ライフサイエンスコーパス: beta-myosin

1 old greater for rat beta-myosin than for pig beta-myosin.

2 leavage rates were nearly 30% faster for rat beta-myosin.

3 n, almost twice the velocities observed with beta-myosin.

4 erved in hearts expressing approximately 70% beta-myosin.

5 on was approximately 3.8-fold faster for rat beta-myosin (135 s(-)(1)) than for pig beta-myosin (35 s

6 r rat beta-myosin (135 s(-)(1)) than for pig beta-myosin (35 s(-)(1)).

7 s than slow myosins (MHC-II-1, also known as beta-myosin) and it has been well established that ADP b

8 developmental myosins but minimal effects in beta myosin, and magnitude of changes correlated partial

9 e MYH7 (beta-myosin heavy chain) and MYBPC3 (beta-myosin-binding protein C).

10 -sliding velocity of alpha-myosin by 20% and beta-myosin by 36% compared with their respective non-ac

11 sliding velocity of alpha-myosin by 20% and beta-myosin by 36%, compared to their respective non-ace

12 alphaalpha-tropomyosin, and masseter muscle beta-myosin complexes; masseter myosin, which shares seq

13 alcium-independent positive inotropy in slow beta-myosin-dominant rabbit and human failing ventricula

14 ons within the coiled-coil rod region of the beta-myosin gene (MYH7) are the predominant mutations ca

15 C1 1-37) and the short loop of human cardiac beta-myosin (hcM398-414) have been shown to interact wit

16 In adult skeletal muscle, beta myosin heavy chain (betaMyHC) gene expression is pr

17 Missense variants in the MYH7-encoded MYH7 (beta myosin heavy chain 7) represent a leading cause of

18 transgenic mice further exhibited decreased beta myosin heavy chain expression compared to age match

19 displayed cardiac hypertrophy and increased beta myosin heavy chain expression.

20 mechanism of regulation of cardiac alpha and beta myosin heavy chain gene by naturally occurring anti

21 psilonRACK resulted in selectively increased beta myosin heavy chain gene expression and normally fun

22 re abnormal in comparison with the alpha and beta myosin heavy chain knockdowns and controls.

23 3beta [GSK3beta], a 20-fold up-regulation of beta myosin heavy chain RNA and elevated G(s)alpha/G(i)a

24 in, we report the expression of an antisense beta myosin heavy chain RNA in the normal rodent myocard

25 genes coding for atrial natriuretic peptide, beta myosin heavy chain, medium chain acyl-CoA dehydroge

26 t 8 contractile protein genes, most commonly beta myosin heavy chain, myosin binding protein C, and c

27 tification of a mutation in the MYH7-encoded beta myosin heavy chain.

28 ch encodes the sarcomeric protein (beta-MHC [beta myosin heavy chain]) expressed in cardiac and skele

29 other structural proteins, such as alpha and beta myosin heavy chains and cardiac alpha actin, play c

30 nt with decreased alpha myosin and increased beta myosin heavy chains, suggesting an alpha-to-beta co

31 naturietic factor ( approximately 55-fold), beta-myosin heavy chain ( approximately 8-fold), and alp

32 performed in a genotyped HCM population with beta-myosin heavy chain (beta -MHC) mutations.

33 se chain reaction was conducted to coamplify beta-myosin heavy chain (beta-MHC) and alpha-skeletal ac

34 the fetal program of skeletal alpha-actin or beta-myosin heavy chain (beta-MHC) gene expression.

35 Reexpression of the fetally expressed beta-myosin heavy chain (beta-MHC) gene is a well docume

36 l post-translational modifications (PTMs) on beta-myosin heavy chain (beta-MHC) in normal and failing

37 a4fl/fl) were crossed with mice containing a beta-myosin heavy chain (beta-MHC) or alpha-MHC promoter

38 ected reporter gene driven by 3542 bp of rat beta-myosin heavy chain (beta-MHC) promoter was increase

39 ese include atrial natriuretic factor (ANF), beta-myosin heavy chain (beta-MHC), and skeletal muscle

40 dium results in enhanced expression of fetal beta-myosin heavy chain (beta-MyHC) and reduced expressi

41 ) is the R403Q mutation in the gene encoding beta-myosin heavy chain (beta-MyHC).

42 gene profile was observed, ie, expression of beta-myosin heavy chain (betaMHC), atrial/brain natriure

43 and reactivates many fetal genes, including beta-myosin heavy chain (betaMyHC) and skeletal alpha-ac

44 To examine the role of the beta-myosin heavy chain (betaMyHC) distal muscle CAT (MC

45 In adult mouse skeletal muscle, beta-myosin heavy chain (betaMyHC) gene expression is pr

46 In adult mouse skeletal muscle, beta-myosin heavy chain (betaMyHC) gene expression is pr

47 er type transition concurrent with decreased beta-myosin heavy chain (betaMyHC) gene expression.

