ライフサイエンスコーパス: beta3 integrin

1 etic depletion or functional inactivation of beta3 integrin.

2 ts and surface GluA2 levels compared with WT beta3 integrin.

3 PP1gamma phosphatase activated by alpha(IIb)beta3 integrin.

4 te, it is unlikely that PKA acts directly on beta3 integrin.

5 resistant acid phosphatase, cathepsin K, and beta3 integrin.

6 after expression of a constitutively active beta3 integrin.

7 critical for interaction between VEGFR-2 and beta3 integrin.

8 by activating pp60(c-Src) kinase and alpha(v)beta3 integrin.

9 fluorescent analogue targeted at the alpha(v)beta3 integrin.

10 downstream of the M-CSF receptor and alpha(v)beta3 integrin.

11 lation of the suPAR receptor Itgb3, encoding beta3 integrin.

12 active sites are not required for binding to beta3 integrin.

13 on and a tightly associated N-P-L-Y motif of beta3-integrin.

14 ducing a kink in the transmembrane domain of beta3-integrin.

15 onstrated to associate in cis with beta1 and beta3 integrins.

16 en alpha-actinin competes with talin to bind beta3 integrins.

17 ytoplasmic tails of alpha4, beta1, beta2 and beta3 integrins.

18 do not contain paxillin, vinculin, and beta1/beta3 integrins.

19 on and activity are independent of beta1 and beta3 integrins.

20 f an inability to activate beta1, beta2, and beta3 integrins.

21 uperfamily that interacts with and activates beta3 integrins.

22 F3 domain of talin is sufficient to activate beta3 integrins.

23 an mediate scaling through the regulation of beta3 integrins.

24 es in talin-mediated activation of beta1 and beta3 integrins.

25 ent manner without altering total alpha5 and beta3 integrins.

26 nction-blocking antibodies against beta1 and beta3 integrins.

27 emaphorin-integrin (PSI) domain of inactive, beta3 integrins.

28 ing beta1-integrins and mimicked by blocking beta3-integrins.

29 1-mediated activation of platelet beta1- and beta3-integrins.

30 on, demonstrating a mechanistic link between beta3 integrin-activated Src and EGFR regulation of the

31 in ligand) in the absence or presence of the beta3 integrin-activating mAb AP-5 and were identified b

32 s were plated on fibronectin with or without beta3 integrin-activating mAb AP-5.

33 LANs associated with either DEX treatment or beta3 integrin activation contained syndecan-4, PIP(2),

34 Analysis of beta3 integrin activation indicates that inclusion of th

35 f inside-out signaling in platelets, whereby beta3 integrin activation involves the direct binding of

36 Control of alphaIIb beta3 and alphav beta3 integrin activation is critical for cardiovascular

37 phavbeta3 Integrin expression levels and the beta3 integrin activation state were determined by fluor

38 reover, c-Src mediates growth factor-induced beta3 integrin activation, ligand binding, beta3 integri

39 the function of individual N-glycan sites in beta3 integrin activation.

40 he head domain of talin and thereby promotes beta3 integrin activation.

41 Podocyte beta3-integrin activation dropped significantly after PE

42 outcome, suPAR levels, and in vitro podocyte beta3-integrin activation was investigated over a median

43 lowering of plasma suPAR as well as podocyte beta3-integrin activation.

44 asurements detected talin1(W359A) binding to beta3 integrin, albeit with a 2.9-fold lower affinity th

45 We establish that, like the endothelial beta3 integrin alpha(V)beta(3), the platelet integrin al

46 ct residues in the alpha-subunits of the two beta3 integrins alphaIIbbeta3 and alphaVbeta3, but a pot

47 tations resulting in a D723H mutation in the beta3 integrin and a P53L mutation in glycoprotein (GP)

48 Here we investigate the nature of beta3 integrin and AMPAR interaction underlying the beta

49 servations suggest a functional link between beta3 integrin and AMPAR, little is known about the mech

