ライフサイエンスコーパス: biased

1 w that 14-25% of the EC transcriptome is sex-biased.

2 iral monomer units can be disproportionately biased.

3 age-dependent, tissue-specific and expansion-biased.

4 Deep breaths are not sex-biased.

5 ACET flow induced by a biased AC electric field can rapidly convect the analyte

6 ion task with asymmetric rewards reflected a biased accumulate-to-bound decision process (Fan et al.,

7 tially improves and simplifies assessment of biased agonism because the same assay modality is used t

8 Descriptions of biased agonism focusing on the differential engagement o

9 In vitro, 44 showed biased agonism for ERK1/2 phosphorylation and, in vivo,

10 Thus, we demonstrate the biased agonism of TRPA1, a finding that has important im

11 Biased agonism was assessed by comparing k(tau) values f

12 gical concept of functional selectivity (aka biased agonism) might be useful for amplifying beneficia

13 fferent along diverging downstream pathways (biased agonism), and (d) constitutive activity.

14 TT-OAD2 exhibits biased agonism, and kinetics of G-protein activation and

15 emporal signaling and the kinetic context of biased agonism.

16 arr1 complex in lipid nanodiscs bound to the biased agonist formoterol(5), and the crystal structure

17 Thus, Lgmn is a biased agonist of PAR(2) that evokes cancer pain.

18 We found and characterized a biased agonist of S1P(1), SAR247799, which preferentiall

19 We previously identified a G protein-biased agonist of the D(2) dopamine receptor (D2R) that

20 associated with prolonged treatment with the biased agonist SR-17018.

21 (DAMGO) nonbiased agonists and to the TRV130 biased agonist.

22 selective histamine H(2) receptor G protein-biased agonist.

23 is a useful strategy for obtaining G protein biased agonists for the NOP receptor.

24 t mechanistically novel, extremely G protein-biased agonists is in question, as is the underlying ass

25 Biased agonists of G protein-coupled receptors (GPCRs) p

26 G protein-biased agonists of the mu-opioid receptor (MOPr) have be

27 Biased agonists of this nature may therefore be useful f

28 derivatives, respectively) were selected as biased agonists with highly differential "signaling fing

29 The presented 5-HT(1A) receptor-biased agonists, preferentially targeting various signal

30 lergic asthma (AA) is characterized as a Th2-biased airway inflammation that can develop lung inflamm

31 in II (AngII) and two strongly beta-arrestin-biased analogs.

32 y and feedback, social networks can adapt to biased and changing information environments and produce

33 ort, while lighter flowers tend to be female-biased and invest more in sepals to insure their own see

34 t heavier angiosperm flowers tend to be male-biased and invest strongly in petals to promote pollen e

35 these revised guidelines will lead to a less biased and more transparent reporting of research findin

36 pes within the IUTD that are orientationally biased and result in the threading of over 60 amino acid

37 pplied computational methods to identify sex-biased and shared molecular responses to fibrotic injury

38 -mediated domain insertion that was severely biased and sparse for some genes, SPINE generated high-q

39 ive findings, even when they are misleading, biased, and unreliable.

40 from more recent genomes were systematically biased; and inclusion of the DRC66 sequence in tip-dated

41 agnetic texture leads to a strongly exchange biased anomalous Hall effect.

42 ble and induced high levels of effective Th1-biased antibody and T cell responses in mice after two i

43 BJ) dataset to further alleviate concerns of biased ascertainment of GWAS loci and showed that the Sa

44 male microglia is an important cause for sex-biased ASD.

45 filin-decorated (cofilactin) segments and is biased at 1 side of a cluster.

46 lect, who demonstrated significant spatially biased attention after acquired brain injury, were rando

47 he primary outcome, a reduction in spatially biased attention on the Posner cueing task (p = 0.010, C

48 of the potential for regulatory evolution is biased, because most evidence comes from either natural

49 raphics of ACS surgeons, the exclusionary or biased behaviors they witnessed and experienced, and whe

50 and potential functional corollaries of sex-biased brain anatomy in humans.

