ライフサイエンスコーパス: beta-tubulin

1 previously been shown to be associated with beta-tubulin.

2 ntra-HEAT loop residues to engage alpha- and beta-tubulin.

3 with a marked decrease in protein levels of beta-tubulin.

4 cribe a direct interaction between LRRK2 and beta-tubulin.

5 determined by lysine 362 and alanine 364 of beta-tubulin.

6 protein, identified by mass spectrometry as beta-tubulin.

7 the side chains of porcine brain alpha- and beta-tubulin.

8 lity of the protein to interact with RhoA or beta-tubulin.

9 eracting with the acidic C-terminal tails of beta-tubulin.

10 hat this enzyme hyperglutamylates alpha- and beta-tubulin.

11 showed hyperglutamylation of both alpha- and beta-tubulin.

12 ubiquitination and degradation of alpha- and beta-tubulin.

13 n-1 but decreased CRMP2 coprecipitation with beta-tubulin.

14 cetyltransferase San at lysine 252 (K252) of beta-tubulin.

15 tic protein we considered the active site of beta-tubulin.

16 molide binds to the taxane binding pocket in beta-tubulin.

17 I-tubulin represented 3.2% of the total HeLa beta-tubulin.

18 re utilized to probe the DDM binding mode in beta-tubulin.

19 ode to the longitudinal surface of alpha- or beta-tubulin.

20 positive for Thy-1, neurofilament H, and III beta-tubulin.

21 of approximately 200 kDa that also contained beta-tubulin.

22 ich targets a distinct, non-taxoid pocket on beta-tubulin.

23 protein, identified by mass spectrometry as beta-tubulin.

24 colocalization with the cytoskeleton marker beta-tubulin.

25 he purification of a novel trimer, TBCD*ARL2*beta-tubulin.

26 sed for epothilone A in the taxane pocket of beta-tubulin.

27 . elegansNdc80 complex binds more tightly to beta-tubulin.

28 o interact at the colchicine-binding site on beta-tubulin.

29 s may depend on the nature of the alpha- and beta-tubulins.

30 pe, core beta-tubulins and Y-type, divergent beta-tubulins.

31 nfiguration, where alpha-tubulins lie beside beta-tubulins.

32 ly in the T218A variant, compared with other beta-tubulins.

33 single cosegregating mutation (p.R2G) in the beta-tubulin 4a (TUBB4a) gene that was absent in a large

34 ther the mutation resided within the Tubb4a (beta-tubulin 4A) gene, because mutations in the TUBB4A g

35 o heterozygous mutations affecting Arg391 in beta-tubulin 4B isotype-encoding (TUBB4B).

36 gation system include alpha-tubulin (but not beta-tubulin), a dynein subunit (IC2), two signaling pro

37 PDCD5 formed a complex with CCT and beta-tubulin, a key CCT-folding substrate, and specifica

38 Like PDCD5, beta-tubulin also interacts with the CCTbeta apical doma

39 amyl side chains of porcine brain alpha- and beta-tubulin and also generated a form of alpha-tubulin

40 de the H12 helices of both alpha-tubulin and beta-tubulin and are significant for CLIP-170 activity.

41 pitation revealed that NKCC1 interacted with beta-tubulin and beta-actin in spinal cords.

42 -binding pocket is located on the surface of beta-tubulin and characterized by a hydrophobic floor, a

43 d show increased interaction with alpha- and beta-tubulin and HSP-70/HSP-90.

44 whereas Miro depletion destabilizes cortical beta-tubulin and increases divisions.