48 genic analyses revealed that a 600-base pair beta-myosin heavy chain (betaMyHC) promoter conferred me

49 The other is the endogenous beta-myosin heavy chain (bMHC) gene modified to code for

50 n SMC alpha-actin (encoded by ACTA2) and the beta-myosin heavy chain (encoded by MYH11).

51 n (CHIP), increased SRF activity, as well as beta-myosin heavy chain (MHC) and myocardin expressions.

52 point mutation at residue 403 (R403Q) in the beta-myosin heavy chain (MHC) caused a severe form of FH

53 heart contains two cardiac myosin isoforms: beta-myosin heavy chain (MHC) is found predominantly in

54 TPase (SERCA), phospholamban, and alpha- and beta-myosin heavy chain (MHC) proteins were assayed in h

55 The R403Q mutation in the beta-myosin heavy chain (MHC) was the first mutation to

56 CM-associated pathogenic variants in cardiac beta-myosin heavy chain (MYH7) and titin (TTN) can impai

57 pathy, DCM) associated with mutations in the beta-myosin heavy chain (MYH7) gene product (Myosin-7).

58 The most commonly affected is beta-myosin heavy chain (MYH7), where missense mutations

59 nd R719W) as highly malignant defects in the beta-myosin heavy chain (MYH7).

60 2S, G256E, F513C, V606M, R719Q, and L908V of beta-myosin heavy chain (MYH7); S179F of troponin T (TNN

61 (TH)-responsive genes, including alpha- and beta-myosin heavy chain (MyHC) and sarcoplasmic reticulu

62 HCM caused by a common point mutation in the beta-myosin heavy chain (MyHC) gene, R400Q.

63 tor (RAR) controlled by either the alpha- or beta-myosin heavy chain (MyHC) promoter were generated.

64 ), alpha-skeletal muscle actin (p<0.05), and beta-myosin heavy chain (p<0.05) were observed in AC6-KO

65 on of the slow molecular motor of the heart (beta-myosin heavy chain [MyHC]) is well known to occur i

66 d expression of hypertrophic markers BNP and beta-myosin heavy chain accompanied adult-onset cardiac

67 the use of a green fluorescent protein or a beta-myosin heavy chain adenovirus.

68 ith mild hypertrophy, elevated expression of beta-myosin heavy chain and alpha-skeletal actin genes,

69 sed by 28%, and upregulation of the mRNA for beta-myosin heavy chain and alpha-skeletal actin was obs

70 The expression of beta-myosin heavy chain and ANF mRNA was greater in male

71 wever, adult transgenic ventricles expressed beta-myosin heavy chain and atrial natriuretic factor.

72 enes associated with pathologic hypertrophy (beta-myosin heavy chain and atrial natriuretic peptide)

73 Both soleus beta-myosin heavy chain and cytochrome C oxidase express

74 ic response is increased cellular content of beta-myosin heavy chain and cytochrome oxidase subunit V

75 riuretic peptide, brain natriuretic peptide, beta-myosin heavy chain and myosin light chain (2- to 5-

76 MYH7 and MYBPC3, encoding beta-myosin heavy chain and myosin-binding protein C, re

77 Hypertrophic marker genes, including the beta-myosin heavy chain and transforming growth factor-b

78 Mutations in the MYH7 gene encoding for the beta-myosin heavy chain are the underlying genetic cause

79 Also, alpha- and beta-myosin heavy chain expression is modified in respon

80 enhancer factor 2C), and down-regulation of beta-myosin heavy chain expression, a key determinant of

81 ban:SERCA2 (>/=2.6:1) exhibited increases in beta-myosin heavy chain expression, associated with card

82 to determine the prevalence and phenotype of beta-myosin heavy chain gene MYH7 mutations in a large c

83 e been linked with missense mutations in the beta-myosin heavy chain gene.

84 ickness and a selective up-regulation of the beta-myosin heavy chain gene.

85 nergic signaling, the aberrant expression of beta-myosin heavy chain in adult Gsalpha-DF but not cont

86 sarcomeric reorganization, and expression of beta-myosin heavy chain in myocytes with IC(50) values o

87 , 5.11; theta=0), where the gene for cardiac beta-myosin heavy chain is encoded.

88 ated with preserved expression of alpha- and beta-myosin heavy chain isoforms and sarcoplasmic reticu

89 Comparison of mammalian cardiac alpha- and beta-myosin heavy chain isoforms reveals 93% identity.

90 tures and containing predominately alpha- or beta-myosin heavy chain isoforms were found to be consis

91 r (ANF), and altered expression of alpha and beta-myosin heavy chain isoforms.

