ライフサイエンスコーパス: beta-catenin

1 ytoskeleton, and enhances the acetylation of beta-catenin.

2 manized FRG mouse livers demonstrated active beta-catenin.

3 bearing short polyQ tract AR and stabilized beta-catenin.

4 yos, while NCC defects could be rescued with beta-catenin.

5 stress damage through anabolic pathways and beta-catenin.

6 cer tumoroids harboring a mutation at S45 of beta-catenin.

7 r littermates that expressed only stabilized beta-catenin.

8 presence of a proteasome degradable form of beta-catenin.

9 d to BBR after pharmacological inhibition of beta-catenin.

10 new perspective for therapeutic targeting of beta-catenin.

11 nts to achieve high efficient degradation of beta-catenin.

12 that are reduced by inhibiting Akt-activated beta-catenin.

13 pression increased in the presence of active beta-catenin.

14 mistry (IHC) for CTNNB1 (beta-Catenin; clone beta-Catenin-1) was performed on the constructed TMAs.

15 ex: (1) maintains composition and binding to beta-catenin, (2) moves toward the plasma membrane, and

16 ceptors that promote differentiation towards beta-catenin, a driver of proliferation and colorectal t

17 rable chemical environment for non-enzymatic beta-catenin acetylation downstream of WNT signalling.

18 ances its phosphorylation by Src, leading to beta-catenin activation and disseminating phenotypes in

19 velopmental mechanism for post-translational beta-catenin activation and is required to complete EGA.

20 ry connections, Yap/Taz accumulated upon Myc/beta-catenin activation and were required not only for t

21 Moreover, there was also less DNA damage and beta-catenin activation in H. pylori-infected Smox(-/-)

22 rostaglandin E(2) (PGE(2)), which stimulates beta-catenin activation of GSC and M2-like TAM polarizat

23 Prostate tumors with beta-catenin activation relied on the noncanonical WNT l

24 These findings suggest that stromal beta-catenin activation results in histological and mole

25 We discover that, while elevated, sustained beta-catenin activation sequentially promotes proliferat

26 Thus, OTULIN-mediated Wnt/beta-catenin activation upon genotoxic treatments promot

27 The link between SMOX and beta-catenin activation was confirmed in human gastric o

28 beta-Catenin activation, independent of the cell of orig

29 ase, is essential for the DNA damage-induced beta-catenin activation.

30 Addition of the Wnt/beta-catenin activator CHIR99021 reduced wound closure i

31 rtical rotation to generate a dorsal pole of beta-catenin activity [4-8], and the release of Nodal si

32 y, MYC expression levels strongly influenced beta-catenin activity, indicating that inter-tumor heter

33 te and prevents renal fibrosis by repressing beta-catenin activity, whereas KCTD1 deficiency leads to

34 gressive liver tumors marked by elevated Myc/beta-catenin activity.

35 cells showed high level expression of active beta-catenin, alpha-fetoprotein, and SOX9, suggesting th

36 ently identified ubiquitin ligase of nuclear beta-catenin and a suppressor of colorectal cancer (CRC)

37 n analyses revealed increased recruitment of beta-catenin and AR on the c-Myc gene regulatory locus i

38 Overall, WNT/beta-catenin and AR signaling are reciprocally inhibited

39 region (IDR) of APC, which contains multiple beta-catenin and Axin interacting sites, undergoes liqui

40 ations, such as APC mutations that stabilize beta-catenin and cause intestinal tumors in mice and hum

41 LEF1 levels were sensitive to inhibition of beta-catenin and cholesterol pathways.

42 signaling including nuclear localization of beta-catenin and E-cadherin.

43 ylation, and unphosphorylated Hsp27 binds to beta-catenin and enhances its phosphorylation by Src, le

44 ession of AnxA8 led to an increase in active beta-catenin and GSK-3beta phosphorylation.