45 protein levels of class III neuron-specific beta-tubulin and microtubule-associated protein 2 were s

46 iptional up-regulation of cardiac alpha- and beta-tubulin and microtubule-stabilizing microtubule-ass

47 Immunostaining using antineuron-specific-beta-tubulin and monoclonal antibodies for KS, DS, and C

48 lide microtubule stabilizers covalently bind beta-tubulin and overcome clinically relevant taxane res

49 hetic peptides as well as soluble alpha- and beta-tubulin and paclitaxel-stabilized microtubules usin

50 The hyperglutamylation of alpha- and beta-tubulin and subsequent death of Purkinje cells in p

51 s behavior contrasts with that of alpha- and beta-tubulin and the bacterial tubulin-like proteins Btu

52 ional cell growth through phosphorylation of beta-tubulin and the resulting destabilization of cortic

53 ranscribed spacer region and portions of the beta-tubulin and translation elongation factor 1-alpha g

54 We identified four beta-tubulin and two alpha-tubulin mutations in patients

55 dTBCB) affects the levels of both alpha- and beta-tubulins and dramatically destabilizes the MT netwo

56 tubulin localizes at the interface of alpha-/beta-tubulins and interacts with the phosphate group of

57 a fundamental dichotomy between F-type, core beta-tubulins and Y-type, divergent beta-tubulins.

58 e the disordered anionic tails of alpha- and beta-tubulin, and a flexible cationic domain to bind the

59 als how TTL discriminates between alpha- and beta-tubulin, and between different post-translationally

60 bl's tyrosine kinase binding domain bound to beta-tubulin, and both c-Cbl and Cbl-b displaced HDAC6.

61 mon housekeeping genes, such as actin, alpha/beta-tubulin, and elongation factor 1-alpha.

62 (LSU, ITS1-2, and the genes encoding actin, beta-tubulin, and intein PRP8) revealed that this fungus

63 So far all such therapeutics target beta-tubulin, and structural biology has explained the b

64 hat CLIP-170 binds to both alpha-tubulin and beta-tubulin, and that binding is not limited to the aci

65 nal transcribed spacer region and 5.8S rRNA, beta-tubulin, and translation elongation factor coding g

66 ed HtrA1 associates with purified alpha- and beta-tubulins, and immunoprecipitation of endogenous Htr

67 ore beta-tubulins (plant-like) and divergent beta-tubulins (animal and fungal).

68 e immunostained with an anti-neuron-specific beta-tubulin antibody (TUJ1).

69 ith the myoepithelial cell, as visualized by beta-tubulin antibody, lining the acinar lumen in a web-

70 -translational modifications (PTMs) of alpha/beta-tubulin are believed to regulate interactions with

71 Mutations in alpha- and beta-tubulins are increasingly recognized as a major cau

72 the molecular level, in which the alpha- and beta-tubulins are separately processed in a chaperone-de

73 ssential for various cellular activities and beta-tubulins are the target of benzimidazole fungicides

74 rotubule (MT) protofilament reveals that the beta-tubulin Arg391 residue contributes to a binding poc

75 cs approach, we identified alpha tubulin and beta tubulin as proteins that interact with activated MA

76 ones and the Arl2 GTPase regulate alpha- and beta-tubulin assembly into heterodimers and maintain the

77 Immunostaining with neuronal (MAP2a and beta-tubulin), astrocyte (GFAP), and oligodendrocyte (CN

78 bulin monomer repeat, recognizing alpha- and beta-tubulin at both intra- and inter-tubulin dimer inte

79 ted that these compounds bind efficiently to beta-tubulin at the colchicine binding site.

80 The mutation is highly conserved in the beta-tubulin autoregulatory MREI (methionine-arginine-gl

81 ode of action as CA4P and bind reversibly to beta-tubulin, believed to be a key feature in avoiding t

82 ed spacer (ITS) region, and fragments of the beta-tubulin (BenA), calmodulin (CaM), and RNA polymeras

83 he sequence data show that the gene encoding beta-tubulin, benA, has high interspecies variability at

84 Beta-tubulin (beta-Tub) was used as a loading control to

85 roteins, including RhoA, dynamin-1, kinesin, beta-tubulin, beta-actin, oxysterol-binding protein (OSB

86 aralogs of alpha-tubulin (alpha1/alpha2) and beta-tubulin (beta1/beta2) genes but alpha2-tubulin gene

87 Evidence suggests that class III beta-tubulin (betaIII-tubulin) may represent a prognosti

88 nstability of mutant proteins, and defective beta-tubulin binding in a subset of the tested mutants.

