ライフサイエンスコーパス: beta 2-microglobulin

1 lasma cells, plasma cell labeling index, and beta(2) microglobulin).

2 , which does not associate with the L chain (beta(2)-microglobulin).

3 effect of Cu(II) binding on the structure of beta-2-microglobulin.

4 telets, and higher lactate dehydrogenase and beta-2-microglobulin.

5 is formed upon Zn(II) binding to the protein beta-2-microglobulin.

6 including MHC class I, mannose receptor, and beta(2)-microglobulin.

7 er small ligands, nor does it associate with beta(2)-microglobulin.

8 association between HLA class I H chain and beta(2)-microglobulin.

9 rrelated positively with serum M protein and beta(2)-microglobulin.

10 and OV-6 but do not stain with antibodies to beta(2)-microglobulin.

11 binase-activating gene-1 (Rag-1), ICAM-1, or beta(2)-microglobulin.

12 y-49D binds H-2D(d) in the presence of mouse beta(2)-microglobulin.

13 ro a heavy-chain homodimer structure lacking beta(2)-microglobulin.

14 ciated with antigen processing, tapasin, and beta(2)-microglobulin.

15 ressing cells exhibit impaired assembly with beta(2)-microglobulin.

16 s, i.e., that at 11.75 kD, was identified as beta(2)-microglobulin.

17 The amyloid consists of Asp76Asn variant beta(2)-microglobulin.

18 successfully with the amyloidogenic protein beta(2)-microglobulin.

19 51, 53% Durie-Salmon stage III, median serum beta-2-microglobulin 3.1 g/L, median C-reactive protein

20 s of amyloid fibrils formed from full-length beta(2)-microglobulin, a 99-residue protein involved in

21 riatal and limbic volumes, and CSF levels of beta(2)-microglobulin, a non-specific and non-excitotoxi

22 h, we then determined the Zn binding site of beta-2-microglobulin, a protein associated with metal-in

23 following independent characteristics: age, beta-2 microglobulin, absolute lymphocyte count, sex, Ra

24 nds of CD8 that are involved in contact with beta(2)-microglobulin affected interaction with the H-2K

25 Previous studies of beta(2)-microglobulin aggregation have not shown such am

26 n all beta-sheet proteins, transthyretin and beta(2)-microglobulin, alpha-pleated sheet structure for

27 ognition of infected targets by CD8+ CTL was beta 2-microglobulin and MHC class I dependent and was n

28 LIR-1 contacts the mostly conserved beta(2)-microglobulin and alpha3 domains of HLA-A2.

29 eation theory (ANT) to amyloid nucleation of beta(2)-microglobulin and amyloid beta(40) allows us to

30 lele and developed NOD mice expressing human beta(2)-microglobulin and HLA-A*1101 or HLA-B*0702, whic

31 n the structure of an amyloidogenic state of beta(2)-microglobulin and how it may corrupt a soluble c

32 synthesized MHC-I-Hc fails to associate with beta(2)-microglobulin and is retrotranslocated to the cy

33 e conformational properties of acid-unfolded beta(2)-microglobulin and its variants at pH 2.5 as meas

34 ombocytopenia, hypercalcemia, elevated serum beta(2)-microglobulin and lactate dehydrogenase levels,

35 System stages II and III, incorporating high beta(2)-microglobulin and low albumin, are considered to

36 le than random coil structures, for example, beta(2)-microglobulin and the SH3 domain.

