ライフサイエンスコーパス: beta-strand

1 tor's binding loop (encompassing the contact beta-strand).

2 1) included in a "kink" followed by an extra beta strand.

3 cific mutation SY242CS, located in the third beta strand.

4 tein in the crystal lattice to form an extra beta-strand.

5 a disordered solvent-exposed amino-terminal beta-strand.

6 acting in an antiparallel fashion with a PDZ beta-strand.

7 uence-independent manner by inducing a short beta-strand.

8 resulting in a shortening of the C-terminal beta-strand.

9 posed of domains formed by alpha helices and beta strands.

10 led the LytTR domain, which mainly comprises beta strands.

11 he parallel/antiparallel organization of the beta strands.

12 boxylated agarose use a scaffold of unpaired beta-strands.

13 the peptide hydrogen bonded between parallel beta-strands.

14 n-like shape composed of mostly antiparallel beta-strands.

15 31 and 157, which increased the formation of beta-strands.

16 the orientation of residues in transmembrane beta-strands.

17 of only approximately 4.8 A between stacked beta-strands.

18 r by packing of their hydrophobic C-terminal beta-strands.

19 rils differ in intermolecular arrangement of beta-strands.

20 ace of hbeta2m containing the A, B, E, and D beta-strands.

21 consistent with the behavior of amphipathic beta-strands.

22 ty and two D-lysines to limit the lengths of beta-strands.

23 n partially solved and are made up mainly of beta-strands.

24 f intrinsically disordered domains (IDDs) or beta-strands.

25 Glu-79 and Glu-416 are located in beta-strands 1 and 12, respectively.

26 In the other orientation, beta-strands 1-3 and helix 2 on the opposite face of the

27 We identified substitutions in beta-strand-1 and C-terminal residues of yeast Rps5 that

28 Consistently, the beta-strand-1 substitution greatly destabilized the 'PIN

29 ation properties of split proteins involving beta-strands 10 and 11.

30 with both host proteins interacting with Vif beta-strand 2.

31 the cavity located between alpha-helix D and beta-strand 2A.

32 Ser(P)(279)to interact with the back face of beta-strand 3 (Tyr(286)is on the front face) and loop 2,

33 t coordination of Ser(P)(282)with the end of beta-strand 3 enables Ser(P)(279)to interact with the ba

34 putative dockerin-binding site, centered at beta-strands 3, 5, and 6, is likely to be conserved in o

35 local conformational changes in helix 2 and beta-strand 4, both of which are compromised to maintain

36 The Phe65-Phe71 pair spans beta-strands 4 and 5 in the beta-barrel, which lack inte

37 ng the N-terminal tail and a loop connecting beta-strands 4 and 5, consistent with interactions invol

38 lices 3 and 7 and the degree of structure in beta-strand 5.

39 red to as HPR motif) is also present between beta-strands 5 and 6 of TILs.

40 SAM-binding fold but the region linking core beta strands 6 and 7 (the 'beta6/7 linker') has a unique

41 RD not involved in carbohydrate recognition (beta-strands 7-9; residues approximately 200-220), formi

42 constrained into either a 310-helix (1-6) or beta-strand (7-9) conformation, with variable numbers of

43 8-9)FNI, demonstrated that binding occurs by beta-strand addition.

44 t beta-barrel made up of seven anti-parallel beta-strands along with two surrounding alpha-helices.

45 -cooperatively folded, with exchange between beta strands and helical conformations.

46 cal IgV-like topology including an extra "H" beta-strand and "clamping" disulfide, absent in known Ig

47 domain that interact with PCSK9, notably the beta-strand and a discontinuous short alpha-helix, and i

48 the linker connecting the helix to the first beta-strand and adjacent barrel residues.

49 d an in-depth analysis of the alpha-helix-to-beta-strand and beta-strand-to-alpha-helix transitions a

50 flexible disulfide-anchored loop to a rigid beta-strand and by traditional cystatin domain swapping.

51 racy, with a blind three-state (alpha-helix, beta-strand and coil) secondary structure prediction acc

52 s, while salt and alkali fractions contained beta-strand and coils.

53 lding leads to the exposure of a hydrophobic beta-strand and nucleates aggregation which results in p

54 tructure, which includes the relocation of a beta-strand and repositioning of the functionally import

55 lyroll domain B was inserted between the 7th beta-strand and the 7th alpha-helix of the catalytic dom

56 aining half were equally distributed between beta-strand and unordered chains.

