ライフサイエンスコーパス: beta

1 thereby increasing the production of amyloid-beta.

2 hange from childhood to age 70 (standardized beta = 0.100).

3 rease in white matter hyperintensity volume (beta = 0.11, 95% CI = 0.01-0.21).

4 a lower intake of nuts, seeds, and legumes (beta = -0.05 per gram; 95% CI: -0.09, -0.01).

5 iated with MABC-2 motor scores at 4.5 years (beta = -0.095, 95% confidence interval = -0.184 to -0.00

6 of white matter injury volume (standardized beta = -0.22).

7 antly associated with lower cognitive score (beta: -0.119; 95% CI: -0.208, -0.029; P = 0.009).

8 everse transcriptase (TERT) (58.1%), catenin beta 1 (CTNNB1) (30.7%), tumor protein 53 (TP53; 18.7%),

9 Mutations in the galactosidase beta 1 (GLB1) gene cause lysosomal beta-galactosidase (b

10 sed expression of transforming growth factor beta 1 (TGF-beta1) because of interleukin-4 (IL-4)- and

11 We show the HCMV receptor integrin beta 1 dissociates from extracellular matrix proteins, b

12 The beta(1)-adrenoceptor (beta(1)AR) is a G-protein-coupled

13 Phosphorylation occurred independently of beta(1)-AR activation, but was abolished after pharmacol

14 The beta(1)-adrenoceptor (beta(1)AR) is a G-protein-coupled receptor (GPCR) that c

15 ucosidases catalyze the hydrolysis beta-1,4, beta-1,3 and beta-1,6 glucosidic linkages from non-reduc

16 beta-glucosidases catalyze the hydrolysis beta-1,4, beta-1,3 and beta-1,6 glucosidic linkages from

17 tolerance by repressing GALS1 expression and beta-1,4-galactan accumulation.

18 The accumulation of beta-1,4-galactan negatively affects salt tolerance.

19 talyze the hydrolysis beta-1,4, beta-1,3 and beta-1,6 glucosidic linkages from non-reducing end of sh

20 The exopolysaccharide poly-beta-(1->6)-N-acetylglucosamine (PNAG) is a major struct

21 corticomotor excitability, mu (9-14 Hz), and beta (15-25 Hz) oscillations over sensorimotor cortex.

22 ; P < 0.001) and the habitual energy intake (beta: 16.052, R2 = 0.123; P = 0.001).

23 the energy intake from the ad libitum meal (beta: 17.612, R2 = 0.213; P < 0.001) and the habitual en

24 howed that vinculin, talin, integrin alpha(M)beta(2), and other components of podosomes are present i

25 entified residues specifically important for beta(2)AR signaling, mutations in the human population t

26 onstrated that ESAT-6 protein interacts with beta-2-microglobulin (beta2M) and affects class I Ag pre

27 eptide content and abrogated by anti-alpha(v)beta(3)) but not by A2780 (same as PEGylated particles).

28 For FGbeta(3) cells, dysregulated integrin beta(3)-KRAS signaling drives tumor progression.

29 ted by MAdCAM, the natural ligand of alpha(4)beta(7) that is expressed on gut endothelial cells.

30 Trafficking of alpha(4)beta(7)-expressing lymphocytes to the gut is mediated by

31 genetic or pharmacological inhibition of IFN-beta, a key component of type I IFN mechanisms to addres

32 trate this method in the case of the amyloid beta (Abeta) peptide, whose oligomers are associated wit

33 ection could be an initial source of amyloid beta (Abeta) peptide-containing amyloid plaque developme

34 characterized by the accumulation of amyloid-beta (Abeta) plaques and tau neurofibrillary tangles in

35 cerebral microhemorrhages (MHs) and amyloid beta accumulation in Alzheimer disease (AD), but to the

36 ted cells during S-phase as a consequence of beta-ADP-heptose/ ALPK1/TIFA/NF-kappaB signaling.