45 al epithelial cells results in activation of beta-catenin and increased expression of lymphoid enhanc

46 Furthermore, nuclear beta-catenin and its activity were significantly increas

47 t Fzd7 may act through the activation of Wnt/beta-catenin and Jagged1 expression to control EC prolif

48 f APC results in pathologic stabilization of beta-catenin and oncogenesis.

49 amentous junctions stabilized by N-cadherin, beta-catenin and p120-catenin, which undergo kinetic tur

50 The Wnt-beta-catenin and PI3K-Akt pathways cooperate to promote

51 on of axin, reducing targeted destruction of beta-catenin and promoting beta-catenin-mediated transcr

52 s in the tumor tissues expressing stabilized beta-catenin and shorter polyQ tract AR.

53 of intestinal epithelial cells with nuclear beta-catenin and SRY-box transcription factor 9 in APC(+

54 including an inactivating phosphorylation of beta-catenin and two microtubule depolymerizing phosphor

55 tion of the key regulators of Wnt signaling, beta-catenin, and E-cadherin, to the nucleus.

56 suppressed phosphorylation of Smad3, STAT3, beta-catenin, and expression of Snail after ureteral obs

57 athways including STAT3, NFkappaB, PI3K/Akt, beta-catenin, and Notch signaling, which are critical fo

58 ed by single-cell live imaging of endogenous beta-catenin, and subsequent target gene transcription.

59 eatment also caused decreases in E-cadherin, beta-catenin, and YAP in the striola, and stimulated rob

60 pacts on Wnt target genes transcription in a beta-catenin- and TCF/LEF-dependent manner.

61 ich both murine Met transgene and stabilized beta-catenin are conditionally co-expressed in prostatic

62 As both BCR and beta-catenin are important mediators of cell survival an

63 Wilms tumor 1 (WT1) and beta-catenin are two master regulators that play opposin

64 ct accumulation and nuclear translocation of beta-catenin, as measured by single-cell live imaging of

65 Mechanistically, SOSTDC1 blocks the WNT-beta-catenin axis and facilitates T(FR) cell differentia

66 n content and activity of the ROS/AMPK/EP300/beta-catenin axis are opposite in healthy versus tumor s

67 Deletion of the beta-catenin-binding domain of LEF1 in HNF-1beta-deficie

68 dgehog (Shh), wingless-integrated site (Wnt)/beta-catenin, bone morphogenetic protein (Bmp), and fibr

69 reducing destruction complex-phosphorylated beta-catenin, but high-molecular-weight beta-catenin is

70 induced dissociation between VE-cadherin and beta-catenin, but increased association between N-WASP a

71 Through direct binding to beta-catenin, C2 renders the target inactive that eventu

72 We report the discovery of beta-catenin(+) cancer cells that coexpress E-cadherin a

73 d the aberrant activation of HGF/MET and Wnt/beta-catenin cascades in prostate tumorigenesis by using

74 Immunohistochemistry (IHC) for CTNNB1 (beta-Catenin; clone beta-Catenin-1) was performed on the

75 aled elevated levels of LRP5/6 and FZD10 and beta-catenin co-localization with enhancer of zeste 2 po

76 Sox17 and beta-catenin co-occupy hundreds of key enhancers.

77 BCL9 and PYGO are beta-catenin cofactors that enhance the transcription of

78 -catenin signaling increased binding of Tcf4/beta-catenin complex and upregulated its enhancer functi

79 Activation of the WNT/beta-catenin (CTNNB1) signaling pathway plays a critical

80 beta-catenin deficiency in these cells indeed causes ins

81 he molecular mechanism by which APC promotes beta-catenin degradation is unclear.

82 mplex, eventually leading to inactivation of beta-catenin degradation.

83 tal cells promotes Axin puncta formation and beta-catenin degradation.

84 complex organization and BRB properties in a beta-catenin-dependent manner.

