ライフサイエンスコーパス: be well defined

1 key clinical features of the disease may not be well defined.

2 of Itk in the T cell activation and function is well defined.

3 ound the 99.5% confidence level for which PI is well defined.

4 in, a model client whose aggregation pathway is well defined.

5 f the membrane-spanning part of this pathway are well defined.

6 actors to describe enzymatic activities that are well defined.

7 e molecular targets of several of these DMTs are well defined.

8 rticularly torsades de pointes, risk factors are well defined.

9 P-43 in the adult nor its downstream targets are well defined.

10 ns, such as the selectins and their ligands, are well defined.

11 ial pressure, and cerebrovascular reactivity are well defined.

12 ductive interactions underlying this process are well defined.

13 m(s) of action nor their molecular target(s) are well defined.

14 central pore, and the NTD-CTD linker region, are well defined.

15 localized surface plasmon resonances (LSPRs) are well-defined.

16 ial residues, including His 173 and Ser 172, are well-defined.

17 tect bexB in 10 strains whose capsule status was well defined.

18 d severity of RSV disease in adults have not been well defined.

19 RK1 and ERK2) in cancer progression have not been well defined.

20 t T cell activation in vitro and in vivo has been well defined.

21 subcellular localization had not previously been well defined.

22 (GFR) the year before and after OLT have not been well defined.

23 o-chaperones in autophagy regulation has not been well defined.

24 rtality, independent of FVC decline, has not been well defined.

25 n by broadly neutralizing antibodies has not been well defined.

26 ctors for severe COVID-19 infection have not been well defined.

27 ation with conventional risk factors has not been well defined.

28 and colonize the gastric epithelium have not been well defined.

29 ons and operative risk for mortality has not been well defined.

30 the immunopathology of periodontitis has not been well defined.

31 that regulates serotonergic neurons has not been well defined.

32 s capable of shaping Th17 responses have not been well defined.

33 nisms control lymphocyte development has not been well defined.

34 also crucial during bone homeostasis has not been well defined.

35 fect of pseudomonas on BOS and death has not been well defined.

36 periprosthetic joint infection (PJI) has not been well defined.

37 ading to cell exit from the bloodstream have been well defined.

38 hierarchical assembly of ribosomes, have not been well defined.

39 onse to different environmental cues has not been well defined.

40 ticipation on postoperative outcomes has not been well defined.

41 tact activation in severe infections has not been well defined.

42 e-specific CD8(+) T cell populations has not been well defined.

43 lth care-associated infections (HAI) has not been well defined.

44 e orchestrated to initiate lactation has not been well defined.

45 r North African non-Jewish neighbors has not been well defined.

46 VD undergoing heart transplantation have not been well defined.

47 h no retinal or neurologic morbidity has not been well defined.

48 s, but its role during EBV infection has not been well defined.

49 tional significance of this process have not been well defined.

50 on on various different Z functions have not been well defined.

51 thology during acute viral infection has not been well defined.

52 respiratory compromise at delivery have not been well defined.

53 regulation of pilin gene expression has not been well defined.

54 contributions to the DNA expansion have not been well defined.

55 or adipocyte retinoid metabolism has yet not been well defined.

56 ts role in adaptive immune responses has not been well defined.

57 biosynthetic mechanism of P-cluster has not been well defined.

58 gic neurons that modulate breathing have not been well defined.

59 ia during ACS in community practice have not been well defined.

60 the peripheral nervous system (PNS) has not been well defined.

61 its functional consequences in vivo have not been well defined.

62 d fibroblasts from nonneoplastic tissue have been well defined.

63 s that induce macrophage activation have not been well defined.

64 ogic roles of VEGF in tumorigenesis have not been well defined.

65 y often implicated in tumorigenesis, has not been well defined.

66 viduals have residual plasma viremia has not been well defined.

67 cking evidence of immunosuppression have not been well defined.

68 s and functions of CD4 memory cells have not been well defined.

69 creening tool in asymptomatic adults has not been well defined.

70 its impact on viral fitness in vivo has not been well defined.

71 role and functional activity have not always been well defined.

72 ls that are provided by hemodialysis has not been well defined.

73 ergen-induced airway responsiveness have not been well defined.

74 rvivin-2B in regulation of apoptosis has not been well defined.

75 ce of INPs in the ambient atmosphere has not been well defined.