37 SED we developed a context-specific model of beta-adrenergic cardiac hypertrophy.

38 Upon cold or beta-adrenergic stimulation, Aifm2 associates with the o

39 report that octopamine activity through the beta-adrenergic-like receptor Octbeta1R drives aversive

40 reliever therapy with as-needed short-acting beta-agonists (SABAs), while anti-inflammatory maintenan

41 pening product, dibenzosuberenone, bearing a beta-amino-alpha-ketone group was secured by X-ray cryst

42 AD.SIGNIFICANCE STATEMENT Elevated levels of beta-amyloid (Abeta) in the brain are thought to contrib

43 whose processing can result in formation of beta-amyloid (Abeta).

44 We found beta-amyloid staining, predominantly in Cortical Layers

45 The functions of importin-alpha/importin-beta and importin-11 have been verified in avian cells,

46 tion of the kinases Lyn and protein kinase C-beta and MAPKs MKK-3/6 and p38MAPK or to upregulate MEK-

47 associated with increased expression of IFN-beta and other IFN-related genes.

48 1 induces Fak kinase to inactivate Gsk3alpha/beta and stabilize beta-catenin while increasing the pho

49 nteractions between tau proteins and amyloid-beta and study the resulting coupled behavior between to

50 is characterized by the presence of amyloid-beta and tau deposition in the brain, hippocampal atroph

51 cerebrospinal fluid concentration of amyloid-beta and tau.

52 ase (BC), carboxyltransferase (CT)-alpha, CT-beta, and biotin carboxyl carrier protein (BCCP1 or BCCP

53 reatments targeting vascular health, amyloid-beta, and tau levels may more effectively preserve cogni

54 here reducing end amines exist solely as the beta-anomer.

55 as characterized in vitro (receptor binding, beta-arrestin2 recruitment, ERK1/2 phosphorylation, cAMP

56 ree-dimensional (3D) structures of activated beta-arrestin2 stabilized by phosphorylated muOR bound t

57 th the generation of synthetically important beta-aryl ketone intermediates in a chemoselective fashi

58 reveal increased oscillatory activity in the beta band (~20 Hz) at triplet transitions that indexes l

59 This activation was manifested in the beta-band (12-30 Hz), ramping up slowly over 500 ms afte

60 s now established, it can be challenging for beta-barrel proteins, which are important in cellular tr

61 beta-Barrels are sheets of beta-strands wrapped into a c

62 ciated with general fluid cognitive ability (beta between -0.11 and -0.17).

63 If medical treatment is selected, either beta-blockers or nondihydropyridine calcium channel bloc

64 Exercise restriction, beta-blockers, and surgical intervention were discussed

65 this ionization source is demonstrated using beta-blockers, peptides, and proteins.

66 el pentameric folding repeats, which we term beta-bracelets, in the intermediate shaft region.

67 ing can facilitate volitional suppression of beta bursts in sensorimotor cortex in healthy motor cont

68 ing in facilitating voluntary suppression of beta bursts to speed up movement initiation.SIGNIFICANCE

69 Despite efforts for beta-C-H functionalization in carbon-carbon and carbon-h

70 arbon is 3.6 kcal/mol lower than that to the beta-carbon, thus favoring the linear chiral aldehyde ov

71 unstable metabolic intermediate, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS), can no

72 availability, resulting in higher lutein and beta-carotene absorption, disruption of the food matrix

73 The study of beta-carotene interaction with proteins showed, on the o

74 lkene moieties like limonene, valencene, and beta-caryophyllene is among the most difficult molecular

75 velopmental mechanism for post-translational beta-catenin activation and is required to complete EGA.

76 ry connections, Yap/Taz accumulated upon Myc/beta-catenin activation and were required not only for t

77 aled elevated levels of LRP5/6 and FZD10 and beta-catenin co-localization with enhancer of zeste 2 po

78 doxorubicin (DXR) as an inhibitor of the Akt-beta-catenin interaction at low doses.

79 While the regulatory effect of RUNX3 in beta-catenin is already known, our results suggest the p

80 athogenic process in the hepatic conditional beta-catenin knockout mouse model.

81 rimethylation repressive marks and increases beta-catenin occupancy at a site 4 kb upstream to Lef1.