51 findings establish conserved aspects of sex-biased brain development in humans and mice, and shed li

52 criticized for being flawed, subjective and biased, but research into peer review has been hindered

53 ure as a complementary resource, likely more biased, but suffused with the extensive clinical knowled

54 of 43%), standard uptake values (SUVs) were biased by a maximum of 44%.

55 ased by prejudicial attitudes and indirectly biased by an aggrieved sense of disempowerment and White

56 as, hate crime perceptions were specifically biased by an ethnonationalist view of Hispanic immigrant

57 preserved chemistry of fossil melanosomes is biased by biotic and abiotic factors is, however, unknow

58 ecovered representations were systematically biased by category membership, with larger biases for ex

59 parcellation, and anatomical searchlight are biased by design toward finding localized representation

60 ve status measures, suggesting they were not biased by general cognitive deficits in the patients.

61 administration-induced dependence and may be biased by individual differences in predispositional ins

62 This association did not appear to be biased by intrapartum antibiotics, breastfeeding behavio

63 Human decisions can be biased by irrelevant information.

64 Moreover, the data are biased by mislabeling "caries-free" populations.

65 t traditional index methods are unstable and biased by pharmacological and experimental conditions, w

66 dgment: hate crime perceptions were directly biased by prejudicial attitudes and indirectly biased by

67 ape and composition; but the findings may be biased by residual confounding.

68 ropose a framework in which drug choices are biased by selective sampling of individual memories duri

69 ating human-made decisions may inherently be biased by the fallible and dogmatic nature of human expe

70 e much of the existing results may have been biased by the overly complicated prediction algorithms,

71 analyses that are conducted can be strongly biased by the standard models employed by seismologists.

72 Results of survival analyses may be biased by treatment indication and disease severity.

73 tional comparisons of NOACs are likely to be biased by unmeasured confounders.

74 ccination induced type 1 helper T-cell (Th1)-biased CD4 T-cell responses and low or undetectable Th2

75 were contained mostly within the plasma-cell-biased CD80(+) subset, and few GCs arose following heter

76 up to fourteen neuron subtypes, many showing biased cell body distributions across the DR.

77 at that frequency, to test whether astrocyte-biased cells could be separated from the other cell type

78 at different degrees of actin polymerization biased cells toward various endodermal lineages and that

79 Astrocyte-biased cells were successfully enriched from hNSPC cultu

80 for label-free enrichment of human astrocyte-biased cells.

81 chanisms regulating centrosome asymmetry and biased centrosome segregation are unclear.

82 Individual strategies were related to sex-biased changes in neuronal activation in early learning.

83 ue of individual offers and thus predictably biased choices.

84 ings reveal domain-specific and eccentricity-biased connectivity in the earliest days of life, placin

85 Biased crossover resolution was observed, consistent wit

86 butions of FEF and caudate neurons to reward-biased decision-making and put experimental constraints

87 ntrosome, providing a possible mechanism for biased delivery of cell fate determinants.

88 particles subjected to the gradient exhibit biased diffusion toward the center.

89 een two groups of tumor samples will lead to biased discovery of DM sites if not properly accounted f

90 Our results are in line with male-biased dispersal being driven by local mate competition

91 Sex-biased dispersal is usually driven by a combination of i

92 Clear sex-biased dispersal was not detected based on relatedness,

93 omplication in explaining the drivers of sex-biased dispersal.

94 populations by passive processes such as sex-biased dispersal.

95 all of the above trends without requiring a biased distribution of epistasis.

96 allenge, which may account for the seemingly biased distribution of T1PKSs in fungi and bacteria: sma

97 eiotic recombination intermediates may drive biased DNA cleavage.

98 rategy for G protein-coupled receptor (GPCR) biased drug screening.

99 The ability to design 'biased' drugs that selectively activate G protein-couple

100 nalyses to evaluate whether estimates may be biased due to horizontal pleiotropy.