50 resorption by its inclusion with the alpha v beta3 integrin and c-Src in a signaling complex, which i

51 urther analyses indicated a central role for beta3 integrin and c-Src in msuPAR2 signaling and in hum

52 as preferential binding to activated alpha(v)beta3 integrin and can track the injury-induced vascular

53 their cognate cell-surface receptors (i.e., beta3 integrin and CD44), nor plasminogen are essential

54 -sulfhydration impaired interactions between beta3 integrin and Galpha13 (guanine nucleotide-binding

55 We show that beta3 integrin and GluA2 subunit form a complex in mouse

56 We show that fibrinogen acts as a ligand for beta3 integrin and induces the transactivation of EGF re

57 d spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enh

58 ich is caused by maternal antibodies against beta3 integrin and occasionally by maternal antibodies a

59 lated complex formation between its receptor beta3 integrin and protein-tyrosine phosphatase SHP-2.

60 ion kinase (FAK) and vinculin to the alpha(v)beta3 integrin and reduced FAK and Src activation in res

61 6 antibody contributes to its binding to the beta3 integrin and subsequent antibody-induced platelet

62 equirements for the cross-activation between beta3 integrin and tyrosine kinase receptor 2 for vascul

63 This extracellular catalysis stimulates beta3 integrins and activates FAK to induce t-SP and pro

64 eraction between the bent conformation beta5/beta3 integrins and an arginine-glycine-aspartic acid (R

65 to serve as an adhesion coreceptor for beta1/beta3 integrins and as an enzyme that catalyzes the cros

66 ed fibrin structure via interactions between beta3 integrins and fibrin.

67 MBP-primed Th2 cells expressed alpha5 and beta3 integrins and functional blocking antibodies again

68 tTG functions as a co-receptor for beta1 and beta3 integrins and stabilizes extracellular matrix prot

69 These observations identify a link between beta3 integrins and VEGF in tumor growth and angiogenesi

70 The central importance of beta3 integrins and VEGF responses in vascular leak and

71 ractions leave periodic rows of matrix bound beta3-integrin and paxillin while generating waves of re

72 endent of fibrinogen, von Willebrand factor, beta3 integrin, and platelets.

73 y deprivation elevates surface expression of beta3 integrins, and in turn, beta3 integrins are requir

74 -49) M28L, chosen for its selectivity toward beta3-integrins, and rEch (1-40) M28L, a carboxy-termina

75 R4A1 regulates expression of both beta1- and beta3-integrins, and unlike other beta1-integrin inhibit

76 tegrins) and monoclonal antibody m7E3 (a rat beta3 integrins antagonist) inhibited the effects of OPN

77 Soluble beta3 integrin antibodies, however, induced CLANs and ac

78 proteins was blocked by anti-beta1 and anti-beta3 integrin antibodies.

79 anti-beta1 integrin antibody but not by anti-beta3 integrin antibody.

80 orylation were inhibited only by murine anti-beta3 integrin antisera and human anti-HPA-1a IgG purifi

81 The relationship between VEGFR-2 and beta3 integrin appears to be synergistic, because VEGFR-

82 s suggest that nascent adhesions composed of beta3 integrins are initially linked to the actin cytosk

83 e 4 (CCR4) chemokine receptors and beta1 and beta3 integrins are necessary to transduce these chemome

84 expression of beta3 integrins, and in turn, beta3 integrins are required for synaptic scaling.

85 l cycle in mammary epithelial cells, whereas beta3-integrins are involved in migration.

86 ransition (EMT) and metastasis, we exploited beta3 integrin as a therapeutic target to treat TNBC by

87 In contrast, beta3 integrin associates with GluA1 AMPAR subunit only

88 er our data indicate that reduction of talin-beta3 integrin binding affinity results in decelerated a

89 a C-terminal fragment and possesses reduced beta3-integrin binding.

90 reproduced in neonates by injection of anti-beta3 integrin, but not anti-GPIbalpha antisera.

