ライフサイエンスコーパス: bicuspid aortic valve

1 women, 161 (46%) had either a unicuspid or a bicuspid aortic valve.

2 ying aortic valve abnormalities as seen with bicuspid aortic valve.

3 center, 245 patients were identified to have bicuspid aortic valve.

4 on are common complications in patients with bicuspid aortic valve.

5 cardiovascular specialist after diagnosis of bicuspid aortic valve.

6 lterations from 4D flow MRI in patients with bicuspid aortic valve.

7 ing may improve clinical outcomes of TAVR in bicuspid aortic valve.

8 eneration Evolut R/PRO or Sapien 3 valves in bicuspid aortic valve.

9 ociated cardiac malformation that included a bicuspid aortic valve.

10 ne had truncus arteriosus, and another had a bicuspid aortic valve.

11 yzed by microscopy to identify tricuspid and bicuspid aortic valves.

12 stify surgical intervention in patients with bicuspid aortic valves.

13 ysms (maximal diameter > 4.0 cm), and 10 had bicuspid aortic valves.

14 ng aorta with ventricular septal defect, and bicuspid aortic valves.

15 the development of atrial septal defects and bicuspid aortic valves.

16 ith Loeys-Dietz syndrome, 2 women (10%) with bicuspid aortic valves, 2 women (10%) with a family hist

17 ); partially fused aortic valve, 12% (n=25); bicuspid aortic valve, 23% (n=47); and unicuspid aortic

18 yndrome (21.5% versus 3.1%; P<0.001) but not bicuspid aortic valve (3.6% versus 3.2%; P=0.77).

19 randomized clinical trial, 220 patients with bicuspid aortic valve (43 women; 46+/-13 years of age) w

20 ression) and, as a clinical correlate, human bicuspid aortic valves (63% reduction).

21 rison, outcomes of 13,205 adults (2,079 with bicuspid aortic valves, 73 with Marfan syndrome, and 11,

22 xcluding individuals with Marfan syndrome or bicuspid aortic valve, a family history of AD was associ

23 Patients with bicuspid aortic valves also showed significantly increas

24 ers, and congenital heart disease, including bicuspid aortic valve, among others.

25 The aim of the BAVARD (Bicuspid Aortic Valve Anatomy and Relationship With Devi

26 th Sapien 3 and Evolut R/PRO implantation in bicuspid aortic valve anatomy; a higher rate of moderate

27 -dominant aortic valve disease consisting of bicuspid aortic valve and aortic valve calcification was

28 In patients with bicuspid aortic valve and dilated proximal ascending aor

29 n reducing the growth of aortic diameters in bicuspid aortic valve and if it slows the progression of

30 One had baseline bicuspid aortic valve and mild aortic regurgitation that

31 In the community, asymptomatic patients with bicuspid aortic valve and no or minimal hemodynamic abno

32 zygous Mib1 Cep192 Tmx3;Bcl7a mice developed bicuspid aortic valve and other valve-associated defects

33 ient-specific computer simulation of TAVR in bicuspid aortic valve and to determine whether patient-s

34 s imply higher energy losses associated with bicuspid aortic valves and dilated ascending aortic geom

35 e risk of aortic dissection in patients with bicuspid aortic valves and severe aortic enlargement: th

36 ar septal defects, patent ductus arteriosus, bicuspid aortic valve, and coarctation of the aorta as w

37 ts were more likely to have Marfan syndrome, bicuspid aortic valve, and prior aortic surgery (all, p

38 ch1, or RBPJ displayed enlarged valve cusps, bicuspid aortic valve, and septal defects, indicating th

39 rbidities, including prevalent hypertension, bicuspid aortic valve, and the Marfan syndrome.

40 Partially fused aortic valve, bicuspid aortic valve, and unicuspid aortic valve were s

41 isk factors for dissection: Marfan syndrome, bicuspid aortic valves, and larger aortic dimensions.