85 In addition to microbes, beta-catenin-dependent pattern formation is also affecte

86 X3 as context-dependent component of the Wnt/beta-catenin-dependent transcriptional complex.

87 Senescent beta-catenin-depleted hepatocytes in aged mice create an

88 Thus, we screened new potent targets from beta-catenin destruction complex associated with GC prog

89 We have proposed that sequestration of beta-catenin destruction complex components in multivesi

90 option to influence AXIN1 expression and the beta-catenin destruction complex in Wnt-driven intestina

91 In response, the endogenous beta-catenin destruction complex reoriented toward the l

92 interactions between APC and Axin drives the beta-catenin destruction complex to form biomolecular co

93 ch assembles Wnt signalosomes to inhibit the beta-catenin destruction complex via recruitment of Axin

94 gesting that PTPRF functions upstream of the beta-catenin destruction complex.

95 signaling such that in response to Wnt, the beta-catenin destruction complex: (1) maintains composit

96 m Lck-Dlx5;Lck-MyrAkt mice demonstrated that beta-catenin directly regulates genes involved in sterol

97 load and significantly reduces viability of beta-catenin-driven cancer cells.

98 fore these studies have identified a pool of beta-catenin effectively shielded from regulation by Wnt

99 -activated protein kinase (AMPK), can reduce beta-catenin expression and downstream signaling in HCC

100 Finally, suppressing beta-catenin expression is able to rescue deficits of Na

101 DCLK1 downregulation inhibited 48-kDa beta-catenin expression.

102 f a cytoplasmic protein complex that targets beta-catenin for destruction.

103 x that scaffolds GSK3beta and CK1 to earmark beta-catenin for proteosomal degradation.

104 O phenotype, suggesting caution in targeting beta-catenin globally for all cholestatic conditions.

105 Further, we find that beta-catenin has a cell autonomous role in the developme

106 mouse model of CAC, we show that the LRP5/6-beta-catenin-IL-10 signaling axis in intestinal CD11c(+)

107 relimbs, BCL9 proteins sustain the action of beta-catenin in a largely PYGO-independent manner.

108 Genetic activation of beta-catenin in beta-cells restores the diabetes-like ph

109 udying pharmaceutical agents that can target beta-catenin in cancer cells, we observed that the plant

110 inhibition is likely due to stabilization of beta-catenin in cohesin-mutant cells, and that Wnt-respo

111 o gain a better insight into the role of Wnt/beta-catenin in dentinogenesis, we used dental pulp cell

112 Loss of beta-catenin in fetal mouse mesoderm causes loss of Tbx4

113 el mechanistic link between DOCK6, Rac1, and beta-catenin in GCCSC for the first time, supporting the

114 Short-term induction of MYC and beta-catenin in hepatocytes, followed by RNA-sequencing

115 generalize these observations, we suppressed beta-catenin in Mdr2 knockout (KO) mice, which develop s

116 a and CRC were associated with activation of beta-catenin in physically fit, overweight and obese pat

117 earing different polyQ tracts and stabilized beta-catenin in prostate tumorigenesis using newly gener

118 We interrogated the dual functions of beta-catenin in relation to CK5.

119 is likely to increase the levels of nuclear beta-catenin in the intestinal crypt, augmenting CRC tum

120 t morphogenesis, as ectopic stabilization of beta-catenin in the ventral hindgut via gain- or loss-of

121 well-established HCC oncogene (either MYC or beta-catenin) in combination with an additional alterati

122 Here we have identified a beta-catenin-independent function of BCL9 in a poor-prog

123 ersely, inhibition of miR-466o-3p alleviated beta-catenin-induced podocyte dysfunction.

124 proliferation and differentiation, transient beta-catenin induces apoptosis.

125 Since Akt can activate beta-catenin, inhibiting this interaction might target t

126 nhibitor bortezomib did not block the 48-kDa beta-catenin, instead, caused a threefold accumulation,

127 doxorubicin (DXR) as an inhibitor of the Akt-beta-catenin interaction at low doses.

128 While the regulatory effect of RUNX3 in beta-catenin is already known, our results suggest the p

129 Interestingly, Sox9 binding to beta-catenin is enhanced in Med23(fx/fx);Wnt1-Cre mutant

130 We show that beta-catenin is neddylated; and inhibiting beta-catenin

131 oprecipitation experiments demonstrated that beta-catenin is part of a protein complex that binds the

132 n signaling, the transcriptional coactivator beta-catenin is regulated by its phosphorylation in a co

133 ated beta-catenin, but high-molecular-weight beta-catenin is unexpectedly increased by Wnt signaling.