57 allow the structural behavior of individual beta-strands and alpha-helices to be targeted selectivel

58 structure, which is formed by regular (i.e. beta-strands and alpha-helices) and non-periodic structu

59 monly depicted as simplistic combinations of beta-strands and alpha-helices, the actual properties an

60 hains of nonpolar residues stemming from the beta-strands and alpha-helices.

61 and C-terminal subdomain consisting of eight beta-strands and an alpha-helix that adopts a substantia

62 beta-barrel containing 19 membrane spanning beta-strands and an N-terminal alpha-helical region.

63 ng advantage of self-sorting between peptide beta-strands and hydrocarbon chains, we have demonstrate

64 e with alpha-helical domains on one side and beta-strands and loops on the other.

65 bular domain structure, consisting mostly of beta-strands and random coil with two small alpha-helice

66 eric medin comprising a stable core of three beta-strands and shorter more labile strands at the term

67 terfaces, one involving interactions of ABED beta-strands and the other involving GFCC'C'' beta-stran

68 are consistent with a mixture of beta-turn, beta-strand, and random-chain secondary elements in aque

69 widespread negative epistasis, especially in beta-strands, and a high frequency of negative sign epis

70 structure, formed from an elongated stack of beta-strands, and have a rigidity similar to that of sil

71 ed beta-barrel fold with mostly antiparallel beta-strands, and the loops extending out the beta-barre

72 ese experiments revealed that the N-terminal beta-strand-and, in particular, a single amino acid poly

73 n which the ATP-binding P-loop and adjoining beta strands are swapped between two chains in the dimer

74 acking interactions by which the constituent beta-strands are assembled hierarchically into protofila

75 ogen-bonded dimers are antiparallel, and the beta-strands are fully aligned, with residues 17-23 of o

76 e chemical shift assignments indicate that 4 beta-strands are present in the fibril's secondary struc

77 topological changes during fusion using the beta-strand as the fusogenic conformation.

78 y high susceptibility to cleavage (loops and beta strands) as well as regions that were entirely unaf

79 can be achieved to atomic-level accuracy by beta-strand assembly or through metal-mediated interacti

80 drogen-bonded residue pairs between adjacent beta-strands at an accuracy of approximately 70%.

81 eous lateral gate opening and sliding of the beta-strands at the gate interface for N. gonorrhoeae, i

82 B24) to a 60 degrees rotation of the B25-B28 beta-strand away from the hormone core to lie antiparall

83 able structures of VDAC proteins show a wide beta-stranded barrel pore, with its N-terminal alpha-hel

84 transfer structural motifs range from multi-beta-strand barrels, to beta-sheet cups and baskets cove

85 glutamine-based aggregates contain identical beta-strand-based cores.

86 cF) consists of an N-terminal domain of four beta-strands (beta1-beta4) connected by four alpha-helic

87 boxylate side chain at the tip of the second beta-strand (beta2-Asp/Glu).

88 However, mutations in beta strands beta5 and beta6 do not perturb G protein ac

89 a domain-swapped dimer in which the last two beta-strands (beta9 and beta10) are exchanged forming a

90 ded alpha-helix II and hairpin turns between beta-strands betaC-betaD and betaE-betaF as well as seve

91 84, Cys88, and Cys91 located after the first beta-strand bind a [4Fe-4S] cluster.

92 ibrillogenic hotspot located at the CDR1 and beta-strand C of the protein, which was confirmed by sca

93 HTH) motifs asymmetrically arranged around a beta-stranded channel, too narrow to accommodate DNA.

94 peats are semirigid even though they exhibit beta-strand character and the proline-rich domains under

95 dual substrate specificity within the seven beta-strand class of lysine-specific methyltransferases,

96 hese results give insight into split protein beta-strand complementation and enhance a distinct appro

97 By contrast, nine beta-strands comprise the fibrils formed from DeltaN6, i

98 ed-monomeric conformation and a more regular beta strand configuration in an excited-state dimer, as

99 tory alteration in switch I, which adopted a beta-strand configuration normally provided by the delet

100 ich the ligand main chain adopts an extended beta-strand conformation by interacting in an antiparall

101 ates that approximately 70 residues are in a beta-strand conformation in the fibril core.

102 The ability of the beta-strand conformation of the fusion peptide to genera

103 , which revealed that each molecule adopts a beta-strand conformation that stack together to form par

104 ture reveals that the peptide approximates a beta-strand conformation whose helical symmetry matches

105 due segment termed the stalk, which adopts a beta-strand conformation, instead of forming an alpha-he

106 and PHF6 hexapeptide motifs, the latter in a beta-strand conformation.

