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1 stem to remove CO2 from blood in the form of bicarbonate.
2 y metabolized to [1-(13)C]lactate and [(13)C]bicarbonate.
3 ueous solutions of acetic acid, ammonia, and bicarbonate.
4 e of 0.96 mmol/L (0.45 to 1.47; p=0.0003) in bicarbonate.
5 consuming only water) before measurements of bicarbonate.
6 ated more pyruvate conversion to lactate and bicarbonate.
7 creased pancreatic and biliary fluid rich in bicarbonate.
8 iobium-tantalum bearing minerals with sodium bicarbonate.
9 agnostic criteria to distinguish the role of bicarbonate.
10 rganic cofactor biotin for the activation of bicarbonate.
11 binding site for the physiological activator bicarbonate.
12 pidly the interconversion of aqueous CO2 and bicarbonate.
13 oteins, whereas sAC is uniquely activated by bicarbonate.
14 ding is strongly enhanced by the presence of bicarbonate.
15 annel for small anions, such as chloride and bicarbonate.
16 via a neuronal activity-dependent release of bicarbonate.
17 was completely dependent on the presence of bicarbonate.
18 tural abundance, in inorganic carbonates and bicarbonates.
19 ity interval exercise trial following either bicarbonate (0.40 g/kg) or placebo ingestion in a double
20 per 1.73 m(2)) and metabolic acidosis (serum bicarbonate 12-20 mmol/L), who had completed the 12-week
21 vate ratio but had no effect on the [1-(13)C]bicarbonate + (13)CO2:[1-(13)C]pyruvate ratio, an index
23 M-NanoSIMS) isotopic imaging to study (13) C-bicarbonate, (15) N-ammonium and (34) S-sulfate uptake.
25 74g.L(-1)), hydrogen peroxide (21.0g.L(-1)), bicarbonate (4.0g.L(-1)), carbonate (4.0g.L(-1)), chlori
26 s evidenced by significant changes in [(13)C]bicarbonate (-48%), [1-(13)C]acetylcarnitine (+113%), an
28 und that AE2 deficiency led to intracellular bicarbonate accumulation and increased expression and ac
30 justed odds ratio, 0.07; 95% CI, 0.06-0.08), bicarbonate (adjusted odds ratio, 2.0; 95% CI, 1.8-2.3),
31 ion with 0.9% sodium chloride or 1.4% sodium bicarbonate administered with the same infusion protocol
34 ous electrolytes (ammonium acetate, ammonium bicarbonate, ammonium formate, and piperidine) was studi
37 reactivity of aqueous U and As mixtures with bicarbonate and Ca for acidic and neutral pH conditions.
38 7 was observed in reactors containing 10 mM bicarbonate and Ca, suggesting a kinetic reaction of aqu
41 r 1 (AE1) is responsible for the exchange of bicarbonate and chloride across the erythrocyte plasma m
45 trations of inorganic forms of carbon (i.e., bicarbonate and CO2) in order to improve the efficiency
46 carboxysomes play key roles in accumulating bicarbonate and CO2, but other regulatory elements of ca
47 Biophysical CCMs operate by concentrating bicarbonate and converting it into CO(2) in a compartmen
50 aled that manganese uptake depends on pH and bicarbonate and is up-regulated by lipopolysaccharide, a
54 y ion mass spectrometry combined with (13)C (bicarbonate and propionate) and (15)N-ammonia isotope la
56 ed mode chromatography with aqueous ammonium bicarbonate and pyridine buffer solutions as mobile phas
57 s with the observed zero-order dependence in bicarbonate and simulated interfacial concentration grad
59 effective complexation of chloride, nitrate, bicarbonate and sulfate anions via hydrogen bonding.
60 ined as the difference between the converted bicarbonate and the initial carbonate concentration.
