ライフサイエンスコーパス: be well understood

1 rocess, the salt dissolution behavior should be well understood.

2 documented; however, the sources have yet to be well understood.

3 gh energy and high dose-per-pulse beams must be well understood.

4 , all aspects of their mode of action should be well understood.

5 decapping is thought, for the most part, to be well understood.

6 tical period for experience in visual cortex is well understood.

7 uired to trigger adverse behavioral outcomes is well understood.

8 Neither of these types of pain sensitization is well understood.

9 ition by G Protein-Coupled Receptors (GPCRs) is well understood.

10 r sequential membrane targeting and assembly is well understood.

11 he genesis of short APs lasting milliseconds is well understood.

12 orm clathrin-coated vesicles, a process that is well understood.

13 tau aggregation, although neither mechanism is well understood.

14 hich Tel1 contributes to telomere metabolism is well understood.

15 H3.3 recruitment nor its essential function is well understood.

16 architecture of the closed promoter complex is well understood.

17 eptors in directed migration of immune cells is well understood.

18 essing by the core of its chemotaxis pathway is well understood.

19 ortical targeting nor the regulation thereof is well understood.

20 hydroxyecdysone (20E), but not of JH action, is well understood.

21 pment and at birth, following IVF treatment, is well understood.

22 ity of oxoG, which induces G to T mutations, is well understood.

23 on from growth-related activities to defence is well understood.

24 Yet, few deactivation pathways are well understood.

25 to lethal cell damage under ion irradiation are well understood.

26 hydrolases at the trans-Golgi network (TGN) are well understood.

27 nor the cis-regulatory elements they govern are well understood.

28 nction, and role in the life cycle of a cell are well understood.

29 e relevant ecological mechanisms and drivers are well understood.

30 of surveillance of DNA and protein integrity are well understood.

31 ce grating couplers have been developed that are well understood.

32 e stability of quadruplexes nor their repair are well understood.

33 trxG-mediated gene silencing and activation are well understood.

34 les that contribute to homeostasis in health are well understood.

35 sferases that are essential for this process are well understood.

36 ng systems and their steady-state properties are well understood.

37 al age on offspring's health and development are well understood.

38 ctories are determined by flagellar dynamics are well understood.

39 the effects, nor mechanisms, of isoflavones are well understood.

40 ith Clostridium difficile-associated disease are well understood.

41 lip morphogenesis nor the cause of cleft lip are well understood.

42 les for mixing lights to make a target color are well understood.

43 karyotic BK and bacterial MthK K(+) channels are well understood.

44 circadian clocks in multicellular organisms are well understood.

45 o inflammation nor its enduring consequences are well understood.

46 at interest for the scientific community and are well-understood.

47 bolites and metabolic pathways play have not been well understood.

48 rious tissues, such as liver and muscle, has been well understood.

49 nd the consequence of such violation has not been well understood.

50 vades an attack by the immune system has not been well understood.

51 water and other resources scarcity have not been well understood.

52 mining and processing facilities but has not been well understood.

53 omposition and its potential causes have not been well understood.

54 rmed acoustic droplet vaporization, have not been well understood.

55 al modifications such as acetylation has not been well understood.

56 betic patients, but the pathogenesis has not been well understood.

57 ive immune responses to vaccination have not been well understood.

58 hough the function of LTBP-2 in vivo has not been well understood.

59 rsity in tissue-specific stem cells have not been well understood.

60 determined, their mechanistic roles have not been well understood.

61 s both DNA strands of a double helix has not been well understood.

62 their chromatin targeting mechanisms has not been well understood.

63 metabolic cues to stem-cell function has not been well understood.

64 e, its persistence for over 20 years has not been well understood.

65 -time-scale gene expression changes have not been well understood.

66 effect of chronic CaMKII inhibition has not been well understood.

67 tion, but the molecular basis for it has not been well understood.

68 f these unusually large differences have not been well understood.

69 The mechanism of MTF1 activation has not been well understood.

70 However, the underlying mechanisms have not been well understood.

71 and plasticity of effector Th cells have not been well understood.

72 onsequences for cellular physiology have not been well understood.

73 s of amorphous one-dimension system have not been well understood.

74 ts of these emission trends on O(3) have not been well understood.

75 and their hybrid progeny Tenera has not yet been well understood.

76 es, and their activation mechanisms have not been well-understood.

77 s nor functions of codon-mediated regulation were well understood.