89 uggest that PDCD5 sterically interferes with beta-tubulin binding to the CCTbeta apical domain and in

90 01 binds to the colchicine-binding domain on beta-tubulin, but in a novel orientation.

91 the low molecular neurofilament subunit and beta-tubulin, but very little for beta-actin, consistent

92 Centrosomes concentrate soluble alpha/beta tubulin by about 10-fold over the cytoplasm, reachi

93 ar pathway whereby direct phosphorylation of beta-tubulin by MNB inhibits tubulin polymerization, a f

94 High-resolution separation of alpha- and beta-tubulin by sodium dodecyl sulfate-polyacrylamide ge

95 Additional sequence analysis of beta-tubulin, calmodulin, minichromosome maintenance fac

96 or the cytoplasm of neuron-specific type III beta-tubulin(+) cells.

97 ast cancers, as modeled by MDA-MB-231 cells, beta-tubulin class III is a biomarker for cell survival

98 urthermore, decreased miR-200c and increased beta-tubulin class III were associated with poor outcome

99 exogenous miR-200c was also shown to reduce beta-tubulin class III, one of its predicted targets.

100 tified a low-energy binding model of the DCT/beta-tubulin complex (Pose-2/Conf-2) that is gratifyingl

101 stal structure of epothilone A with an alpha,beta-tubulin complex and for 2) a saturation transfer di

102 We conclude that the TBCD*ARL2*beta-tubulin complex represents a functional intermediat

103 cycle of tubulin by using a point mutant in beta-tubulin confers hyperstable microtubules at low tem

104 ed Ribbons contain acetylated alpha-tubulin, beta-tubulin, conserved protein Rib45, >95% of the axone

105 covalent interaction of AJ with a peptide of beta-tubulin containing the cyclostreptin-binding sites.

106 te that residue changes within the conserved beta tubulin core are largely responsible for the observ

107 chicine and TN-16, which both bind the alpha,beta-tubulin dimer.

108 entration, since they are required for alpha-beta-tubulin dimerization in vitro.

109 ules are built from linear polymers of alpha-beta tubulin dimers (protofilaments) that form a tubular

110 assembly-incompetent T2S complex (two alpha:beta tubulin dimers per molecule of stathmin), and by in

111 rictions associated with the co-evolution of beta-tubulin during the radiation of eukaryotes, underli

112 statically with one another and the tails of beta-tubulin, enabling septin-septin interactions that l

113 shed light on the binding of dictyostatin to beta-tubulin, establish a validated linker strategy for

114 Both alpha- and beta-tubulin exist as numerous isotypes, differing in th

115 Finally, alpha- and beta-tubulin expression is increased approximately 2.5-f

116 ysis identified one amino acid substitution--beta-tubulin F224--which was highly lineage specific.

117 represents a functional intermediate in the beta-tubulin folding pathway whose activity is regulated

118 gested a possible mechanism of inhibition of beta-tubulin folding.

119 ng to the CCTbeta apical domain and inhibits beta-tubulin folding.

120 ction at least in part through inhibition of beta-tubulin folding.

121 olding substrate, and specifically inhibited beta-tubulin folding.

122 ntage of cells expressing neuronal class III beta-tubulin following their differentiation in the pres

123 Investigation of beta-tubulin for other phylogenetically restricted amino

124 Alpha- and beta-tubulin form a heterodimer that polymerizes to form

125 ntibody, we identify a Cterminally truncated beta-tubulin form with the same -EEEG C-terminal sequenc

126 hese MSAs on photolabeling were distinct for beta-tubulin from different sources.

127 ified by amplification and sequencing of the beta- tubulin gene.

128 utations in the Caenorhabditis elegans mec-7/beta-tubulin gene cause ectopic axon formation in mechan

129 t intron sequences from members of the plant beta-tubulin gene family as a target for plant DNA ident

130 but differentially expressed members of the beta-tubulin gene superfamily have been investigated for

131 riants that affect adjacent amino acids in a beta-tubulin gene TUBB2A.

132 anscribed spacer (ITS) and a fragment of the beta-tubulin gene.