91 lin and alpha-actinin compete for binding to beta3 integrins, but cooperate in binding to beta1 integ

92 cally-derived cells express beta1, beta2 and beta3 integrins, but defective inside-out signaling caus

93 onstrated that Src associated with wild-type beta3 integrins, but Src and integrins lacking the C ter

94 A second shRNA to either alphav-integrin or beta3-integrin, but not to another alphav-binding partne

95 e was increased angiogenesis in mice lacking beta3-integrins, but no difference in structure of the v

96 Mutations affecting alpha(IIb)beta3 integrin cause the bleeding disorder termed Glanzm

97 in decreased EC expression of the alphav and beta3 integrin chains.

98 We further found beta1- and beta3-integrins colocalize with IgE-FcepsilonRI at patte

99 beta3 integrin contains a serine residue at position 752

100 indicate that both endothelial and platelet beta3 integrins contribute to extracellular PDI binding

101 Here, we report that postsynaptic beta3 integrins control synaptic strength by regulating

102 pecific for platelet antigens, most commonly beta3 integrin, cross the placenta and destroy fetal pla

103 was mediated by the C-terminal region of the beta3 integrin cytodomain, and mutants of beta3 that wer

104 The beta3 integrin cytoplasmic domain, and specifically S752

105 l adhesion protein, interacts with beta1 and beta3 integrin cytoplasmic domains.

106 into a molecular complex with the beta1A and beta3 integrin cytoplasmic domains.

107 ing of the cytoskeletal protein talin to the beta3 integrin cytoplasmic tail is required for beta3 ac

108 an increase in serine phosphorylation of the beta3 integrin cytoplasmic tail.

109 s and assures the tight association with the beta3-integrin cytoplasmic segment.

110 ing by both undermining talin binding to the beta3-integrin cytoplasmic tail and inducing a kink in t

111 Platelet beta3-integrin deficiency was sufficient to disrupt hemo

112 Plaur-transgenic mice on a beta3 integrin-deficient background were protected from

113 t pathogenic hantaviruses, similar to alphav beta3 integrin-deficient cells, specifically enhance VEG

114 In contrast, beta3-integrin-deficient (beta3-/-) mice are not protect

115 Myeloid-specific beta3-integrin deletion was sufficient to perturb bone m

116 onists inhibit expression of both beta1- and beta3-integrin, demonstrating a novel mechanism-based ap

117 t matrix-bound BMP-2 is sufficient to induce beta3 integrin-dependent C2C12 cell spreading by overrid

118 d beta3 integrin activation, ligand binding, beta3 integrin-dependent cell adhesion, directional migr

119 Truncated R-Ras also stimulates more beta3 integrin-dependent cell migration than full-length

120 ntegrin and AMPAR interaction underlying the beta3 integrin-dependent control of synaptic AMPAR expre

121 The implantation of beta3-integrin-depleted tumor cells led to a dramatic de

122 In addition, the implantation of beta3-integrin-depleted tumors elicited an abscopal immu

123 When combined with anti-PD-1, beta3-integrin depletion led to durable therapy and elic

124 MRI revealed a pattern of increased alpha(v)beta3-integrin distribution within the atherosclerotic w

125 Additional loss of beta3 integrins dramatically aggravates the bleedings an

126 cular dynamics simulations of fully hydrated beta3 integrin ectodomains revealed strikingly different

127 The beta3 integrin/EGFR pathway also has a positive role in

128 etween the calf-1 and calf-2 domains and the beta3 Integrin-Epidermal Growth Factor (I-EGF) 2 to 4 do

129 The CA beta3 integrin-expressing cell line showed increased alp

130 Compensatory beta3 integrin expression also 1) enhances the growth of

131 U0126 (an ERK inhibitor) blocked LPS induced beta3 integrin expression and WISP1 enhanced TNF-alpha r

132 erefore examined the role of NFATc1 in human beta3 integrin expression in osteoclast differentiation.