76 ve the generation of Th17 responses have not been well defined.

77 ugh the proximal signaling pathways have not been well defined.

78 cids, whose function and regulation have not been well defined.

79 mammalian epithelial carcinogenesis have not been well defined.

80 sm of regulation of these chemokines has not been well defined.

81 ole in Th2-mediated immune responses has not been well defined.

82 ovascular risk in the post-MI period has not been well defined.

83 sms of epithelial mucous regulation have not been well defined.

84 g events that are downstream of Akt have not been well defined.

85 other than renal papillary carcinoma has not been well defined.

86 disease, its prognostic significance has not been well defined.

87 the mitochondrial signaling pathway have not been well defined.

88 B, although the underlying mechanism has not been well defined.

89 italized for worsening heart failure has not been well defined.

90 nsporter proteins in PCa progression has not been well defined.

91 nder which RPV confers an advantage have not been well defined.

92 mechanisms regulating this process have not been well defined.

93 lead to accelerated liver fibrosis have not been well defined.

94 rain-specific neutralizing responses has not been well defined.

95 important difference in AFEQT score has not been well defined.

96 s that drive single-cell phenotypes have not been well defined.

97 ns, resulting in such preservation, have not been well defined.

98 ssue-resident T(R) cell populations have not been well defined.

99 ary trajectory of lung preneoplasia have not been well defined.

100 mediated control of M. tuberculosis have not been well defined.

101 in antigen-specific T cells in vivo has not been well defined.

102 rs in CRC such as the NLR, PLR, and mGPS has been well defined.

103 of mutations and tumor development have not been well defined.

104 and consumers, and quality of care have not been well defined.

105 e risk of NC in these patients has still not been well defined.

106 sterile inflammation and oncogenesis has not been well defined.

107 role of age on surveillance outcomes has not been well defined.

108 terial systems its mechanistic basis has not been well defined.

109 mits for iodine intake in pregnancy have not been well defined.

110 hanisms that coordinate these steps have not been well defined.

111 BBB breakdown and ensuing pathology has not been well defined.

112 , the initial attachment receptor(s) has not been well defined.

113 association between these disorders has not been well-defined.

114 mportant pathways of the system have not yet been well-defined.

115 in gastric carcinogenesis and injury has not been well-defined.

116 the role of neutralizing antibodies has not been well-defined.

117 t-infarction ventricular arrhythmias has not been well-defined.

118 ll accuracy of these tests, however, has not been well-defined.

119 the learning curve for new operators has not been well-defined.

120 structures to the rest of the brain have not been well-defined.

121 to evaluate sarcomeric architecture have not been well-defined.

122 esidue in carbon-metal bond cleavage has not been well-defined.

123 were less organ parasites and the granulomas were well defined.

124 ogical mechanisms of cancer cell destruction are well defined(3-5), but whether immune-mediated cance

125 Many stem cell niches are well defined anatomically, thereby allowing their ro

126 s (AEs) associated with the fluoroquinolones are well defined and a prospective part of the developme

127 from specific functional group interactions are well defined and constant parameters.

128 ve life histories of human subjects and mice are well defined and describe a unique story of evolutio

129 se risk factors for disseminated candidiasis are well defined and frequently of limited duration, vac

130 Such particles are well defined and have intriguing properties, thus, t

131 Medical indications for mastectomy are well defined and present in a minority of patients,

132 tory distress syndrome and acute lung injury are well defined and readily recognised clinical disorde

133 using a yeast model, where prion attributes are well defined and readily tested.

134 ircuit analysis because its input and output are well-defined and accessible to physiological measure

135 The quantities, which are well-defined and characterized for spin models, are

136 atterns and electrostatic potential profiles are well-defined and distinctive features of activated v

137 anodiscs are native-like lipid bilayers that are well-defined and potentially monodisperse.

138 mplex than predicted by classical models but are well-defined and quantifiable.

139 el fungus Saccharomyces cerevisiae (ScCdc14) are well-defined and unique among characterized phosphat

140 y, the only nuclear import sequence that had been well defined and characterized was the classical NL

141 However, the effect of SLD has not been well defined and no tool has been developed to esti

142 unctional motifs of ATPase and nuclease have been well defined and the ATPase atomic structure has be

143 usceptibility to young-onset type 1 diabetes is well defined and does not predispose to type 2 diabet

144 hese aspects, because cerebellar development is well defined and identified neurons in the circuitry

145 In such networks, the longest path is well defined and in some cases is known to be a bette

146 gainst nonfatal cutaneous leishmaniasis (CL) is well defined and mediated by rapidly recruited, IFN-g

147 re of the CYP3A4-MDZ complex, where the drug is well defined and oriented suitably for hydroxylation

148 and the time required for such communication is well defined and preserved.