133 onsequence, genetic variations affecting all beta-tubulin genes expressed at high levels in the brain

134 ns in a number of neuron-specific alpha- and beta-tubulin genes have been identified in both lissence

135 s drive functional diversification of alpha-/beta-tubulin genes in different fungal lineages, and res

136 Phylogenetic analysis showed that alpha-/beta-tubulin genes underwent multiple independent duplic

137 e, we find an inverse correlation among five beta-tubulin genes whereby the more abundant macronuclea

138 he nuclear ribosomal RNA (nrRNA), actin, and beta-tubulin genes.

139 rgoes a conformational change in response to beta-tubulin GTP hydrolysis [2, 3].

140 impaired growth of microtubules formed with beta-tubulin harboring Cys239, but not beta(3) tubulin e

141 Cell lines expressing mutant beta-tubulin have also been reported to be resistant to

142 he multigene families that encode alpha- and beta-tubulins, have recently been implicated in these di

143 ), generated by polymerization of alpha- and beta-Tubulin hetero-dimers.

144 quired for the de novo assembly of the alpha/beta tubulin heterodimer.

145 t encode the structural component (the alpha/beta-tubulin heterodimer) can give rise to severe, spora

146 amino acids in diverse regions of the alpha-/beta-tubulin heterodimer, including the nucleotide bindi

147 interface and correct formation of the alpha/beta-tubulin heterodimer.

148 suggest a conformational change in the alpha/beta-tubulin heterodimer.

149 Microtubules are polymers composed of alpha-beta tubulin heterodimers that assemble into microtubule

150 scale their relationship from binding alpha-beta tubulin heterodimers to the larger proportions of m

151 appropriate amount of correctly folded alpha/beta-tubulin heterodimers is critical for microtubule dy

152 Cellular microtubules composed of alpha-beta-tubulin heterodimers that are essential for cell sh

153 ts that are dynamically assembled from alpha/beta-tubulin heterodimers.

154 ghly dynamic polymers composed of alpha- and beta-tubulin heterodimers.

155 l displacement that are assembled from alpha/beta-tubulin heterodimers.

156 BrdU/beta-tubulin/HNA/DAPI, BrdU/GFAP/HNA/DAPI, Ngn1/DAPI, an

157 lutathione s-transferase pi [GST-pi], Bcl 2, beta tubulin II [betaT-2], and HER2 neu) was evaluated b

158 s associated with differentiation, including beta-tubulin III (TuJ1) and TAG1.

159 neas were stained with mouse monoclonal anti-beta-Tubulin III antibody, and images were acquired to b

160 es, aberrant expression of the neural marker beta-tubulin III, and an overall reduction in numbers of

161 expression of neural markers neurofilament, beta-tubulin III, GFAP; or keratocyte-specific markers k

162 ing aberrant expression of the neural marker beta-tubulin III.

163 itive astrocytes; 2) SMI-311-, MAP2a/b-, and beta-tubulin(III)-positive neurons; and 3) galactocerebr

164 The beta-tubulin immunofluorescence analysis indicated that

165 grade labelings with Fluorogold (FG) and III beta-tubulin immunohistochemistry were compared.

166 e newly-generated cells differentiate into N-beta-tubulin-immunoreactive neurons.

167 on in corneal nerve density as detected with beta-tubulin immunoreactivity 2 hr after stimulation.

168 Cytosolic gamma-tubulin nucleates alpha- and beta-tubulin in a growing microtubule by forming the rin

169 y complex natural product acts by binding to beta-tubulin in assembled microtubules.

170 so unaffected by overexpression of class III beta-tubulin in HeLa transfected cells.

171 direct covalent binding of WA to Cys(303) of beta-tubulin in MCF-7 cells.