37 Levels of beta-2 microglobulin and CD40 antigen and presence of he

38 CTOT14 analysis, several proteins, including beta-2 microglobulin and CD40, correlated with GFR chang

39 ved before functional loss at P22, including beta-2 microglobulin and Cx3cr1, and during vision loss

40 Western blot analysis of beta-2 microglobulin and myosin light chain was used to

41 Beta-2 microglobulin and TAP1 (transporter associated wi

42 Further, mice lacking beta(2)-microglobulin (and hence deficient in major hist

43 H-2Kb heavy chain, mouse beta 2-microglobulin, and an ER-targeted version of a pe

44 sic, but its glycosylation, association with beta(2)-microglobulin, and antigenicity at the cell surf

45 ell lines lacking MHC class I, MHC class II, beta(2)-microglobulin, and CD1, as well as tumor cell li

46 IFN-induced transmembrane protein 2 (1-8D), beta(2)-microglobulin, and CD69, were also increased in

47 n was largely dependent on the expression of beta(2)-microglobulin, and experiments with congenic rec

48 e homozygous for targeted disruption of HFE, beta(2)-microglobulin, and for a truncating mutation of

49 h a linear composition of antigenic peptide, beta(2)-microglobulin, and H chain connected by flexible

50 from RNA splicing factor SRp20, histone H2A, beta(2)-microglobulin, and MHC class II I-A(k)beta.

51 as transthyretin, islet amyloid polypeptide, beta(2)-microglobulin, and polyglutamine.

52 creatinine, but did not correlate with age, beta-2-microglobulin, and CA.

53 clophilin; the H3 histone family 3A protein; beta(2) microglobulin; and a cleavage and polyadenylatio

54 e, stage, serum lactate dehydrogenase [LDH], beta(2) microglobulin) appeared to influence outcome exc

55 We previously showed that mice lacking beta(2)-microglobulin are highly susceptible to tumors i

56 gh levels of serum lactate dehydrogenase and beta(2)-microglobulin as characteristics associated with

57 Using myoglobin, cytochrome c, and beta-2-microglobulin as model protein systems, we demons

58 ral marrow activity-strongly correlated with beta-2-microglobulin as surrogate imaging markers of tum

59 normal levels of the MHC class I H chain and beta(2)-microglobulin, as well as normal levels of TAP,

60 all of which associate specifically with the beta 2-microglobulin-assembled, open form of the class I

61 K408A was also associated with more folded, beta(2)-microglobulin-assembled HLA-B8 molecules than wi

62 peptide associated with Alzheimer's disease, beta(2)-microglobulin associated with dialysis-related a

63 sid protein presented by Q9, a member of the beta(2) microglobulin-associated Qa-2 family.

64 with a short cytoplasmic tail expressed as a beta(2)-microglobulin-associated 48-kDa glycoprotein and

65 LILRB1 exclusively bound folded beta(2)-microglobulin-associated class I, whereas LILRB2

66 hout concomitant re-expression of endogenous beta(2)-microglobulin-associated class I.

67 For members of the CD1 family of beta(2)-microglobulin-associated lipid-presenting molecu

68 r of previous regimens, and concentration of beta(2) microglobulin at screening.

69 Mutants of Ly49A, H-2D(d), and beta(2)-microglobulin at intermolecular contacts and the

70 elongation of the 100-residue protein human beta(2)-microglobulin at pH 2.5, commencing from an acid

71 int abnormalities, -13 or 13-q) and with low beta-2-microglobulin at diagnosis.

72 In rats transgenic for human HLA-B27 and beta(2) -microglobulin (B27-transgenic rats), colitis an

73 ins that lack murine MHC class I and II [NSG-beta-2-microglobulin ( B2M) (null) ( IA IE)(null) and NS

74 agnetic nanoparticle (MN) probe that targets beta(2) microglobulin (B2M), a key component of the majo

75 e weight or levels of the housekeeping genes beta-2 microglobulin (B2M) and glyceraldehyde-3-phosphat

76 Disruption of the Beta-2 Microglobulin (B2M) gene eliminates surface expre

77 is of the importance of the plasma levels of beta-2 microglobulin (B2M) in 553 patients with myelodys

78 r greater, previous nonprotocol therapy, and beta-2 microglobulin (B2M) of 3 mg/dL or greater as prog