107 V1V2 antigens, suggesting recognition of the beta-strand conformation.

108 branes, the TMD changes significantly to the beta-strand conformation.

109 ions, our experiments show that the extended beta-strand conformational state of PHF6((*)) is readily

110 observed, indicating the coexistence of two beta-strand conformations.

111 g of two stacked beta-hairpins with opposing beta-strands connected by two parallel disulfide bonds,

112 ch repeat domain of PP32 is composed of five beta-strand-containing repeats anchored by terminal caps

113 ic and tetrameric oligomers that are rich in beta-strand content.

114 teinase-assisted removal of their N-terminal beta strand, creating an extended hydrophobic groove tha

115 amyloidogenic conditions (pH6.4-3.7), where beta-strand D and regions of the D-E and E-F loops were

116 ues from the N terminus, 40s turn, and third beta-strand (defined as beta-domain) is novel.

117 t (T142A) within the S/T region of the first beta strand delineates the kinetics of the interconversi

118 structure or changing from alpha helical to beta strand depending on the solvents and molecules adde

119 tion of hairpins connecting two antiparallel beta-strands determines overall folding.

120 Here we show that alpha helices and beta strands differ significantly in their ability to to

121 hich consists of a short alpha-helix and ten beta-strands distributed in three beta-sheets.

122 that rupture and re-insertion of individual beta-strands do not take place locally but require the S

123 two Ig-like domains followed by an elongated beta-stranded domain with a new fold.

124 its N-terminal alpha-helical and C-terminal beta-strand domains, respectively.

125 bilized by a core domain assembled from four beta strands donated by one VipA and two VipB molecules.

126 gh backbone-to-backbone interactions at open beta-strand edges, in a manner that resembles the inter-

127 ntiparallel arrangement of alpha-helices and beta-strands, enumerated all possible topologies formed

128 ive strategies for mimicking alpha-helix and beta-strand epitopes have been developed, producing valu

129 he other beta-sheet are limited to the outer beta-strand F, which packs against strand F' in the tetr

130 Here we identify beta-strands F and H as necessary for TTR aggregation.

131 ve substrates, which harbor mutations within beta-strands, fail to associate productively with the Ba

132 ty of amyloidogenic peptides to convert into beta-strands for their polymerization into amyloid fibri

133 the Protein Data Bank where alpha-helices or beta-strands form critical contacts.

134 d shape and showed a significant increase in beta-strand formation in the final tetramer unit relativ

135 esented here indicate that there is a second beta-strand formed by residues 11-24.

136 alpha-Strands and beta-strands formed in the initially unstructured N-term

137 he lipid-facing surface of the last two BamA beta-strands forms weaker, conformationally heterogeneou

138 ey Abeta self-recognition sites spanning the beta strands found in cross-beta protofibril structures,

139 tes dissociation of a noncovalently attached beta-strand from a circularly permuted split GFP, allowi

140 ted that detachment of the short, C-terminal beta-strand from the soluble fold exposes key amyloidoge

141 the hypothesis that increasing the number of beta-strands, from two to three, increases the stability

142 al residues of the Abeta subunit, indicating beta strand-g3p interactions.

143 parallel beta-sheets have swapped their last beta-strands giving a novel sheet topology which is an i

144 cess, however the analogous approach for the beta-strand has received less attention.

145 er induce or stabilize secondary structures (beta-strands, helices, reverse turns) in short peptide s

146 Using the same 12-aa beta-strand-hinge-alpha-helix domain, superantigens enga

147 nt upstream of the cleavage site as an extra beta-strand in a central beta-sheet.

148 n the DOPC/DOPG membrane, and is primarily a beta-strand in the DOPE membrane.

149 truncated GFP by substituting as a surrogate beta-strand in the groove vacated by the native strand.

150 However, the deletion of the last beta-strand in the NBD2 (i.e. N1419X) causes gating dysf

151 r of Abeta42 molecules, each containing four beta-strands in a S-shaped amyloid fold, and arranged in

152 into cruciform tetramers consisting of eight beta-strands in a two-layered assembly.

153 The identification of seven beta-strands in hbeta2m fibrils indicates that approxima

154 tation results in a deletion of the last two beta-strands in NBD2 and the whole C-terminal region, we

155 f NBD2 reveal the importance of the last two beta-strands in NBD2 for maintaining proper gating funct

156 e Sec61/SecY complex to translocate IDDs and beta-strands in the absence of alpha-helical domains.