101 proposed by Rubin ("Rubin's rules" (RR)) is biased due to incompatibility between imputation and ana

102 tion studies of unrelated individuals can be biased due to uncontrolled confounding from familial eff

103 ositional differences, sequential release of biased (enriched) components, via fractal-like paths, al

104 By integrating sex-biased eQTLs with genome-wide association study data, we

105 However, this analysis provides a biased estimate of the exposure coefficient (slope) and

106 Cox proportional hazards models may provide biased estimates of the causal effect of treatment when

107 ometric analysis may result in imprecise and biased estimates of the influence of the independent var

108 to correct for male mutation bias results in biased estimates of X:A effective population size ratios

109 hat these types of designs usually give less biased estimates than simpler observational designs.

110 Larger sample sizes led to equally biased estimates with narrower CIs.

111 entation of differential privacy can lead to biased estimates.

112 of distinct sets of proteins; however, a non-biased examination of the de novo proteome in this proce

113 nd systems to full-membrane representations, biased-exchange umbrella sampling simulations are perfor

114 TCR repertoire of reservoir cells is heavily biased: expanded clonotypes are present in all individua

115 A total of 37% of all genes exhibit sex-biased expression in at least one tissue.

116 Genes with sex-biased expression in Drosophila are thought to underlie

117 nomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on

118 es and the accumulation of genes with testis-biased expression, many of which are recent duplicates.

119 ivore communities, such as predation or size-biased extinction, have the potential to alter the nutri

120 s of neuropsychological assessments in a non-biased fashion.

121 ded chemical libraries that are structurally biased for a class of protein targets.

122 and found that the proto face network shows biased functional connectivity with foveal V1, while the

123 veal V1, while the proto scene network shows biased functional connectivity with peripheral V1.

124 e (GC) content, suggesting a key role for GC-biased gene conversion and/or repair after the breakage

125 We show that this result cannot be caused by biased gene conversion or hypermutable CpG sites.

126 ene repression and participate in parentally biased gene expression-including in recently described,

127 for Z-linked loci primarily reflects female-biased gene flow, arising from a hybrid-male disadvantag

128 l rearrangements, homoeologous exchanges, or biased gene loss, in contrast to many other allopolyploi

129 Reprogramming of Majors upregulates Minor-biased genes and downregulates Major-biased genes, engag

130 d constraints governing the evolution of sex-biased genes in the somatic tissues of Drosophila are la

131 ve the expression evolution of X-linked male-biased genes than other X-linked genes.

132 s Minor-biased genes and downregulates Major-biased genes, engaging molecular pathways fundamental to

133 Here we demonstrate biased genome-wide integration of the Sleeping Beauty (S

134 Altogether, biased hate crime perceptions can be purposive and revea

135 Astrocyte-biased hNSPCs differ from other cell types in electrophy

136 HSCR), TashT (TashT(Tg/Tg), a model for male-biased HSCR), Piebald-lethal (Ednrb(s-l//s-l), a model f

137 Enriched astrocyte-biased human cells enable future experiments to determin

138 ibeiro, as the resulting Rt estimates may be biased if the underlying structural assumptions are not

139 ay, reinforcement learning, selective payoff-biased imitation, and foresight.

140 by infants respond to microorganisms through biased immune tolerance rather than resistance strategie

141 IgE is the central antibody isotype in TH2-biased immunity and allergic diseases.

142 io, indicative of augmented OVA-specific Th1-biased immunity.

143 ip degrees faster than IBIS, the fastest are biased in admixed samples, with KING inferring 30.8% few

144 The available data are often biased in favor of acute data from laboratory-controlled

145 identification of genetic variants, has been biased in favour of pedigrees with higher penetrance.

146 Relative GMV is female biased in prefrontal and superior parietal cortices, and

147 Consequently, polygenic scores are biased in that they recapitulate environmental structure

148 results show that most dosimetry models were biased in their predicted clinical dosimetry compared to

149 tal and superior parietal cortices, and male biased in ventral occipitotemporal, and distributed subc

150 yet highly relevant to health given the sex-biased incidence of many diseases(4).

151 ither visual experience with faces nor fovea-biased inputs is necessary for face-selectivity to arise

152 al meaning or constraints, they are prone to biased interpretation.