79 acking both Hfe and its interacting protein, beta-2 microglobulin (B2m), deposit more tissue iron tha

80 s in two patterns: the most common contained beta-2 microglobulin (B2M, m/z=11,732) plus one or more

81 beta-2-microglobulin (B2M) is the most commonly altered

82 gene encoding the antigen-presenting protein beta-2-microglobulin (B2M) was identified in a third pat

83 deletions or loss of heterozygosity (LOH) in beta-2-microglobulin (B2M), an essential component of MH

84 sociation with cytolytic activity, including beta-2-microglobulin (B2M), HLA-A, -B and -C and Caspase

85 at AAPCs stably expressing HLA-A*0201, human beta(2)-microglobulin, B7.1, intercellular adhesion mole

86 ent complex containing a class I heavy chain-beta 2 microglobulin (beta 2 m) dimer is assembled onto

87 ized MHC class I heavy chains associate with beta 2-microglobulin (beta 2m) and the soluble chaperone

88 beta 2-Microglobulin (beta 2m) has been demonstrated to

89 kDa heavy chain and a 12 kDa soluble subunit beta 2-microglobulin (beta 2m), and which bind an 8-10 a

90 Beta 2-microglobulin (beta(2)m) is known to form amyloid

91 beta(2) -Microglobulin (beta(2) -m) and retinol-binding

92 umin, alpha(1) -microglobulin (alpha(1) -m), beta(2) -microglobulin (beta(2) -m) and retinol-binding

93 by incubation of recombinant wild-type human beta(2)-microglobulin (beta(2)M) ab initio in vitro at l

94 Beta(2)-microglobulin (beta(2)m) amyloid deposits are li

95 ultiple myeloma are elevated serum levels of beta(2)-microglobulin (beta(2)M) and activation or inhib

96 MHC class I molecules and beta(2)-microglobulin (beta(2)m) are membrane glycoprote

97 Heterodimers of MHC class I glycoprotein and beta(2)-microglobulin (beta(2)m) bind short peptides in

98 In this study, we examined whether exogenous beta(2)-microglobulin (beta(2)m) can induce apoptosis in

99 Mice deficient in the product of the beta(2)-microglobulin (beta(2)M) class I light chain fai

100 and quality control of CD1 heavy chain (HC).beta(2)-microglobulin (beta(2)m) complexes is unclear.

101 ass I heavy chains (HCs) and peptide-free HC-beta(2)-microglobulin (beta(2)m) dimers from exiting the

102 otein DeltaN6, a truncation variant of human beta(2)-microglobulin (beta(2)m) found in amyloid deposi

103 TG-->ATA) and in codon 31 (TCA-->TGA) of the beta(2)-microglobulin (beta(2)m) gene were identified in

104 a heterodimeric complex of a heavy chain and beta(2)-microglobulin (beta(2)m) in the endoplasmic reti

105 ous assembly of amyloid fibrils of wild-type beta(2)-microglobulin (beta(2)M) in vitro, under acid co

106 myloidosis (DRA) involves the aggregation of beta(2)-microglobulin (beta(2)m) into amyloid fibrils.

107 e accumulation of the immunoglobulin protein beta(2)-microglobulin (beta(2)m) into amyloid plaques in

108 Beta(2)-Microglobulin (beta(2)m) is one of over 20 prote

109 The D76N variant of human beta(2)-microglobulin (beta(2)m) is the causative agent

110 Beta(2)-microglobulin (beta(2)m) is the major structural

111 ed Rai and Binet stage disease, higher serum beta(2)-microglobulin (beta(2)M) levels, a greater perce

112 heavy chain of FcRn was associated with the beta(2)-microglobulin (beta(2)m) light chain in U937 and

113 Upon self-recognition of beta(2)-microglobulin (beta(2)M) molecules, PIR-B served

114 ining complexes of H chain (alpha-chain) and beta(2)-microglobulin (beta(2)m) or as beta(2)m-free H c

115 of TPKTSVT placental homing in mice lacking beta(2)-microglobulin (beta(2)m) suggests FcRn/beta(2)m

116 They include defects in beta(2)-microglobulin (beta(2)m) synthesis, loss of the

117 er when it is expressed with Chinese hamster beta(2)-microglobulin (beta(2)m) than murine beta(2)m.