157 learning approach (boctopus2) for predicting beta-strands in the barrel.

158 tenon' motifs are shown to join neighbouring beta-strands in the C-terminal barrel domain, and mutati

159 psin-like protease conformation in which two beta-strands in the core of the protease domain undergoe

160 inding, is a flexible loop that connects two beta-strands in the cytokine-binding domain (DII) of IL-

161 rn break crucial hydrogen-bonds bridging two beta-strands in the Greek key motifs at the "tyrosine co

162 from the presence of preformed amyloidogenic beta-strands in the native state.

163 bility mapping to identify several potential beta-strands in the Tom40 protein in isolated mitochondr

164 The precise location and length of beta-strands in the two fibril forms also differ.

165 rearrangement compared with the location of beta-strands in their native immunoglobulin folds.

166 We show that certain beta-strands in transthyretin tend to unfold and sample

167 al differences occur in loops connecting the beta-strands, in surface electrostatics used to dock the

168 ructure becomes more stable as the number of beta-strands increases, via comparisons among peptides d

169 We show that ACS202 CDRH3 forms a "beta strand" interaction with the exposed hydrophobic FP

170 en compensated for by increased intersubunit beta-strand interactions at the icosahedral 3-fold axes.

171 ing alpha-subdomain compaction, facilitating beta-strand intercalation, and optimizing translation ki

172 mbrane, but it is unclear whether it threads beta-strands into the lipid bilayer in a stepwise fashio

173 located in the GTPase domain on a conserved beta strand is part of an aromatic network in the core o

174 ctations, NMR data indicate that this second beta-strand is organized into a parallel beta-sheet desp

175 stinct, second conformation wherein the last beta-strand is retracted to extend the Ser65 loop and sh

176 with a parallel in-register organization of beta-strands is capable of seeding the conversion of ful

177 observed in a parallel orientation with the beta-strands, is a typical feature of type A CBMs, altho

178 Mutant constructs show that the beta-strand itself is not required for transcriptional a

179 hereas peptoid substitutions in the opposing beta-strands led to "chameleonic" species that were rigi

180 s that the C-terminal tail of STING adopts a beta-strand-like conformation and inserts into a groove

181 partially unfolded exchanging among multiple beta-strand-like conformations in solution.

182 We discuss the prominent role of beta-strand-like intermediates in flight toward the nati

183 beta-strand LK peptides with a periodicity of 2.0 induce

184 The loop region linking the beta-strands (loop 4) presents residue 24 in a configura

185 uent hairpin fragments and comparable-length beta-strand-loop-beta-strand models, indicate 2-state fo

186 tophan residues that stabilize a distinctive beta-strand:loop:PPII-helix topology.

187 (OM) beta-barrel proteins composed of 12-18 beta-strands mediate cellular entry of small molecules i

188 ily, which encompasses proteins with a seven-beta-strand methyltransferase domain.

189 pon the presence of Hpm1p, a candidate seven-beta-strand methyltransferase.

190 This domain is buried in the 6-beta-stranded MinE "closed" structure, but is liberated

191 otease accessibility studies, support the 19 beta-strand model for Tom40 with the C-terminal end of t

192 Theoretical calculations on beta-strand models analogous to 7, 8 and 9 provide furth

193 ments and comparable-length beta-strand-loop-beta-strand models, indicate 2-state folding for all top

194 The helix, turn, and beta-strand motifs of biopolymer folded structures have

195 osed of four structured domains, including a beta-stranded N-terminal domain.

196 2 site 2 TQC motif forms a uniquely extended beta-strand, not observed in other dynein light chain-ta

197 th an N-terminal segment preceding the first beta-strand occluding the lumen of the barrel.

198 The first alpha helix and beta strand of LF and EF unfold and dock into a deep amp

199 ntermolecular beta sheet with the N-terminal beta strands of arrestin.

200 de-bond crosslinking, we find that the first beta-strand of a laterally 'open' form of the BamA beta-

201 A chimaera S-peptide composed of the 10th beta-strand of GFP (s10) and a kinase substrate peptide

202 l, placed at the N-terminal end of the first beta-strand of Het-s fibrils, is significantly reduced i

203 and sfCherry11 are derived from the eleventh beta-strand of super-folder GFP and sfCherry, respective

204 lecular beta-sheet around a highly divergent beta-strand of the BTB domain.