78 le the underlying mechanism remains far from being well understood.

79 pite remarkable recent progress, is far from being well understood.

80 holine receptors (nAChRs) are still far from being well understood.

81 tial feature of living cells, it is far from being well-understood.

82 orward signals from the retina to the cortex is well understood [1, 2], the functional role of the ex

83 onents and biochemistry of the W/SRC pathway are well understood, a basic understanding of how cells

84 individual receptors regulate transcription are well understood, a quantitative perspective is less

85 Although many details of mTORC1 regulation are well understood, a systems-level, predictive framewo

86 ough catalytic mechanisms in natural enzymes are well understood, achieving the diverse palette of re

87 lular behaviors that underlie skeletogenesis are well understood and a complex transcriptional gene r

88 governing blood flow in the vascular system are well understood and can be solved with well-establis

89 Plant growth responses to RSLR are well understood and represented in century-scale for

90 ugs used to treat Mycobacterium tuberculosis are well understood and therefore should be amenable to

91 al causes of many occupational lung diseases are well understood and they should be amenable to contr

92 ent changes of the thermoelectric properties are well-understood and correlate with complex phase tra

93 ects dominate the spectral variance and must be well understood and modeled before analyzing the very

94 Whilst resonant transmission is well understood and can be fully harnessed for crysta

95 e lens elements of a fluorescence microscope is well understood and corrected for.

96 The detection of dehydration is well understood and involves signals of peripheral or

97 The induction of the SOS response is well understood and involves the cleavage of the LexA

98 While positioning of chlorophyll cofactors is well understood and rationalized by the principle of

99 profits can only be achieved if the fishery is well understood and the regulations are strategically

100 chemical mechanism of protein trans-splicing is well-understood and has been exploited to develop sev

101 Although the oxygen affinity of blood is well-understood and routinely assessed in patients by

102 ther the stabilization nor the recent growth are well understood, as evidenced by multiple competing

103 While electric field doping is well understood, assessment of mobility and density a

104 vindoline from the MIA precursor tabersonine is well understood at the molecular and biochemical leve

105 ates that their thermal-transport properties be well understood because heat dissipation frequently l

106 us (HCV) to infect human liver cells has not been well understood because of the number of cell surfa

107 The latter process is well understood because it can be studied in vitro, b

108 Climate impacts from plantations need to be well understood before considering implementation.

109 teins often occurs in a two-state manner and is well understood both experimentally and theoretically

110 182 Ma) are well understood but a lack of robust palaeotemperatu

111 and socio-economic effects of eutrophication are well understood but its effect on organic carbon (OC

112 the activation of mast cells and basophils, is well understood but the mechanisms related to prevent

113 ning enzymes.Catalytic mechanisms of enzymes are well understood, but achieving diverse reaction chem

114 sponses of forest foliar traits to elevation are well understood, but far less is known about trait d

115 and environmental determinants of loneliness are well understood, but its genetic basis is not.

116 The early stages of HR are well understood, but later stages remain mysterious.

117 IFN gamma) production during Th1 development are well understood, but mechanisms that silence this cy

118 es of vlPAG activation in fearful situations are well understood, but much less is known about the pa

119 The evolution of many forms of mimicry are well understood, but the evolution of mimicry in the

120 ntiate between vein and intervein cell fates are well understood, but the genetic pathways underlying

121 chanisms leading to duplicate gene retention are well understood, but the long-term impacts of paralo

122 sive forces generated by muscles and tendons are well understood, but there has been little recogniti

123 e advantages of living in cooperative groups are well understood, but why some species breed in small

124 The tertiary structure of the folded domains is well understood, but describing the dynamic inter-dom

125 'trans-splicing' process in lower eukaryotes is well understood, but events in higher eukaryotes are

126 Topo IIalpha function is well understood, but how its expression is regulated

127 2D Rac-driven lamellipodial migration is well understood, but how these features apply to 3D m

128 Their photochemistry is well understood, but is only responsible for part of

129 The role of Cav channels during axon growth is well understood, but it is unclear whether Kv channel

130 The impact of transcription on DNA damage is well understood, but our research reveals that this a

131 lor sensory system controlling PC expression is well understood, but PE regulation has not been resol

132 surface Urban Heat Island (UHI) effect that is well understood, but the causes of the more recently

133 as an indicator of cellular nitrogen status is well understood, but the function of ATP/ADP binding