134 ns form a multiprotein complex that includes beta-catenin, it remained unclear how this would contrib

135 athogenic process in the hepatic conditional beta-catenin knockout mouse model.

136 ficantly attenuated BBR-induced reduction of beta-catenin levels and expression of its downstream tar

137 poly(ADP-ribosyl) polymerase that regulates beta-catenin levels, undergoes programmed translation du

138 a rare homozygous missense M466V mutation in beta-catenin-like protein 1 (CTNNBL1).

139 Thus, beta-catenin likely represents another player through wh

140 C2 selectively inhibits beta-catenin, lowers its cellular load and significantly

141 We find that shape change is regulated by a beta-catenin-mediated decrease in RhoA activity and subs

142 These results indicate a role of HGF/MET in beta-catenin-mediated prostate cancer cell growth and pr

143 5 is also required to sustain cell-intrinsic beta-catenin-mediated signaling to promote cellular adhe

144 ed destruction of beta-catenin and promoting beta-catenin-mediated transcription of target genes, inc

145 samples, implicating a novel role of MET in beta-catenin-mediated transcription.

146 , as its histone-binding capability promotes beta-catenin-mediated Wnt signaling and transcriptional

147 report that intratumor heterogeneity of Wnt/beta-catenin modulator delta-catenin controls individual

148 beta-catenin mRNA expression showed a strong positive co

149 t beta-catenin is neddylated; and inhibiting beta-catenin neddylation increases its nuclear accumulat

150 patterns of seven candidate genes, including beta-catenin, Notch1, GATA6, CDX2, miR-34a, miR-181a, an

151 their complex formation, while not affecting beta-catenin nuclear localization.

152 epithelial-mesenchymal transition (EMT) and beta-catenin nuclear translocation to promote cell migra

153 rimethylation repressive marks and increases beta-catenin occupancy at a site 4 kb upstream to Lef1.

154 anism revealed that BBR-induced reduction of beta-catenin occurs independently of AMPK activation and

155 enes and tumor suppressors such as Ras, Myc, beta-catenin, p53, and APC.

156 Our findings indicate that BBR antagonizes beta-catenin pathway by inhibiting beta-catenin translat

157 C1q inhibitors blocked the beta-catenin pathway in both the expanding HPCs and the

158 as the unorthodox signal that activated the beta-catenin pathway in periportal HPCs and was responsi

159 demonstrate that C1q- mediated activation of beta-catenin pathway in periportal HPCs is a previously

160 43-GJIC influences the expression of the Smp/beta-catenin pathway in the lateral skeletal precursor c

161 Thus, obesity and WNT/beta-Catenin pathway seem to be independent in African A

162 as a transcriptional co-activator of the Wnt/beta-catenin pathway, which plays critical roles in CRC

163 vide a mechanism for efficient inhibition of beta-catenin phosphorylation upon Axin recruitment to th

164 ly viral protein E4orf1 sufficient to induce beta-catenin phosphorylation.

165 3beta phosphorylation and increased level of beta-catenin phosphorylation.

166 gh protein complexes comprising relatives of beta-catenin (plakoglobin) and p120 catenin (plakophilin

167 These results shift the paradigm from Wnt/beta-catenin primarily as an activator of transcription

168 As acetylated beta-catenin promotes mesodermal rather than neural fate

169 uncover a new pathogenic mechanism by which beta-catenin promotes podocyte injury and proteinuria in

170 -associated histone H3K9 by interacting with beta-catenin, promoting HP1gamma removal and transcripti

171 beta-catenin rather participated to the regulation of NF

172 ibitor cycloheximide antagonized BBR-induced beta-catenin reduction, suggesting that BBR affects beta

173 ontribution of centrosomes to Wnt signaling, beta-catenin regulation, and posttranslational modificat

174 tal enhancers of the IrxB locus that promote beta-catenin-responsive ovary expression.