61 e of aqueous sample was buffered with sodium bicarbonate and treated with triethyloxonium tetrafluoro
62 applied to soluble inorganic carbonates and bicarbonates and then extended to insoluble carbonates b
63 otal bile production, biliary bilirubin, and bicarbonate), and significantly lowered levels of lactat
65 CPC), hydrogen peroxide (H(2) O(2) ), sodium bicarbonate, and antioxidants on periodontal/oral health
68 ium, thiosulfate, sulfate, sulfite, sulfide, bicarbonate, and other macromolecule-stabilizing (kosmot
70 ined the (13)C/(12)C ratio of carbonates and bicarbonates ( approximately 50-100 mg) with a precision
73 h we name DabA and DabB, for DABs accumulate bicarbonate-assemble into a heterodimeric complex, which
74 the digests were eluted with 200 mM ammonium bicarbonate at pH 8.2 for CZE-MS/MS analysis using 1 M a
75 be a unique type of PII protein that senses bicarbonate availability, consistent with its apparent g
77 ery of oil bodies from rapeseed using sodium bicarbonate-based soaking and grinding media (pH 9.5) wa
79 P=0.003), sodium (beta=0.101; P=0.006), and bicarbonate (beta=0.094; P=0.009) were associated with h
80 g; P = .25), although daily changes of serum bicarbonate (between-group difference, -0.8 mEq/L; 95% C
81 tly higher ratios of [1-(13)C] lactate (Lac)/bicarbonate (Bicar) and [1-(13)C] Lac/total carbon (tC),
82 (kosmotropic), whereas ammonium formate and bicarbonate (both chaotropic) caused structural changes.
83 Protein analysis was done using ammonium bicarbonate buffer and size exclusion chromatography (SE
85 racellular fluid pH under OA by accumulating bicarbonate but exhibited a slight alkalosis in response
86 and SbtA, where BicA has a low affinity for bicarbonate but high flux rate, and SbtA has a high affi
88 ociated with chloride, sodium, potassium and bicarbonate by running linear mixed models adjusting for
89 asopressin, amiodarone, lidocaine, atropine, bicarbonate, calcium, magnesium, and dextrose each year
90 des inhibit the function of the chloride and bicarbonate channel CFTR, causing intestinal cell stress
91 e Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is act
92 K activity, and both were reduced by sodium bicarbonate co-transporter (P </= 0.0001) and carbonic a
93 on, they modulate the activity of the sodium-bicarbonate co-transporter, leading to a hyperpolarizati
94 hydrogen ion exporters, particularly sodium bicarbonate co-transporters and carbonic anhydrases, whi
95 energy profiles of the metabolic substrates, bicarbonate, CO(2) and ribulose bisphosphate and the pro
96 CA) is a key constituent of the universal CA/bicarbonate/CO(2) buffer maintaining the pH of both bloo
97 n, sAC acts as a physiological sensor for pH/bicarbonate/CO2, and it has been implicated as a therape
98 iron, as iron chelation combined with sodium bicarbonate completely protected endothelial cells from
103 e of 4 mmol/L or more from baseline in serum bicarbonate concentration or serum bicarbonate in the no
104 y ammonium excretion was 25% lower and serum bicarbonate concentration was 1.3 meq/L higher in HD-NaH
108 at week 52 (63% vs 38%, p=0.0015) and higher bicarbonate concentrations were observed with veverimer
109 out of astrocytes by the electrogenic sodium bicarbonate cotransporter (NBCe1) played a crucial role
110 (NBCe1 and NBCe2), the electroneutral sodium-bicarbonate cotransporter (NBCn1), and the sodium-depend
113 S695T - and included the electrogenic sodium-bicarbonate cotransporter isoforms 1 and 2 (NBCe1 and NB
115 des the widely-expressed electrogenic sodium bicarbonate cotransporter NBCe1, results in the bicarbon
117 racterize Fe plaque using dithionite-citrate-bicarbonate (DCB) extraction and elemental analysis reve
118 of BCCP-BADC-BC subcomplexes catalyzing the bicarbonate-dependent hydrolysis of ATP, which is the fi
125 emisorbed CO(2) species (e.g., alkylammonium bicarbonate, ditethered carbamic acid and silylpropylcar
126 ular pH (mean, 6.96 +/- 0.05; P = .02) using bicarbonate during TACE increased peri- and intratumoral
130 ible compared to manually prepared carbonate-bicarbonate eluents and with considerable savings in tim
135 tly regulates the intercalated cell chloride/bicarbonate exchanger pendrin is unclear, as are potassi
139 ed that PDK-deficient livers produce more HP-bicarbonate from HP-[1-(13)C]pyruvate than age-matched c
142 values were associated with low BDI: biliary bicarbonate greater than 18 mmol/L (P = 0.002), biliary
143 saline group and 53 patients (35.1%) in the bicarbonate group (absolute risk difference, -1.8%; 95%
145 in 110 of 2511 patients (4.4%) in the sodium bicarbonate group as compared with 116 of 2482 (4.7%) in
147 on veverimer than placebo had an increase in bicarbonate (>=4 mmol/L or normalisation) at week 52 (63
149 ous acid production, and serum potassium and bicarbonate), hazard ratios of the composite outcome of
152 ifferent concentrations (1, 3, and 10 mM) of bicarbonate (HCO3(-)) under light and dark conditions.