153 ulting in sustained negative predictions and biased learning.

154 Such early biased legitimate reprogramming of the responsive TFs al

155 PCR is prone to create biased libraries - especially with the extremely high de

156 After screening an RNA-biased library using a peptide-displacement assay, we id

157 demonstrated to function as a beta-arrestin-biased ligand for the beta(2)AR, stimulating beta-arrest

158 he classic opioid morphine and the G protein-biased ligand TRV130.

159 evaluated the most recent and promising MOR-biased ligands and assessed their pharmacological profil

160 At the mu-opioid receptor (MOR), G protein-biased ligands have been proposed to induce less constip

161 Biased ligands to muOR that induce G protein signaling w

162 s into understanding the mechanisms of these biased ligands.

163 known, making it difficult to design optimum biased ligands.

164 Thus, NGF and NT-3 are "biased" ligands for Trk-A.

165 (TLR) 7 and TLR8 reportedly results in male-biased litters by selectively disrupting the motility of

166 involved in interpreting and amplifying the biased local motion signals into a global illusion of tr

167 idual skyrmions at zero-field in an exchange-biased magnetic multilayer with exposure to soft X-rays.

168 rary patterns on a massive scale in exchange-biased magnetic multilayers is presented.

169 lular signal-regulated kinase signaling in a biased manner.

170 our information about genes is gathered in a biased manner: poorly studied genes are more likely to b

171 Lgmn activated PAR(2) by biased mechanisms in HEK293 cells to induce Ca(2+) mobil

172 Using the device, we identify an anteriorly biased mesodermal stiffness gradient along which cells m

173 disorder, but repeats, while compositionally biased, might also induce ordered structures.

174 jective annotations may be instable or yield biased models.

175 investigating the translational value of NOP biased modulation.

176 eption and indicates that pain perception is biased more toward predictions and less toward nocicepti

177 We propose that to understand causes of sex-biased mortalities, more complex analyses are needed tha

178 chromosome (BAC)-transgenic mouse lines with biased mTEC(lo) or mTEC(hi) expression of model antigens

179 on was either buprenorphine or the G protein-biased mu opioid receptor agonist TRV130.

180 We propose that G protein-biased mu opioid receptor agonists, currently in develop

181 characterized its advantages, including non-biased multiplex mutagenesis, over existing site-directe

182 We observed that inside the voltage-biased nanopore, polyarginine-conjugated DNA-PNA duplexe

183 f Cell, Slosky et al. report a beta-arrestin-biased neurotensin receptor ligand that may curtail drug

184 iotic capture and transport across a voltage-biased OmpF nanopore is dominated by the electroosmotic

185 Moreover, genetic models of G protein-biased opioid receptors and replication of previous knoc

186 Experimentally, such apparently G protein-biased opioids have been shown to exhibit low intrinsic

187 isions.SIGNIFICANCE STATEMENT The brain is a biased organ, frequently generating systematically disto

188 Finally, we show that Carbetocin, a biased OTR-Gq agonist, increases social approach in stre

189 ng loss of engraftment ability and a myeloid-biased output.

190 fects of sPLA(2)-X that result in the type 2-biased OVA-specific adaptive immune response in the lung

191 vity to autonomously present compositionally biased oxides on the surface of these metals.

192 d a statistically significant but small male-biased parasite prevalence.

193 lies on a few advisors, making them prone to biased perceptions; and 3) in the absence of trust betwe

194 PPARdelta is necessary for obtaining the M2-biased phenotype.

195 1 biased) phenotype to a proregenerative (M2 biased) phenotype characterized by expression of CD206 a

196 ft of macrophages from a proinflammatory (M1 biased) phenotype to a proregenerative (M2 biased) pheno

197 Illumination of a voltage-biased plasmonic Ag cathode during CO(2) reduction resul

198 which alters actin network assembly through biased polymerization and internetwork competition.

199 rgans, in which immune cells adopt spatially biased positions to promote effective host defence(2,3).