134 Single-molecule cytoplasmic dynein function is well understood, but there are major gaps in mechanis

135 harides derived from N-linked glycoproteins, is well understood, but whether a similar fate awaits O-

136 Cooper pairing instability in a Fermi liquid is well understood by the BCS theory, but pairing mechan

137 ile the pH-dependent behavior of select IOCs is well-understood, complex mixtures of IOCs, e.g., from

138 g of drug molecules to their protein targets are well understood, detailed experimental characterizat

139 The catalytic mechanism of Complex I has not been well understood, due to the complicated structure o

140 Their function is well-understood during passive stimulation but, under

141 in Escherichia coli and other enterobacteria is well understood, except for the events leading to mat

142 Whereas these fluctuations are well understood for flat membranes, curved shells sh

143 Rates and drivers of primary productivity are well understood for many terrestrial ecosystems, but

144 Theoretical conditions for such outbreaks are well understood for measles, yet the information req

145 and twin boundaries in mechanical properties are well understood for metals and alloys.

146 While this switch is well understood for an individual protein, how regula

147 tant applications of information theory, and is well understood for channels modelled by classical ph

148 gands on the synthesis and properties of QDs is well understood for their applications in various dev

149 ies interactions and environmental variation is well-understood for pairwise interactions but not for

150 Filament turnover and dynamics are well understood from in vitro biochemical analyses a

151 While the overall pathogenesis is well understood, functional relations between cellula

152 However, it had not been well understood how the complex network of Myc targ

153 Although it is well understood how BRs are produced and how their si

154 While it is well understood how IdeR functions as a repressor, ho

155 It is well understood how mobile introns home to allelic si

156 enin in cell-cell adhesion and Wnt signaling are well understood, how beta-catenin is regulated at th

157 nitric oxide synthesis mechanisms in animals are well understood, how nitric oxide is synthesized and

158 any of the individual subunits of AB5 toxins are well understood, how they self-associate and the eff

159 underlying Par-mediated apical determination are well-understood, how Scrib module proteins specify t

160 STIM proteins and coupling to Orai1 channels is well understood, how mitochondria communicate with Or

161 the biochemical composition of peptidoglycan is well understood, how the peptidoglycan architecture c

162 Although the circuitry for selection is well understood, how these nuclei evaluate the outcom

163 T nectin-like protein-5 (necl-5) interaction is well understood, how TIGIT engages nectin-2, a recept

164 gy and neuroanatomy of these reflex pathways are well understood, however, the mechanisms and functio

165 gical blockers of voltage-gated ion channels are well understood; however, this knowledge is rarely c

166 l assembly of the synaptic release machinery is well understood; however, how signalling factors modu

167 iveness of newly approved therapeutic agents is well understood; however, the strength of the clinica

168 the molecular level, so mechanistic details are well understood in many species and are often involv

169 The parameters of both domains are well understood in terms of the structural propertie

170 with which stimulus kinetics can be resolved are well understood in vision, audition, and somatosensa

171 ysical mechanism of bacterial chemotaxis has been well understood in individual cells, the role of co

172 Although the functions of J-proteins have been well understood in the context of Hsp70s, their add

173 While BeAT regulation is well understood in adults, the critical signals regul

174 heterogeneity is a feature, not a "bug" (as is well understood in biology and in personalized medici

175 Whereas cryptochrome-mediated entrainment is well understood in Drosophila, integration of light i

176 Embryonic anterior-posterior patterning is well understood in Drosophila, which uses 'long germ'

177 Heat capacity is well understood in gases and solids but not in the th

178 The biogeochemistry of iron is well understood in natural wetlands but knowledge abo

179 The biogeochemistry of iron is well understood in natural wetlands, but knowledge ab

180 Chemotaxis of the bacterium Escherichia coli is well understood in shallow chemical gradients, but it

181 wer colour influencing pollinator behaviour, is well understood in some species, but the genetic chan

182 tory traits on resource competition outcomes is well understood in the context of a constant resource

183 Neural cell fate specification is well understood in the embryonic cerebral cortex, whe

184 It is well understood in the medicinal chemistry community

185 While this property is well understood in unbounded space, it has not been s

186 ms that drive mitotic chromosome segregation are well understood, in oocytes of most species atypical

187 many aspects of the phenomenon are far from being well understood including what determines droplets

188 etails of antagonist-BIR domain interactions are well understood, it is not clear how this binding ev

189 global patterns in standing species richness are well understood, it is poorly known which environmen

190 While selection on early dispersal is well understood, it is less clear whether costs are a

191 f transcriptional regulatory networks (TRNs) is well understood, it is not clear what constrains gove

192 mechanism for AHR induction of target genes is well understood, it is not known how AHR activation p

193 Although the physics of structural colours is well understood, it remains a challenge to create art

194 ic activities of the replicative DNA Pol III are well understood, its dynamics within the replisome a

195 chanisms controlling NtcA activity appear to be well understood, its regulon remains poorly defined.