92 [AT(1)R]), p47(phox) NADPH oxidase subunit, beta-myosin heavy chain isozyme switch, accumulation of

93 Ca2+ sensitivity, a significant increase in beta-myosin heavy chain mRNA and protein, normal cardiac

94 expression of skeletal alpha-actin mRNA and beta-myosin heavy chain mRNA at 5 days, but it did not a

95 weight ratio, atrial natriuretic factor and beta-myosin heavy chain mRNA expression, myocyte area, a

96 ha-myosin heavy chain mRNA and a decrease in beta-myosin heavy chain mRNA.

97 st, there was no relationship between either beta-myosin heavy chain or cytochrome C oxidase expressi

98 binding by E1A, relieved E1A's repression of beta-myosin heavy chain promoter activity while having n

99 Embryos that express tbx5 driven by a beta-myosin heavy chain promoter throughout the primitiv

100 expressing one such allele, I183P, under the beta-myosin heavy chain promoter.

101 roteins decreased the activity of alpha- and beta-myosin heavy chain promoters to nearly the same ext

102 ansfected reporter genes driven by alpha- or beta-myosin heavy chain promoters was markedly diminishe

103 Overexpression of the beta-myosin heavy chain protein contributes to the patho

104 Moreover, an increased amount of beta-myosin heavy chain protein was found in hearts from

105 hypothesis, we screened 30 5- to 6-month-old beta-myosin heavy chain Q403 transgenic rabbits by echoc

106 al remodeling, including decreased alpha- to beta-myosin heavy chain ratios, and induced maladaptive

107 oponin T (TnT) and missense mutations in the beta-myosin heavy chain share abnormalities in common, a

108 However, the alpha- to beta-myosin heavy chain switch did not occur in Ang II-t

109 nsforming the disorder from a disease of the beta-myosin heavy chain to a disease of the cardiac sarc

110 t induction of atrial natriuretic factor and beta-myosin heavy chain transcripts, interstitial fibros

111 ed by the treatment, whereas upregulation of beta-myosin heavy chain was not reversed.

112 in hypothyroidism, whereas phospholamban and beta-myosin heavy chain were increased.

113 tic factor, alpha-skeletal muscle actin, and beta-myosin heavy chain) and collagens were observed bet

114 ryonic genes (atrial natriuretic peptide and beta-myosin heavy chain) and elevated nuclear factor kap

115 hypertrophic cardiomyopathy (HCM) are MYH7 (beta-myosin heavy chain) and MYBPC3 (beta-myosin-binding

116 brain natriuretic peptides, skeletal actin, beta-myosin heavy chain), and fibrosis (collagen III), a

117 MYBPC3 (myosin-binding protein C3) and MYH7 (beta-myosin heavy chain), are indistinguishable at prese

118 trophy (atrial natriuretic factor, CARP, and beta-myosin heavy chain), uncoupling protein 2 (UCP2), a

119 genes (GRK2, atrial natriuretic factor, and beta-myosin heavy chain).

120 trophy markers atrial natriuretic factor and beta-myosin heavy chain).

121 an increase in NFAT-dependent expression of beta-myosin heavy chain, a sensitive marker for patholog

122 istry revealed de novo expression of desmin, beta-myosin heavy chain, alpha-actinin, cardiac troponin

123 n genes including atrial natriuretic factor, beta-myosin heavy chain, and alpha-skeletal actin.

124 TA-4, atrial natriuretic peptide, alpha- and beta-myosin heavy chain, and cardiac troponin T) by day

125 ism, electrical stimulation increased c-fos, beta-myosin heavy chain, and Cyt c promoter activities.

126 n, connexin 43, myosin light chain 2a, alpha/beta-myosin heavy chain, and troponin I.

127 s using muscle-specific promoters, alpha- or beta-myosin heavy chain, are partially rescued.

