ライフサイエンスコーパス: beta-position

1 esence of an extra oxygen substituent in the beta position.

2 , including those with hydrogen atoms in the beta position.

3 of that recorded for hydrolysis at the alpha-beta position.

4 he alpha position and 1.013 +/- 0.006 at the beta position.

5 he alpha position and 1.017 +/- 0.005 at the beta position.

6 leading to the delivery of the copper to the beta-position.

7 d N-heterocycles at either the alpha- or the beta-position.

8 ypically delivers a boron substituent at the beta-position.

9 ring a vinyl group at a chiral carbon at the beta-position.

10 he direct functionalization of amines in the beta-position.

11 cyano-substituted aryl rings at the carbonyl beta-position.

12 hydes bearing heteroatom substituents in the beta-position.

13 zines, they decrease the reactivities of the beta-position.

14 carbon-sulfur bond yielding a radical in the beta-position.

15 a single deuterium atom at the former enone beta-position.

16 onegative hetero- atoms (O, F, N, Cl) in the beta-position.

17 nfavorable delta(deltaH) when SiH3 is in the beta-position.

18 ontaining electron-withdrawing groups at the beta-position.

19 with analogues substituted at the alpha- and beta- position.

20 lkyl-substitution patterns at the alpha- and beta-positions.

21 thynyl]phenyl group at diametrically opposed beta-positions (2, 12).

22 pyrromethene (BODIPY) dyes formylated in the beta'-position (2b, 2c) have been treated with L-cystein

23 onor zinc-porphyrin (ZnP, donor(1)) to whose beta positions a secondary electron-donor ferrocene (Fc,

24 he (R)-phenyl vicinal diol via attack at the beta-position, albeit with significantly reduced efficie

25 When installed at the beta-position, aminomethyl substituents with amine pK(a)

26 Betidamino acids (a contraction of "beta" position and "amide") are N'-monoacylated (optiona

27 Betidamino acids (a contraction of "beta" position and "amide") are N'-monoacylated (optiona

28 noperoxidation of the carbonyl groups in the beta-positions and the transformation of the delta-carbo

29 vel, p-tolyl substituents at opposing (2,12) beta-positions, and the absence (H-BC) or presence (MeO-

30 s of analogs with substitutions at the 4 and beta positions are influenced by sequences distal to thi

31 ion or a tertiary carbon at the beta- and/or beta'-position are recalcitrant or have limited biodegra

32 erted pyrrole ring connected via alpha'- and beta-positions are described.

33 rporation of a single deuterium at the enone beta-position as an equimolar mixture of epimers, inferr

34 tuted Bodipy dyes with a boronic acid at the beta-position (BBB).

35 groups, which react with nucleophiles at the beta-position, BCB-Bpin reacts with a diverse set of het

36 ves as an electrophile being attacked at the beta-position by the amine nitrogen atom.

37 lled by the chiral peptide chain, and at the beta-position by using chiral allylic substrates.

38 h expressers migrated more slowly toward the beta position compared with the pre-beta-mobility of non

39 cts and transfers the 4 beta-proton to the 6 beta-position, contribute 10(4.7) and 10(5.6) to the rat

40 ary role in dictating orientation, but the V beta positions diverge widely.

41 ing stereocontrol elements at the alpha- and beta-positions exhibit variable and unpredictable select

42 mical strategy for site-selective tryptophan beta-position functionalization.

43 step, monolignols invariably couple at their beta-positions, generating chiral centers.

44 ficient route to pyrroles substituted in the beta-position has been achieved in four high yielding st

45 ion from the phosphotyrosyl (pTyr) mimetic's beta-position has previously been shown to enhance Grb2

46 stereomer (differing in configuration at the beta-position (i.e. its beta-epimer)) was produced only

47 s, overcoming their propensity to add to the beta position in the absence of a catalyst, but do so wi

48 15)N at the central (alpha) versus terminal (beta) position in nitrous oxide and serves as a robust i

49 results indicate that modification of the 3 beta-position in 1 and 2 maintains activity at the neuro

50 nes yields the pyrrolines substituted in the beta-position in excellent yields.

51 enzyme binds a single divalent cation at the beta-position in the active site via ligation to Glu-131

52 dyl variant quite dramatically, favoring the beta-position in the newly formed cyclopentenone ring.

53 as 2- and 3-thiophene and 2-furan favor the beta-position in the newly formed cyclopentenone ring.

54 amides 1-4 with variations at the alpha- and beta-positions in the gamma-turn.

55 ses conductance, whereas placing them at the beta-position increases conductance: for example, the C-

56 C-H bond; in this case, C-H addition at the beta-position is followed by beta-migration of the arylo

57 ed nucleophiles reacted with BCB-Bpin at the beta'-position leading to cyclopropanes with high trans-

58 l, annulation chemoselectively occurs at the beta position, leading to a range of aliphatic cyclic et

59 imary and secondary acetates bearing, at the beta'-position, linear or branched alkyl groups and aryl

60 erized hydrolysis of 8-oxo-dGTP at the alpha-beta position, MutT cleaves at the beta-gamma phosphate

61 lectron-withdrawing substituents at the heme beta-positions, nu(FeN) and nu(NO) become positively cor

62 mplexes possessing alkyl substituents at the beta-position occurred at rates that were similar to tho

63 Alkyl branching at the beta position of a polyketide intermediate is an importa

64 irect displacement of alkoxy groups from the beta position of aromatic and unsaturated esters and ket

65 nexpected vinylogous Michael addition at the beta position of isatylidene-malononitriles, followed by

66 A tertiary carbon at the beta position of ketone, however, led to complete revers

67 yl, fluoro, hydroxyl and amino groups at the beta position of the parent acid, thus providing a route

68 arylation of pyrazoles with allenes at the C-beta position of triple bond.