118 f a nonclassical MHC class I alpha-chain and beta(2)-microglobulin (beta(2)m) that binds two ligands,

119 e glycoprotein (heavy chain) associated with beta(2)-microglobulin (beta(2)m) that presents lipid ant

120 Once MHC class I heavy chain binds beta(2)-microglobulin (beta(2)m) within the endoplasmic

121 Allergen-induced AHR, however, develops in beta(2)-microglobulin (beta(2)m)(-/-) mice, which lack c

122 n genes but not genes encoding light chains (beta(2)-microglobulin (beta(2)m)), transporter associate

123 composed of a heavy chain, the small subunit beta(2)-microglobulin (beta(2)m), and a peptide.

124 vy chain, a noncovalently associated protein beta(2)-microglobulin (beta(2)m), and a peptide.

125 subunits, the 45-kDa heavy chain, the 12-kDa beta(2)-microglobulin (beta(2)m), and an approximately 8

126 ed of the lumenal domain of the heavy chain, beta(2)-microglobulin (beta(2)m), and peptide.

127 beta(2)-microglobulin (beta(2)m), labeled with a single

128 to amyloid-like fibrils formed in vitro from beta(2)-microglobulin (beta(2)m), the amyloid fibril pro

129 riant of the naturally amyloidogenic protein beta(2)-microglobulin (beta(2)m), to determine the solut

130 cated variant (DeltaN6) of the human protein beta(2)-microglobulin (beta(2)m), which assembles into a

131 heterodimer consisting of a heavy chain and beta(2)-microglobulin (beta(2)m), which is essential for

132 HC class I recognition by alphabeta T cells, beta(2)-microglobulin (beta(2)m)-associated MHC class I

133 ting dissociation of target organ disease in beta(2)-microglobulin (beta(2)m)-deficient MRL-Fas(lpr)

134 rates of nucleation and elongation of human beta(2)-microglobulin (beta(2)m).

135 entiation 1) heavy chain in association with beta(2)-microglobulin (beta(2)m).

136 like H chain in noncovalent association with beta(2)-microglobulin (beta(2)m).

137 concentrations of mRNA encoding H chain and beta(2)-microglobulin (beta(2)m).

138 th amyloid-like fibrils formed in vitro from beta(2)-microglobulin (beta(2)m).

139 eristics associated with CR included age and beta(2)-microglobulin (beta-2M).

140 nic high-flux dialysis, as defined by higher beta-2 microglobulin (beta(2)M) clearance, compared with

141 growth as monitored by serum levels of human beta-2 microglobulin (beta(2)mu) and by prolonged surviv

142 Beta-2-microglobulin (beta(2)m) has been shown to form a

143 ce, while HSC from class I-deficient donors (beta(2)-microglobulin(-/-) (beta(2)m(-/-))) failed to en

144 played greater susceptibility than CD8(-/-), beta(2)-microglobulin(-/-) (beta(2)m(-/-)), or WT mice t

145 anced Rai stage (P < .001), higher levels of beta(2)-microglobulin (beta2-M) (P < .001), and the abse

146 of expression of FcRn or its binding partner beta 2 microglobulin (beta2M) renders cells resistant to

147 ha2/alpha3 domains of the H2D(d) H chain and beta(2)-microglobulin (beta2m) and is the functional bin

148 orms classical heterotrimeric complexes with beta(2)-microglobulin (beta2m) and peptide and (beta2m f

149 isk untreated patients < 70 years with serum beta-2 microglobulin (beta2M) >/= 4 mg/L.