155 (80 Torr), +/- tromethamine (THAM) or sodium bicarbonate (HCO3) +/- AC probes in a micropuncture mode
156 ese data are consistent with the presence of bicarbonate, HCO3(-), since it is commonly observed at a
158 ne and sulfate and production of sulfide and bicarbonate, (ii) methane loss coupled to production of
159 t that disrupting pH homeostasis by blocking bicarbonate import might broadly relieve the common resi
160 hich is then exchanged for urea and ammonium bicarbonate in a centrifugal filter, before treating wit
161 tosynthesis in many aquatic plants relies on bicarbonate in addition to carbon dioxide (CO(2)) to com
162 e-mediated process, particularly the role of bicarbonate in increasing CO2 reduction rates, is still
163 rapid interconversion of carbon dioxide and bicarbonate in the cells, where carbon dioxide is produc
165 in serum bicarbonate concentration or serum bicarbonate in the normal range of 22-29 mmol/L, assesse
167 nd 1000 K indicate a higher concentration of bicarbonates in water than previously considered at cond
169 ectroscopies (XAS) show that the addition of bicarbonate increased manganese retention but decreased
170 conversion of (13)C1-pyruvate to lactate and bicarbonate, indicating active glycolytic and OxPhos met
175 ever, the underlying mechanisms of action of bicarbonate intake on skeletal muscle metabolism have ye
178 bonic anhydrase 4 catalyzes the formation of bicarbonate ions (HCO[Formula: see text]), for accumulat
179 ngle components of pancreatic juice, such as bicarbonate ions and calcium carbonate crystals, induce
189 vate via PDH (pyruvate dehydrogenase, [(13)C]bicarbonate), lactate dehydrogenase ([1-(13)C]lactate),
191 We suggest that: 1) clinicians use a serum bicarbonate level <27 mmol/L to exclude the diagnosis of
192 ltinomial logistic regression model, a serum bicarbonate level less than 10 mEq/L (compared with >/=1
193 ; PO(2), 89 mmHg; normal range, 75-100 mmHg; bicarbonate level, 17 mEq/L [17 mmol/L]; normal range 22
195 with epidermal growth factor (EGF) and that bicarbonate levels directly correlate with the extent of
196 could identify patients with CKD and normal bicarbonate levels who might benefit from alkali before
202 e rat lenses cultured for 48 hours in TC-199 bicarbonate media through physical trauma, 10 mM ouabain
203 Notably, neutralizing tumor acidity with bicarbonate monotherapy impaired the growth of some canc
204 inary ammonium excretion and increased serum bicarbonate more than the lower dose but was associated
205 arterial pH generated by infusion of sodium bicarbonate (NaHCO(3) ), and completely abrogated by a c
207 line, statin, N-acetylcysteine (NAC), sodium bicarbonate (NaHCO3), NAC+NaHCO3, ascorbic acid, xanthin
208 remote basic site in the anion namely, OH of bicarbonate, NH of prolinate, and activated water in the
211 iography to receive intravenous 1.26% sodium bicarbonate or intravenous 0.9% sodium chloride and 5 da
213 SS (Kcnj16-/-) rats chronically treated with bicarbonate or the carbonic anhydrase inhibitor hydrochl
214 , there was no benefit of intravenous sodium bicarbonate over intravenous sodium chloride or of oral
215 rlier acid-base indicator of risk than serum bicarbonate, particularly in patients without acidosis.