196 While its biosynthesis is well understood, its fate, once in circulation, is le

197 the pharmacokinetics of caffeine in the body is well-understood, its alertness-restoring effects are

198 Although terrestrial circadian clocks are well understood, knowledge of clocks in marine organ

199 the signals that contribute to Teff function are well understood, less is known about the signals con

200 ompetition of microbes for simple substrates are well-understood, less is known about how complex, st

201 lthough the role of insulin in the periphery is well understood, less is known about its multifactori

202 Although RA-mediated gene activation is well understood, less is known about the mechanisms f

203 basic principles of conventional solar cells are well understood, little attention has gone towards m

204 t activate Igo/ENSA to bind and inhibit PP2A are well understood, little is known about how Igo/Ensa

205 erpinnings of animal and plant domestication are well understood, little is known about microbe domes

206 Although steps in the activation phase are well understood, little is known on how signal termi

207 While the cues that trigger flowering are well-understood, little is known about what determin

208 ptibility to Clostridium difficile infection are well-understood, little is known about what drives d

209 While GA signalling is well understood, little is known about how GA is tran

210 the enzymatic activity of the MTHFD2 protein is well understood, little is known about its larger rol

211 ch auxin triggers changes in gene expression is well understood, little is known about the specific r

212 Whereas thermal effects in flat membranes are well understood, many natural and artificial microst

213 Although overall the mechanism of RNAi is well understood, many molecular details of this compl

214 Based on the few MDR loci that are well-understood, MDR is conditioned by diverse mecha

215 Although the biochemical action of DAPK1 is well understood, mechanisms that regulate its express

216 Although microcompartment structure is well understood, much less is known about their assem

217 ping in a fold bifurcation of an equilibrium is well understood, much less is known about tipping of

218 ochemistry of cyclic dinucleotide metabolism is well understood, much remains to be discovered about

219 Although many DNA repair pathways are well understood, new pathways continue to be discove

220 gh several aspects of this regulatory system are well understood, no BirA superrepressor mutant strai

221 e the direct physical impact on seabed biota is well understood, no studies have defined thresholds t

222 While DNA G4s are well understood on structural and, to some extent, f

223 by laser irradiation, i.e., laser ablation, are well understood on the micrometer length scale, it w

224 they are targeted to specific loci have not been well understood on a genome-wide scale.

225 ell protrusion on two-dimensional substrates are well understood, our knowledge of the actin structur

226 biological functions of ephrin-Eph signaling are well understood, our mechanistic understanding remai

227 of ectoine and 5-hydroxyectoine biosynthesis is well understood, our understanding of their catabolis

228 ic resistance genes (ARG) in the environment are well understood processes.

229 While protein secondary structure is well understood, representing the repetitive nature o

230 While their theoretical properties are well-understood, specific methodology for their opti

231 While the steps in the activation phase are well understood, steps in the termination pathway ar

232 post-transcriptional regulation of IFN-gamma is well understood, subsequent modifications of secreted

233 It is well understood that antigen-presenting cells (APCs)

234 Although it is well understood that CD develops in genetically predi

235 It is well understood that differences in the cues used by

236 In animals, it is well understood that exposing animals to a more stimu

237 It is well understood that intermolecular forces are direct

238 Although it is well understood that N(ICD) forms a transcriptional a

239 While it is well understood that nanoparticle (NP) physico-chemic

240 It is well understood that the brain integrates information

241 It is well understood that this free theory, and even inter

242 While it is well understood that, structurally, cholesterol exhib

243 It is well-understood that many bacteria have evolved to su

244 hough many details of the signaling cascades are well understood, the initial mechanism and regulatio

245 d its role in initiating centriole formation are well understood, the mechanisms by which SAS-5 and i

246 g pathways involved in hepatic specification are well understood, the mechanisms through which FGFs i

247 e essential requirements for immune activity are well understood, the physiological cues that regulat