82 Our findings indicate that BBR antagonizes beta-catenin pathway by inhibiting beta-catenin translat

83 uncover a new pathogenic mechanism by which beta-catenin promotes podocyte injury and proteinuria in

84 in the inhibition of apoptosis found in the beta-catenin S45F mutants.

85 Wnt/beta-catenin signaling achieves this in part by increasi

86 monstrated that RSPOs 2 and 3 potentiate WNT/beta-catenin signaling in cells lacking leucine-rich rep

87 ic targets for tumors having deregulated Wnt/beta-catenin signaling induced by this mutation.

88 beta-catenin signaling is aberrantly activated in differ

89 , we show that genotoxic agent-activated Wnt/beta-catenin signaling is independent of the FZD/LRP het

90 Our results uncover a role for the beta-catenin signaling pathway in fine tuning the granul

91 These results suggest that FL3 inhibits Wnt/beta-catenin signaling via PHB1-dependent activation of

92 tagonizes beta-catenin pathway by inhibiting beta-catenin translation and mTOR activity and thereby r

93 e to inactivate Gsk3alpha/beta and stabilize beta-catenin while increasing the phosphatase activity o

94 cells showed high level expression of active beta-catenin, alpha-fetoprotein, and SOX9, suggesting th

95 X3 as context-dependent component of the Wnt/beta-catenin-dependent transcriptional complex.

96 ytoskeleton, and enhances the acetylation of beta-catenin.

97 r littermates that expressed only stabilized beta-catenin.

98 -2C targeting cells expressing IL-2 receptor beta cause an acute decrease in cellularity of Peyer's P

99 <15 um diameter were identified in 5%-12% of beta cell containing aggregates, 3-76 months posttranspl

100 effects of metabolic stress predominate and beta cell death or dysfunction occurs.

101 egenerative medicine approaches to enhancing beta cell growth and survival represent potential treatm

102 ctors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with type 2

103 induced diabetes is beta-cell autonomous, as beta cell-specific Galpha(z)-null mice phenocopy the ful

104 is suggests that 1,5-(PP)(2)-InsP(4) impacts beta-cell activity by regulating granule localization an

105 ha(z)-null mice from HFD-induced diabetes is beta-cell autonomous, as beta cell-specific Galpha(z)-nu

106 s produced from human embryonic cell-derived beta-cell clusters.

107 receptor; however, its impact on pancreatic beta-cell function is unknown.

108 eases absolute insulin secretion but impairs beta-cell function, 2) causes insulin resistance, and 3)

109 asting glucose, insulin, insulin resistance, beta-cell function, and adiponectin at age 11.5 years.

110 ed similar levels of insulin sensitivity and beta-cell function.

111 lycemia associated with continued decline in beta-cell function.

112 ulation of key transcription factors ensures beta-cell function.

113 -type Ca(V) channels is a key determinant of beta-cell glucose-stimulated Ca(2+) entry and thus the s

114 Active maintenance of beta-cell identity through fine-tuned regulation of key

115 novel function of the Delta/Notch pathway in beta-cell insulin secretion.

116 strongly suggest that TSPAN-7 modulation of beta-cell L-type Ca(V) channels is a key determinant of

117 has proven to be a powerful tool to quantify beta-cell mass (BCM) in vivo.

118 ts on novel strategies to protect functional beta-cell mass.

119 asis of this disorder highlights fundamental beta-cell mechanisms.

120 equipped "hub" or "leader" cells within the beta-cell network drive islet oscillations and that elec

121 GPRC6A's unique regulation of beta-cell, skeletal muscle and hepatic function may repr

122 SC-beta cells differentiated from four hPSC lines exhibited

123 The cause of this selective loss of beta cells needs to be further elucidated but overall, o

124 In beta cells, Ca(2+), cyclic adenosine monophosphate (cAMP

125 the insulin secretory granules of pancreatic beta cells.

126 By their nature and function, beta-cells are prone to biosynthetic stress with limited

127 Here we show that beta-cells express abundant Kindlin-2 and deleting its e

128 (NOD) mice, protecting the insulin-producing beta-cells from destruction.