133 odeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo.

134 Carotid alpha(v) and beta3 integrin expression was maximal at 1 week and decr

135 ibeta3 was sufficient to effectively silence beta3 integrin expression, attenuate TGFbeta-mediated EM

136 pendent upon this HoxA10-induced increase in beta3 integrin expression.

137 Knockdown of beta3-integrin expression attenuates Rac1 activity, impa

138 Undetected in normal muscle, beta3-integrin expression in mouse hindlimb muscles is i

139 The source of beta3-integrin expression is found to be activated satel

140 inhibitory effects of decreased endothelial beta3-integrin expression.

141 These data indicate that beta3-integrin, FAK and cofilin constitute a signaling p

142 xpression of mutants on substrates that bind beta3 integrins (fibronectin and vitronectin) versus sub

143 We have crossed beta3-integrin-floxed (beta3-floxed) mice to 2 endotheli

144 beled peptide (NC100692) targeted at alpha(v)beta3 integrin for imaging in an established murine mode

145 and 2), that can activate beta1, beta2, and beta3 integrins, for their effects on integrin signaling

146 by lipids, plays opposite roles in beta1 and beta3 integrin function and in neither case is responsib

147 In UMR106 cells, inhibition of beta1/beta3 integrin function had no effect on strain-related

148 Furthermore, neither anti-mouse beta3 integrin function-blocking monoclonal antibody (mA

149 e muddied by the use of a global knockout of beta3-integrin function.

150 h pathogenic hantavirus inhibition of alphav beta3 integrin functions, and hantavirus-directed permea

151 et membrane glycoprotein, usually alpha(IIb)/beta3 integrin (GPIIb/IIIa) when the drug is present.

152 conformational states similarly to beta2 and beta3 integrins has not been characterized.

153 on on stability of the metal ion at LIMBS in beta3 integrins has not been explored.

154 These results suggest that beta3-integrins have cell-specific roles in complex biol

155 s recently discovered that certain beta1 and beta3 integrin heterodimers are critical mediators of HC

156 which was inhibited by a dominant-negative >beta3 integrin; however, an active form of Akt failed to

157 l migration through extracellular matrix via beta3 integrins, identifying a unique mechanism to regul

158 proteins were the integrins and focusing on beta3 integrin in detail we found that S-sulfhydration a

159 Here, we show that the loss of beta3 integrin in fibroblasts results in enhanced focal

160 transgenic mice expressing dominant-negative beta3 integrin in oligodendrocytes display no myelinatio

161 The surface level of beta3 integrin in postsynaptic neurons directly correlat

162 ng this remodeling phase, mRNA expression of beta3 integrin in the heart decreases significantly as v

163 e confirm a role for macrophage cell surface beta3 integrin in this dl922-947-induced inflammation.

164 omplex formation between VEGF receptor-2 and beta3 integrin in wild-type but not in mutant beta3 knoc

165 hibited the activation of platelet beta1 and beta3 integrins in response to platelet agonists.

166 rdination was recently reported for EGFR and beta3 integrins in the context of HCMV entry.

167 e responses are explained by the presence of beta3-integrin in beta1-integrin-null cells, indicating

168 3KOM strains of mice, we studied the role of beta3-integrin in hemostasis, bone resorption, and subcu

169 nerated to study the conditional deletion of beta3-integrin in platelets [knockout in platelets (KOP)

170 Conditional deletion of myeloid beta3-integrins in beta3KOM mice resulted in osteopetros

171 Tissue-specific deletion of platelet beta3-integrins in beta3KOP mice did not affect bone mas

172 anscription of the ITGB3 gene, which encodes beta3 integrin, increases during myeloid differentiation

173 DEX pretreatment increased beta3 integrin-induced CLAN formation nearly sixfold and

174 blocking antibodies against both alpha5 and beta3 integrins inhibited the ability of MBP-primed Th2