200 Our results showed that the biased potential of +0.4 V was the most suitable potenti

201 At highly biased potentials, electrochemistry grants access to sil

202 this unrealistic compensation would lead to biased predictions of future land carbon sink.

203 oth features show systematic crowded errors (biased predominantly toward the flanker identities) and

204 ly in males than females, a dramatically sex-biased prevalence that suggests the involvement of sex-d

205 tLgamma) nuclease has been implicated in the biased processing of meiotic recombination intermediates

206 gate the neural mechanisms that underlie the biased processing of real-world political content.

207 D45+ HSPCs; an initial wave of lymphomyeloid-biased progenitors, followed by precursors of hematopoie

208 R-DeeP is independent of any potentially biased purification procedures.

209 the characteristic of an asymmetrically gate biased quantum point contact with the assistance of a fo

210 stic chemotaxis up a chemical gradient, in a biased random walk at the thermodynamic limit.

211 rphyrinoid dimers of nonplanar subunits with biased reactivity.

212 sions enables accurate measurement of strand-biased repair processes, quantification of oncogenic sel

213 further shows that cultivation results in a biased representation of the in situ linuron-assimilatin

214 rylation enables the formation and crossover-biased resolution of double-Holliday Junction intermedia

215 at least one crossover via the formation and biased resolution of recombination intermediates known a

216 liding clamp PCNA is important for crossover-biased resolution.

217 s trial, demonstrating an induction of a Th1-biased response characterized by interferon-gamma and tu

218 saRNA LNP immunizations induce a Th1-biased response in mice, and there is no antibody-depend

219 Our data indicate a Th1-biased response to Cb, consistent with previous reports,

220 In contrast, all aPV vaccines showed a Th2-biased response.

221 ign of most high-impact critical care trials biased results toward the null by overestimating control

222 r confounding by severity of illness lead to biased results.

223 tween remembered positions were persistently biased, revealing distorted memory maps that explained b

224 Non-biased RNA sequencing analysis using liver and kidney sh

225 demonstrated by replacing the enzymatically biased RNA-to-DNA reverse transcription step of RT-qPCR

226 Because it has been hypothesized that biased RTK ligands induce differential stabilization of

227 to 96.7% greater than the true value for the biased sampling scenarios considered, while the average

228 verage rate ranged from 46.4% to 69.5% under biased sampling, and was equal to 75% for the unbiased s

229 ACD can be manifested in the biased segregation of macromolecules, the differential p

230 ding antibodies were readily identified from biased selection designed to enrich such antibodies.

231 and the RBD proteins using both unbiased and biased selection strategies.

232 ple prototype systems; however, very uneven (biased) sequencing coverage has been reported, which ind

233 Biased seroprevalence estimates can occur using serologi

234 We report a male-biased sex-distorter gene drive (SDGD) in the human mala

235 ce activates cancer-protective beta-arrestin-biased signaling (beta-arr-BS).

236 insight into fentanyl mediated beta-arrestin biased signaling and a rational framework for further op

237 er, the molecular mechanisms responsible for biased signaling are unresolved due to a lack of insight

238 t into the molecular and biological roles of biased signaling downstream RTK and provides a novel "sy

239 s and biological pathways that engender PAR1 biased signaling in endothelial cells.

240 AR4, these data provide further evidence for biased signaling in PAR4 since membrane blebbing was dep

241 us in this region, which appears to act as a biased signaling switch, may predispose the AT1R and cer

242 eterminants critical for agonist binding and biased signaling through PAR4.

243 Biased signaling, in which different ligands that bind t

244 Despite progress in understanding PAR1 biased signaling, the proteins and pathways utilized by

245 devoid of G(i) signaling at MT(1), implying biased signaling.

246 ailable downstream signal cascades is termed biased signaling.

247 t, we find that this projection conveys male-biased signals from the VMHvl to downstream lPAG(vGlut2)

248 e leads to T helper type 1-/T helper type 17-biased skin inflammation before significant body weight

249 We demonstrate biased snatching of numerous host RNAs, particularly sma

250 an indirect cue of success, and when success-biased social learning is unavailable.