175 educed ability to promote phosphorylation of beta-catenin, resulting in enhanced Wnt signaling.

176 nchymal transition (CDH1, SNAI2, TWIST1, and beta catenin); ruxolitinib blocked these effects.

177 at the apoptosis mechanism is deregulated in beta-catenin S45F mutants, resulting in decreased induct

178 in the inhibition of apoptosis found in the beta-catenin S45F mutants.

179 Inhibiting OTULIN or Wnt/beta-catenin sensitizes triple-negative breast cancer xe

180 Myc and beta-catenin show a strong cooperative action in liver c

181 Wnt/beta-catenin signaling achieves this in part by increasi

182 Wnt/beta-catenin signaling activates the transcription of ta

183 Pharmacological stimulation of Wnt/beta-catenin signaling activity by small-molecule GSK-3

184 and to define the mediators of activated Wnt/beta-catenin signaling after hyperoxia injury.Methods: T

185 apeutics have been shown to activate the Wnt/beta-catenin signaling although the underlying mechanism

186 vestigated the crosstalk between BCR and WNT/beta-catenin signaling and analyzed their impact on cell

187 ganoids was facilitated through elevated Wnt/beta-catenin signaling and greater intestinal stem cell

188 al coactivators known to be activated by WNT/beta-catenin signaling and to cooperate with MYC in mito

189 owed increased cell surface Frizzled and Wnt/beta-catenin signaling and were responsive to porcupine

190 Thus, canonical Wnt/beta-catenin signaling appears to be principally reliant

191 We identified Fzd7/beta-catenin signaling as new regulator of pathological

192 These findings identify the Wnt-KDM4C-beta-catenin signaling axis as a critical mechanism for

193 reaching picomolar IC(50) inhibition in WNT/beta-catenin signaling cellular reporter assay.

194 Inhibition of beta-catenin signaling compromised activation of the eme

195 Finally, we demonstrated that Nodal and Wnt/beta-catenin signaling cooperate to promote the dorsal-s

196 anscription to a more nuanced view where Wnt/beta-catenin signaling drives both widespread gene repre

197 EVI)/Wntless-dependent manner, activated Wnt/beta-catenin signaling in 2D and 3D cell culture experim

198 roteins as mechanotransducers that fine-tune beta-catenin signaling in a manner dependent on the epit

199 F7L6 potently activates WNT/beta-catenin signaling in a manner similar to Wnt3a.

200 monstrated that RSPOs 2 and 3 potentiate WNT/beta-catenin signaling in cells lacking leucine-rich rep

201 tions identified a mechanism to regulate Wnt/beta-catenin signaling in cortical development.

202 t these phenotypes are not caused by reduced beta-catenin signaling in ECs, despite the close resembl

203 Norrin inhibited cell growth via beta-catenin signaling in GSCs that had low expression l

204 gnaling modulator Rspondin3, which activates beta-catenin signaling in lung interstitial macrophages

205 , we further identify a critical role of WNT/beta-catenin signaling in regulating human cortical neur

206 -spondin1 (RSPO1) mediated activation of WNT/beta-catenin signaling in XX gonads.

207 Activating beta-catenin signaling increased binding of Tcf4/beta-ca

208 ic targets for tumors having deregulated Wnt/beta-catenin signaling induced by this mutation.