129 ings, focusing on studies performed on human beta-cells or on samples obtained from patients with dia

130 lecular mechanisms underlying the failure of beta-cells to respond to glucose in T2D remains unknown.

131 us description of the HLA-A2/A3 peptidome of beta-cells, we analyzed the HLA-A3-restricted peptides t

132 val = -0.184 to -0.005), with a standardized beta coefficient (-0.16) that was similar to that of whi

133 beta-Coronavirus-induced exploitation of lysosomal organ

134 randomized into 4 arms (n = 23): HP-diet and beta-cryptoxanthin (hypocaloric HP-diet + beta-cryptoxan

135 n), HP-diet (hypocaloric HP-diet + placebo), beta-cryptoxanthin (standard hypocaloric diet + beta-cry

136 a-cryptoxanthin (standard hypocaloric diet + beta-cryptoxanthin), and control (standard hypocaloric d

137 nd beta-cryptoxanthin (hypocaloric HP-diet + beta-cryptoxanthin), HP-diet (hypocaloric HP-diet + plac

138 their acute cholesterol depletion by methyl-beta-cyclodextrin as a tool to describe the physiologica

139 threonine motif (T788/T789) in the integrin beta cytoplasmic domain increases integrin activity.

140 to determine the respective CMCs of n-octyl beta-d-glucopyranoside (OG), n-dodecyl beta-d-maltopyran

141 short chain oligosaccharides, alkyl and aryl beta-D-glucosides and disaccharides.

142 octyl beta-d-glucopyranoside (OG), n-dodecyl beta-d-maltopyranoside (DDM), and lauryldimethylamine N-

143 in, predicted to possess 2 motifs related to beta-defensins and 6 disulfide bridges.

144 ormation of a ketoimine rather than an alpha,beta-dehydro-amino acid intermediate during C(alpha)-thi

145 Peroxisome proliferator activated receptor beta/delta (PPARbeta/delta) has pro-angiogenic functions

146 d-beta1-42, vascular and parenchymal amyloid-beta deposits, and astrocytosis (31%, 47-80%, and 33%, r

147 and movement in the GPi, which also had more beta desynchronization during movement.

148 where it co-clusters with beta-dystroglycan (beta-DG).

149 Supported by a beta-diketiminate ligand, the three-coordinate copper(II

150 g medication were associated with alpha- and beta-diversity.

151 the cell surface, where it co-clusters with beta-dystroglycan (beta-DG).

152 c, punicic, alpha-eleostearic, catalpic, and beta-eleostearic acids after 30 days-storage, respective

153 oreover, chemical releasing methods, such as beta-elimination/Michael addition, are not specific to O

154 production; and ultimately cellular death of beta-endorphin neurons.

155 s in which GCase was inhibited by conduritol beta-epoxide did not increase the amount of insoluble mo

156 tamiR-US5-2 mutant resulted in decreased TGF-beta expression and restoration of myelopoiesis.

157 partially redundant with that of another TGF-beta family member, activin A.

158 epigenetically reprograms members of the TGF-beta family, including neuronal regeneration-related pro

159 This TIC-driven, IL-33-TGF-beta feedforward loop could potentially be exploited for

160 r phase-of-firing at a 10-25 Hz band-limited beta frequency at which they synchronize across lateral

161 However, the oxygen sensors based on beta-Ga(2)O(3) and other existing materials lack in resp

162 B1) gene cause lysosomal beta-galactosidase (beta-Gal) deficiency and clinical onset of the neurodege

163 ystem together with a bifunctional 6-phospho-beta-gal/glucosidase, Gan1D.

164 ctosidase beta 1 (GLB1) gene cause lysosomal beta-galactosidase (beta-Gal) deficiency and clinical on

165 with multiple proteins (e.g. BSA, HSA, GOx, beta-galactosidase) and monomer classes including acryla

166 Comparing alpha and beta gene occupancy at PPP sites and gene bodies suggest

167 released more efficiently into the bodies of beta genes than alpha genes at 3 hpi and that repression

168 globally, characterised by reduced or absent beta-globin chain synthesis.

169 F6, do not impact the abundance of (1,3;1,4)-beta-glucan in mature grain.

170 gG1 titer and SNP rs3901533 of dectin-1, the beta-glucan receptor.