251 supporting the key predictions that prestige-biased social learning is used when it constitutes an in

252 Prestige-biased social learning occurs when individuals preferent

253 at, as predicted, participants used prestige-biased social learning when the prestige cue was an indi

254 has tested the basic predictions of prestige-biased social learning.

255 inconsistent measurements of predation risk, biased spatiotemporal scales at which responses are meas

256 d, we 'trap' and maintain cells in a lineage-biased stem cell state through multiple passages.

257 d mainly on relatively few, small, selection-biased studies at experienced centers, and thus we lack

258 ersibly collides with an ultramicroelectrode biased sufficiently positive for concurrent oxidation of

259 The developmental strategies generating "biased" synaptic distributions remain largely unknown.

260 In marked contrast to the biased T cell receptor (TCR) usage associated with HLA-D

261 Interestingly, male-biased TE expression diminishes across development in D.

262 er core, together competing against radially biased tension in the cortical gray matter.

263 ons or at finer spatial scale to correct for biased testing and imperfect diagnostic accuracy to prov

264 Far from being biased, the key conclusion of our meta-analysis still st

265 t dentate gyrus and CA(2,3) (DG/CA(2,3)) are biased to differentiate highly similar memories, whereas

266 that dipraglurant and (RS)-remeglurant were biased toward (affinity) receptor internalization and aw

267 vant induced CD4+ T-cell responses that were biased toward a Th1 phenotype.

268 temporal resolution, making it fundamentally biased toward detecting changes in ambient light and coa

269 ient loads that were high for their size and biased toward dissolved inorganic forms.

270 for fear-related disorders, such as PTSD, is biased toward females, we examined whether H2A.Z cKO als

271 ted data from every cell in the circuit, are biased toward inferring connections between unconnected

272 , we show the HSC gene expression program is biased toward myelopoiesis and differentiation skewed to

273 ever, the predicted PC scores from SP can be biased toward NULL.

274 We find that exons biased toward prenatal and postnatal expression preferen

275 of the nonvesicular exRNA fraction is highly biased toward specific tRNA-derived fragments capable of

276 on of subregions in the VTA and were largely biased toward synaptic contact with local GABA neurons.

277 ly regulated in disease and are specifically biased toward the expansion of the secretory primed basa

278 avior and habits has been hypothesized to be biased toward the latter in individuals with cocaine use

279 rts of the direction of the moving dots were biased toward the predicted direction.

280 ture domain, the evoked neuronal response is biased toward the stimulus that has a stronger signal st

281 ethod is that different taxonomic groups are biased toward using different metabolic reactions.

282 ody measurements using whole antigens may be biased towards conserved, immunodominant epitopes.

283 existing feature selection methodologies are biased towards considering only one out of multiple biol

284 CaMKII-beta, with a ~200 residue linker, is biased towards inhibitory autophosphorylation.

285 following infection, individual T cells are biased towards particular phenotypes.

286 All programs were biased towards selecting start codons that were upstream

287 While searches were biased towards the beacons, we did not find any evidence

288 Our understanding of cyclone ecology is biased towards the North Atlantic Basin, because cyclone

289 ts on birthweight and gestational age may be biased towards the null.

290 cKO neurons develop properly, but then show biased transcriptional downregulation of long genes, sig

291 th stereotyped saccades, whose direction was biased upwind by the timing of prior odor encounters, wh

292 In line with this, minocycline biased use of boundary- compared to landmark-based infor

293 fects of vaccination on noninfluenza viruses biased vaccine effectiveness in our study.

294 culin results in the appearance of lymphatic-biased venous endothelial cells caused by ectopic expres

295 single family, the Thripidae, resulting in a biased view of their evolution.

296 igger the insulator-to-metal transition in a biased VO(2) nanogap.

297 studies should not be considered inherently biased vs. a hypothetical RCT.

298 ent proposals that humans are egocentrically biased when learning to obtain monetary rewards for self

299 etic ancestry inference can be substantially biased with existing methods that ignore contamination,

300 First, available 3D data are geographically biased, with significant gaps in the tropics.