216 and As mixtures, 10 mM Ca, and without added bicarbonate (pCO(2) = 3.5), aqueous U decreased to <0.25
217 tridges with solutions of tetraethylammonium bicarbonate, perchlorate or tosylate in polar aprotic so
218 evidence that pore dilatation increases the bicarbonate permeability (P HC O3/ Cl ) of anion channel
223 w baseline chloride was associated with high bicarbonate, poor diuretic response, less hemoconcentrat
226 the hypothesis that impeding the reuptake of bicarbonate produced extracellularly by CA9 could exacer
227 Immunoblotting experiments confirmed that HP-bicarbonate production from HP-[1-(13)C]pyruvate paralle
228 ular experiments revealed that intracellular bicarbonate proportionally dictates total protein phosph
229 d L-lactate, showing that CanB is crucial in bicarbonate provision for pyruvate carboxylase-mediated
230 renal function, the benefit of using sodium bicarbonate rather than isotonic sodium chloride for pre
232 re produced by ambient drying using ammonium bicarbonate, rather than a conventional low surface tens
233 e 60 minutes after occlusion, the lactate-to-bicarbonate ratio in the AAR recovered but was still ele
241 mulates the exocrine pancreatic secretion of bicarbonate-rich fluid from the acinar cells of the panc
242 e device permitting detection of the eluting bicarbonate salt conductometrically in a background of n
243 increase with the concentration of ammonium bicarbonate salts from 360 to 530 m(2) g(-1), and that o
244 activity-dependent release of ATP triggering bicarbonate secretion by astrocytes via activation of me
246 estinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detoxifies lipopolysaccharide (LP
247 stinal (GI) tract CFTR promotes chloride and bicarbonate secretion, playing an essential role in ion
251 ative AEC CO(2) sensor and effector as it is bicarbonate sensitive and controls key mediators of AEC
256 g of the downstream metabolites showed (13)C-bicarbonate signal mainly confined to the left ventricul
257 rized [1-(13)C]pyruvate, the resulting (13)C-bicarbonate signal was found to be 24 +/- 6% lower in th
259 co-occurring oxo-anions (phosphate, sulfate, bicarbonate, silicate, and nitrate) were selected due to
261 lusion of the base (in situ generated sodium bicarbonate/sodium biphosphate) is found to be energetic
262 molarity of medium used; the use of a sodium bicarbonate solution (pH 9.5, 0.1M) in the grinding and
264 ncludes transport of carbon dioxide, oxygen, bicarbonate, sucrose/glucose, bacteria, and autoinducer-
265 be inefficient conversion of gaseous CO2 to bicarbonate, the required substrate of various carboxyla
266 intestinal lumen, unlike current oral sodium bicarbonate therapy for metabolic acidosis that only neu
269 at least one third of all astrocytes release bicarbonate to buffer extracellular H(+) loads associate
273 injured hemisphere, while the hyperpolarized bicarbonate-to-lactate ratio was 33 +/- 8% lower in the
277 ting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial
278 xpression and function of the Sodium-Coupled Bicarbonate Transporter (NCBT) family of base loaders we
283 a small-molecule inhibitor of sodium-driven bicarbonate transporters, increased apoptosis in the cel
284 rs associated with strenuous exercise and/or bicarbonate treatment responses, whereas structural eluc
290 at was not statistically significant: sodium bicarbonate versus IV saline in patients receiving low-o
291 eGFR was 36+/-9 ml/min per 1.73 m(2), serum bicarbonate was 24+/-2 meq/L, and median (IQR) ACR was 1
293 The conversion of pyruvate into lactate and bicarbonate was imaged by using dedicated MR sequences a
294 arbonate cotransporter NBCe1, results in the bicarbonate-wasting disease proximal renal tubular acido
295 ction and biliary secretion of bilirubin and bicarbonate were significantly higher after HMP, compare
297 carcinoma cell line A431, we discovered that bicarbonate, which reacts with H(2)O(2) to form the more
298 active uptake of CO2 (70% contribution) and bicarbonate, while at high CO2 , cells were restricted t
299 )C isotope ratio in inorganic carbonates and bicarbonates with applications in different fields, such