42 paroxysmal, persistent, or chronic AF, with bicuspid aortic valves, and patients who died within 48

43 n criteria were connective tissue disorders, bicuspid aortic valves, and survivors of a prior AAE.

44 Making the decision regarding the timing of bicuspid aortic valve aneurysm surgery even more difficu

45 n the physiopathologic processes involved in bicuspid aortic valve aortopathy.

46 ding thoracic aortic aneurysm resection with bicuspid aortic valve aortopathy.

47 Bicuspid aortic valves are associated with valve dysfunc

48 Patients with bicuspid aortic valve (AV) stenosis were excluded from t

49 Bicuspid aortic valve (BAV) (39%) and Marfan syndrome (M

50 tic hemodynamics, with separate networks for bicuspid aortic valve (BAV) (994 in the training set and

51 o the presence of other risk factors such as bicuspid aortic valve (BAV) and hypertension.

52 A shared genetic basis for familial bicuspid aortic valve (BAV) and hypoplastic left heart s

53 Both bicuspid aortic valve (BAV) and Marfan syndrome have bee

54 ic valve replacement (SAVR) in patients with bicuspid aortic valve (BAV) aortic stenosis (AS) versus

55 ay a role contributing to the progression of bicuspid aortic valve (BAV) aortopathy.

56 The prevalence and characteristics of bicuspid aortic valve (BAV) are mainly reported from sel

57 tic valve (TAV) replacement in patients with bicuspid aortic valve (BAV) disease (TAV-in-BAV).

58 The correlation between bicuspid aortic valve (BAV) disease and aortopathy is no

59 ar ejection fraction (LVEF) in patients with bicuspid aortic valve (BAV) disease has not been previou

60 Bicuspid aortic valve (BAV) disease is a congenital defe

61 Bicuspid aortic valve (BAV) disease is frequently accomp

62 Ascending aortic dilation is important in bicuspid aortic valve (BAV) disease, with increased risk

63 Familial clustering of HLHS and bicuspid aortic valve (BAV) has been observed, and pedig

64 Patients with bicuspid aortic valve (BAV) have a higher risk of develo

65 al tricuspid aortic valve (TAV) in 172 and a bicuspid aortic valve (BAV) in 66 subjects.

66 Bicuspid aortic valve (BAV) is a common congenital heart

67 Bicuspid aortic valve (BAV) is a heritable condition tha

68 Bicuspid aortic valve (BAV) is a heritable congenital he

69 determine whether the morphologic subtype of bicuspid aortic valve (BAV) is associated with valve int

70 Importance: Bicuspid aortic valve (BAV) is considered an autosomal d

71 Bicuspid aortic valve (BAV) is regarded as a relative co

72 Bicuspid aortic valve (BAV) is the most common adult con

73 Bicuspid aortic valve (BAV) is the most common congenita

74 Bicuspid aortic valve (BAV) is the most common congenita

75 Bicuspid aortic valve (BAV) is the most common congenita

76 Bicuspid aortic valve (BAV) is the most prevalent congen

77 Thoracic aortic disease and bicuspid aortic valve (BAV) likely have a heritable comp

78 ittle is known about the association between bicuspid aortic valve (BAV) morphologic findings and the

79 increase in the proportion of patients with bicuspid aortic valve (BAV) morphology as the age of the

80 ltered ascending aorta (AAo) hemodynamics in bicuspid aortic valve (BAV) patients and its association

81 tic root in first-degree relatives (FDRs) of bicuspid aortic valve (BAV) patients.

82 This large multicenter, international bicuspid aortic valve (BAV) registry aimed to define the

83 The bicuspid aortic valve (BAV) represents a complex anatomi

84 d to increased use of TAVR for patients with bicuspid aortic valve (BAV) stenosis despite the exclusi

85 Participants with bicuspid aortic valve (BAV) with aneurysm (n = 879), Mar

86 s with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV), and healthy controls.