149 d each interfacial potential within the cell is well defined and reproducible, so that the response o

150 The ventricular sympathetic network topology is well-defined and characteristic for each mammalian sp

151 ese link groups, indicating that the binding is well-defined and electronically selective.

152 nsertion loops, and presensor 1 (PS1) loops, are well defined, and many of them interact extensively

153 the macromolecules necessary to build tissue are well defined, and we have a robust estimate of the o

154 Indeed, tau prions have been well defined, and research suggests that both alpha

155 growth factor (IGF) system in breast cancer is well defined, and inhibitors of this pathway are curr

156 ocial neuroscience because its genetic basis is well-defined, and the unique phenotype reflects dimen

157 The resulting glycopolymers were well-defined, and a range of molecular weights from

158 The limit of detection (LOD, S/N = 3) is well defined as 4.7 x 10(-8) mol L(-1).

159 hinosinusitis (CRS) pathophysiology have not been well defined but might have important ramifications

160 w the inflammatory response is initiated has been well defined but relatively little is known about h

161 ckle red blood cell (RBC) life span have not been well-defined but may include both intrinsic factors

162 Regulation of Yops and LcrV is well defined but little is known about bacteriostasis

163 ses where catalytic protein film voltammetry is well-defined but nonturnover signals elusive.

164 Almost all are well defined, but how to determine before the fact w

165 Brain pathways that control song production are well defined, but little is known about the sites an

166 Clathrin-coated pits are well defined, but the identity, mechanism and functi

167 siological functions of cytoplasmic Akt have been well defined, but little is known about the nuclear

168 ying COPII-mediated protein trafficking have been well defined, but the extent of regulation of this

169 ets and gata factors in hemangioblasts have been well defined, but the significance of FoxH1 in vess

170 ion of autophagy by nutrient-sensing kinases is well defined, but longer-term transcriptional regulat

171 nflammatory markers in type 2 diabetes (T2D) is well defined, but the role of anti-inflammatory cytok

172 Anophelin residues 32-61 are well-defined by electron density, completely occupyi

173 Prinomastat binding is well defined by electron density maps with its pyridy

174 Helix III is well-defined by numerous NMR-derived distance restrai

175 KPC-, VIM-, and NDM-producing P. aeruginosa were well defined by the conventional mCIM and eCIM test

176 re the operating mode of the acoustic device is well defined, characterized and its temperature caref

177 Although there are well-defined clinical risk factors for AF, a signifi

178 The susceptibility of infants to infections is well defined clinically, and immunologic abnormalitie

179 , tertiary, and quaternary protein structure are well defined, details about the protein-matrix conta

180 Reported are well-defined donor-acceptor alternating copolymers p

181 Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction o

182 DNA methylation, and RNA-mediated silencing are well-defined epigenetic mechanisms that control the

183 tures for alpha-RgIA and its three analogues were well defined, except at the chain termini.

184 at control the reactivity of these reactions are well-defined experimentally, but the mechanistic det

185 Although its core elements are well defined, factors modulating Hippo transcription

186 Although the active site subsites are well defined for a few model LPMOs, the molecular de

187 Although integration profiles are well defined for members of the lentivirus, spumaret

188 nomic regions (e.g., >50 Mb), mapped regions are well defined for RV-NPL.

189 Such environmental factors are well defined for smoking-induced lung cancer; howeve

190 ct physiologic and pathologic roles have not been well defined for this pathway.

191 tance of matching at the HLA C locus has not been well defined for unrelated umbilical-cord blood tra

192 The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is

193 On ultrasound, there were well-defined, heterogeneous, predominantly hypoecho

194 pathogen-associated molecular patterns have been well defined, how allogeneic cellular stimuli evoke

195 Although endolysosomal trafficking is well defined, how it is regulated and coordinates wit

196 FGFR4) in regulating bile acid synthesis has been well defined; however, its reported role on glucose

197 C) self-renewal and oncogenic potential have been well defined; however, the comprehensive epigenetic

198 mechanism of action for UVB carcinogenicity is well defined; however, the mechanistic involvement of

199 in is incomplete; regions of the pocket that are well defined in high-affinity PX domains are highly

200 uce output beams of high modal purity, which are well defined in three dimensions.