69 le to record (1)H dispersion profiles at the beta positions of Asx, Cys, Ser, His, Phe, Tyr, and Trp

70 sp(3) C-H functionalization at the alpha-and beta positions of cyclic amines to their corresponding 3

71 ately equal to 1.032 was observed at the C3 (beta) position of cyclohexenone, while a much smaller 12

72 philic attack of the iodonium ylide on the C(beta) position of the diphenylketene, followed by cycliz

73 all-carbon quaternary carbon centers at the beta-position of aliphatic acids.

74 erforms selective hydride insertion into the beta-position of alpha,beta-unsaturated carbonyl compoun

75 placement of an aryl/heteroaryl group at the beta-position of alpha-cyano aliphatic acids for the fir

76 e investigation of vinyl substitution at the beta-position of alpha-cycloalkyl-substituted glycines.

77 macrocycles that employ ring closure at the beta-position of key pTyr-mimicking residues.

78 ha-position and formation of C-O bond at the beta-position of styrenes was achieved under metal-free

79 ectivity upon hydrogen-alkyl exchange at the beta-position of the alkene.

80 However, substituents at the alpha- or beta-position of the alpha,beta-enal substrate are typic

81 s to enhance activity by modification of the beta-position of the beta-alanyl carboxylate group of 29

82 fferent arylsilanes with substitution at the beta-position of the enamide and functionalization on th

83 The presence of two fluorine atoms at the beta-position of the enamide moiety endows unique electr

84 Hydride abstraction from the beta-position of the enolato ligand of the previously re

85 at is, products derived from coupling at the beta-position of the enone.

86 Introduction of sulfur at the beta-position of the flexible alkyl chain reverses this

87 study, a polyamide with an acetamide at the beta-position of the gamma-turn resulted in animal morbi

88 troduced aryl or aralkyl substituents at the beta-position of the hydroxamate analogue of 2.

89 The introduction of a syn methyl at the beta-position of the lactone further improved chemical s

90 drug discovery campaign by building off the beta-position of the literature inhibitor ABH (1).

91 ected by a hexatriene linker at the meso- or beta-position of the macrocycle is not because of the in

92 deliver cytotoxic agents, conjugated to the beta-position of the Michael acceptor, via an addition-e

93 duction of a small methyl substituent at the beta-position of the N3 side-chain improved the GnRH bin

94 a transfer of hydride from the flavin to the beta-position of the olefinic bond, concomitant with or

95 talysts indicated that the acid group at the beta-position of the pyrrolidine ring of the catalyst pl

96 hydrogen appears to be transferred from the beta-position of the thiazole to the methyl group in the

97 3l, with deuterium exclusively at the former beta-position of the vinyl moiety.

98 rein, we report the functionalization of the beta-positions of deutero- and protoporphyrin IX dimethy

99 with varied substitutions at the alpha- and beta-positions of the acrylamide moiety.

100 high regioselectivity between the alpha- and beta-positions of the alkene unit.

101 oupling of activated aryl groups attached to beta-positions of the porphyrin ring provides convenient

102 wo steps: C-C bond homocouplings between the beta-positions of thiophenes and annelation between the

103 a methyl group on the side chain nitrogen ("beta" position) of the same analogues, with one of the d

104 ) groups specifically at the middle (sn-2 or beta) position on the glycerol backbone, and there is ev

105 As with a quaternary carbon at the alpha- or beta-position or a tertiary carbon at the beta- and/or b

106 ar N...S interaction, whereas linkage in the beta-position prevents intramolecular N...S interaction,

107 the C-H bond cleavage occurs directly at the beta position rather than at the alpha position followed

108 SiH3 substitution in the beta-position (relative to the sulfur atom) is found to

109 ly on natural amino acids, especially at the beta-position, remains challenging.

110 alkylation of carbonyl compounds at alpha & beta positions represents a significant challenge.

111 lls fluoro and aryl groups at the alpha- and beta-positions, respectively.

112 iral acyl hydride with a stereocenter at the beta-position reveal that ionization of the carbanion oc

113 he phenyl ring, the indole nitrogen, and the beta position show up to 40-fold potency differences for

114 At ambient temperature, racemization of the beta-position through a putative reversible Michael addi

115 ytic fragmentation of the substituent in the beta-position to generate the olefin cation radical (5).

116 Substrates with a tertiary carbon at the beta-position to the arene generated a carbocation inter

117 ectivity of the process is extended from the beta-position to the remote delta-position of the 2,4-di

118 he corresponding pyrroles substituted in the beta-position was achieved.

119 ones linked to the steroidal nucleus via the beta-position were more potent glucocorticoid agonists t

120 ubstituted with simple alkyl groups at the 3 beta-position were synthesized and found to be active in

121 a single regioisomer (o-xylyl groups in both beta-positions) while coupling of 1,3-dimethyl-5-(phenyl

122 enediynes that possess a carbonyl group in a beta position with respect to the one of acetylenic term

123 lic ketones, can be directly arylated at the beta-position with complete site-selectivity and excelle

124 Tryptamines disubstituted at the beta-position with fluorine have been synthesized as par

125 eneral and gives pyrroles substituted in the beta-position with linear and branched alkyl, benzyl, or

126 ctionalization for activating the tryptophan beta-position with nucleophiles.

127 evidence that 5-OH-CA cross couples (at its beta-position) with syringyl and guaiacyl units (at thei