87 y who also exhibited LVOT defects, including bicuspid aortic valve (BAV), coarctation of the aorta (C

88 evelops in most patients with a congenitally bicuspid aortic valve (BAV), in others with this anomaly

89 dies have established familial clustering of bicuspid aortic valve (BAV), presumably indicating genet

90 Dcbld2(-/-) mice have a high prevalence of bicuspid aortic valve (BAV), spontaneous aortic valve ca

91 Bicuspid aortic valve (BAV), the most common congenital

92 randomized, controlled trials have excluded bicuspid aortic valve (BAV), which is the most frequent

93 RATIONALE: The pathogenesis of bicuspid aortic valve (BAV)-associated aortopathy is poo

94 flow alterations in patients with congenital bicuspid aortic valve (BAV).

95 complex aortic valve anatomies, such as the bicuspid aortic valve (BAV).

96 efined compared to Marfan syndrome (MFS) and bicuspid aortic valve (BAV).

97 te the genetic relationship between HLHS and bicuspid aortic valve (BAV).

98 tion in the ascending aorta in patients with bicuspid aortic valves (BAV) have influenced strategies

99 r transcatheter aortic valve implantation in bicuspid aortic valves (BAV) remains controversial.

100 ic aortic aneurysms (ATAAs) in patients with bicuspid aortic valves (BAV) versus patients with tricus

101 Bicuspid aortic valves (BAVs) are associated with premat

102 Explanted, stenotic bicuspid aortic valves (BAVs) from pediatric patients we

103 first-degree relatives (FDR) of people with bicuspid aortic valves (BAVs).

104 idney and cardiovascular malformation (i.e., bicuspid aortic valve, bicuspid aortic valve with coarct

105 Bicuspid aortic valves calcify at a significantly higher

106 s, left ventricular noncompaction (LVNC) and bicuspid aortic valve, can be caused by a set of inherit

107 ith Marfan syndrome compared with those with bicuspid aortic valves confirm that operative management

108 Severe calcification of a congenital bicuspid aortic valve continues to be an important cause

109 fibrillation, and had a higher prevalence of bicuspid aortic valve, diabetes, and peripheral vascular

110 rtic disease, peripheral artery disease, and bicuspid aortic valve disease have been updated with new

111 rtic disease, peripheral artery disease, and bicuspid aortic valve disease have been updated with new

112 ng aortic aneurysm surgery in the setting of bicuspid aortic valve disease is complex, with multiple

113 oracic aortopathy after AVR in patients with bicuspid aortic valve disease is substantially different

114 aortic disease such as the Marfan syndrome, bicuspid aortic valve disease, and hereditary aortic ane

115 h aortic regurgitation, and in patients with bicuspid aortic valve disease.

116 uses underdeveloped aortic root leading to a bicuspid aortic valve due to the absence of non-coronary

117 Because we have previously found that bicuspid aortic valve experience greater stretch, we inv

118 ndocardial genes whose inactivation leads to bicuspid aortic valve formation and calcific aortic valv

119 In patients with bicuspid aortic valves, guidelines call for regular foll

120 hymal transition, and NOTCH1 mutations cause bicuspid aortic valve; however, the temporal requirement

121 e heterozygous MIB1 missense allele leads to bicuspid aortic valve in a NOTCH-sensitized genetic back

122 lities, including Marfan's syndrome in four, bicuspid aortic valve in four, and aortitis in one.

123 co-segregating with tetralogy of Fallot and bicuspid aortic valve in maternal relatives (p.Tyr2819Te

124 shared genetic substrate underlying LVNC and bicuspid aortic valve in which MIB1-NOTCH variants plays

125 t to abnormalities (such as Marfan syndrome, bicuspid aortic valve, inflammatory vasculitis, atherosc

126 Bicuspid aortic valve is frequent and is reported to cau

127 Bicuspid aortic valve is frequently an antecedent to aor

128 1,000 live births if the potentially serious bicuspid aortic valve is included), and of all forms inc

129 Bicuspid aortic valve is the most common congenital hear

130 Bicuspid aortic valve is the most common type of cardiac

131 similar to the pattern seen in nonsyndromic bicuspid aortic valve, is equally prevalent (20-30%) in