171 stration of Bacille Calmette-Guerin (BCG) or beta-glucan reprograms HSCs in the bone marrow (BM) via

172 Importantly, beta-glucan treatment reduced c-MAF expression in macrop

173 rbohydrates decreased; starch increased; and beta-glucan unchanged except for the surface area.

174 l phenolic content and antioxidant capacity, beta-glucans, pyridoxine, folates and silicon were quant

175 beta-glucosidases catalyze the hydrolysis beta-1,4, beta

176 ease (EIIC) genes in MGAS5005, the annotated beta-glucoside PTS transporter (bglP) was found to be cr

177 Thus, our results indicate that the beta-glucoside PTS transports salicin and its metabolism

178 the glucosidic derivative N-caprylhistamine-beta-glucoside was isolated from ripe tomato fruits and

179 effector gradients where importins alpha and beta gradually tune the activities of spindle assembly f

180 ta(17-23) and Abeta(30-36) that fold to form beta-hairpins and assemble to form trimers.

181 DNA polymerase beta has two DNA-binding domains that interact with the

182 TDP-43, tau and amyloid-beta have all been linked to hippocampal atrophy.

183 We show that beta-HPV E6 more broadly impairs cellular signaling, ind

184 35A), having substitutions in the core alpha/beta hydrolase-fold domain and the hairpin, exhibited ho

185 The corresponding beta-hydroxyamides can be furnished with yields up to 92

186 entrations of non-esterified fatty acids and beta-hydroxybutyrate than mid-postpartum animals and con

187 Amyloid-beta immunodepletion alleviated some but not all of the

188 These findings identify a function of TGF-beta in the development of ILC2s from their progenitors.

189 d in vitro through two major interfaces: (i) beta-interface, mapped to Switch I and effector-binding

190 , ATR, as well as the noncovalent binding of beta-ionone, an antagonist for G protein activation.

191 IFN-beta is a key component of the innate immune response to

192 d novel candidate genes (putatively encoding beta-ketoacyl-(acyl-carrier-protein) synthases, peroxiso

193 ndensation of the latter and a gem-dimethyl, beta-ketoester-substituted BC dihydrodipyrrin afforded t

194 The reaction of beta-ketosulfones with different alpha-functionalized ni

195 Here, we demonstrate that deletion of beta-klotho in glutamatergic, but not GABAergic, neurons

196 d to synthetize the 2-OMe-alpha-l-Rha-(1->2)-beta-l-Rha fragment.

197 emonstrated that 20 restored the activity of beta-lactam antibiotics against carbapenem-resistant Pse

198 inding protein 2X (PBP2X), a major target of beta-lactam antibiotics in pathogenic bacteria.

199 es isolates with characterized mechanisms of beta-lactam resistance, 180 clinical isolates from the M

200 ss the impact of peptidoglycan substrates on beta-lactam targeting of transpeptidation, and (d) demon

201 as determined by treating clinicians and the beta-lactam was administered for 7 days.

202 treatment implications, particularly for new beta-lactam/beta-lactamase inhibitor combinations.

203 e tropics annually acquire extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL

204 plications, particularly for new beta-lactam/beta-lactamase inhibitor combinations.

205 This Perspective is focused on beta-lactamase inhibitors that disable the most prevalen

206 Class A serine beta-lactamases (SBLs) are key antibiotic resistance det

207 nems, and monobactams), by the production of beta-lactamases.

208 ivation of the most widely used antibiotics, beta-lactams (penicillins, cephalosporines, carbapenems,

209 Prolonging the clinical effectiveness of beta-lactams, which remain first-line antibiotics for ma

210 quickly quantify the pathogen's response to beta-lactams.

211 mplete hydrolysis of the main whey proteins, beta-Lactoglobulin (beta-Lg) and alpha-lactalbumin (alph

212 dentification of glycomacropeptide (GMP) and beta-lactoglobulin (beta-lg) present in cheese whey is d

213 interaction between the major whey protein, beta-Lactoglobulin (betaLG) and vitamin B12, was studied

214 ectric fields during thermal denaturation of beta-lactoglobulin were examined through an in situ circ

215 ide biosynthesis, fatty acid activation, and beta-lactone formation.