205 x of the muscle endplate AChR is linked to a beta-strand of the extracellular domain that extends to

206 n linker immediately N-terminal to the first beta-strand of the PH domain.

207 ntiparallel orientation relative to the last beta-strand of the preceding subunit in the pilus.

208 ly heterogeneous interactions with the first beta-strand of the substrate that likely represent inter

209 forms a rigid interface with the C-terminal beta-strand of the substrate.

210 ions in WDR1 affecting distinct antiparallel beta-strands of Aip1 were identified in all patients.

211 When beta-strands of an amyloid are arranged parallel and in

212 etwork flips nearly 90 degrees , and the two beta-strands of each monomeric unit move apart, to give

213 selective loss of O-Man glycans on specific beta-strands of EC domains, suggesting that each isoenzy

214 de scan revealed that TamA and BamA bind the beta-strands of FimD, and do so selectively.

215 r structure but intercalates between the two beta-strands of the amyloid fibril and binds to hydropho

216 eta-barrel of BamA to induce movement of the beta-strands of the barrel and promote insertion of the

217 we identified a "latch" between the C and D beta-strands of the binding face as the source of the PD

218 e C-terminal helices or the three N-terminal beta-strands of the catalytic domain face the membrane.

219 These included Cys pairs on adjacent beta-strands of the N-domain (intra-N) and Cys pairs tha

220 highly conserved sites localized to specific beta-strands of their extracellular cdh (EC) domains.

221 nd F' in the tetramer, while the B, C, and E beta-strands of this sheet remain stable.

222 oop and to plasticity in accommodating extra beta-strands of variable length.

223 ns reveal that interactions between shearing beta-strands on the threaded and knotting loops provide

224 r interactions with MinD, giving rise to a 4-beta-stranded "open" structure through an unknown mechan

225 h at the C terminus, whereas the presence of beta-strands or only a short alpha-helical stretch leads

226 We corroborated this unexpected scheme for beta-strand organization using multiple two-dimensional

227 Ig-like fold encompassing seven antiparallel beta-strands organized in two beta-sheets, packed into a

228 atic interactions across non-hydrogen-bonded beta-strands outside the iLBPs, arguing for the generali

229 lical monomers are less stable than those of beta-strands, partially due to the lack of a consistent

230 s are also suggested to occur in coassembled beta-strand peptide systems.

231 rmation, in which the substrate binds atop a beta-strand platform in the 130's region.

232 hanges to Val(8) on the exterior side of the beta-strand, possibly through contacts to Lys(18) Thus G

233 te that strictly alternating arrangements of beta-strands predominate in coassembled CATCH structures

234 AP1, revealed an extension of the N-terminal beta-strand previously shown to cross between protomers

235 uite different characteristics: The swaps of beta-strands proceed via global unfolding, whereas the a

236 between the Met-129 and Val129 proteins, but beta-strand propensity was similar.

237 dified conformational ensemble typified by a beta-strand rearrangement.

238 egatively charged and is occupied by a short beta-strand, referred to as the intrinsic ligand, explai

239 escent protein (GFP), i.e., split GFP with a beta-strand removed, that were found to behave different

240 rvation of a continuous 20-residue elongated beta-strand (residues 39-58), the latter being a salient

241 ha-helices enwrapping a pair of antiparallel beta-strands (ribbon).

242 O binds to TRiC directly, mainly through its beta-strand rich, DNA-binding domain (AML-(1-175)), with

243 binding to TRiC mapped predominantly to the beta-strand rich, DNA-binding domain of Stat3.

244 X-ray scattering (SAXS) data show that this beta-strand-rich conformation converts the PE membrane t

245 tor, NDUFAF5, belongs to the family of seven-beta-strand S-adenosylmethionine-dependent methyltransfe

246 he results suggest that specific residues in beta strand S2 of FtsZ affect the conformational switch

247 by amino acid substitutions F37I and F37R in beta strand S2 of FtsZ.

248 esidues in the helices and on the surface of beta-strands S3, S9, and S10.

249 pic labels at I32, M35, G37, and V40 exhibit beta-strand secondary chemical shifts in 2-dimensional (

250 We present solid-state NMR measurements of beta-strand secondary structure and inter-strand organiz

251 hemical shifts for EmrE were consistent with beta-strand secondary structure for the loop connecting

252 s of labeled residues that are indicative of beta-strand secondary structure.