175 We show that acute depletion of endothelial beta3-integrin inhibits tumor growth and angiogenesis pr

176 Pharmacological blockade of beta3-integrins inhibits neointimal lesion formation in

177 We report that both platelet beta1 and beta3 integrins interact in an activation-dependent mann

178 d cysteines in endothelial cell proteins and beta3 integrin intraprotein disulfide bond rearrangement

179 The alpha(v)beta3 integrin is activated in angiogenic vessels and re

180 Expression of the beta3 integrin is required for normal osteoclast functio

181 Thus, beta3-integrin is a mediator of satellite cell different

182 However, as beta3-integrin is expressed by a wide variety of cells,

183 Cell, Desgrosellier et al. (2014) show that beta3-integrin is required downstream of hormonal signal

184 Because previous studies coupled beta3 integrin (ITGB3) to epithelial-mesenchymal transit

185 d kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitat

186 nduced reinstatement, which was prevented by beta3 integrin knockdown and FAK inhibition.

187 beta3 integrin knockdown prevented t-SP as measured by p

188 Using beta3 integrin knockout mice injected intraperitoneally

189 In 2002, we reported that beta3-integrin-knockout mice exhibit enhanced tumor grow

190 Mural-beta3-integrin loss also enhances tumor growth in implan

191 At a molecular level, mural-cell beta3-integrin loss enhances signaling via FAK-p-HGFR-p-

192 xamine the endothelial-specific contribution beta3-integrin makes to tumor growth and angiogenesis.

193 of major cell adhesion receptors (alphav and beta3 integrins), matrix metalloproteinases (MMP-2 and -

194 Only anti-beta3 integrin-mediated FNAIT reduced brain and retina v

195 o reverses the suppression by NO of alphaIIb/beta3 integrin-mediated platelet adhesion on immobilized

196 y occurred in fetuses and neonates with anti-beta3 integrin-mediated, but not anti-GPIbalpha-mediated

197 that force-dependent reinforcement of alphav/beta3-integrin-mediated cell-matrix connections requires

198 ressing neurons requiring ECM stimulation of beta3-integrin-mediated phosphorylation of FAK (p-FAK) a

199 blocking studies demonstrated that alphaIIb beta3 integrin mediates platelet adhesion to fibrinogen,

200 The alpha(v)beta3-integrin mediates intimal SMC accumulation that co

201 beta3 integrin(-/-) mice have defective platelet and ost

202 -N452 N-glycan at the I-EGF1 domain rendered beta3 integrin more active than the wild type.

203 with impaired capacity to interact with the beta3 integrin MPR (L325R) or NPLY sequence (W359A).

204 in hippocampal pyramidal neurons, expressing beta3 integrin mutants with either increased or decrease

205 l data correlating high percentages of mural-beta3-integrin-negative tumor BVs with increased tumor s

206 In addition, a beta3-integrin-neutralizing antibody similarly blocked m

207 tegrin inhibitors which induce prometastatic beta3-integrin, NR4A1 antagonists inhibit expression of

208 Furthermore, beta3 integrin-null endothelial cells, when treated with

209 A similar response was seen in beta3 integrin-null platelets.

210 d muscle regeneration in cardiotoxin-injured beta3-integrin-null mice are impaired, as indicated by d

211 myeloid lineage commitment were mediated by beta3 integrin on hematopoietic progenitors.

212 e released TSP-1 interacted with the alpha(v)beta3 integrin on the EC surface.

213 hantaviruses inhibit the function of alphav beta3 integrins on endothelial cells, and hemorrhagic di

214 rrow transplants suggest that the absence of beta3-integrins on bone marrow-derived host cells contri

215 beta3 Integrin or CD47 activation significantly increase

216 Knockdown of beta3 integrin or FAK inhibitor, but not beta1 integrin

217 ite outgrowth is reversed by blocking either beta3 integrin or phoshorylation of EGFR.

218 erved in tumors grown in mice lacking either beta3-integrins or selectins.