128 A mutation in the cardiac beta-myosin heavy chain, Arg403Gln (R403Q), causes a sev

129 of pathological hypertrophy like: alpha- and beta-myosin heavy chain, atrial natriuretic factor, phos

130 tion demonstrated an increased expression of beta-myosin heavy chain, brain natriuretic peptide, and

131 s in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen syntha

132 expressed expected cardiac markers including beta-myosin heavy chain, myosin light chain 2v, and atri

133 -response genes (e.g., alpha-skeletal actin, beta-myosin heavy chain, natriuretic peptides) were simi

134 ) levels of atrial natriuretic factor (ANF), beta-myosin heavy chain, sarcoplasmic reticulum Ca2+-ade

135 tudy prompted a search of the genes encoding beta-myosin heavy chain, troponin T, troponin I, and alp

136 l (SMC)-specific isoforms of alpha-actin and beta-myosin heavy chain, two major components of the SMC

137 marker genes, atrial natriuretic factor and beta-myosin heavy chain, were not up-regulated in E33A-t

138 atriuretic factor, skeletal alpha-actin, and beta-myosin heavy chain, which in adult rat ventricle ar

139 performed in nontransgenic (n=24), wild-type beta-myosin heavy chain-arginine(403) (n=14), and mutant

140 ty with heart defects, whereas deletion with beta-myosin heavy chain-cre (betaMHC-cre) produced viabl

141 heavy chain-arginine(403) (n=14), and mutant beta-myosin heavy chain-glutamic acid(403) (n=24) transg

142 on and relaxation were reduced in the mutant beta-myosin heavy chain-glutamic acid(403) transgenic ra

143 hypoplasia and ventricular septal defects in beta-myosin heavy chain-miR-195 transgenic mice.

144 We randomized 24 beta-myosin heavy chain-Q(403) rabbits to treatment with

145 function, and reduced ERK1/2 activity in the beta-myosin heavy chain-Q(403) rabbits.

146 We tested this hypothesis in beta-myosin heavy chain-Q(403) transgenic rabbits.

147 rrhythmia in a transgenic (TG) rabbit model (beta-myosin heavy chain-Q403) of human hypertrophic card

148 myotrophin-induced mRNA levels of c-fos and beta-myosin heavy chain.

149 to 50-fold increase in steady state mRNA for beta-myosin heavy chain.

150 arkers such as atrial natriuretic factor and beta-myosin heavy chain.

151 retic factor, brain natriuretic peptide, and beta-myosin heavy chain.

152 stream effectors such as Jun, cyclin D1, and beta-myosin heavy chain.

153 the phenotype of those with mutations in the beta-myosin heavy chain.

154 igated the kinetic properties of rat and pig beta-myosin heavy chains (beta-MHC) in which we have fou

155 In the soleus muscle, mRNA for both beta-myosin heavy chains and cytochrome C oxidase III (n

156 tor (PDGF)-A and -B isoforms with alpha- and beta-myosin heavy chains as well as connexin43.

157 raction rate, surface area, or expression of beta-myosin heavy chains was significantly greater in AK

158 iac-specific genes, including the alpha- and beta-myosin heavy chains, skeletal alpha-actin, and brai

159 e tested whether patients with HCM caused by beta-myosin heavy-chain (beta-MHC) gene mutations exhibi

160 Mutations in the beta-myosin heavy-chain (betaMyHC) gene cause hypertroph

161 n the sarcoplasmic reticulum, and alpha- and beta-myosin heavy-chain isoforms) and of genes associate

162 Cardiac beta-myosin heavy-chain missense mutations (Ser532Pro an

163 er shown to be affected (in 2005) by a novel beta-myosin heavy-chain mutation that caused HCM, after

164 METHODS AND We treated 2-year-old beta-myosin heavy-chain Q403 transgenic rabbits with est

165 vy chain, we observed high concentrations of beta-myosin in distinct areas such as at the tip of papi

166 Protein isoform analysis revealed that beta-myosin is predominantly expressed even at the earli

167 ed with increased relative expression of the beta-myosin isoform (25+/-6 versus 63+/-5%beta, CTRL ver

168 c hypertrophy, and alterations in alpha- and beta-myosin isoform expression.

169 alpha-Myosin and beta-myosin isoform mRNAs were affected by CAN, but alph

170 eavy chain alpha, cardiac myosin heavy chain beta, myosin light chain 1A, myosin light chain 1V and N

171 e to cysteine mutation in embryonic, but not beta, myosin may reduce pre-powerstroke lever arm primin

172 1208G>A (p.R403Q) pathogenic variant (PV) in beta-myosin (MYH7) is a common and well-studied PV that

173 A 112-residue segment of the beta-myosin S2 domain was subjected to constant-magnitud

174 ATPase activity was 2.9-fold greater for rat beta-myosin than for pig beta-myosin.

175 Cardiac beta-myosin variants cause hypertrophic (HCM) or dilated

176 ion of additional myosin genes (Myosin 1 and beta-Myosin) via the miR-499/Sox6 pathway.

177 ntrast, the only measured effect of R671C in beta myosin was a larger step size.

178 of alpha-myosin were exchanged for those of beta-myosin were expressed in vivo.

179 muscle-specific isoforms of alpha-actin and beta-myosin, which are known to cause familial TAAD when