216 the main whey proteins, beta-Lactoglobulin (beta-Lg) and alpha-lactalbumin (alpha-La), was achieved

217 comacropeptide (GMP) and beta-lactoglobulin (beta-lg) present in cheese whey is difficult on SDS-PAGE

218 The TGF-beta ligand DAF-7 likely acts upstream of IIS and links

219 LDs were also found in the islet beta-like cells produced from human embryonic cell-deriv

220 ) and frontal (rho = 0.27; P = .005) amyloid beta load and global tau load (rho = 0.31; P = .001).

221 such as APOEepsilon4 and subcortical amyloid-beta may identify participants closest to MCI for second

222 nventional CD4(+) T cells that underwent TGF-beta-mediated conversion in the periphery (called periph

223 sterol content with a cholesterol scavenger (beta-methylcyclodextrin) or statin compound (simvastatin

224 d on the binding mode of adenosine 5'-(alpha,beta-methylene)diphosphate (AOPCP) with human CD73, we d

225 the oxides, ranging from no power produced (beta-MnO(2)) to 1.18 +/- 0.01 W/m(2) (sodium manganese o

226 P-tau217 did not change in amyloid-beta-negative participants, or in patients with mild cog

227 sis confirmed Wnt activation following local beta-NGF injections.

228 fts alkylations of N-methylindole with trans-beta-nitrostyrene and 2,2,2-trifluoroacetophenone and th

229 -labeled dimeric lignin model compounds with beta-O-4 linkages were evaporated and ionized using nega

230 of S-nitrosothiols to solutions of NBT plus beta- or alpha-NADP did not produce diformazan, (5) S-ni

231 of S-nitrosothiols to solutions of NBT plus beta- or alpha-NADPH elicited rapid formation of diforma

232 fication, (2) addition of S-nitrosothiols or beta- or alpha-NADPH to solutions of NBT did not elicit

233 ting of water-soluble azobenzene and alpha-, beta-, or gamma-cyclodextrins, have been proposed as a m

234 MS inputs arriving at the excitable phase of beta oscillations in the motor cortex are known to lead

235 regulates lipid mobilization and fatty acid beta-oxidation during seed germination and seedling esta

236 ofibrate also induced autophagy and promoted beta-oxidation of fatty acids and stimulated gene expres

237 Transcriptome profiling displayed that TGF-beta pathway activation and ossification-related process

238 These data provide novel insights into beta-PE biosynthesis and advance our understanding of th

239 The amyloid-beta peptide is correlated with Alzheimer's disease and

240 , and to a family of 3-19 nM-affinity, alpha/beta-peptide-based binders to 14-3-3.

241 ) crystal and a heavy metal (Pt or Ta in its beta phase).

242 only functional group, such as alpha-pinene, beta-pinene and camphene, or two alkene moieties like li

243 opodia-like protrusions, which are absent in beta-Pix mutants.

244 arrangement of multiple forms of alpha- and beta-polypeptides in an individual LH1 ring.

245 We found higher beta power during rest and movement in the GPi, which al

246 tein docking was used to delineate a Vif/CBF-beta/PPP2R5 complex in which Vif is predicted to bind th

247 ed goblet cell hyperplasia and increased TGF-beta production.

248 neoplastic cells) domains(7), and WDR41 is a beta-propeller protein that binds to SMCR8 such that the

249 is used as a surrogate marker of non-amyloid-beta protein aggregation.

250 Sheet/barrel and mixed-alpha/beta proteins exhibit more conventional structure-dynami

251 troduce an alternative photosynthesis model (beta (PSII) model) incorporating parameters from rapid f

252 that depletion of transforming growth factor-beta receptor 2 (TGFBR2) in CD4(+) T cells, but not CD8(

253 HMGCR) and ATP-citrate lyase (ACLY) in a TGF-beta receptor/PI3K/protein kinase B-dependent manner, to

254 Lymphotoxin beta-receptor (LTbetaR) signalling promotes lymphoid neo

255 We investigated the integrity of cardiac beta-receptor responsiveness, an important mechanism inv

256 tients with HFpEF displayed impaired cardiac beta-receptor sensitivity compared with senior controls.