219 By interacting with fibrin and platelet beta3 integrin, pFn plays a self-limiting regulatory rol

220 The alpha(v)beta3 integrin plays a critical role in cell proliferati

221 Activated beta3 integrin-positive adhesions increased nearly fivef

222 rom binding to the cytoplasmic domain of the beta3 integrin prevents outside-in signaling and infecti

223 AMPARs via Rap1 signaling, and expression of beta3 integrins produces robust changes in the abundance

224 -calcineurin pathway in regulating the human beta3 integrin promoter was further confirmed using the

225 nNFAT inhibited RANKL induction of the human beta3 integrin promoter.

226 Pharmacological perturbation targeting beta3 integrins promotes endocytosis of GluR2-containing

227 or growth via paracrine signals regulated by beta3-integrin, providing a previously unrecognized mech

228 by trans-activation of IGF-IR induced by the beta3 integrin receptor.

229 capsid, retargeting the virus to the alphav beta3 integrin receptors, which are overexpressed in tum

230 beta3 integrin regulates a multistep process to control

231 -type 1 matrix metalloprotease [MT1-MMP] and beta3 integrin) required for invadosome formation in res

232 Of importance, compensatory expression of beta3 integrin rescues the growth and pulmonary metastas

233 y to beta1 integrins, high tension increases beta3 integrin residence time in adhesive regions.

234 Inhibition of beta1 or beta3 integrin resulted in a significant decrease in mig

235 this study, we show that PKD1 complexes with beta3-integrin, resulting in activation of mitogen-activ

236 stream signaling events reveals that loss of beta3 integrin results in a loss of protein kinase A-dep

237 beta3 integrin S-sulfhydration was required for endothel

238 ow-induced dilatation, and failure to detect beta3 integrin S-sulfhydration, all of which were rescue

239 Tumors with "activatable" but not "inactive" beta3 integrin secrete high levels of VEGF, which in tur

240 beled peptide (NC100692) targeted at alpha(v)beta3 integrin selectively localized to endothelial cell

241 ta1 integrin function-blocking antibodies on beta3 integrin serine phosphorylation and EC-ralpha4LN f

242 have tested an hypothesis that PKA regulates beta3 integrin serine phosphorylation indirectly through

243 protein kinase (PKA) activity and increases beta3 integrin serine phosphorylation.

244 I domain occur in an order different than in beta3 integrins, showing that integrin beta subunits can

245 -induced CLAN formation may involve enhanced beta3 integrin signaling in HTM cells, possibly by an in

246 ory cytokine interferon-gamma (IFNgamma) and beta3 integrin signaling in murine HSC function by a nov

247 beta3 Integrin signaling involvement was determined usin

248 hose formation can be regulated by beta1 and beta3 integrin signaling pathways.

249 Here, we determined whether beta3-integrin signaling through FAK and cofilin (actin

250 aline, and the p-FAK and cofilin depended on beta3-integrin signaling.

251 f a cyclic RGD-mimetic-specific inhibitor of beta3 integrin significantly attenuates the cytokine rel

252 erapeutic target to treat TNBC by delivering beta3 integrin siRNA via lipid ECO-based nanoparticles (

253 nd elicits robust compensatory expression of beta3 integrin solely in malignant MECs, but not in thei

254 ntegrin elicits metastatic progression via a beta3 integrin-specific mechanism, indicating that dual

255 for pup) enabled us to predict the Thy-1 and beta3-integrin status of stem cells in neonate and pup t

256 ential (DeltaPsim)(lo), Ep-CAM(+), Thy-1(+), beta3-integrin(+) stem cells in neonate rat testes becom

257 Sc(lo), DeltaPsim(hi), Ep-CAM(+), Thy-1(lo), beta3-integrin(-) stem cells in pup rat testes.

258 In hippocampal neurons, the beta3 integrin subtype is required for homeostatic synap

259 Expression of an inactive beta3 integrin subunit abolishes p190RhoGAP tyrosine pho

260 l and strong cytoplasmatic expression of the beta3 integrin subunit but also an intense expression of

261 stration protocol reduced the content of the beta3 integrin subunit in postsynaptic density of the ac

262 ected the entire intracellular domain of the beta3 integrin subunit to unbiased random mutagenesis an

263 atelets binds to the cytoplasmic tail of the beta3 integrin subunit via its SH3 domain.