132 addition, another 20/1,000 live births have bicuspid aortic valves, isolated anomalous lobar pulmona

133 ient-specific computer simulation of TAVR in bicuspid aortic valve may predict the development of imp

134 iseases, including calcific aortic stenosis, bicuspid aortic valves, mitral valve prolapse, and rheum

135 tricuspid aortic valves (n = 27), calcified bicuspid aortic valves (n = 23), and control tissue from

136 Nonsyndromic bicuspid aortic valve (nsBAV) is the most common congeni

137 Bicuspid aortic valve occurs in 1% of the population, ma

138 In addition, bicuspid aortic valve occurs in more than one-half of th

139 Bicuspid aortic valve (odds ratio [OR], 2.20; 95% CI, 1.

140 R, 1.11; 95% CI, 1.07-1.15), patients with a bicuspid aortic valve (OR, 1.09; 95% CI, 1.05-1.13), in-

141 85), ventricular septal defect (P=0.12), and bicuspid aortic valve (P=0.14) did not carry an increase

142 METHODS AND We studied 969 consecutive bicuspid aortic valve patients (50+/-13 years; 87% men)

143 retrospective study was performed on TAVR in bicuspid aortic valve patients that had both pre- and po

144 In bicuspid aortic valve patients with dilated proximal asc

145 survival both for tricuspid aortic valve and bicuspid aortic valve patients, with the latter being si

146 urther obstructs left ventricular outflow in bicuspid aortic valve patients.

147 with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population.

148 Bicuspid aortic valves present distinct anatomical and p

149 m that operative management of patients with bicuspid aortic valves should not be extrapolated from M

150 placement in low-surgical risk patients with bicuspid aortic valve stenosis achieved favorable 30-day

151 Eligible patients had severe bicuspid aortic valve stenosis and met American Heart As

152 replacement (TAVR) in low-risk patients with bicuspid aortic valve stenosis have not been studied in

153 (Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valv

154 s self-expandable valve for the treatment of bicuspid aortic valve stenosis) registry included 353 co

155 The use of TAVI in severe bicuspid aortic valve stenosis, asymptomatic severe aort

156 rates of Marfan syndrome and lower rates of bicuspid aortic valve than those undergoing bio-CVG or m

157 neurysmal progression in Npr2(+/-) mice with bicuspid aortic valves than those with tricuspid valves.

158 Furthermore, pediatric stenotic bicuspid aortic valves that have lost normal extracellul

159 tic valve, partially fused aortic valve, and bicuspid aortic valve+unicuspid aortic valve, respective

160 ricle, aberrant semilunar valve development, bicuspid aortic valve, ventricular septal defects, and e

161 Bicuspid aortic valve was associated with more intense h

162 County, Minn (age, 32+/-20 years; 65% male), bicuspid aortic valve was diagnosed between 1980 and 199

163 Bicuspid aortic valve was diagnosed in 227 patients (73.

164 During cardiac surgery, a congenital bicuspid aortic valve was found to be the predisposing f

165 Follow-up care for patients with bicuspid aortic valve was highly variable, and surveilla

166 Bicuspid aortic valve was identified in 74 individuals (

167 ortic aneurysms variably associated with the bicuspid aortic valve was used for identification of add

168 Bicuspid aortic valve, whereby the aortic valve forms wi

169 rm and ectoderm caused glandular defects and bicuspid aortic valve, which indicates that the FGF8 end

170 r malformation (i.e., bicuspid aortic valve, bicuspid aortic valve with coarctation of the aorta, or

171 ve since expanded the eligible population to bicuspid aortic valve with feasible anatomy; small aorti

172 Incompetent bicuspid aortic valves with dilated aortic annuli are al

173 Bicuspid aortic valves with raphe had a significantly hi

174 of mice heterozygous for Npr2 had congenital bicuspid aortic valves, with worse aortic valve function

175 Among patients with bicuspid aortic valve without severe valvular dysfunctio