150 In dialysis patients, beta-2 microglobulin (beta2m) can aggregate and eventual

151 Beta-2 microglobulin (beta2m) is a small globular protei

152 Beta-2 Microglobulin (beta2m) is a small, globular prote

153 beta-2 microglobulin (beta2m) is an amyloidogenic protei

154 egaly, hepatomegaly, hemoglobin (Hgb) level, beta-2 microglobulin (beta2M) level in the serum, number

155 ions to compare the native state dynamics of Beta-2 microglobulin (beta2m), whose aggregation is asso

156 ctures of ThT with two alternative states of beta-2 microglobulin (beta2m); one monomeric, the other

157 onstrated that ESAT-6 protein interacts with beta-2-microglobulin (beta2M) and affects class I Ag pre

158 Using beta-2-microglobulin (beta2m) as a model amyloid-forming

159 Here, using the protein beta-2-microglobulin (beta2m) as a model, we measure the

160 The deposition of beta-2-microglobulin (beta2m) as amyloid fibers results

161 s-related amyloidosis is the accumulation of beta-2-microglobulin (beta2m) as amyloid fibrils in the

162 long-term hemodialysis is the deposition of beta-2-microglobulin (beta2m) as amyloid plaques in the

163 Beta-2-microglobulin (beta2m) deposits as amyloid fibril

164 ly of amyloid-like fibrils formed from human beta-2-microglobulin (beta2m) in vitro.

165 Beta-2-microglobulin (beta2m) self-associates into fibri

166 /=60, elevated lactic dehydrogenase (LDH) or beta-2-microglobulin (beta2M), advanced stage, and bone

167 in both native and unfolded conformations of beta-2-microglobulin (beta2m).

168 growth as monitored by serum levels of human beta-2-microglobulin (beta2mu; P < .01), and prolonged s

169 those known to be produced by keratinocytes (beta-2 microglobulin, betaIG-H3, calgranulin A, cathepsi

170 o inhibit the expression of the light chain, beta(2)-microglobulin, block the dislocation of Class I

171 Pattern 2 lacked beta-2 microglobulin but contained several degradation p

172 phy, was positively linked to high levels of beta-2-microglobulin, C-reactive protein, and lactate de

173 x consisting of the MHC class I heavy chain, beta(2)-microglobulin, calreticulin, tapasin, Erp57 (ER6

174 a full-strength primary response depends on beta(2)-microglobulin (class I major histocompatibility

175 Beta 2 microglobulin clearance of F80B was < 5.0 ml/min

176 Beta 2 microglobulin clearance of T220L dialyzers was <

177 Urea, creatinine, and beta 2 microglobulin clearances were measured at blood f

178 ibility complex (MHC) class I, MHC class II, beta(2)-microglobulin, clusterin, interleukin-13 recepto

179 ither the FcRn H chain alone or FcRn H chain-beta(2)-microglobulin complex and appeared to be maintai

180 g of the free MHC-I-Hc, and not the MHC-I-Hc-beta(2)-microglobulin complex, by p12(I) represents a no

181 asmic reticulum, the class I heavy (H) chain-beta(2)-microglobulin complexes are detected in associat

182 Pretreatment plasma beta(2)-microglobulin concentrations decreased with time

183 Four markers (albumin, beta-2-microglobulin, cystatin C, and osteopontin) were

184 The natural human variant of beta(2)-microglobulin (D76N beta(2)-m) is associated wit

185 -beta 1-/- mice in the genetic background of beta 2-microglobulin deficiency (beta 2M-/-).