172 ualizing the spatial proximity of alpha- and beta-tubulin in microtubules using super-resolution dete

173 erved that PKCepsilon colocalizes with alpha/beta-tubulin in specific areas of the marginal tubular-c

174 However, expression of transgenic beta-tubulin in the larval brain leads to increased tubu

175 Instability of beta-tubulin in the mgr larval brain is less pronounced

176 co-purification of guanine nucleotide on the beta-tubulin in the trimer is also shown, with implicati

177 tively induce degradation of both alpha- and beta-tubulins in a variety of human cancer cell lines in

178 tally confirmed functional divergence of two beta-tubulins in Fusarium and identified type II variati

179 Together our results suggest that MEC-7/beta-tubulin integrity is necessary for the correct numb

180 site Thr166 promoted incorporation of mutant beta-tubulin into microtubules.

181 The specificity of taccalonolide binding to beta-tubulin is demonstrated by immunoblotting, which al

182 5C and polymerized TUBB3, the highly dynamic beta-tubulin isoform in neurons, is essential for netrin

183 Furthermore, transcripts of several beta-tubulin isoforms were increased in the Rassf1a-defi

184 However, by shifting the profile of beta-tubulin isoforms, cancer cells become resistant to

185 LRRK2 selectively interacts with three beta-tubulin isoforms: TUBB, TUBB4, and TUBB6, one of wh

186 e that encodes the neuronal-specific protein beta-tubulin isotype 3, can cause isolated or syndromic

187 ted to know whether changes in ZEB1 parallel beta-tubulin isotype changes, implicating beta-tubulin i

188 ive feedback regulation of mRNA for ZEB1 and beta-tubulin isotype classes I, III, and IVB in MDA-MB-2

189 ZEB1 silencing also reduced beta-tubulin isotype classes I, III, and IVB mRNA, where

190 ubulin from different sources, with distinct beta-tubulin isotype content, were specifically photolab

191 d the identity and relative quantity of each beta-tubulin isotype determined.

192 cterize tubulin heterodimers that have human beta-tubulin isotype III (TUBB3), as well as heterodimer

193 tions in TUBB3, encoding the neuron-specific beta-tubulin isotype III, result in a spectrum of human

194 ions in TUBB3, which encodes neuron-specific beta-tubulin isotype III.

195 It is the major beta-tubulin isotype of hematopoietic tissue and forms t

196 In conclusion, modulation of a beta-tubulin isotype plays a role in muscle differentiat

197 ng microtubule plus ends, and TUBB encodes a beta-tubulin isotype that is expressed abundantly in the

198 hat paclitaxel-induced reduction of ZEB1 and beta-tubulin isotypes are, in part, due to increased act

199 vious studies, these findings highlight that beta-tubulin isotypes function in both conserved and div

200 Altered expression of beta-tubulin isotypes has been reported in cancer cell l

201 We have examined the distribution of beta-tubulin isotypes in mouse primary cultured cortical

202 el beta-tubulin isotype changes, implicating beta-tubulin isotypes in ZEB1-associated cell survival p

203 There are seven beta-tubulin isotypes present in distinct quantities in

204 n the kinesin motor protein KIF21A or in the beta-tubulin isotypes TUBB3 or TUBB2B.

205 It was found that compared with other beta-tubulin isotypes, betaIII-tubulin bound the least a

206 exact amount of drug that binds to different beta-tubulin isotypes, bovine brain tubulin was photolab

207 espite the high degree of conservation among beta-tubulin isotypes, mutations affecting residue 365 d

208 The regulation of beta-tubulin isotypes, the primary targets for antimitot

209 standard peptides for quantification of the beta-tubulin isotypes.

210 ides represent residues 274-281 in different beta-tubulin isotypes.

211 indicated that the latter may bind at alpha-beta tubulin junction in a protofilament at sites distin

212 Reactivity to 4 antigens, vimentin, beta-tubulin, lamin A/C, and apolipoprotein L2, was sign

213 iated by interaction with the taxane site of beta-tubulin, leading to microtubule stabilization and c

214 function resulted in decreased soluble alpha/beta-tubulin levels and accelerated microtubule polymeri

215 C2, including simultaneous quantification of beta-tubulin levels to control for loading error.

216 site for Taxol is in a hydrophobic pocket in beta-tubulin, little was known about the effects of this

217 K252 of beta-tubulin localizes at the interface of alpha-/beta-t

218 Strong selective sweeps surrounding the beta-tubulin locus, a target of benzimidazole anthelmint

219 l markers (nestin, neuron-specific class III beta-tubulin, Map2 a/b, and neurofilament), and photorec

220 tion of the possible disruption of the alpha,beta-tubulin-microtubule and/or G-actin-F-actin equilibr

221 ipitation experiments demonstrated that Cx43-beta-tubulin molecular interaction was depleted due to p

222 t heterodimer composed of one alpha- and one beta-tubulin monomer.