209 beta-catenin signaling is aberrantly activated in differ

210 Wnt/beta-catenin signaling is essential for intestinal homeo

211 We show that the activation of Wnt/beta-catenin signaling is highly restricted to pulp cell

212 , we show that genotoxic agent-activated Wnt/beta-catenin signaling is independent of the FZD/LRP het

213 emonstrated that the spatial activity of Wnt/beta-catenin signaling is located in presumptive dorsal

214 e, and provided functional evidence that Wnt/beta-catenin signaling is necessary for the specificatio

215 Both positive and negative effects of Wnt/beta-catenin signaling on dentinogenesis have been repor

216 WNT/beta-Catenin signaling pathway has a potential to be use

217 The Wnt/beta-catenin signaling pathway has a well-described role

218 Our results uncover a role for the beta-catenin signaling pathway in fine tuning the granul

219 We also investigated the role of Wnt/beta-catenin signaling pathway in IL-1beta induced infla

220 The Wnt/beta-catenin signaling pathway is central to metazoan de

221 Dysregulation of the Wnt/beta-catenin signaling pathway is critically involved in

222 athogenesis likely via the modulation of Wnt/beta-catenin signaling pathway, a key signaling pathway

223 lvement of DOCK6-correlated genes in the WNT/beta-catenin signaling pathway.

224 ogene receptor tyrosine kinase (MET) and Wnt/beta-catenin signaling pathways has been observed in adv

225 as well as those associated with RAR and Wnt/beta-catenin signaling pathways.

226 These findings reveal that Wnt-KDM4C-beta-catenin signaling represents a novel mechanism for

227 Lastly, activation of Wnt/beta-catenin signaling skewed the profile of human and m

228 Activation of WNT/beta-catenin signaling strongly accelerated MYC-driven c

229 Our results expand the current model of Wnt/beta-catenin signaling such that in response to Wnt, the

230 n the extracellular domain hyperactivate Wnt/beta-catenin signaling through formation of inactive dim

231 These results suggest that FL3 inhibits Wnt/beta-catenin signaling via PHB1-dependent activation of

232 ays, demonstrated that the activation of WNT/beta-catenin signaling was compromised as a consequence

233 SPOs) with high affinity, and potentiate Wnt-beta-catenin signaling, presumably by the same mechanism

234 In Wnt/beta-catenin signaling, the transcriptional coactivator

235 sm whereby nuclear MET promotes aberrant Wnt/beta-catenin signaling-mediated prostate tumorigenesis.

236 carbamazepine can suppress FZD8-mediated Wnt/beta-catenin signaling.

237 to that caused by EC-specific reductions in beta-catenin signaling.

238 like protein modification, in inhibiting Wnt/beta-catenin signaling.

239 n increases its nuclear accumulation and Wnt/beta-catenin signaling.

240 in, which is a key mediator of canonical Wnt/beta-catenin signaling.

241 tures, as well as a greatly reduced level of beta-catenin signaling.

242 inflammation, DNA damage, and activation of beta-catenin signaling.

243 ance LRP6 phosphorylation and potentiate Wnt-beta-catenin signaling.

244 the Apc(Min/+) mouse model by inhibiting Wnt/beta-catenin signaling.

245 deficiency is associated with an increase in beta-catenin signaling.

246 ing intracellular crowding and elevating Wnt/beta-catenin signaling.

247 es and the ability of AM-ADSC to inhibit Wnt/beta-catenin signaling.

248 functionally redundant manner to permit WNT/beta-catenin signalling and their genetic deletion leads

249 During kidney development, WNT/beta-catenin signalling has to be tightly controlled to

250 Wnt/beta-catenin signalling thus has a dual role in promotin

251 us testis differentiation with canonical Wnt/beta-catenin signals paramount for promoting the ovary p

252 ole in cancer progression and may induce Wnt-beta-catenin signals that expand cancer stem cells.

253 Finally, the Myc/beta-catenin signature was enriched in a subset of human

254 filing, allowed the identification of a "Myc/beta-catenin signature," composed of a discrete set of M

255 A Wnt3a-beta-catenin-Sp5/8 pathway, which is active in the dorsa

256 l for translesion DNA synthesis, potentiates beta-catenin stability/activity by inducing proteasome-i

257 tors of epithelial morphogenesis enriched in beta-catenin-stabilized adrenals.

258 , or fibroblast-specific genetic ablation of beta-catenin strongly decreased the number of cancer-ass

259 In some cases, Sox17 and beta-catenin synergistically activate transcription appa

260 Disruption of the beta-catenin-TCF/LEF interaction resulted in the accumul

261 factor (dnTCF4) that specifically abrogates beta-catenin-TCF/LEF interaction.