186 red onto a combined class I-deficient mouse (beta-2 microglobulin deficient; beta2m(0)) and class II-

187 idual CD8+ cells present in the periphery of beta 2-microglobulin-deficient (beta 2m-/-) mice are unk

188 no IL-4 or IgE responses to anti-IgD Ab and beta 2-microglobulin-deficient mice make large in vivo I

189 We now find that the failure of beta 2-microglobulin-deficient mice to make an IgE respo

190 burnetii Nine Mile phase I vaccine (PIV) in beta(2)-microglobulin-deficient (B2m KO) and MHC-II-defi

191 NK cells from beta(2)-microglobulin-deficient (B2m(-/-)) and wild-type

192 herpesvirus 68 (gammaHV68) infection of BALB beta(2)-microglobulin-deficient (BALB beta(2)m(-/-)) mic

193 ferentiate into IFN-gamma-producing cells in beta(2)-microglobulin-deficient (beta(2)m(-/-)) B6 recip

194 we also generated K14-OVA Tg chimeras using beta(2)-microglobulin-deficient (beta(2)m) congenic dono

195 conditioned B6 mice rejected both BALB/c and beta(2)-microglobulin-deficient BMCs.

196 BALB/c--> B6 chimeras rejected a low dose of beta(2)-microglobulin-deficient bone marrow cells (BMC)

197 terial burden compared with that of infected beta(2)-microglobulin-deficient mice that lack MHC class

198 erved that engraftment of CD34(+) cells in a beta(2)-microglobulin-deficient nonobese diabetic/severe

199 Cytoxicity was beta-2-microglobulin dependent and largely TAP dependent

200 Thus, CD1-responsive T cells and other beta 2-microglobulin-dependent T cells are not required

201 studies clearly indicate the importance of a beta(2)-microglobulin-dependent but CD8 T-cell- and iNK

202 ys demonstrated induction of a population of beta(2)-microglobulin-dependent, MHC class Ib-restricted

203 abeta does not contact the MHCI alpha(2)- or beta(2)-microglobulin domains.

204 ic value of PCLI response was independent of beta(2)-microglobulin, elevated creatinine, serum M-spik

205 We report here on the critical importance of beta(2)-microglobulin expression during murine K. pneumo

206 e (human and monkey) MHC class I H chain and beta(2)-microglobulin failed to associate to form the no

207 e amyloid-forming proteins human insulin and beta(2)-microglobulin for segments that form fibrils.

208 in if patients with spondylarthritis express beta(2)-microglobulin-free HLA-B27 heavy chains in the f

209 I-deficient due to targeted mutation in the beta-2-microglobulin gene (SJL/J B2m (-/-) mice).

210 ed in mice deficient in micro heavy chain or beta-2 microglobulin genes, slightly extended in mice de

211 6), Thr(238), Arg(239), and Asp(241); and in beta(2)-microglobulin, Gln(29) and Lys(58)) of the Ly49A

212 Multivariate analysis identified beta(2)-microglobulin >/= 3 mg/L (P < .001) and age >/=

213 isted of four factors (one point each; serum beta(2)-microglobulin >=5 mg/dL, lactate dehydrogenase >

214 s follows: TP53 aberration, prior treatment, beta-2 microglobulin >= 5 mg/L, and lactate dehydrogenas

215 T3b, age >/=65 years, male gender, levels of beta-2-microglobulin >5.5 mg/L, and multiple myeloma rel

216 Two partially folded intermediates of beta(2)-microglobulin have been identified experimentall

217 Male rats transgenic for HLA-B27 and human beta(2) -microglobulin (hbeta(2) m) spontaneously develo

218 spondylarthritis that develops in B27/human beta(2)-microglobulin (Hubeta(2)m)-transgenic rats.

219 monstrated for a simultaneous immunoassay of beta(2)-microglobulin, IgG, bovine serum albumin, and C-

220 t, vascular endothelial growth factor, Ptx3, beta(2)-microglobulin, IL-1alpha, Mcp-1 and -3, RANTES (

221 res assembly of MHC class I with peptide and beta 2-microglobulin in the endoplasmic reticulum.