253 omains, which are each assembled from paired beta strands secured by disulfide bonds and grasp two si

254 pts a beta-helical architecture, in which 18 beta-strand segments are arranged in six consecutive win

255 h of BacA filaments, and the distribution of beta-strand segments identified by solid-state NMR, we p

256 drophobic residues located in the identified beta-strand segments suggest that bactofilin folding and

257 repeat unit comprising at least two extended beta-strands, separated by a turn stabilized by a Asp(25

258 ucture prediction programs predicted a short beta-strand separating two acidic domains.

259 cs experiments indicated that the N-terminal beta-strand shapes the broader ATG8 interactor profiles,

260 tations in the moving beta5 and neighbouring beta-strands shift the Ub/Ub-CR equilibrium.

261 d beta-barrel consisting of six antiparallel beta-strands similar to what was observed in the hepatit

262 We build upon our previous report of a beta-strand spanned by residues 30-42, which arranges in

263 topology formed by 2 sheets of antiparallel beta strands stabilized by the hallmark disulfide bond b

264 ystine knot structure, with two antiparallel beta-strands stabilized by three disulfide bridges.

265 ch causes a backbone twist in the N-terminal beta strand, stabilizing the monomeric form.

266 mog1p"-fold consisting of seven antiparallel beta strands stacked between alpha helices.

267 oligomers are characterized by a near random beta-strand stacking, leading to a distinct amorphous ph

268 llel heterodimeric coiled-coil motif for the beta-strand stalk in this antibody.

269 3 (CDR3H) that folds into a solvent-exposed beta-strand "stalk" fused to a disulfide crosslinked "kn

270 By modifying the beta-strand "stalk" of BLV1H12 with sequences derived fr

271 ed hairpin feature is its anti-parallel, two beta-strand stem, which we show by mutagenesis to be cri

272 ton are mediated by a drastic alpha-helix-to-beta-strand structural transition.

273 ttern of high and low SASA consistent with a beta strand structure.

274 domains display a similar three antiparallel beta-strand structure and interact with the same Cx43CT(

275 ETTA and MD simulations resulted in a unique beta-strand structure distinct from the conventional amy

276 Solid-state NMR demonstrated that beta-strand structure of the cross-linking domains domin

277 ely folded proteins with an all antiparallel beta-stranded structure.

278 tend to distances commensurate with extended beta-strand structures within the earliest stages of agg

279 yl group of the terminal adenosine towards a beta-strand, such that an aminoacylated tRNA at this pos

280 only loops but also rigid alpha-helixes and beta-strands, suggesting their involvement in allosteric

281 he isolated TrkAIg2 domain crystallizes as a beta-strand-swapped dimer in the absence of NGF, occludi

282 The N-terminal portions of HAP form a beta-strand that inserts between two IL-17A monomers whi

283 The Ana2 peptides form beta-strands that extend a central composite LC8 beta-sa

284 R) spectroscopy, we observe that the pair of beta-strands that mediate dimerisation partially unfold

285 result in the ordering of two anti-parallel beta-strands that protrude from each monomer and allowed

286 wo peptides is the type of beta-hairpins and beta-strands they populate.

287 ion into amyloid fibrils, they also use such beta-strands to stabilize the disrupted catalytic site r

288 ithin the N-terminal domain, which undergoes beta-strand-to-alpha-helix and alpha-helix-to-beta-stran

289 alysis of the alpha-helix-to-beta-strand and beta-strand-to-alpha-helix transitions and domain motion

290 structural features that included an unusual beta-strand topology, a number of extended loops and a p

291 eta-strand-to-alpha-helix and alpha-helix-to-beta-strand transitions during catalysis, interacts with

292 a-helical domains have to precede the IDD or beta-strands, whereas in mammalian cells, C-terminally l

293 point, causing the local formation of short beta-strands, which move the path of the chain by 120 de

294 lar oligomers have more parallel in-register beta-strands, which ultimately lead to amyloid fibrils,

295 nterfered with the interaction of a collagen beta-strand with the beta-sheet structure of Fn modules

296 ayers of beta-sheets possessing antiparallel beta-strands with each being anchored by a pair of cyste

297 eta-strands and the other involving GFCC'C'' beta-strands, with the former burying one prominent glyc

298 This destabilizes the beta-strands within the (beta/alpha)8-barrel domain and

299 ate antiparallel intermolecular alignment of beta-strands within the oligomers.

300 beta-Barrels are sheets of beta-strands wrapped into a cylinder, in which the first