262 ortantly, genetic and chemical inhibition of beta-catenin-TCF/LEF signaling in human CD34+ cells redu

263 whereas on other enhancers, Sox17 represses beta-catenin/Tcf-mediated transcription to spatially res

264 endocytosis, followed by the activation of a beta-catenin/TCF4-dependent partial epithelial-to-mesenc

265 associated with increased levels of nuclear beta-catenin, TCF7L2, JMJD6, and c-Myc in BETi-P/R sAML

266 ide significant associations pointing to wnt/beta-catenin, TGF-beta and sonic hedgehog pathways.

267 high-molecular-weight form of phosphorylated beta-catenin that is constitutively degraded in the abse

268 y rather unspecific genetic manipulations of beta-catenin that yielded contradictory results.

269 ecause FRZB is a Wnt antagonist, we assessed beta-catenin, the canonical transducer of Wnt signaling,

270 (Delta14/+) c-Cbl(+/-) crypts showed nuclear beta-catenin throughout the length of the crypts and up-

271 d blocks its interaction with phosphorylated beta-catenin to prevent degradation, leading to activate

272 by FZD7 expression and dependent on the FZD7-beta-catenin-Tp63-GPX4 pathway for survival.

273 prin upon its relaxation, thereby regulating beta-catenin transcription.

274 ddition, Zic1 could physically interact with beta-catenin/transcription factor 4 (TCF4) and disrupt t

275 creased GJA1 mRNA transcripts dependent upon beta-catenin transcriptional activity during Ad5 infecti

276 Knockout or knockdown of CK5 ablated beta-catenin transcriptional activity in response to pro

277 /EBP-alpha expression through suppression of beta-catenin transcriptional activity, and also through

278 as a candidate tissue-specific member of the beta-catenin transcriptional complex.

279 An inhibitor targeting beta-catenin transcriptional interactions hindered both

280 tagonizes beta-catenin pathway by inhibiting beta-catenin translation and mTOR activity and thereby r

281 tenin reduction, suggesting that BBR affects beta-catenin translation.

282 induced cell morphology changes, and induced beta-catenin translocation and GSK-3beta phosphorylation

283 d nuclear exclusion of FoxO1 and concomitant beta-catenin translocation to the nucleus, collectively

284 been characterized previously, in mediating beta-catenin-triggered WT1 inhibition.

285 RAD6B expression is induced by beta-catenin, triggering a positive feedback loop betwee

286 argeting HCCs that express mutated/activated beta-catenin variants that are currently undruggable.

287 beta-catenin was detected in all leukemic MCL samples an

288 was also improved, and the expression of Wnt/beta-catenin was elevated.

289 When beta-catenin was knocked down (KD) in KO for 2 weeks, he

290 Norrin signaling through beta-catenin was required for BRB restoration, but glyco

291 einase 3, the integrins beta6 and beta8, and beta-catenin) were significantly different in epithelial

292 OTULIN inhibits linear ubiquitination of beta-catenin, which attenuates its Lys48-linked ubiquiti

293 revealed that SOX10 directly interacts with beta-catenin, which is a key mediator of canonical Wnt/b

294 ct with and sequester a key pro-ovary factor beta-CATENIN, which may lead to up-regulation of testis-

295 on revealed an interaction between AnxA8 and beta-catenin, which was reduced in the presence of activ

296 e to inactivate Gsk3alpha/beta and stabilize beta-catenin while increasing the phosphatase activity o

297 e TAMs in GBM, indicating that targeting Wnt/beta-catenin-WISP1 signaling may effectively improve GBM

298 ociated with an induction of a 48-kDa active beta-catenin with a preserved hypophosphorylated N-termi

299 Disruption of colocalization of nuclear beta-catenin with TBL1 and TCF7L2 by the small-molecule

300 c pathways in MPNST cells, including the Wnt/beta-catenin, YAP/TAZ, RB/E2F, and BET pathways, which c