222 ere was no significant binding of m4/gp34 to beta(2)-microglobulin in the absence of class I H chain,

223 a as inclusion bodies and refolded them with beta(2)-microglobulin in the presence or absence of a ra

224 families bound HLA-B27 in both classical and beta(2) microglobulin-independent forms.

225 lin-associated 48-kDa glycoprotein and novel beta(2)-microglobulin-independent 37-kDa nonglycosylated

226 Furthermore, tumor recognition was beta(2)-microglobulin-independent.

227 The self-assembly of beta(2)-microglobulin into fibrils leads to dialysis-rel

228 veal any differences in the association with beta(2)-microglobulin, invariant chain of class II MHC,

229 In multivariate analysis, however, beta(2)-microglobulin is the most important prognostic f

230 beta -2 microglobulin knockout (KO) mice were protected

231 beta 2 microglobulin knockout (beta2M-/-) mice lack CD8+

232 ese diabetic-severe combined immunodeficient-beta(2) microglobulin knockout (NOD/SCID/beta(2)m(-/-))

233 model of psychological stress and OVA-loaded beta(2)-microglobulin knockout "donor" cells that cannot

234 minished in mice deficient in CTL, including beta(2)-microglobulin knockout (KO), CD8 KO, and SCID mi

235 beta(2)-Microglobulin knockout animals controlled infect

236 Beta(2)-microglobulin knockout mice displayed significan

237 As beta(2)-microglobulin knockout mice lack both CD8(+) T c

238 account for the increased mortality noted in beta(2)-microglobulin knockout mice.

239 placed orthotopically in eyes of C57BL/6 and beta-2 microglobulin knockout mice (deficient in CD8(+)

240 beta-2 Microglobulin knockout mice showed rejection of c

241 ing early, acute rejection, yet T cells from beta-2 microglobulin knockout recipients of corneal allo

242 Using beta(2)-microglobulin-knockout, IFN-gamma-knockout, and

243 type mice, active disease was more severe in beta(2)-microglobulin KO mice.

244 ysis, factors predicting for longer FFS were beta(2)-microglobulin less than 3 mg/L (P =.01) and ATT

245 bsence of t(4;14), del(17p), and 1q gain and beta(2)-microglobulin less than 5.5 mg/L.

246 ating CD20 levels correlated positively with beta(2)-microglobulin level (p =.006) and percentage of

247 High serum beta(2)-microglobulin level and International Staging Sy

248 ient subgroups, including those based on the beta(2)-microglobulin level, cytogenetic profile, and re

249 ctive of survival include the patient's age, beta(2)-microglobulin level, monoclonal protein level, h

250 abnormal karyotype (P =.002) and high serum beta(2)-microglobulin levels (P =.0005), were most preva

251 CD8(+) T cells was measured, as were plasma beta(2)-microglobulin levels.

252 t stratum more frequently had elevated serum beta-2 microglobulin levels, high-risk Rai stage, and we

253 Low beta-2-microglobulin levels less than 2 mg/L were indepe

254 me 13 (triangle up13) abnormalities and with beta-2-microglobulin </= 2.5 mg/L, C-reactive protein </

255 Transthyretin, beta(2)-microglobulin, lysozyme, and the prion protein a

256 severe combined immunodeficiency (NOD/SCID) beta(2) microglobulin(-/-) mice, engrafted with human CD

257 Immunization and challenge studies with beta(2)-microglobulin(-/-) mice indicated that the reduc

258 CMV infection as compared with K(b-/-)D(b-/-)beta(2)-microglobulin(-/-) mice that lack expression of

259 th MIP-1 alpha was significantly impaired in beta(2)-microglobulin(-/-) mice.

260 An optimal ratio of three beta-2 microglobulin molecules per single HLA heavy chai

261 Irradiated beta(2)-microglobulin mutant mice or mice with mutations

262 In contrast, mouse H chains associated with beta(2)-microglobulin normally and bound peptide at leas

263 with normal CG, PCLI of less than 0.5%, and beta(2)-microglobulin of 3 mg/L.