223 s to contribute to the sorting of alpha- and beta-tubulin monomers that associate following tubulin f

224 Surprisingly, a beta-tubulin mutant that dramatically slows disassembly

225 B3), as well as heterodimers with one of two beta-tubulin mutations (D417H or R262H).

226 ion was not inhibited in cells with acquired beta-tubulin mutations that prevent taxane-induced micro

227 Among beta-tubulin mutations, only those in TUBB3 have been sh

228 Analysis of the sequences of beta-tubulin near the Taxol binding site indicated that,

229 To understand why, we analysed the beta-tubulin Neighbor-Net and demonstrated a fundamental

230 to the acidic C-terminal tails of alpha- and beta-tubulin on the microtubule surface.

231 antibodies to the cytosol by employing anti-beta-tubulin or anti-nuclear pore complex antibody as ca

232 in through episomal expression of alpha- and beta-tubulin or introduction of a brief pulse of the mic

233 ese microtubules by loss of either the MEC-7 beta-tubulin or MEC-12 alpha-tubulin or by growth in 1 m

234 these microtubules (loss of either the MEC-7 beta-tubulin or MEC-12 alpha-tubulin or growth in 1 mM c

235 ting from altered alpha-tubulin or class III beta-tubulin overexpression.

236 Comparative analyses of all loci, including beta-tubulin paralogs, indicate a lack of recombination

237 e autoregulatory capability of the wild-type beta-tubulin peptide, affirming the role of the cytoskel

238 photoprobe led to the identification of the beta-tubulin peptides TARGSQQY and TSRGSQQY as targets o

239 nstrated a fundamental division between core beta-tubulins (plant-like) and divergent beta-tubulins (

240 Class III beta-tubulin plays a prominent role in the development o

241 95% of Rbpms-positive cells were FG- and III beta-tubulin-positive after injury caused by optic nerve

242 d to the core beta-tubulins, while divergent beta-tubulins possessed Y224.

243 h destabilizes microtubules by deacetylating beta-tubulin, protected both the microtubule network and

244 beta-spectrin, PTL-1 tau/MAP2-like and MEC-7 beta-tubulin proteins in Caenorhabditis elegans.

245 Both alpha- and beta-tubulin proteins possess carboxy-terminal tail regi

246 lar co-localization of TaGW7 with alpha- and beta-tubulin proteins, the building blocks of microtubul

247 ation (0.58 +/- 0.06 vs. 0.38 +/- 0.03 pAMPK/beta-tubulin ratio; P <= 0.01) and TBC1 (Tre-2/USP6, BUB

248 y use of the internal transcribed spacer and beta-tubulin regions.

249 nes (SSU-rDNA, actin, alpha-tubulin and five beta-tubulin sequences) to their abundance as macronucle

250 is indicative of a mechanism in which alpha,beta-tubulin subunit addition is tightly coupled to ATP

251 ity is coupled to the GTPase activity of the beta-tubulin subunit of the tubulin heterodimer.

252 P are required for the folding of alpha- and beta-tubulin subunits and assembly into heterodimers.

253 of the C-terminal helices in both alpha- and beta-tubulin subunits suggests an effect on interactions

254 ned that IC97 interacts with both alpha- and beta-tubulin subunits within the axoneme.

255 minal tail peptides found on both alpha- and beta-tubulin subunits.

256 interprotofilament contacts between adjacent beta-tubulin subunits.

257 cell lines harboring a Thr238Ala mutation in beta-tubulin sufficient to induce compound resistance.