248 gh the effects of kinetics on crystal growth are well understood, the role of substrate curvature is

249 Although many aspects of blood production are well understood, the spatial organization of myeloid

250 rocesses governing this threshold in soil pH are well understood, the threshold has not been quantifi

251 r repairing several forms of genomic insults are well understood, the upstream signalling pathways th

252 ent autokinase and phosphotransfer reactions are well-understood, the mechanism by which sensors acce

253 dissociation and nascent peptide degradation are well-understood, the molecular sensors of aberrant m

254 While the mechanistic details in many cases are well-understood, the reductive cleavage of SAM remai

255 olecular pathogenesis of these fatty changes is well understood, the biochemical and pharmacological

256 Although the neuropathology of RTT is well understood, the cellular and molecular mechanism

257 dical SAM cluster in generating the 5'-dA(*) is well understood, the detailed role of the auxiliary c

258 ough pigment inactivation by phosphorylation is well understood, the enzyme(s) responsible for pigmen

259 g lipid-driven domains has been explored and is well understood, the existence and relevance of such

260 e of these proteins in mitigating DNA damage is well understood, the function of AidB is less clear.

261 pathophysiology of hypothalamic POMC neurons is well understood, the genetic program that establishes

262 While the contribution of diffusion is well understood, the influence of density gradient-dr

263 the mechanism of hypoxia-driven angiogenesis is well understood, the link between inflammation-induce

264 le the mechanism of SIRT6-mediated silencing is well understood, the mechanism of SIRT6-mediated tran

265 Whereas the mechanism of class A is well understood, the molecular details of methylation

266 Although SA biosynthesis is well understood, the pathways by which SA is cataboli

267 hough the lectin-oligosaccharide association is well understood, the polypeptide-based interaction is

268 sen because the transposition of L1 elements is well understood, the population dynamics of cancer tu

269 the transcriptional regulation of Th17 cells is well understood, the posttranscriptional regulation o

270 f glucose and glutamine in cancer metabolism is well understood, the relative contribution of acetate

271 While the role of chitin in plant infection is well understood, the role of beta-1,3-glucan is unkno

272 l significance of Ser(22/23) phosphorylation is well understood, the role of other cTnI phosphorylati

273 The first type of diffusion resistance is well understood, the second is receiving increasing a

274 on transfer (PCET) under buffered conditions is well understood, the situation is more complicated in

275 on-brownian suspensions in the dilute regime is well understood, their behavior in the dense limit re

276 letion of atomic BECs in thermal equilibrium is well understood theoretically but is difficult to mea

277 identity in the fly Drosophila melanogaster is well understood, there are very few cases in which th

278 l and chemical basis for ocean acidification is well understood, there exist few field data of suffic

279 ch as diamond carbon, silicon, and germanium is well understood, there is a gap in knowledge regardin

280 e development of the zebrafish immune system is well understood, thereby use of larvae enables invest

281 While immune specificity and memory are well understood to underpin immunisation in vertebra

282 Despite the fact that NOD2 is well understood to have a key role in regulating inna

283 The FOXA family of transcription factors is well understood to have pioneer capacity.

284 Acetylcholine is well-understood to enhance cortical sensory responses

285 of antipsychotics (APs) on neuronal function are well understood, very little is known about their ef

286 otein folding and the UPR/ERAD pathways each are well-understood, very little is known about any dire

287 functional groups at the core of dendrimers is well-understood, very little is known about their int

288 CsA action in causing cancer was thought to be well understood via immunosuppression.

289 ugh the molecular origin of force generation is well understood, we currently lack an understanding o

290 This behavior is well understood when all subunits within a cluster ar

291 sicle fusion during neurotransmitter release are well understood, whereas little is known about the p

292 The role of the former in neovascularization is well understood, whereas the latter is capable of dir

293 ular vestibule and the transmembrane channel is well understood, whereas the specific ion conduction

294 Although it is well understood which individuals are at risk of radi

295 r its exact role in the disease pathogenesis is well understood, which is largely due to limitations

296 e underlying controls of tooth size have not been well understood, with hypotheses ranging from morph

297 Proton reduction is well-understood, with catalysts achieving quantum yie

298 tal nature of 2D MoS2-metal contacts has not been well understood yet.

299 channels in receptor-evoked Ca(2+) signaling is well understood, yet little is known about the physio

300 iosis in bacterial symbiont genome evolution is well understood, yet the ways that symbiosis shapes h