is thought to occur between a tone's characteristic freq

215 To date, ganglion-to-ganglion cell coupling is thought to occur only between cells of the same type.

216 Traditionally, tolerance was thought to occur by termination of mu-opioid recepto

217 Although most aneuploid conceptions are thought to originate from meiotic division errors in

218 osi sarcoma herpesvirus (KSHV) infection and is thought to originate from lymphatic endothelial cells

219 Astrocytes are thought to play a pivotal role in coupling neural ac

220 Selective sweeps are thought to play a significant role in shaping patter

221 Shine-Dalgarno (SD) motifs are thought to play an important role in translational i

222 cell (ipRGC) subtypes are two RGC types that are thought to play major roles in pattern vision.

223 Historically, type I glial-like TBCs have been thought to play a supportive role in the taste bud,

224 YIPF5 resides in the Golgi apparatus and is thought to play a critical role in vesicular traffick

225 p-regulated in aggressive breast cancers and is thought to play a role in breast cancer metastasis.

226 The vaginal microbiota is thought to play a role in modulating risk of high-ris

227 posure to a diverse environmental microbiome is thought to play an important role in "educating" the

228 ntilation of carbon stored in the deep ocean is thought to play an important role in atmospheric CO(2

229 The endogenous opioid system is thought to play an important role in the regulation o

230 e influenza viruses (CIVs) prevalent in dogs are thought to pose a public health threat arising from

231 Abnormal phosphorylation is thought to precede aggregation and therefore to promo

232 eme among several neurological disorders and is thought to precede neurodegeneration.

233 The lack of exposure to these factors is thought to prevent proper education and training of t

234 These processes are thought to proceed with the participation of a pleth

235 The reaction is thought to proceed via electrophilic aromatic substit

236 All modern scleractinian corals are thought to produce skeletons exclusively of the calc

237 These organisms are thought to produce toxic byproducts that stimulate i

238 Projected climate changes are thought to promote emerging infectious diseases, tho

239 SGs form during viral infection and are thought to promote the antiviral response because ma

240 Serial dependence is thought to promote perceptual stability by compensati

241 This increased perceptual sensitivity is thought to promote the association of rewarding outco

242 nts of the hematopoietic stem cell niche and are thought to protect hematopoietic cells under stress.

243 es protection against tuberculosis (TB), and is thought to provide protection against non-TB infectio

244 This monotonous activity is thought to reflect a high degree of chemical homogene

245 may be part of the mechanism, because alpha is thought to reflect focal neural excitability.

246 all at either end of a neural hierarchy that is thought to reflect the brain's response to cognitive

247 nd chondritic noble gases in the deep mantle is thought to reflect the heterogeneous nature of Earth'

248 Long noncoding RNAs are thought to regulate gene expression by organizing pr

249 hytene piRNAs map to the genome uniquely and are thought to regulate genes required for male fertilit

250 distributed ensemble grouping, because they are thought to regulate neural excitability over visual

251 ctive experience of color but also have long been thought to regulate affect.

252 a pervasive feature of neuronal activity and is thought to regulate communication in neuronal circuit

253 In turn, the AAA+ ATPase torsinA is thought to regulate force transmission from the cytos

254 Quiescent HSCs are thought to rely on glycolysis for their energy, but

255 This sensitivity has long been thought to rely on precise stimulus-driven auditory

256 Mechanistically, this information transfer is thought to rely on interactions between thalamocortic

257 Cerebellar-based learning is thought to rely on synaptic plasticity, particularly

258 This ability is thought to rely on the interaction between the dorsal

259 Episodic memory retrieval is thought to rely on the replay of past experiences, ye

260 Path integration is thought to rely on vestibular and proprioceptive cues

261 er of orbital angular momentum but the spins are thought to remain disordered(7-14).

262 Cells are thought to remove TOP2ccs primarily by proteolytic d

263 specific orbitofrontal cortex (OFC) neurons are thought to represent attributes of specific decision

264 d movement and delayed germination have long been thought to represent alternative risk-spreading str

265 Although parietal cortex activity is thought to represent accumulated evidence for sensory

266 r, only large animal models such as macaques are thought to reproduce the morphological hallmarks of

267 karyotes than eukaryotes, because the method is thought to require many diverse genomes.

268 the mouse, septation occurs postnatally and is thought to require the alveolar myofibroblast (AMF).

269 Aeroponics is thought to resolve a variety of plant physiological c

270 bacterial ferric uptake regulator (Fur) has been thought to respond to ferrous iron to transcription

271 ck related to peripheral fatigue development are thought to restrict motor unit activation and limit

272 In particular, bending of epithelia is thought to result from active torques generated by th

273 Although it is thought to result from chronic ischemia, the underlyi

274 Visual awareness is thought to result from integration of low- and high-l

275 ve mechanisms of execution(3-6), ferroptosis is thought to result from the accumulation of unrepaired

276 The loss of water from Mars to space is thought to result from the transport of water to the

277 apable of inhibiting sirtuin activity, which is thought to result in increased acetylation and protec

278 spinal neurons that inter-connect these CPGs are thought to secure hindlimb-forelimb coordination, en

279 ein 2 (UCP2), a mitochondrial anion carrier, is thought to separately modulate inflammatory and metab

280 ICANCE STATEMENT High-frequency spike-bursts are thought to serve fundamental computational roles wit

281 ead throughout the primate visual system and are thought to shape the selection of visual targets.

282 phasic activity of midbrain dopamine neurons is thought to signal reward prediction errors (RPEs), re

283 Alzheimer's disease neurodegeneration is thought to spread across anatomically and functionall

284 st, a single anti-RBP antibody determination is thought to suffice for clinical purposes.

285 Control networks are thought to support goal-directed cognition and behav

286 The hippocampus is thought to support memory and decisions by binding re

287 ional modifications, a "tubulin code," which is thought to support the diverse morphology and dynamic

288 Fear extinction is thought to take place when animals form a new memory

289 by mechanisms such as TCR endocytosis, which is thought to terminate TCR signalling.

290 Spinal cord injury in mammals is thought to trigger scar formation with little regener

291 ic and life-history traits, and their adults are thought to undergo reproductive diapause associated

292 Though genetic causes are thought to underlie a substantial fraction of idiopa

293 ure leads to changes in gene expression that are thought to underlie the transition from moderate to

294 This bioenergetic failure is thought to underlie pathologies associated with mitoc

295 Phase separation is thought to underlie spatial and temporal organization

296 This process is thought to underpin a myriad of cellular processes in

297 Frustration is thought to underpin biomolecular recognition and the

298 The emergence of these structures is thought to underpin the evolutionary acquisition of c

299 ers do not rely on dopamine for learning and are thought to use model-based learning.

300 Warmer winter soils are thought to yield greater microbial respiration of av