258 These orientations of PDCD5 and beta-tubulin suggest that PDCD5 sterically interferes wi

259 ndle defects can be phenocopied by depleting beta-tubulin, suggesting Mgr function is required for tu

260 with GTP-tubulin shows that it binds to the beta-tubulin surface exposed at microtubule (+) ends.

261 ted into microtubules, contacting alpha- and beta-tubulin surfaces that do not participate in microtu

262 We show that TTLL3 glycylates the beta-tubulin tail at four sites in a hierarchical order

263 ylase, adds glutamates preferentially to the beta-tubulin tail.

264 Here, we show that beta-tubulin tails are necessary and sufficient for seve

265 Our results show that beta-tubulin tails are the most effective at inhibiting

266 It was unclear whether the alpha- and beta-tubulin tails contribute equally to VDAC blockade a

267 larity between the estrogen receptor and the beta-tubulin taxane binding pocket.

268 --the alpha-tubulins TBA-6 and TBA-9 and the beta-tubulin TBB-4--are specifically expressed in overla

269 ify subtle changes in the pose of binding to beta-tubulin that could account for the improved antican

270 We found that the drug binds to a site on beta-tubulin that is distinct from the vinca domain and

271 st revealed that Eribulin binds to a site on beta-tubulin that is required for protofilament plus-end

272 we identified five phosphorylation sites in beta-tubulin that serve as substrates for NEK6 in vitro.

273 hat model confirmed that it is ARL2, and not beta-tubulin, that exchanges GTP in the trimer.

274 al antibody against this neuronal isoform of beta-tubulin (the TuJ-1 antibody), we have termed them T

275 e of the C-terminal tail (CTT) of alpha- and beta-tubulin, the location of detyrosination, polyglutam

276 vealed that it did not affect the ability of beta-tubulin to fold or become assembled into the alpha/

277 ls enabled the purification of the TBCD.ARL2.beta-tubulin trimer found in cell and tissue lysates as

278 We conclude that the TBCD.ARL2.beta-tubulin trimer represents a functional complex whos

279 nuclear ribosomal DNA and a fragment of the beta-tubulin (Tub) gene revealed that Acrophialophora be

280 y selective covalent modifiers for Cys239 of beta-tubulin (TUBB) and Cys53 of protein disulfide isome

281 Perturbation of the beta-tubulin TUBB2B is known to cause polymicrogyria, pa

282 t increased expression of the beta 6 class V beta-tubulin (tubb6) contributes to the microtubule chan

283 ousekeeping genes (HKG), beta-actin (Actin), beta-tubulin (Tubulin), elongation factor 1 alpha (EF1al

284 ype, identified by neuron-specific class III beta-tubulin (TUJ-1) labeling, compared with cultures wi

285 ubule-associated protein 2 (MAP2), class III beta-tubulin TUJ1, synapsin-1, VGluT, and cleaved caspas

286 Class III beta-tubulin (TUJ1)-expressing connections were found be

287 y-terminal tail domains (CTTs) of alpha- and beta-tubulins, using a series of mutants that alter or a

288 These new C-terminally truncated alpha- and beta-tubulin variants, both ending with -EEEG sequence,

289 e examined roles for the hematologic isoform beta-tubulin VI and functional genetic variants in the g

290 Together, our findings define beta-tubulin VI as a hematologic isotype with significan

291 n cell lines stably expressing the different beta-tubulin VI full-length variants, finding that the T

292 atients treated with paclitaxel and carrying beta-tubulin VI T274M exhibited a significantly lower th

293 beta-tubulin VI was highly expressed in blood cells with

294 The TAPE domain binds alpha/beta-tubulin via its conserved, concave surface, includi

295 ated with probe competition, indicating that beta-tubulin was the functional target.

296 Sequence data from a fifth locus, beta-tubulin, was excluded from the study due to the pre

297 Further, complexes containing both Myo10 and beta-tubulin were readily precipitated from osteoclasts

298 was almost completely restricted to the core beta-tubulins, while divergent beta-tubulins possessed Y

299 Further, we generate chimeric beta tubulins with native tail sequences swapped between

300 d that PB-Gly-Taxol bound the target protein beta-tubulin with both high affinity in vitro and high s