264 In multivariate analysis, beta-2-microglobulin of more than 3.5 microg/mL at diagn

265 e characteristics (prior treatment, elevated beta(2)-microglobulin or lactate dehydrogenase, or Rai s

266 due to deletion of the genes encoding either beta(2)-microglobulin or the TCR element J alpha 281.

267 he absence of accessory cells, MHC class II, beta 2-microglobulin, or TAP-1, suggesting that Ag prese

268 (BMPC%; P =.0004), increased levels of serum beta(2)-microglobulin (P =.04), and dominant cardiac amy

269 m levels of soluble IL-2R alpha and/or human beta-2-microglobulin (P <.05, t test) and by survival of

270 with HC10, but not with a mAb to folded B27-beta(2)-microglobulin-peptide complexes.

271 The HLA-B *1502/peptide/beta(2)-microglobulin protein complex showed binding aff

272 on and is stoichiometrically associated with beta(2)-microglobulin, similar to class I molecules.

273 is an increase in the levels of lactoferrin, beta(2)-microglobulin, sodium, lysozyme C, and cystatin

274 rs consisting of an antigenic peptide-spacer-beta(2)-microglobulin-spacer H chain.

275 ammed cell death ligand 1 (PD-L1)(2) and the beta-2 microglobulin subunit of the major histocompatibi

276 P), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural

277 inated when immune complex-loaded DCs lacked beta(2) microglobulin, TAP, or MHC class II, demonstrati

278 ion of MHC class I and related genes such as beta(2)-microglobulin, Tap1, or Lmp2, but did not affect

279 MHC class I antigen presentation, including beta-2 microglobulin, (TAP1), and TAP2.

280 ined high plasma concentrations of wild-type beta(2)-microglobulin, the affected members of this kind

281 Although m4/gp34 requires beta(2)-microglobulin to bind class I, there was no sign

282 ed endocytosis of both FITC-albumin and FITC-beta(2)-microglobulin to similar extents but without alt

283 onse (UPR) in macrophages from HLA-B27/human beta(2)-microglobulin-transgenic (B27-transgenic) rats.

284 Patients with elevated urine beta-2 microglobulin (Ubeta2M) and a diagnosis of TINU w

285 normal renal function and normal circulating beta(2)-microglobulin values.

286 infiltration, immunoglobulin M, albumin, and beta-2 microglobulin values as continuous measures.

287 The Asp76Asn beta(2)-microglobulin variant was thermodynamically unst

288 ehensive biophysical characterization of the beta(2)-microglobulin variant, including its 1.40-A, thr

289 nts with ALK-positive and ALK-negative ALCL, beta(2)-microglobulin was >/= 3 mg/L in 12% and 33% (P =

290 However, if beta(2)-microglobulin was incorporated into the analysis

291 m lactate dehydrogenase was high in 35%, and beta-2 microglobulin was more than 3.0 mg/L in 35% of pa

292 rium loss for fully deuterated ubiquitin and beta(2)-microglobulin were observed after 10 min of back

293 P53 aberration, advanced Rai stage, and high beta-2 microglobulin were independently associated with

294 0 peptides (three from insulin and five from beta(2)-microglobulin) were identified as amyloid-like.

295 inhibitor of metalloproteinase [TIMP]-1, and beta-2-microglobulin) were higher in rAKI versus nAKI (P

296 dy, LTRs had lower baseline plasma levels of beta-2-microglobulin, were more likely to have trisomy 1

297 Recombinant sG1 associated with beta(2)-microglobulin, whereas rsG2 did not.

298 mers accumulate in the absence of tapasin or beta(2)-microglobulin, whereas W6/32-reactive dimers are

299 ion is enhanced by the introduction of human beta(2) -microglobulin, which increases surface expressi

300 Amyloid deposition of WT human beta(2)-microglobulin (WT-hbeta(2)m) in the joints of lo