201 These transitions are well-defined in terms of ion conductance, but their

202 Although these functions are well-defined in the context of tumorigenesis, recent

203 e Atg17 functions in non-selective autophagy are well-defined in the literature, less attention is co

204 IL-2 antibody complex (IL-2C) administration are well-defined in the spleen and peripheral lymph node

205 Overall, our results show that the RRP can be well defined in the mathematical sense, and support t

206 rve, and vagal afferent nerve terminals have been well defined in animals.

207 dy-state fluorescence properties of 2AP have been well defined in diverse settings, interpretation of

208 drive these gene expression changes have not been well defined in human hearts.

209 Disparities in stroke and heart disease have been well defined in many populations in the United Stat

210 t infection in surgical patients, it has not been well defined in medical patients.

211 y relevant immune responses to them have not been well defined in organ transplantation.

212 portance of such additional interactions has been well defined in recent times to stabilize the foldi

213 e their utility and popularity, DAs have not been well defined in the literature, leading to confusio

214 hat establish and regulate pluripotency have been well defined in the mouse, it has been difficult to

215 ic rheumatic disease as osteoporosis has not been well-defined in children.

216 To date, an obesity/asthma link is well defined in adults; however, the nature of such a

217 Although tropomyosin is well defined in electron microscopy helical reconstru

218 ue, NAD(P)H:quinone oxidoreductase 1 (NQO1), is well defined in oxidative stress, neoplasia, and carc

219 for hydrolytic ALDHs, the nicotinamide ring is well defined in the electron density due to direct an

220 of GNLY-induced apoptosis of Jurkat T cells is well defined in vitro, no direct evidence for its in

221 While the phosphate is well-defined in the electron density, the ethanolamin

222 Posterior tumor surface was well defined in 54% of SDOCT vs 100% in UBM images.

223 s disordered: only the N-linked GlcNAc sugar was well-defined in the electron density map.

224 Colony boundaries in all populations were well defined, in spite of reports of a widespread b

225 Water-in-oil microdroplets in microfluidics are well-defined individual picoliter reaction compartme

226 pulation structure and evolutionary genetics are well defined, it is not clear whether pneumococci th

227 he composition and function of VLVs have not been well defined, largely due to the inability to effic

228 echanisms that execute the apoptotic program are well defined, less is known about how cells decide w

229 chanisms of the receptor tyrosine kinase MET are well defined, less is known about its close relative

230 syndrome and the pathologic characteristics are well defined, little is known about its biology and

231 echanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecul

232 harmacological actions of CCBs in the hearts are well-defined, little is known about the drug-specifi

233 sequence and structure for CsrA binding have been well defined, little information exists concerning

234 the mechanism of RAG2 protein downregulation is well defined, little is known about the pathways and

235 osteoclasts through osteocyte-derived RANKL is well defined, little is known about the regulation of

236 tracellular functions of interleukin 33 have been well defined, many aspects of the regulation and se

237 he onset and offset of ictal-like discharges are well-defined mathematical events: a saddle-node and

238 However, in some professions, there are well-defined metrics that quantify career longevity,

239 rified Act d 12 and Act d 13 from kiwi seeds are well-defined molecules involved in in vitro IgE cros

240 revealed the nucleobase peptide assembles to be well-defined nanotubes with an outer diameter of 24.8

241 f anaplastic large-cell lymphoma (ALCL) have been well defined; nevertheless, the notion that ALK is

242 To this point, the field has not been well defined, nor have future options to promote su

243 s, and the diagnosis and management have not been well defined.Objectives: To summarize evidence, ide

244 exes (hereafter referred to as metallogrids) are well-defined oligonuclear metal ion complexes involv

245 a silicon p-n junction, where the interface is well defined on the nanoscale.

246 te that the majority of the C-terminal chain is well-defined on the SH3 surface.

247 uce activation and downstream signaling have been well defined over the last several decades.