264 when expressed at the cytoplasmic end of the beta3 integrin subunit, was able to enhance alphavbeta3-

265 wild type (WT) or constitutively active (CA) beta3 integrin subunit.

266 odies against the alpha5, alphaV, beta1, and beta3 integrin subunits inhibited M-cell invasion by 52

267 ntisense strategy to knock down the beta1 or beta3 integrin subunits or inhibitors to prevent phospho

268 t from the more ordered, membrane-associated beta3 integrin tail.

269 a full-length talin head in complex with the beta3-integrin tail.

270 -1 and kindlin-2 interactions with beta1 and beta3 integrin tails and describe the effect of kindlin

271 The rod domain competes with beta3-integrin tails for binding to F3, and the structur

272 ic mechanism, indicating that dual beta1 and beta3 integrin targeting is necessary to alleviate metas

273 y deficits are consequences of dysfunctional beta3 integrins that normally regulate permeabilizing va

274 of Tgfb1 mRNA, TGF-beta protein, alphav and beta3 integrins that promote activation of latent TGF-be

275 Thus, the beta3-integrin TM domain is able to engage in two mutual

276 pression depends upon the ability of alpha v beta3 integrin to cluster and promote phosphorylation of

277 rowth factor receptor (EGFR) cooperates with beta3 integrin to regulate p190RhoGAP activity in mouse

278 unction studies revealed that the ability of beta3 integrins to specifically sense local tensional or

279 ng in the extracellular matrix (ECM) through beta3-integrin to activate focal adhesion kinase (FAK) a

280 when targeting the endothelial expression of beta3-integrin to inhibit tumor growth and angiogenesis.

281 eeking, and MMP-induced catalysis stimulates beta3-integrins to induce t-SP.

282 Osteoclasts express high levels of alpha(v)beta3 integrin, to which peptides containing the Arg-Gly

283 odel system, structure determinations of the beta3 integrin transmembrane segment and flanking sequen

284 tment and activation of c-Src and subsequent beta3 integrin tyrosine phosphorylation are critical for

285 ere that adhesion- and growth factor-induced beta3 integrin tyrosine phosphorylation are directly med

286 ergistic, because VEGFR-2 activation induces beta3 integrin tyrosine phosphorylation, which, in turn,

287 enerated knock-in mice that express a mutant beta3 integrin unable to undergo tyrosine phosphorylatio

288 The specific requirement for beta3 integrin was apparent when the effect of WISP1 was

289 As bone is replete with ligands for beta3 integrin, we next demonstrated that alphavbeta3 in

290 In this study, beta3 integrins were overexpressed in smooth muscle cell

291 talin for binding to the cytoplasmic tail of beta3-integrin, whereas it cooperates with talin for act

292 Surprisingly, platelets lacking beta3 integrins, which are unable to form thrombi on the

293 Mice deficient in beta2 or beta3 integrins, which have decreased neutrophil and/or

294 Proliferating C2C12 myoblasts also express beta3-integrin, which is further up-regulated transientl

295 Here, we report a regulatory role of beta3-integrin, which was previously thought not express

296 ERp5 binds to beta3 integrin with an equilibrium dissociation constant

297 n of yellow fluorescent protein (YFP)-tagged beta3 integrin with c(RGDfK) peptide.

298 ta1 activation, and talin F3 binds beta1 and beta3 integrins with comparable affinity, expression of

299 though previous reports associated beta1 and beta3 integrins with TGF-beta stimulation of EMT and met

300 all, our results show that BMP receptors and beta3 integrin work together to control Smad signaling a