257 Brain administration of rIFN-beta resulted in microglial activation and complement C3

258 darius soluble FlaG (sFlaG), which reveals a beta-sandwich fold resembling the S-layer-interacting Fl

259 ate serves as a source of methyl radical via beta-scission from a tertiary radical generated upon chl

260 Based on primary and beta-secondary isotope effects, it is established that t

261 fficiently in excellent yields and with high beta-selectivities.

262 induced by plasma, particularly contents of beta-sheet and beta-turn.

263 rdered species and suggested the presence of beta-sheets.

264 ydrophobic interactions holding together the beta-sheets.

265 iven TGFBR2 expression, while inhibiting TGF-beta signaling decreased tECM-mediated expression of int

266 (ROS) levels are elevated, mTOR and IRF/IFN-beta signaling pathways are enhanced, leading to cellula

267 augmenting transforming growth factor (TGF) beta signaling.

268 ein, its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, a

269 y metabolites including emodin, aloe-emodin, beta-sitosterol and rutin.

270 beta-Sitosterol was the dominant phytosterol (80-83%).

271 beta-Barrels are sheets of beta-strands wrapped into a cylinder, in which the first

272 lding progressed to thermodynamically stable beta-structures and then to kinetically trapped alpha-st

273 through its C-terminal region, scaffolds the beta subunit of VGCC and the p11/Anxa2 complex.

274 synapses, by stimulus-dependent ATP synthase beta subunit translation; this increases the ratio of AT

275 sue-specific manner through co-assembly with beta subunits KCNE1-5.

276 n, a heterotetramer of paralogous alpha- and beta-subunits that mediates respiratory oxygen transport

277 nterface in K-Ras4B homodimerization and the beta-surface in effector binding.

278 Here, we found transforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) sign

279 Transforming Growth Factor Beta (TGFbeta) and insulin-like growth factor-1 (IGF-1)

280 ystem such as primary immunodeficiencies and beta-thalassaemia.

281 Transfusion-dependent beta-thalassemia (TDT) and sickle cell disease (SCD) are

282 The beta-thalassemia syndromes are the most prevalent geneti

283 ltered nonmalignant homeostasis, we selected beta-thalassemia, a hemoglobin disorder, as a paradigm.

284 acerbated or did not improve splenomegaly in beta-thalassemic mice.

285 is resulted in fewer TNRs synthesized by pol beta than those removed by FEN1, thereby leading to repe

286 inine biosynthesis) and virulence genes (eg, beta-toxin, delta-toxin) that defined a pathogenic ecolo

287 teracted with CCAAT/enhancer-binding protein beta transcription factor (TF), while the T allele did n

288 ect of calcitriol on homeostatic (M-CSF, TGF-beta-treated) and proinflammatory (GM-CSF-treated) human

289 ion, whereas the bivalent IgG fully inhibits beta-tryptase activity in a hinge-dependent manner.

290 sma, particularly contents of beta-sheet and beta-turn.

291 cyclopropanes and a broad selection of alpha,beta-unsaturated aldehydes.

292 A series of steroidal alpha,beta-unsaturated hydrazones is presented whose behavior

293 alpha-Arylation of alpha,beta-unsaturated ketones constitutes a powerful syntheti

294 al examples of cascade cyclizations of alpha,beta-unsaturated thioesters proceeding are reported, whi

295 ty at age-70 baseline (range of standardized beta-values = -0.178 to 0.302), and the polygenic score

296 cardium containing macrophages expressing FR-beta, which were also present in human cardiac sarcoid l

297 s around K, but higher temporal variation in beta within herds.

298 , by combining femtosecond Fe K(alpha) and K(beta) X-ray emission spectroscopy (XES) with Fe K-edge X

299 spin-sensitive femtosecond Fe K(alpha) and K(beta) X-ray emission spectroscopy at an X-ray free-elect

300 Hydrophobic Beta zeolites containing framework Sn atoms catalyze the