248 e of DNA triplex structures in the gas phase is well-defined over the experimental time scale, with t

249 ment and supplementation guidelines have not been well defined, practitioners should aim for a serum

250 The resulting beta-lactones are well-defined precursors for a wide variety of aldol-

251 role of CD36 in other vascular cells has not been well defined, previous studies have demonstrated th

252 stablish which short- and long-term outcomes are well-defined, reliable, and reflective of how patien

253 ation exposure and certain genetic syndromes are well-defined risk factors for malignant glioma.

254 ar layer (ONL) and Henle's fiber layer (HFL) were well defined, showing that the ONL ends before the

255 e of the GAAA tetraloop-receptor interaction is well defined solely from experimental NMR data, shows

256 ing phosphatidylserine and phosphoinositides are well defined, specific recognition of the headgroup

257 These particles appear to be well-defined structures that package the RNA for tran

258 "Molecular flasks" are well-defined supramolecular cages that can encapsula

259 More advantageous for characterization are well-defined synthetic (hyper)-branched polymers.

260 ristics of transcription factor (TF) binding are well defined, TF interactions with chromatin and oth

261 ological features of transplant vasculopathy are well defined, the causative mechanisms are not compl

262 s genomic characteristics of these subgroups are well defined, the extent to which cellular diversity

263 signalling pathways regulating CDK1 activity are well defined, the functional significance of epigene

264 the adenosine 5'-triphosphate binding sites are well defined, the literature describes 10 different

265 al determinants important for entry into ECs are well defined, the molecular determinants regulating

266 of binding site and channel gating machinery are well defined, the structural basis of the activation

267 controlling conventional T cell development are well defined, the transcription factors and genetic

268 h the DNA sequence requirements for affinity are well-defined, the dynamic mechanisms that execute co

269 Although the role of hotspot mutations is well defined, the impact of uncommon mutations is sti

270 en (HLA) class I alleles and HIV progression is well defined, the interaction of HLA-mediated protect

271 echanism for recognition of H3K27me3 by PRC1 is well defined, the interaction of PRC2 with H2AK119u1

272 capacity of Plg/Pla to induce cell migration is well defined, the mechanism underlying this process i

273 Although gut microbiome composition is well defined, the mechanisms underlying community ass

274 ircadian rhythms regulating daily activities is well defined, the molecular basis for the photoperiod

275 ough the clinical progression of the disease is well defined, the molecular events responsible for gl

276 the physiological mechanism of this pathway is well defined, the molecular mechanism and the sites o

277 Although the genetic etiology is well defined, the molecular mechanism underlying the

278 While the role of HA in malignancy is well-defined, the mechanisms driving its biosynthesis

279 a marker for Th2 cell and mast cell activity were well defined, the complexities of IL-33 regulation,

280 If performance criteria are well defined, theory allows one to predict the reopt

281 Despite the fact that apoptotic mechanisms are well defined, there is still no substantial therapeu

282 lthough the characteristics of these viruses are well defined, they are still unpredictable with incr

283 ifferentiation of the other major Th subsets are well defined, those responsible for Tfh cell respons

284 e and cellular pathways triggering arthritis are well defined, those responsible for the resolution o

285 to host plants, but their functions have not been well defined to date.

286 t from the first few residues, the structure is well defined up to around residue 35 and does adopt a

287 e of the TNF-alpha receptors (TNFRs) has not been well defined using in vivo models.

288 ting TCR diversity for antigenic recognition are well defined, what controls its surface expression i

289 atients and control subjects) are assumed to be well defined, when biologically they are often highly

290 l evolution are maximized when the selection is well defined, which enables linking genotype, phenoty

291 tag, the H2-H3 region of the AIM2(PYD) F27G is well defined with low B-factors.

292 ee-dimensional structure was demonstrated to be well-defined, with an alpha-helix and two 3(10)-helic

293 f model compounds has shown the fractions to be well-defined, with classes of model compounds isolate

294 the charge before and after reaction should be well-defined within the operational pH range; (3) the

295 ecting kringle-2 to the A chain, but Arg-320 is well defined within the activation domain and is not

296 While the role of Nodal is well defined within the context of endoderm commitmen

297 Apoptotic caspase activation mechanisms are well defined, yet inactivation modes remain unclear.

298 ence to control cardiovascular disease (CVD) are well defined, yet multiple studies have identified p

299 A)-4 as a negative regulator of CD4+ T cells is well defined, yet CTLA-4 regulation of CD8+ T cells i

300 the role of the axial ligand in type 1 sites is well defined, yet its role in the binuclear mixed-val